Article
Endocrinology & Metabolism
Jordan C. Barone, Elizabeth Wenzel, Viraja Alluri, Daniel Moriarity, Graziano Pinna, Erin Walsh, David R. Rubinow, Leslie Morrow, Tory A. Eisenlohr-Moul
Summary: This study examined the impact of the menstrual cycle and experimental manipulation on GABAergic neuroactive steroids (NAS) and peripheral cytokines. The results showed that progesterone-derived NAS increased in parallel with progesterone and with the administration of exogenous progesterone and estradiol during the perimenstrual period. Conversely, androstane NAS either did not fluctuate or fluctuated inversely from progesterone and decreased with exogenous hormone administration. Peripheral cytokines did not show cyclical patterns, but were significant predictors of suicidal ideation, depressed mood, and anxiety. Concomitant use of SSRI medication predicted lower androstane NAS.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Behavioral Sciences
Liisa Hantsoo, Jennifer L. Payne
Summary: Premenstrual dysphoric disorder (PMDD) is a severe mood disorder that is associated with hormonal fluctuations, and its underlying biology is not yet fully understood. Recent research suggests that abnormal central nervous system response to neuroactive steroid hormone fluctuations, alterations in serotonergic and GABA transmission, genetic heritability, and cellular vulnerability to sex hormones may contribute to PMDD. However, the findings have not yet been integrated into a complete description of PMDD's underlying biology, and a subtyping approach may be beneficial for future research.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Endocrinology & Metabolism
Erin E. Maher, Ashley M. Strzelecki, Jessica J. Weafer, Cassandra D. Gipson
Summary: Clinically, women may have a higher susceptibility to certain aspects of substance use disorders, and this may be influenced by the steroid hormones 17 beta-estradiol (E2) and progesterone (Pg). This review examines the effects of cycling ovarian hormones on nicotine, cocaine, and opioid-related behaviors, and also explores the potential influence of synthetic steroid hormone use. It further investigates the interactions of E2 and Pg in brain reward pathways and their impact on drug-related behaviors, emphasizing the importance of studying women-specific factors in addiction research.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Article
Substance Abuse
Jordan C. C. Barone, Jaclyn M. M. Ross, Anisha Nagpal, Gabriela Guzman, Erin Berenz, Raina D. D. Pang, Tory A. A. Eisenlohr-Moul
Summary: This study examines the relationship between alcohol use and drinking motives across the menstrual cycle in female psychiatric outpatients. The results show that women are more likely to drink heavily on weekends during the periovulatory and perimenstrual phases, and they are more likely to drink to cope during the perimenstrual phase. These findings highlight the predictable phases of increased high-risk alcohol use and the importance of individual assessment of cyclical changes to prevent heavy drinking during ovulation and menstruation.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Review
Psychiatry
E. Osborn, J. Brooks, P. M. S. O'Brien, A. Wittkowski
Summary: Female individuals with Premenstrual Dysphoric Disorder (PMDD) are at a higher risk of suicidal thoughts, ideation, plans, and attempts, but do not necessarily present a more severe risk profile in terms of impulsivity, frequency, and lethality compared to suicide attempters without PMDD. Identifying and treating symptoms of PMDD can help reduce suicide attempts in this high-risk group. Implications for clinical practice are discussed in the review.
ARCHIVES OF WOMENS MENTAL HEALTH
(2021)
Review
Geriatrics & Gerontology
Steven Jett, Eva Schelbaum, Grace Jang, Camila Boneu Yepez, Jonathan P. Dyke, Silky Pahlajani, Roberta Diaz Brinton, Lisa Mosconi
Summary: Ovarian hormones play a crucial role in women's cognition, and the decline of 17 beta-estradiol during menopause is associated with cognitive aging and Alzheimer's disease risk.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Kathryn E. R. Kennedy, Chidera Onyeonwu, Sara Nowakowski, Lauren Hale, Charles C. Branas, William D. S. Killgore, Chloe C. A. Wills, Michael A. Grandner
Summary: This study analyzed data from 579 menstruating females and found significant associations between short sleep duration, poor sleep quality, and fatigue with heavier bleeding and menstrual cycle irregularity. Long sleep duration and symptoms of insomnia were not found to be related to these outcomes.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Biochemical Research Methods
Jenny Schulze, Tina Suominen, Helena Bergstrom, Magnus Ericsson, Linda Bjorkhem Bergman, Lena Ekstrom
Summary: The interpretation of the steroidal module of the Athlete Biological Passport in female athletes is complicated due to the variation in endogenous urinary steroids, with the menstrual cycle being a major confounder of the steroid profile. This study found that epitestosterone concentrations were significantly higher in the ovulation phase compared to the follicle phase. Significant inter-individual differences were observed, emphasizing the need for additional biomarkers for detecting doping in female athletes.
