Journal
BIOCONJUGATE CHEMISTRY
Volume 33, Issue 4, Pages 726-735Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.2c00100
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Funding
- National Natural Science Foundation of China [22175096]
- Social Development Project of Jiangsu Natural Science Foundation [BE2019744]
- Collaborative Innovation Center of Biomedical Functional Materials
- Priority Academic Program Development of Jiangsu Higher Education Institution
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The combination of photothermal therapy and chemical drug therapy holds promise in cancer treatment. A walnut-shaped nanomotor driven by near infrared light was synthesized to address the limitations of low permeability of therapeutic agents and uneven photothermal therapy. The experimental results demonstrate that the nanomotor has good biocompatibility and photothermal effect.
The combination of photothermal therapy and chemical drug therapy shows good prospects in cancer treatment, but there are also some limitations such as low permeability of therapeutic agents and uneven photothermal therapy. Here, we synthesized a walnut-shaped polydopamine (PDA) nanomotor driven by near infrared (NIR) light. The nanomotor was modified by methoxy polyethylene glycol amine (mPEG-NH2) for improving water solubility. PDA-PEG loaded adriamycin through pi-pi accumulation and hydrogen bonding. The experimental results showed that the PDA nanomotors had good biocompatibility and photothermal effect. Further, the NIR light irradiation and tumor cell microenvironment are conducive to drug release. In addition, under the irradiation of an NIR laser, the asymmetry of walnut-shaped nanoparticles makes the particles obtain the ability of autonomous movement, which can improve the permeability of particles in 3D tumor balls, which can provide support for drug penetration and heat dispersion. This strategy materials for photothermal/chemotherapy synergistic therapy of tumors.
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