Article
Rheumatology
Ai Phuong Tran, Daniel Tassone, Johannes Nossent, Nik Sheng Ding
Summary: The study found that continuing DMARD therapy in patients with immune-mediated inflammatory disease may lead to lower antibody responses after vaccination, while withholding therapy can help increase antibody levels. At least 2 vaccinations are recommended.
Article
Rheumatology
Sakir Ahmed, Pankti Mehta, Aby Paul, S. Anu, Somy Cherian, Veena Shenoy, Kaveri K. Nalianda, Sanjana Joseph, Anagha Poulose, Padmanabha Shenoy
Summary: This study assessed the incidence and risk factors for breakthrough COVID-19 infections in vaccinated patients with autoimmune rheumatic diseases (AIRDs) and found that the levels of antibodies against the receptor binding domain of spike protein were associated with susceptibility to such infections. Breakthrough infections occurred in 7.4% of patients and were associated with seronegativity following vaccination.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Anja Strangfeld, Martin Schafer, Milena A. Gianfrancesco, Saskia Lawson-Tovey, Jean W. Liew, Lotta Ljung, Elsa F. Mateus, Christophe Richez, Maria J. Santos, Gabriela Schmajuk, Carlo A. Scire, Emily Sirotich, Jeffrey A. Sparks, Paul Sufka, Thierry Thomas, Laura Trupin, Zachary S. Wallace, Sarah Al-Adely, Javier Bachiller-Corral, Suleman Bhana, Patrice Cacoub, Loreto Carmona, Ruth Costello, Wendy Costello, Laure Gossec, Rebecca Grainger, Eric Hachulla, Rebecca Hasseli, Jonathan S. Hausmann, Kimme L. Hyrich, Zara Izadi, Lindsay Jacobsohn, Patricia Katz, Lianne Kearsley-Fleet, Philip C. Robinson, Jinoos Yazdany, Pedro M. Machado
Summary: Factors associated with COVID-19-related death in people with rheumatic diseases include age, sex, comorbidities, disease activity, and specific medications. Adequate disease control with disease-modifying anti-rheumatic drugs (DMARDs) without increasing glucocorticoid dosages is important, while caution may be required with certain medications such as rituximab and sulfasalazine.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Robert B. M. Landewe, Sofia Ramiro, Remy L. M. Mostard
Summary: The CHIC study compares immunosuppressive treatment with supportive treatment in COVID-19 patients with hyperinflammation. Results show that immunosuppressive treatment leads to significant improvement in 14-day outcomes and 30-day/90-day survival rates, with CRP-mediated effects playing a crucial role in patient recovery.
Article
Rheumatology
Jean Liew, Milena Gianfrancesco, Carly Harrison, Zara Izadi, Stephanie Rush, Saskia Lawson-Tovey, Lindsay Jacobsohn, Clairissa Ja, Kimme L. Hyrich, Laure Gossec, Anja Strangfeld, Loreto Carmona, Martin Schaefer, Elsa Frazao-Mateus, Inita Bulina, Frances Stafford, Abdurrahman Tufan, Christine Graver, Gozde Kubra Yardimci, Julija Zepa, Samar Al Emadi, Claire Cook, Fatemah Abutiban, Dfiza Dey, Genevieve Katigbak, Lauren Kaufman, Emily Kowalski, Marco Ulises Martinez-Martinez, Naomi J. Patel, Greta Reyes-Cordero, Evelyn Salido, Ellison Smith, David Snow, Jeffrey Sparks, Leanna Wise, Suleman Bhana, Monique Gore-Massy, Rebecca Grainger, Jonathan Hausmann, Emily Sirotich, Paul Sufka, Zachary Wallace, Pedro M. Machado, Philip C. Robinson, Jinoos Yazdany
Summary: This study analyzed the clinical characteristics of patients with rheumatic disease who developed breakthrough COVID-19 after receiving the SARS-CoV-2 vaccine. The results showed that more than half of fully vaccinated patients who required hospitalization were receiving B cell-depleting therapy or mycophenolate.
Article
Rheumatology
Hannah Bower, Thomas Frisell, Daniela di Giuseppe, Benedicte Delcoigne, Gerd-Marfie Ahlenius, Eva Baecklund, Katerina Chatzidionysiou, Nils Feltelius, Helena Forsblad-d'Elia, Alf Kastbom, Lars Klareskog, Elisabet Lindqvist, Ulf Lindstrom, Carl Turesson, Christopher Sjowall, Johan Askling
Summary: Patients with inflammatory joint diseases (IJDs) have an increased risk of serious COVID-19 outcomes, potentially due to medical conditions other than IJD itself. The COVID-19 pandemic has measurable effects on rheumatology care provision, which will require further assessment for future impact.