DRUG TESTING AND ANALYSIS
(2021)
Article
Endocrinology & Metabolism
Viola Schon, Michael P. Hengartner, Enrico Tronci, Toni Mancini, Fabian Ille, Susanna Roblitz, Tillmann Kruege, Brigitte Leeners
Summary: This study investigated the relationship between steroid hormones and women's sexual attraction, and found no significant effect of steroid hormone levels on sexual attraction in naturally cycling women or women undergoing fertility treatment.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Psychiatry
Tory Eisenlohr-Moul, Madeline Divine, Katja Schmalenberger, Laura Murphy, Brett Buchert, Melissa Wagner-Schuman, Alyssa Kania, Sabina Raja, Adam Bryant Miller, Jordan Barone, Jaclyn Ross
Summary: This study found high rates of self-injurious thoughts and behaviors in individuals reporting a diagnosis of PMDD, emphasizing the need for further research on understanding and preventing STBs in PMDD. Clinical practice guidelines for PMDD should address comorbidities and include frequent screenings for suicide risk. STBs should be considered for inclusion in future updates of the DSM PMDD diagnostic criteria.
Article
Psychology, Clinical
Sarah A. Owens, Katja M. Schmalenberger, Savannah Bowers, David R. Rubinow, Mitchell J. Prinstein, Susan S. Girdler, Tory A. Eisenlohr-Moul
Summary: Suicide is a major cause of death among reproductive-aged women, and the menstrual cycle may contribute to acute suicide risk. Previous studies have found a higher frequency of suicide attempts and deaths in the weeks surrounding menstruation compared to other cycle phases. In this study, daily ratings were used to examine the relationship between the menstrual cycle and suicidal ideation (SI) as well as other cyclical symptoms in a group of naturally cycling outpatients.
JOURNAL OF PSYCHOPATHOLOGY AND CLINICAL SCIENCE
(2023)
Article
Chemistry, Analytical
Mengpan Liu, Yuqi Ge, Xin Xu, Lei Liao
Summary: A method for simultaneous quantification of urinary steroids was developed using supported liquid extraction technique in combination with gas chromatography-triple quadruple tandem mass spectrometry. The method showed linear response for all steroids with high accuracy. The technique offered better extraction efficiency compared to conventional preparation methods, providing a useful tool for detecting hormonal fluctuations in the menstrual cycle.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Health Care Sciences & Services
Jessica M. Gannon, Jaspreet S. Brar, Susanna Zawacki, Tiffany Painter, Kelly O'Toole, K. N. Roy Chengappa
Summary: The study found that there were no significant differences in patient participation and clinical outcomes between telehealth and office-based psychiatric IOP programs during the COVID-19 pandemic, and clinical or sociodemographic factors did not greatly influence results. Publicly insured patients may experience care disparities and further study is needed in this area. Telehealth IOP appears to be a clinically appropriate option for a diverse psychiatric population.
TELEMEDICINE AND E-HEALTH
(2022)
Article
Psychiatry
Liisa Hantsoo, Shivani Rangaswamy, Kristin Voegtline, Rodion Salimgaraev, Liudmila Zhaunova, Jennifer L. Payne
Summary: Premenstrual symptoms, including food cravings, mood swings, and fatigue, affect a large proportion of women worldwide. Age is associated with an increase in certain symptoms, but mood symptoms remain consistent across age groups. Premenstrual symptoms can significantly impact the everyday lives of some women.
ARCHIVES OF WOMENS MENTAL HEALTH
(2022)
Review
Oncology
Christopher T. V. Swain, Ann E. Drummond, Leonessa Boing, Roger L. Milne, Dallas R. English, Kristy A. Brown, Eline H. van Roekel, Suzanne C. Dixon-Suen, Michael J. Lynch, Melissa M. Moore, Tom R. Gaunt, Richard M. Martin, Sarah J. Lewis, Brigid M. Lynch
Summary: Physical activity has an effect on sex steroid hormone levels, with a decrease in estrogens, progestins, and androgens, and an increase in sex hormone binding globulin. These findings support the role of physical activity in preventing breast cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)