Engineering Isopropanol Dehydrogenase for Efficient Regeneration of Nicotinamide Cofactors

Discovery and Engineering of Bacterial (−)‐Isopiperitenol Dehydrogenases to Enhance (−)‐Menthol Precursor Biosynthesis

(2021) Jing‐Ru Zhan et al.   ADVANCED SYNTHESIS & CATALYSIS

Improving the Oxygenation Performance of a Cyanobacterial Lipoxygenase by Oxygen Channel Engineering

(2021) Yi-Ke Qi et al.   ACS Sustainable Chemistry & Engineering

Rational Engineering of Formate Dehydrogenase Substrate/Cofactor Affinity for Better Performance in NADPH Regeneration

(2020) He-Wen Jiang et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Evolution of Glucose Dehydrogenase for Cofactor Regeneration in Bioredox processes with Denaturing Agents

(2020) Wen-Zhuo Qian et al.   CHEMBIOCHEM

Enzymatic Preparation of the Chiral (S)-Sulfoxide Drug Esomeprazole at Pilot-Scale Levels

(2020) Na Xu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

In Vivo Selection for Formate Dehydrogenases with High Efficiency and Specificity toward NADP+

(2020) Liliana Calzadiaz-Ramirez et al.   ACS Catalysis

Single cobalt atom anchored on carbon nitride with well-defined active sites for photo-enzyme catalysis

(2020) Wengang Liu et al.   Nano Energy

Utility of B-Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability

(2019) Zhoutong Sun et al.   CHEMICAL REVIEWS

Can Machine Learning Revolutionize Directed Evolution of Selective Enzymes?

(2019) Guangyue Li et al.   ADVANCED SYNTHESIS & CATALYSIS

Stereodivergent Protein Engineering of a Lipase To Access All Possible Stereoisomers of Chiral Esters with Two Stereocenters

(2019) Jian Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes

(2019) Ge Qu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Coenzyme Binding Site Analysis of an Isopropanol Dehydrogenase with Wide Substrate Spectrum and Excellent Organic Solvent Tolerance

(2019) Wei Jiang et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Statistical Analysis of the Benefits of Focused Saturation Mutagenesis in Directed Evolution Based on Reduced Amino Acid Alphabets

(2019) Aitao Li et al.   ACS Catalysis

Efficient Synthesis of 12‐Oxochenodeoxycholic Acid Using a 12α‐Hydroxysteroid Dehydrogenase from Rhodococcus ruber

(2019) Shou‐Cheng Shi et al.   ADVANCED SYNTHESIS & CATALYSIS

Engineering an Alcohol Dehydrogenase for Balancing Kinetics in NADPH Regeneration with 1,4-Butanediol as a Cosubstrate

(2019) Guochao Xu et al.   ACS Sustainable Chemistry & Engineering

Discovery of an acidic, thermostable and highly NADP+ dependent formate dehydrogenase from Lactobacillus buchneri NRRL B-30929

(2018) Saadet Alpdağtaş et al.   BIOTECHNOLOGY LETTERS

Baeyer–Villiger Monooxygenase-Mediated Synthesis of Esomeprazole As an Alternative for Kagan Sulfoxidation

(2018) Yong Koy Bong et al.   JOURNAL OF ORGANIC CHEMISTRY

Protein Engineering for Nicotinamide Coenzyme Specificity in Oxidoreductases: Attempts and Challenges

(2018) Andrea M. Chánique et al.   Frontiers in Microbiology

Enhancing cofactor recycling in the bioconversion of racemic alcohols to chiral amines with alcohol dehydrogenase and amine dehydrogenase by coupling cells and cell‐free system

(2018) Ji Liu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Development of an Engineered Ketoreductase with Simultaneously Improved Thermostability and Activity for Making a Bulky Atorvastatin Precursor

(2018) Xu-Min Gong et al.   ACS Catalysis

Switching Cofactor Dependence of 7β-Hydroxysteroid Dehydrogenase for Cost-Effective Production of Ursodeoxycholic Acid

(2018) Zhi-Neng You et al.   ACS Catalysis

Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations

(2017) Zhoutong Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pretreating cellulases with hydrophobins for improving bioconversion of cellulose: an experimental and computational study

(2016) Zhiyou Zong et al.   GREEN CHEMISTRY

Structure-Guided Triple-Code Saturation Mutagenesis: Efficient Tuning of the Stereoselectivity of an Epoxide Hydrolase

(2016) Zhoutong Sun et al.   ACS Catalysis

A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases

(2016) Jackson K. B. Cahn et al.   ACS Synthetic Biology

Structural basis for double cofactor specificity in a new formate dehydrogenase from the acidobacterium Granulicella mallensis MP5ACTX8

