Recent Advances of Poly(ester amide)s-Based Biomaterials

Biodegradable and biocompatible biomaterials have offered much more opportunities from an engineering standpointfor treating diseases and maintaining health. Poly(ester amide)s (PEAs), as an outstanding family among such biomaterials, haverisen overwhelmingly in the past decades. These synthetic polymers have easily and widely available raw materials and a diversity ofsynthetic approaches, which have attracted considerable attention. More importantly, combining the superiorities of polyamides andpolyesters, PEAs have emerged with better functions. They could have improved biodegradability, biocompatibility, and cell-material interactions. The PEAs derived from alpha-amino acids even allow the introduction of pendant sites for further modification orfunctionalization. Meanwhile, it is gradually recognized that the chemical structures are closely related to the physiochemical andbiological properties of PEAs so that their properties can be precisely controlled. PEAs therefore become significant materials in thebiomedicalfields. This review will attempt to summarize the recent progress in the development of PEAs with respect to thepreparation materials and methods, structure-property relationships along with their latest biomedical accomplishments, especially for drug delivery and tissue engineering

Automated summary

Biodegradable and biocompatible poly(ester amide) biomaterials offer great opportunities in disease treatment and health maintenance. These materials, with easily available raw materials and diverse synthetic approaches, combine the advantages of polyamides and polyesters, resulting in improved functions and controllable properties.