Article
Immunology
Liliwe Shuping, Tsidiso G. Maphanga, Serisha D. Naicker, Ruth Mpembe, Nqobile Ngoma, Sithembiso Velaphi, Firdose Nakwa, Jeannette Wadula, Prenika Jaglal, Nelesh P. Govender
Summary: During an outbreak in a neonatal unit in South Africa, one third of patients were colonized by Candida auris according to a point-prevalence survey. The sensitivity of direct PCR for rapid colonization detection was 44% compared to culture. The infection incidence rate decreased by 85% after the survey and implementation of isolation/cohorting.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Annabelle de St Maurice, Urvashi Parti, Victoria E. Anikst, Thomas Harper, Ruel Mirasol, Ayrton J. Dayo, Omai B. Garner, Kavitha K. Prabaker, Shangxin Yang
Summary: This study demonstrates the establishment of a robust Candida auris surveillance program using both active and passive surveillance, involving multidisciplinary efforts from the microbiology laboratory and the hospital epidemiology team. In Los Angeles County, C. auris strains are highly related, and echinocandins should be used for empiric therapy.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Immunology
Emily F. Eix, Chad J. Johnson, Kayla M. Wartman, John F. Kernien, Jennifer J. Meudt, Dhanansayan Shanmuganayagam, Angela L. F. Gibson, Jeniel E. Nett
Summary: Candida auris can efficiently colonize the skin of patients, leading to nosocomial outbreaks. However, other Candida species, including those closely related to C. auris, do not show the same high growth in the skin microenvironment. This study provides two ex vivo skin models for C. auris colonization, which can be used to compare clinical isolates and genetically mutated strains.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Federica Briano, Laura Magnasco, Chiara Sepulcri, Silvia Dettori, Chiara Dentone, Malgorzata Mikulska, Lorenzo Ball, Antonio Vena, Chiara Robba, Nicolo Patroniti, Iole Brunetti, Angelo Gratarola, Raffaele D'Angelo, Vincenzo Di Pilato, Erika Coppo, Anna Marchese, Paolo Pelosi, Daniele Roberto Giacobbe, Matteo Bassetti
Summary: Candida auris (C. auris) is an emerging nosocomial pathogen that has shown a sharp rise in colonization and infection cases during the COVID-19 pandemic. This study found a high cumulative incidence of C. auris candidemia in colonized patients, with multisite colonization being an independent risk factor for candidemia development.
INFECTIOUS DISEASES AND THERAPY
(2022)
Article
Public, Environmental & Occupational Health
G. Piatti, M. Sartini, C. Cusato, A. M. Schito
Summary: This study retrospectively analyzed the incidence of Candida auris infections in the intensive care units of an Italian hospital and compared the relationship between cutaneous and intestinal colonization. The results showed that the proportion of skin and intestinal colonization by Candida auris was similar, and intestinal colonization was associated with an increased risk of urinary tract infections.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Immunology
Diprasom Das, Harm HogenEsch, Shankar Thangamani
Summary: This study reveals that treatment with broad-spectrum antibiotics increases the colonization and dissemination of Candida auris from the intestine. Furthermore, the intestinal colonization of C. auris alters the microbiome composition of antibiotic-treated mice. In C. auris infected mice, the number of CD11b+ CX3CR1+ macrophages in the intestine is significantly decreased, while the increase of Th17 and Th22 cells is comparable to Candida albicans infection. Candida-specific IgA is significantly increased in the serum of C. auris infected mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Microbiology
Qihui Wang, Shitong Cheng, Yinling Wang, Fushun Li, Jingjing Chen, Wei Du, Hui Kang, Zhongqing Wang
Summary: A bibliometric analysis was conducted to summarize research trends and hotspots for controlling C. auris infection. The analysis revealed that drug resistance, accurate identification technologies, nosocomial outbreaks, and biofilm formation were the main research focuses. The most influential country, research institution, and researcher were identified.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Umran Elbahr, Amira Khairy, Farouq Dayyab, Clark Steven Delos Reyes, Jennie Pastrana, Chithra Vineeth, Suha Hejres, Shruti Prem Sudha, Ozge Keskin, Shiv Singh Rana, Elias Fadel, Hakan Erdem, Oguz Resat Sipahi
Summary: The use of chlorhexidine for bathing and cleaning may have some effect on the decolonization rate of Candida auris carriers, but it may not be very effective for patients with other concomitant diseases.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Microbiology
Alessio Mesini, Carolina Saffioti, Marcello Mariani, Angelo Florio, Chiara Medici, Andrea Moscatelli, Elio Castagnola
Summary: Candida auris is a multidrug-resistant pathogen that can lead to severe complications and may be transmitted from mother to infant. In high colonization environments, antifungal prophylaxis for premature infants should be considered.
