Article
Multidisciplinary Sciences
Chor Hong Lim, Tomoko Soga, Ishwar S. Parhar
Summary: Social disturbance in interpersonal relationships is a primary source of stress in humans. This study investigated the regulatory relationship between the central 5-HT system and SPX1a gene expression in Nile tilapia. The results showed that 5-HT can down-regulate the expression of SPX1a, and socially defeated tilapia exhibited increased SPX1a expression and up-regulated 5-HT receptors. Citalopram treatment normalized SPX1a gene expression in socially defeated fish.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Pharmacology & Pharmacy
Andy Tran, Wenyuan He, Jim T. C. Chen, Denise D. Belsham
Summary: This review discusses the involvement of spexin in the hypothalamic control of energy homeostasis and reproduction, as well as the disorders and treatments related to energy homeostasis and reproduction that alter spexin expression. The review also explores the biochemical basis of spexin, its interaction with its cognate receptors, and the potential for developing therapeutics for energy homeostasis and reproductive disorders.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Endocrinology & Metabolism
Izzati Mohd Zahir, Satoshi Ogawa, Nisha Angela Dominic, Tomoko Soga, Ishwar S. Parhar
Summary: Research has shown that SPX and GAL play important roles in energy regulation, reproduction, stress, and social behaviors. SPX acts as an appetite suppressant and anxiolytic factor, while GAL acts as an orexigenic factor and has varying effects on depression. These findings are significant for understanding the physiological functions of neuropeptides.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Ping Yu, Jing Luo, Huahua Song, Tianwei Qian, Xuan He, Jie Fang, Wenpei Dong, Xiaolan Bian
Summary: N-acetylcysteine (NAC) has a protective effect against nephrotoxicity induced by vancomycin (VCM) by inhibiting oxidative stress and apoptosis via the P38 MAPK/JNK pathway.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Amira M. Badr, Layla A. Al-Kharashi, Hala Attia, Samiyah Alshehri, Hanaa N. Alajami, Rehab A. Ali, Yasmen F. Mahran
Summary: The study aimed to investigate the protective effects of N-acetylcysteine (NAC) and chlorogenic acid (CGA) against cisplatin (Cp)-induced nephrotoxicity. The results showed that Cp can lead to renal dysfunction, oxidative stress, inflammatory response, and cell apoptosis. NAC and CGA were found to protect the kidney from Cp-induced damage by inhibiting inflammation and oxidative stress pathways.
Article
Biochemistry & Molecular Biology
Tuba Yalcin, Sercan Kaya, Tuncay Kuloglu, Akin Yigin
Summary: This study aimed to determine whether N-acetylcysteine (NAC) may reduce AL-induced oxidative stress, inflammation, and germ cell apoptosis in testicular tissues and its effects on METRNL levels. It was found that AL exposure caused histomorphometric and histopathological changes, oxidative stress, apoptosis of germ cells, and inflammation in testicular tissues. Additionally, AL caused an increase in METRNL levels. NAC treatment significantly reduced the negative effects of AL and may serve as a protective strategy in reproductive toxicity due to AL exposure.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Behavioral Sciences
Shermel B. Sherman, Mitchell Harberson, Rebecca Rashleigh, Niraj Gupta, Riley Powers, Ramya Talla, Ashima Thusu, Jennifer W. Hill
Summary: This study found that the novel neuropeptide spexin has a regulatory role in thermoregulatory behaviors and adipose tissue metabolism in female mice. Supraphysiological levels of spexin treatment did not lead to weight loss, but increased nest building behavior and disrupted the thermogenic profile of adipose tissue.
HORMONES AND BEHAVIOR
(2022)
Review
Endocrinology & Metabolism
Edouard G. Mills, Chioma Izzi-Engbeaya, Ali Abbara, Alexander N. Comninos, Waljit S. Dhillo
Summary: Bioactive peptides galanin, spexin and kisspeptin share a common ancestral origin and play crucial roles in metabolism, pancreatic beta-cell function, energy homeostasis, mood and behavior. Therapeutic interventions targeting these peptides' signaling pathways may offer potential treatments for conditions ranging from obesity to mood disorders, but further research is needed to address gaps and controversies in their therapeutic potential.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Petr Mlejnek
Summary: In laboratory experiments, many cytotoxic agents induce cell death accompanied by reactive oxygen species (ROS) production and/or depletion of glutathione (GSH). N-acetylcysteine (NAC), used as a ROS scavenger and precursor of GSH biosynthesis, can inhibit ROS production, restore GSH levels, and prevent cell death. However, NAC has limitations in interacting with important ROS and is used at unnecessarily high concentrations. The possibility of NAC directly interacting with cytotoxic electrophiles to form non-cytotoxic adducts is often overlooked, despite being a common protective mechanism.
Article
Biochemistry & Molecular Biology
Ahmed Fareed Alkandari, Sampath Madhyastha, Muddanna S. Rao
Summary: Oxidative stress and depletion of glutathione play a crucial role in the onset and progression of Alzheimer's disease. N-Acetylcysteine amide (NACA), a form of glutathione precursor, has extended bioavailability and shows neuroprotective effects in AD animal models. This study investigates the potential neuroprotective effects of NACA against AD-like pathology induced by Aβ1-42 peptide in rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Tsvetelina Petkova, Aneliya Milanova
Summary: The study characterized the population pharmacokinetics of orally administered N-acetylcysteine (NAC) in broilers, showing that NAC was absorbed in all experimental chickens and reached maximum plasma concentrations in healthy chickens at 2.47±0.45 hours after dosing. The population pharmacokinetic analysis indicated no need for dose adjustment of NAC in M. gallisepticum-infected broilers or when combined with doxycycline.
VETERINARY SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Micaely Cristina dos Santos Tenorio, Nayara Gomes Graciliano, Fabiana Andrea Moura, Alane Cabral Menezes de Oliveira, Marilia Oliveira Fonseca Goulart
Summary: NAC is a widely used medication for treating paracetamol overdose and inflammatory diseases, known for its safety and antioxidant/anti-inflammatory effects. Its mechanisms of action include increasing intracellular glutathione levels and suppressing inflammatory cytokines.
Article
Biochemistry & Molecular Biology
Marta Pelczynska, Aniceta Ada Mikulska, Krystyna Czyzewska, Pawel Bogdanski, Teresa Grzelak
Summary: The study suggests that lower NPQ concentration may be associated with obesity-related metabolic syndrome, while CHEM shows no significant correlations with cardiometabolic risk factors. Total muscle mass has an impact on NPQ concentration in the population.
Article
Biochemistry & Molecular Biology
Priyanka N. Bushana, Michelle A. Schmidt, Kevin M. Chang, Trisha Vuong, Barbara A. Sorg, Jonathan P. Wisor
Summary: Non-rapid eye movement sleep (NREMS) is associated with decreased cerebral metabolism, decreased oxidative stress, and the importance of timing antioxidant administration relative to sleep/wake cycles in brain disorders.
Article
Biochemistry & Molecular Biology
Mehmet Kaan Kaya, Sermal Arslan
Summary: This study investigated the levels of circulating molecules TMAO, PNX, ALA, and SPX in ACSCR patients and found a correlation between these molecules and visual acuity and macular thickness. These molecules hold promise as potential diagnostic, therapeutic, and follow-up markers in ACSCR.
Review
Pharmacology & Pharmacy
Regis Bouquie, Guillaume Deslandes, Helene Mazare, Marion Cogne, Julien Mahe, Matthieu Gregoire, Pascale Jolliet
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2018)
Article
Reproductive Biology
Mehmet Bozkurt Ataman, Hasan Huseyin Donmez, Nurcan Doenmez, Emrah Sur, Mustafa Numan Bucak, Kenan Coyan
Article
Biotechnology & Applied Microbiology
H. H. Donmez, N. Donmez, I. Kisadere, I. Undag
BIOTECHNIC & HISTOCHEMISTRY
(2019)
Article
Biotechnology & Applied Microbiology
Sercan Kaya, Hasan Huseyin Donmez
BIOTECHNIC & HISTOCHEMISTRY
(2020)
Article
Veterinary Sciences
Ihsan Kisadere, Mehmet F. Aydin, Hasan H. Donmez
Summary: The aim of this study was to investigate the effects of chitosan oligosaccharide (COS) on hematological parameters and determine the percentage of ANAE positive lymphocytes in rats exposed to cadmium. The results showed that COS had a partially protective effect on some hematological characteristics in cases of chronic Cd exposure.
VETERINARSKI ARHIV
(2022)
Article
Biochemistry & Molecular Biology
Tuba Yalcin, Sercan Kaya, Tuncay Kuloglu, Akin Yigin
Summary: This study aimed to determine whether N-acetylcysteine (NAC) may reduce AL-induced oxidative stress, inflammation, and germ cell apoptosis in testicular tissues and its effects on METRNL levels. It was found that AL exposure caused histomorphometric and histopathological changes, oxidative stress, apoptosis of germ cells, and inflammation in testicular tissues. Additionally, AL caused an increase in METRNL levels. NAC treatment significantly reduced the negative effects of AL and may serve as a protective strategy in reproductive toxicity due to AL exposure.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Veterinary Sciences
Durmus Hatipoglu, Mehmet Ozsan, Hasan Huseyin Donmez, Nurcan Donmez
Summary: This study found that Nigella sativa essential oil has a potential protective effect against acrylamide-induced liver toxicity by significantly reducing oxidative stress and pro-inflammatory cytokine levels in liver tissues.
ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
(2023)
Article
Cell Biology
Sercan Kaya, Tuba Yalcin, Ahmet Tektemur, Tuncay Kuloglu
Summary: This study aimed to evaluate the hepatoprotective effects of N-acetylcysteine (NAC) against Adriamycin-induced hepatotoxicity in rats and investigate the impact of Adriamycin and/or NAC on Meteorin-Like (MtrnL) levels in liver tissue. The results showed that Adriamycin application caused histopathological changes, increased liver enzyme levels, enhanced immunoreactivities of HSP-70 and Casp3, and significantly increased MtrnL levels in liver tissue. However, NAC application significantly regulated these changes induced by Adriamycin, providing hepatic protection.
CELL STRESS & CHAPERONES
(2023)
Article
Cell Biology
Sercan Kaya, Tuba Yalcin
Summary: This study aimed to determine the protective effects of L-arginine (L-Arg) pre-intervention on heart tissue in the experimental myocardial infarction (MI) model. The results showed that L-Arg pre-intervention significantly reduced the increases in cardiac markers, histopathological changes, oxidative stress, inflammation, and apoptosis induced by isoproterenol (ISO) in the experimental MI model. Therefore, L-Arg supplementation may reduce the risks of possible pathophysiological processes in MI.
CELL STRESS & CHAPERONES
(2023)
Article
Toxicology
Tuba Yalcin, Sercan Kaya, Tuncay Kuloglu
Summary: The purpose of this study was to investigate the effects of the natural polyphenol Resveratrol (RSV) on DOX-induced nephrotoxicity. It was found that RSV has antioxidative, anti-inflammatory, and antiapoptotic properties. Additionally, RSV was shown to regulate the levels of nephrin and OTULIN, and protect the kidneys from DOX-induced damage.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
Article
Veterinary Sciences
Fatma Colakoglu, Hasan Huseyin Donmez
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
(2019)
