Article
Immunology
Qinying Sun, Yang Xia, Hao Qin, Wei Zhang, Jun Wang, Yunye Ning, Yuchao Dong
Summary: This study reveals that MEF2 can promote M2 polarization and inhibit M1 polarization of macrophages. Overexpression of MEF2 can alleviate LPS-induced ALI. Furthermore, MEF2 regulates macrophage phenotypes through the modulation of KLF2. MiR-33 may be involved in macrophage polarization by inhibiting MEF2 expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ngan Nguyen, Simin Xu, Terence Yin Weng Lam, Wupeng Liao, W. S. Fred Wong, Ruowen Ge
Summary: This study reveals that ISM1 plays an anti-inflammatory role in acute lung injury (ALI), and its deficiency leads to intensified acute lung inflammation and increased post-ALI lung fibrosis. Recombinant ISM1 effectively suppresses acute lung inflammation and ALI, and inhibits NF-κB activation in mouse alveolar macrophages.
MOLECULAR MEDICINE
(2022)
Article
Neurosciences
Xuezhen Ma, Xuesong Wang, Xuexiao Ma, Xiugong Zhang, Xiaojin Gong, Ruifu Sun, Sunny H. Wong, Matthew T. Chan, William Ka Kei Wu
Summary: Spinal cord injury (SCI) is a disabling condition with limited therapeutic options. Recent studies have shown altered expression of circular RNAs (circRNAs) in the damaged tissue, which play a role in cellular processes relevant to SCI repair and regeneration. However, further investigation is needed to efficiently deliver these regulatory molecules in a cell-type specific manner before translating these findings into clinical benefits.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Yaeko Hashimoto, Akifumi Eguchi, Yan Wei, Hiroyo Shinno-Hashimoto, Yuko Fujita, Tamaki Ishima, Lijia Chang, Chisato Mori, Takuji Suzuki, Kenji Hashimoto
Summary: This study investigated the impact of antibiotic-induced microbiome depletion on LPS-induced acute lung injury (ALI). The results showed that antibiotic treatment significantly attenuated LPS-induced lung injury and altered the diversity of the gut microbiota. Additionally, potential microbial markers and plasma metabolites associated with the ABX + LPS group were identified. Network analysis revealed correlations between IL-6 levels in bronchoalveolar lavage fluid (BALF) and specific gut microbes (or plasma metabolites).
Article
Biochemistry & Molecular Biology
Mengyuan Wang, Xingfang Zhang, Juan Guo, Shangze Yang, Fang Yang, Xingjuan Chen
Summary: Inhibition of TRPC6 can ameliorate LPS-induced acute lung injury (ALI), which may be achieved by acting on the cell adhesion molecule signaling pathway and participating in the regulation of eNOS levels in endothelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Hui Liang, Gaoli Liu, Qinglu Fan, Zhihao Nie, Songping Xie, Renquan Zhang
Summary: Limonin, a naturally occurring tetracyclic triterpenoid, can activate the AMP-activated protein kinase (AMPK)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway, thereby improving inflammation and oxidative stress caused by acute lung injury (ALI).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Jiangwei Ni, Ge Li, Ningfeng Dai, Zijiao Quan, Haibin Tong, Yu Liu
Summary: This study found that Esculin, a compound derived from traditional Chinese medicine, has a protective effect against acute lung injury (ALI). In a lipopolysaccharide (LPS)-challenged ALI mouse model, Esculin significantly reduced lung pathological injury, decreased proinflammatory cytokine levels, and inhibited NF-kappa B signaling activation. Esculin also impaired neutrophil migration and chemotaxis by interacting with beta 2 integrin, thereby blocking neutrophil adhesion and aggregation. These findings demonstrate the potential of Esculin as a novel therapeutic compound.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Xiao-Long Zhang, Jian An, Yong-Zhi Deng, Xuan-Zheng Fang, Cai-Yun Xu, Xu-Fang Liu, Ze-Hong Bai, Gang Zhang, Ming-Yuan Cui