Article
Medicine, General & Internal
Maria del Mar Ayala Gutierrez, Manuel Rubio-Rivas, Carlos Romero Gomez, Abelardo Montero Saez, Ivan Perez de Pedro, Narcis Homs, Blanca Ayuso Garcia, Carmen Cuenca Carvajal, Francisco Arnalich Fernandez, Jose Luis Beato Perez, Juan Antonio Vargas Nunez, Laura Letona Gimenez, Carmen Suarez Fernandez, Manuel Mendez Bailon, Carlota Tunon de Almeida, Julio Gonzalez Moraleja, Mayte de Guzman Garcia-Monge, Cristina Helguera Amezua, Maria del Pilar Fidalgo Montero, Vicente Giner Galvan, Ricardo Gil Sanchez, Jorge Collado Saenz, Ramon Boixeda, Jose Manuel Ramos Rincon, Ricardo Gomez Huelgas
Summary: The analysis of hospitalized COVID-19 patients with autoimmune diseases (ADs) compared to the general population did not show a significant difference in overall prognosis, but individual diseases may have varying effects. Immunosuppressive/immunoregulatory treatments (IST) prior to admission had variable effects on outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Manuela De Michele, Joshua Kahan, Irene Berto, Oscar G. Schiavo, Marta Iacobucci, Danilo Toni, Alexander E. Merkler
Summary: The risk of stroke and cerebrovascular disease complicating SARS-CoV-2 infection has been extensively reported. The rapid development and mass vaccination of DNA and mRNA vaccines against SARS-CoV-2 have led to rare but catastrophic cases of thrombosis. This review provides an overview of stroke and cerebrovascular complications of SARS-CoV-2 infection, as well as vaccinations, with a focus on vaccine-induced immune thrombotic thrombocytopenia. A therapeutic protocol is proposed based on available data.
CIRCULATION RESEARCH
(2022)
Review
Rheumatology
Wei Tang, Leila Khalili, Jon Giles, Yevgeniya Gartshteyn, Teja Kapoor, Cathy Guo, Tommy Chen, Deborah Theodore, Anca Askanase
Summary: Initially thought to be beneficial in treating COVID-19, CQ/HCQ were found to be ineffective in large clinical trials for hospitalized patients, with their role in non-hospitalized patients still being debated.
RHEUMATOLOGY AND THERAPY
(2021)
Review
Multidisciplinary Sciences
Daniel M. Altmann, Rosemary J. Boyton
Summary: A diverse range of first-generation SARS-CoV-2 vaccines have been successful in controlling the COVID-19 pandemic, although inequitable distribution remains an issue. Future challenges include optimizing immunological boosting strategies and building an immune repertoire that can protect against upcoming viral variants.
Article
Rheumatology
Sebastian Bruera, Xiudong Lei, Hui Zhao, Jinoos Yazdany, Mariana Chavez-MacGregor, Sharon H. Giordano, Maria E. Suarez-Almazor
Summary: This study compared the outcomes of patients with or without systemic lupus erythematosus (SLE) who were diagnosed with COVID-19 and evaluated factors associated with severe outcomes in SLE patients. The results showed that patients with SLE had significantly higher rates of mortality, mechanical ventilation, and hospitalization compared to matched controls. Severe disease activity in SLE and prior use of corticosteroids were associated with worse outcomes.
LUPUS SCIENCE & MEDICINE
(2023)
Editorial Material
Biochemistry & Molecular Biology
Allyson M. Pishko, James B. Bussel, Douglas B. Cines
Summary: A study suggests a potential link between the AstraZeneca vaccine and an autoimmune disorder, immune thrombocytopenia, but further research is needed to establish causality.
Editorial Material
Psychology, Biological
Katie Attwell
Summary: A new Resource from the Oxford COVID-19 Government Response Tracker (OxCGRT) project provides detailed information on the vaccination policies of 185 countries during the COVID-19 pandemic. It includes variations in vaccination prioritization, eligibility and availability, cost to individuals, and mandatory vaccination.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Rheumatology
Kevin Winthrop, Juan Ignacio Vargas, Edit Drescher, Conrado Garcia, Alan Friedman, Barbara Hendrickson, Yihan Li, Justin Klaff, Alan Kivitz
Summary: The study assessed the immunogenicity of PCV-13 vaccination in patients with rheumatoid arthritis. Results showed that approximately two-thirds of patients achieved a satisfactory immune response to PCV-13, despite receiving concomitant MTX treatment.