Review
Infectious Diseases
Joseph Pechacek, Michail S. Lionakis
Summary: Understanding the mechanisms by which the host immune system responds to and controls colonization and infection with C. auris and developing a deeper knowledge of tissue-specific host-C. auris interactions and of C. auris immune-evading mechanisms may help devise improved strategies for decolonization, prognostication, prevention, vaccination, and/or directed antifungal treatment in vulnerable patient populations.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Article
Immunology
John Rossow, Belinda Ostrowsky, Eleanor Adams, Jane Greenko, Robert McDonald, Snigdha Vallabhaneni, Kaitlin Forsberg, Stephen Perez, Todd Lucas, Karen A. Alroy, Kara Jacobs Slifka, Maroya Walters, Brendan R. Jackson, Monica Quinn, Sudha Chaturvedi, Debra Blog
Summary: The study investigated factors associated with C. auris colonization in ventilator-capable skilled nursing facilities in New York State. Results showed that being on a ventilator, receiving carbapenem antibiotics, having recent acute care hospital visits, and receiving systemic fluconazole were associated with C. auris colonization. Targeted screening for patients with these risk factors can help identify colonized patients and implement infection control measures, while antimicrobial stewardship may play an important role in preventing C. auris colonization.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Natalia Sasoni, Melani Maidana, Maria Gabriela Latorre-Rapela, Soraya Morales-Lopez, Indira Berrio, Soledad Gamarra, Guillermo Garcia-Effron
Summary: CHROMagar (TM) Candida Plus is effective in differentiating Candida auris from other Candida spp., including other species of the C. haemulonii complex. However, 44.3% of C. parapsilosis strains may be misidentified as C. auris. The addition of 8 mu g/ml fluconazole is proposed to address this issue.
Article
Medicine, General & Internal
Anthony D. Harris, Lisa Pineles, J. Kristie Johnson, Lyndsay M. O'Hara, L. Leigh Smith, Indira French, Jamie Rubin, Rebecca Perlmutter, Ashley Heller, Liore Klein, John Thoguru, David Blythe, Elisabeth Vaeth
Summary: This study aimed to determine the prevalence of Acinetobacter baumannii and Candida auris among patients receiving mechanical ventilation in Maryland. The findings revealed that both pathogens were common among patients receiving mechanical ventilation.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Editorial Material
Microbiology
Arturo Casadevall, Dimitrios P. Kontoyiannis, Vincent Robert
Summary: Global warming has been suggested as a contributing factor to the simultaneous emergence of Candida auris as a nosocomial pathogen on different continents. Isolating C. auris from the remote Andaman Islands supports the hypothesis that it is an environmental organism. The slower growth of one environmental isolate at mammalian temperatures suggests recent thermal adaptation, potentially due to climate change.
Article
Microbiology
James Carty, Anuradha Chowdhary, Douglas Bernstein, Shankar Thangamani
Summary: Candida auris, an emerging fungal pathogen, colonizes the skin efficiently and can cause life-threatening infections. It is resistant to antifungal drugs. Understanding the biochemical mechanisms of its skin colonization is crucial for developing effective therapeutic options.