Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species

Enhancing Oral Absorption of β-Lapachone: Progress Till Date

(2016) Marival Bermejo et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

NQO1-Mediated Tumor-Selective Lethality and Radiosensitization for Head and Neck Cancer

(2016) Long-Shan Li et al.   MOLECULAR CANCER THERAPEUTICS

Perspectives from man’s best friend: National Academy of Medicine’s Workshop on Comparative Oncology

(2016) Amy K. LeBlanc et al.   Science Translational Medicine

Animal models of head and neck squamous cell carcinoma

(2016) Wachiraphan Supsavhad et al.   VETERINARY JOURNAL

Deoxynyboquinones as NQO1-Activated Cancer Therapeutics

(2015) Elizabeth I. Parkinson et al.   ACCOUNTS OF CHEMICAL RESEARCH

NQO1 protein expression predicts poor prognosis of non-small cell lung cancers

(2015) Zhenling Li et al.   BMC CANCER

Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy

(2015) Xinpeng Ma et al.   JOURNAL OF CONTROLLED RELEASE

β-Lapachone and Paclitaxel Combination Micelles with Improved Drug Encapsulation and Therapeutic Synergy as Novel Nanotherapeutics for NQO1-Targeted Cancer Therapy

(2015) Ling Zhang et al.   MOLECULAR PHARMACEUTICS

Feline Oral Squamous Cell Carcinoma: Clinical Manifestations and Literature Review

(2015) Ozgur Bilgic et al.   JOURNAL OF VETERINARY DENTISTRY

NQO1 overexpression is associated with poor prognosis in squamous cell carcinoma of the uterine cervix

(2014) Yue Ma et al.   BMC CANCER

Significance of NQO1 overexpression for prognostic evaluation of gastric adenocarcinoma

(2014) Lijuan Lin et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Clinical implications of high NQO1 expression in breast cancers

(2014) Yang Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Efficient NQO1 Substrates are Potent and Selective Anticancer Agents

(2013) Elizabeth I. Parkinson et al.   ACS Chemical Biology

Feline Drug Metabolism and Disposition

(2013) Michael H. Court   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis

(2012) X. Huang et al.   CANCER RESEARCH

Targeted therapy in head and neck cancer

(2012) S. K. Kundu et al.   TUMOR BIOLOGY

NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones

(2011) David Siegel et al.   BIOCHEMICAL PHARMACOLOGY

Runaway ROS as a Selective Anticancer Strategy

(2011) Elizabeth I. Parkinson et al.   ChemMedChem

Modulating Endogenous NQO1 Levels Identifies Key Regulatory Mechanisms of Action of  -Lapachone for Pancreatic Cancer Therapy

(2011) L. S. Li et al.   CLINICAL CANCER RESEARCH

Characterization of canine osteosarcoma by array comparative genomic hybridization and RT-qPCR: Signatures of genomic imbalance in canine osteosarcoma parallel the human counterpart

(2011) Andrea Y. Angstadt et al.   GENES CHROMOSOMES & CANCER

 -Lapachone Micellar Nanotherapeutics for Non-Small Cell Lung Cancer Therapy

(2010) E. Blanco et al.   CANCER RESEARCH

Chemistry and Biology of Deoxynyboquinone, a Potent Inducer of Cancer Cell Death

(2010) Joseph S. Bair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Towards novel paradigms for cancer therapy

(2010) V Pavet et al.   ONCOGENE

Cisplatin enhances the anticancer effect of β-lapachone by upregulating NQO1

(2009) Kaoru Terai et al.   ANTI-CANCER DRUGS

Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression

(2009) Melissa Paoloni et al.   BMC GENOMICS

Evolutionarily conserved cytogenetic changes in hematological malignancies of dogs and humans – man and his best friend share more than companionship

(2008) Matthew Breen et al.   CHROMOSOME RESEARCH

Mouse xenograft models vs GEM models for human cancer therapeutics

(2008) A. Richmond et al.   Disease Models & Mechanisms