(2015) Stefano Fogal et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

How Green is Biocatalysis? To Calculate is To Know

(2014) Yan Ni et al.   ChemCatChem

Strategies for regeneration of nicotinamide coenzymes emphasizing self-sufficient closed-loop recycling systems

(2014) Werner Hummel et al.   JOURNAL OF BIOTECHNOLOGY

ADH from Rhodococcus ruber expressed in Arxula adeninivorans for the synthesis of 1-(S)-phenylethanol

(2014) Marion Rauter et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Stereoselective synthesis of l-tert-leucine by a newly cloned leucine dehydrogenase from Exiguobacterium sibiricum

(2014) Jing Li et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Optimization and Scale-up of a Bioreduction Process for Preparation of Ethyl (S)-4-Chloro-3-hydroxybutanoate

(2014) Jiang Pan et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of a Practical, Biocatalytic Reduction for the Manufacture of (S)-Licarbazepine Using an Evolved Ketoreductase

(2014) Naga K. Modukuru et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Engineering of Flexible Loops in Enzymes

(2014) Bettina M. Nestl et al.   ACS Catalysis

Group III alcohol dehydrogenase from Pectobacterium atrosepticum: insights into enzymatic activity and organization of the metal ion-containing region

(2013) Skander Elleuche et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Structure- and sequence-analysis inspired engineering of proteins for enhanced thermostability

(2013) Hein J Wijma et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Methods for the regeneration of nicotinamide coenzymes

(2013) Hong Wu et al.   GREEN CHEMISTRY

Efficient Enantioselective Synthesis of (R)-[3,5-Bis(trifluoromethyl)phenyl] Ethanol by Leifsonia xyli CCTCC M 2010241 Using Isopropanol as Co-Substrate

(2013) Qi Ouyang   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH

(2013) S. Brinkmann-Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards the discovery of alcohol dehydrogenases: NAD(P)H fluorescence-based screening and characterization of the newly isolated Rhodococcus erythropolis WZ010 in the preparation of chiral aryl secondary alcohols

(2012) Chi Yang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

An overview of the Amber biomolecular simulation package

(2012) Romelia Salomon-Ferrer et al.   Wiley Interdisciplinary Reviews-Computational Molecular Science

l-Aspartate dehydrogenase: features and applications

(2011) Yinxia Li et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Highly efficient synthesis of chiral alcohols with a novel NADH-dependent reductase from Streptomyces coelicolor

(2011) Li-Juan Wang et al.   BIORESOURCE TECHNOLOGY

New opportunities for biocatalysis: driving the synthesis of chiral chemicals

(2011) Gao-Wei Zheng et al.   CURRENT OPINION IN BIOTECHNOLOGY

Enzymatic reductions for the chemist

(2011) Frank Hollmann et al.   GREEN CHEMISTRY

Biocatalytic process optimization based on mechanistic modeling of cholic acid oxidation with cofactor regeneration

(2010) Michael Braun et al.   BIOTECHNOLOGY AND BIOENGINEERING

New Trends in the Recycling of NAD(P)H for the Design of Sustainable Asymmetric Reductions Catalyzed by Dehydrogenases

(2010) Angel Berenguer-Murcia et al.   CURRENT ORGANIC CHEMISTRY

A novel NADP+-dependent formate dehydrogenase from Burkholderia stabilis 15516: Screening, purification and characterization

(2010) Rujirat Hatrongjit et al.   ENZYME AND MICROBIAL TECHNOLOGY

Separation of isopropyl alcohol–water mixtures by pervaporation using crosslink IPN membranes

(2009) N.R. Singha et al.   CHEMICAL ENGINEERING AND PROCESSING

Efficient enantioselective reduction of 4′-methoxyacetophenone with immobilized Rhodotorula sp. AS2.2241 cells in a hydrophilic ionic liquid-containing co-solvent system

(2009) Wen-Yong Lou et al.   JOURNAL OF BIOTECHNOLOGY

Purification and Characterization of a Novel Recombinant Highly Enantioselective Short-Chain NAD(H)-Dependent Alcohol Dehydrogenase from Thermus thermophilus

(2008) A. Pennacchio et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

TADH, the thermostable alcohol dehydrogenase from Thermus sp. ATN1: a versatile new biocatalyst for organic synthesis

(2008) Volker Höllrigl et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

E factors, green chemistry and catalysis: an odyssey

(2008) Roger A. Sheldon   CHEMICAL COMMUNICATIONS

Regeneration of the nicotinamide cofactor using a mediator-free electrochemical method with a tin oxide electrode

(2008) Yang Hee Kim et al.   ENZYME AND MICROBIAL TECHNOLOGY

Orchestration of Concurrent Oxidation and Reduction Cycles for Stereoinversion and Deracemisation ofsec-Alcohols

(2008) Constance V. Voss et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY