Article
Immunology
Ivan Sanz-Munoz, Sonia Tamames-Gomez, Javier Castrodeza-Sanz, Jose Maria Eiros-Bouza, Raul Ortiz de Lejarazu-Leonardo
Summary: Non-pharmaceutical interventions have successfully reduced the spread of viruses, but may also lead to decreased circulation of pathogens, lowering herd immunity.
Article
Multidisciplinary Sciences
Yaning Liu, Haihang Ye, HoangDinh Huynh, Chen Xie, Peiyuan Kang, Jeffrey S. Kahn, Zhenpeng Qin
Summary: DIAMOND enables rapid and specific detection of respiratory syncytial virus with single-step and single-nanoparticle detection, direct sensing of intact viruses at room temperature, and no complex liquid handling.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Shimon Amar, Yonat Shemer Avni, Norm O'Rourke, Tal Michael
Summary: The study examines the incidence rates of infectious diseases after a successful COVID-19 vaccination campaign and the lifting of social restrictions in Israel. The results suggest that the rates of respiratory and gastrointestinal infections have increased, indicating that similar trends could occur in other countries.
Article
Immunology
Zaid Haddadin, Stockton Beveridge, Kailee Fernandez, Danielle A. Rankin, Varvara Probst, Andrew J. Spieker, Tiffanie M. Markus, Laura S. Stewart, William Schaffner, Mary Lou Lindegren, Natasha Halasa
Summary: Respiratory syncytial virus (RSV) is the leading cause of acute respiratory infections (ARIs) in hospitalized children. RSV-positive children were more likely to be hospitalized, require intensive care unit admission, and receive oxygen compared with children positive for other viruses. Higher viral load, White race, younger age, and higher severity score were independently associated with hospitalization in RSV-positive children.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Chemistry, Analytical
Jianying Zhang, Nana Qin, Mingjing Wang, Xu Hun
Summary: A low-noise double-redox cycling signal amplification photoelectrochemical strategy based on Mo2C-graphyne-AuNPs modified electrode was reported for high sensitivity detection of A beta(1-40) oligomers. This technology demonstrated a promising sensing platform for detecting bioactive substances at ultralow levels.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Microbiology
Kim Chiok, Swechha M. Pokharel, Indira Mohanty, Lindsay Grace Miller, Shou-Jiang Gao, Arthur L. Haas, Kim C. Tran, Michael N. Teng, Santanu Bose
Summary: Understanding the interaction between RSV and the host is crucial for developing effective interventions. This study identifies the RSV nonstructural protein NS2 as the key component in activating autophagy by modulating the ISGylation of Beclin1.
Article
Microbiology
Kim Chiok, Swechha M. Pokharel, Indira Mohanty, Lindsay Grace Miller, Shou-Jiang Gao, Arthur L. Haas, Kim C. Tran, Michael N. Teng, Santanu Bose
Summary: Paramyxoviruses like RSV are a leading cause of viral pneumonia in infants. This study identified the viral protein NS2 as mediating autophagy induction by RSV, providing a potential target for interventions against RSV.
Article
Medicine, General & Internal
Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen
Summary: Based on a study in South African children, the burden of RSV-associated illness was estimated, with newborns and infants being the most affected group. Implementing maternal vaccination and monoclonal antibody products for this group can help reduce the disease burden.
Article
Medicine, General & Internal
Laura L. Hammitt, Ron Dagan, Yuan Yuan, Manuel Baca Cots, Miroslava Bosheva, Shabir A. Madhi, William J. Muller, Heather J. Zar, Dennis Brooks, Amy Grenham, Ulrika Wahlby Hamren, Vaishali S. Mankad, Pin Ren, Therese Takas, Michael E. Abram, Amanda Leach, M. Pamela Griffin, Tonya Villafana
Summary: A single injection of nirsevimab administered before the RSV season protected healthy late-preterm and term infants from medically attended RSV-associated lower respiratory tract infection.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Immunology
Jason R. Gantenberg, Robertus van Aalst, Nicole Zimmerman, Brendan Limone, Sandra S. Chaves, William V. La Via, Christopher B. Nelson, Christopher Rizzo, David A. Savitz, Andrew R. Zullo
Summary: RSV is a major cause of infant hospitalization in the United States. While preterm infants and those with specific comorbidities are at high risk, 80% of RSV infections occur in term infants without comorbidities. Future prevention efforts should target all infants.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Alaa Ahmad, Kingsley Eze, Nicolas Noulin, Veronika Horvathova, Bryan Murray, Mark Baillet, Laura Grey, Julie Mori, Nathalie Adda
Summary: The study demonstrated that EDP-938 was superior to placebo in reducing RSV viral load, total symptom scores, and mucus weight, with a favorable safety profile.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Virology
Yishu Wang, Yiling Chen, Ying Lin, Yingqin Quan, Xiaoping Xiao, Renli Zhang
Summary: RSV infection is a major cause of lower respiratory tract disease, with no effective treatments found yet. Recent studies have shown that TRIM family member TRIM22 plays a crucial role in resisting RSV infection. RSV infection induces TRIM22 expression through the activation of JAK-STAT1/2 signaling.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Anna C. Nilsson, John Pullman, Piotr Napora, Kleber Luz, Anil Gupta, Jorge Draghi, Ana Karla Guzman Romero, Naresh Aggarwal, Galina Petrova, Juliana Ianus, Leen Vijgen, Jane Scott, Rekha Sinha, Sarah Rusch, Dymphy Huntjens, Kristi Bertzos, OSE Study Grp
Summary: This study assessed the antiviral effect, clinical outcomes, and safety of rilematovir in non-hospitalized RSV-infected adults. The results suggest that early use of rilematovir may have potential clinical benefits in adults with RSV infection, supporting the development of therapeutic options for RSV.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Microbiology
Li Wang, Qihui Zhu, Kunlun Xiang, Yaling Zhang, Baocun Li, Xin Yu, Guang Yang, Chungen Liang, Hongying Yun, Meifang Zhang, Ning Qin, Lu Gao
Summary: A novel triazole-oxadiazole derivative named triazole-1 was discovered as an inhibitor of respiratory syncytial virus (RSV) replication. Triazole-1 showed potent inhibition of both RSV A and B subtypes and specifically targeted RSV transcription, with resistance observed due to a single point mutation in the RSV genome.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Immunology
Teresia W. Maina, Elizabeth A. Grego, Scott Broderick, Randy E. Sacco, Balaji Narasimhan, Jodi L. McGill
Summary: Researchers determined the effectiveness of a nanovaccine based on polyanhydride, encapsulating the BRSV post-fusion F and G glycoproteins and CpG, in the neonatal calf model. The nanovaccine, delivered via heterologous or homologous immunization, demonstrated clinical and virological protection in the calves, comparable to a commercial modified-live vaccine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)