Article
Microbiology
Harald Brussow
Summary: This minireview addresses various issues related to vaccine development, regulation, ethics, efficacy, and coverage of variant viruses. The article discusses serious adverse effects observed with adenovirus vectored vaccines and mRNA vaccines in mass vaccination campaigns, as well as ethical problems and specific vaccination issues. Strategies to increase vaccine acceptance in the population are briefly mentioned.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Letter
Rheumatology
Sofia Ramiro, Remy L. M. Mostard, Robert B. M. Landewe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Sofia Ramiro, Remy L. M. Mostard, Robert B. M. Landewe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Medicine, General & Internal
Richard Conway, Declan Byrne, Deirdre O'Riordan, Bernard Silke
Summary: This study investigates the clinical utility and prognostic value of NT-proBNP in emergency medical admissions and finds that it is associated with 30-day in-hospital mortality. Downstream resource utilization differs following an NT-proBNP test, which may be due to case complexity or the uncertainty surrounding such admissions.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Rheumatology
David Roofeh, Kevin K. Brown, Ella A. Kazerooni, Donald Tashkin, Shervin Assassi, Fernando Martinez, Athol U. Wells, Ganesh Raghu, Christopher P. Denton, Lorinda Chung, Anna-Maria Hoffmann-Vold, Oliver Distler, Kerri A. Johannson, Yannick Allanore, Eric L. Matteson, Leticia Kawano-Dourado, John D. Pauling, James R. Seibold, Elizabeth R. Volkmann, Simon L. F. Walsh, Chester Oddis, Eric S. White, Shaney L. Barratt, Elana J. Bernstein, Robyn T. Domsic, Paul F. Dellaripa, Richard Conway, Ivan Rosas, Nitin Bhatt, Vivien Hsu, Francesca Ingegnoli, Bashar Kahaleh, Puneet Garcha, Nishant Gupta, Surabhi Khanna, Peter Korsten, Celia Lin, Stephen C. Mathai, Vibeke Strand, Tracy J. Doyle, Virginia Steen, Donald F. Zoz, Juan Ovalles-Bonilla, Ignasi Rodriguez-Pinto, Padmanabha D. Shenoy, Andrew Lewandoski, Elizabeth Belloli, Alain Lescoat, Vivek Nagaraja, Wen Ye, Suiyuan Huang, Toby Maher, Dinesh Khanna
Summary: This study aimed to establish a framework by which experts define disease subsets in systemic sclerosis associated interstitial lung disease (SSc-ILD). The results showed that using the proposed conceptual framework, international experts were able to achieve a consensus on classifying SSc-ILD patients along the dimensions of disease severity, risk of progression and progression over time.
Article
Rheumatology
Bernard G. Combe, Yoshiya Tanaka, Maya H. Buch, Peter Nash, Gerd R. Burmester, Alan J. Kivitz, Beatrix Bartok, Alena Pechonkina, Katrina Xia, Kahaku Emoto, Shungo Kano, Thijs K. Hendrikx, Robert B. M. Landewe, Daniel Aletaha
Summary: This study examined the efficacy and safety of filgotinib in patients with rheumatoid arthritis who had an inadequate response to methotrexate and had poor prognostic factors. The results showed that filgotinib significantly improved disease activity in patients with both high-risk and low-risk factors. The tolerability of filgotinib was also comparable across different patient subgroups.
RHEUMATOLOGY AND THERAPY
(2023)
Article
Rheumatology
Jeffrey R. Curtis, Bradley Stolshek, Paul Emery, Boulos Haraoui, Elaine Karis, Greg Kricorian, David H. Collier, Priscilla K. Yen, Vivian P. Bykerk
Summary: This study aimed to investigate the effect of treatment withdrawal on patient-reported outcomes in patients with rheumatoid arthritis. The results showed that patient-reported outcomes deteriorated following medication withdrawal, and patients receiving etanercept monotherapy had less deterioration compared to those receiving methotrexate monotherapy.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2023)
Review
Rheumatology
Aurelie Najm, Carl S. Goodyear, Iain B. McInnes, Stefan Siebert
Summary: This review discusses the tissue, cellular, and molecular mechanisms underlying the clinical heterogeneity of PsA. It highlights the importance of tissue-based therapy in PsA treatment and its potential implications for improving clinical outcomes and trial design.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Rheumatology
Victoria Navarro-Compan, Diego Benavent, Dafne Capelusnik, Desiree van der Heijde, Robert B. M. Landewe, Denis Poddubnyy, Astrid van Tubergen, Xenofon Baraliakos, Filip E. van den Bosch, Floris A. van Gaalen, Lianne Gensler, Clementina Lopez-Medina, Helena Marzo-Ortega, Anna Molto, Rodolfo Perez-Alamino, Martin Rudwaleit, Marleen van de Sande, Raj Sengupta, Ulrich Weber, Sofia Ramiro
Summary: This study developed a consensual definition for 'early axial spondyloarthritis-axSpA' and 'early peripheral spondyloarthritis-pSpA' through a systematic literature review and Delphi survey. The results indicated that early axSpA should be based on symptom duration only, without considering the presence of radiographic damage.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Ioana Andreica, Iulia Roman, Imke Redeker, Xenofon Baraliakos, Juergen Braun, Uta Kiltz
Summary: This study investigated the attitudes and perceived factors towards vaccination in patients with rheumatic musculoskeletal diseases, including pneumococci, influenza, and SARS-CoV-2 vaccines. The study found that most patients had good knowledge about vaccination and the facilitators were more important than barriers. Patients generally indicated that healthcare professionals' recommendations were a major motivation for vaccination. There were more barriers towards SARS-CoV-2 vaccination, with personal intrapersonal issues being the most common.
Article
Rheumatology
Mary Lucy Marques, Nuno Pereira da Silva, Desiree van der Heijde, Rosalinde Stal, Xenofon Baraliakos, Juergen Braun, Monique Reijnierse, Caroline Bastiaenen, Sofia Ramiro, Floris A. van Gaalen
Summary: The study investigated the association between inflammation and lower trabecular bone density (TBD) in radiographic axial spondyloarthritis (r-axSpA), and whether a lower TBD increases the likelihood of 2-year bone formation at the same vertebra. The study found that inflammation was associated with lower TBD, but lower TBD itself did not increase the risk of new bone formation at the same vertebra.
Article
Rheumatology
Robert Landewe, Luna Sun, Yun-Fei Chen, Daojun Mo, Desiree van der Heijde
Summary: Demonstrating the inhibition of joint damage in rheumatoid arthritis trials is commonly achieved through statistically significant differences in radiographic progression measured by the mTSS. The frequently used ANCOVA+LE method for handling missing data may not be ideal for long-term extension or paediatric studies. The RC model shows better performance in terms of bias, RMSE, power and type I error rate, making it a more sensitive and precise alternative for analysing mTSS in studies with missing data.
Review
Health Care Sciences & Services
Thomas Davergne, Philippe Meidinger, Agnes Dechartres, Laure Gossec
Summary: This systematic review evaluated the effectiveness of apps providing personalized video exercises for rehabilitation. The results showed that these apps significantly improved physical function and confidence in exercise performance.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Rheumatology
Coen van der Meulen, Lotte A. van de Stadt, Aniek Claassen, Feline P. B. Kroon, Marco J. P. F. Ritt, Frits R. Rosendaal, Sietse E. S. Terpstra, Anne J. H. Vochteloo, Margreet Kloppenburg
Summary: Surgical denervation has been proposed as a treatment for pain in hand osteoarthritis (OA). This review aimed to summarise the available evidence and propose a research agenda. The available evidence suggests that surgical denervation may be effective for pain in hand OA, but higher-quality research is needed for conclusive results.
Article
Rheumatology
Alexandre Sepriano, Bastiaan van Dijk, Sofia Ramiro, Annette van der Helm-van Mil, Bernard Combe, Dirkjan van Schaardenburg, Maarten de Wit, Alison Kent, Elsa Mateus, Robert Landewe
Summary: This study evaluated the long-term prognosis across different phenotypes of early arthritis and found that patients with acute phase reactants/autoantibodies had worse radiographic scores, but no significant differences in HAQ and SF36 were found.
Article
Rheumatology
D. Guellec, G. Carvajal-Alegria, C. Daien, L. Gossec, F. Guillemin, F. Berenbaum, A. Constantin, P. Dieude, M. Dougados, R. M. Flipo, P. Goupille, X. Mariette, C. Richez, O. Vittecoq, B. Combe, A. Saraux
Summary: In patients with recent-onset arthritis, a self-reported familial occurrence of rheumatoid arthritis (RA) is associated with a higher prevalence of extra articular manifestations (EAMs), a higher likelihood of severe EAMs, and a higher probability of initiating targeted DMARD treatment over time.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