Summary: Severe acute lung injury (ALI) is a major cause of morbidity and mortality worldwide. MicroRNAs (miRNAs) have been identified as potential biomarkers and therapeutic targets for ALI. This study reveals a significant role for the miR-762/NFIX pathway in the pathogenesis of ALI, suggesting that targeting this pathway could be beneficial for the diagnosis, prevention, and treatment of ALI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Shanshan Li, Tianyue Feng, Yingwen Zhang, Qiqi Shi, Wanqiao Wang, Jingyu Ren, Gangyi Shen, Haihui Gu, Chengjuan Luo, Yanxin Li
Summary: This study demonstrates that LHQW alleviates acute lung injury and reduces the inflammatory response by promoting anti-inflammatory polarization of macrophages.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Yanggu Shi, Jindong Shang
Summary: Circular RNAs are covalently circularized RNA loops with unique biochemical properties. Their biological functions and clinical indications continue to be discovered. They are increasingly being used as biomarkers due to their unusual specificities and stable circular form. Profiling circRNA expression is crucial in advancing circRNA research and we will review the use of circRNA microarrays in biological and clinical labs, sharing valuable experiences and significant findings.
Article
Plant Sciences
Yao Wang, Yanchun Wang, Jun Ma, Yanan Li, Lu Cao, Tianxiang Zhu, Haiming Hu, Hongtao Liu
Summary: The study demonstrates that Yupingfengsan (YPFS) can alleviate acute lung injury (ALI) and suppress the production of inflammatory factors. Additionally, YPFS reduces pulmonary edema by promoting the expressions of aquaporin and sodium channel-related genes. Furthermore, YPFS exhibits a therapeutic effect on ALI by inhibiting the activation of the NLRP3 inflammasome and MAPK signaling pathways. Finally, YPFS improves gut barrier integrity and suppresses intestinal inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Joseph J. Bivona, Hanna M. Crymble, Blas A. Guigni, Renee D. Stapleton, D. Clark Files, Michael J. Toth, Matthew E. Poynter, Benjamin T. Suratt
Summary: Skeletal muscle tissue may contribute to proinflammatory cytokines following acute endotoxin injury, and leukocytes can enhance this response via TNF alpha secretion.
Article
Chemistry, Multidisciplinary
Wu Luo, Li-bin Yang, Chen-chen Qian, Bao Ma, Gloria M. Manjengwa, Xiao-min Miao, Jie Wang, Cheng-hong Hu, Bo Jin, Ling-xi Zhang, Chao Zheng, Guang Liang, Yi Wang
Summary: This study identified the natural compound flavokawain B (FKB) as a potential therapeutic option for acute lung injury (ALI). FKB demonstrated anti-inflammatory activity by reducing pro-inflammatory cytokine secretion in immune cells and protecting against lung injury in mice, leading to increased survival and reduced mortality in the ALI model.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Immunology
Rong Zhuang, Xiyu Yang, Wenchao Cai, Rongxiao Xu, Liang Lv, Yingying Sun, Yayong Guo, Jingjing Ni, Guangju Zhao, Zhongqiu Lu
Summary: The study revealed that MCTR3 can protect mice from LPS-induced ALI, alleviating lung injury and promoting lung function restoration. These protective effects are mainly achieved through down-regulation of the PINK1 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jianfeng Gao, Li Teng, Sijun Yang, Shuguang Huang, Linrui Li, Li Zhou, Guoquan Liu, Hongbin Tang
Summary: This study investigated the effectiveness of partial inhibition of the MAPK pathway by targeting the MNKs in the prevention and treatment of ALI. The findings demonstrated that MNK inhibition could effectively reduce LPS-induced ALI in mice, suggesting a novel and potential application for MNK-based therapy in treating this serious disease.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)