Tensile-Strained Palladium Nanosheets for Synthetic Catalytic Therapy and Phototherapy

Palladium nanosheets (Pd NSs) are well-investigated photothermal therapy agents, but their catalytic potential for tumor therapy has been underexplored owing to the inactive dominant (111) facets. Herein, lattice tensile strain is introduced by surface reconstruction to activate the inert surface, endowing the strained Pd NSs (SPd NSs) with photodynamic, catalase-like, and peroxidase-like properties. Tensile strain promoting the photodynamic and enzyme-like activities is revealed by density functional theory calculations. Compared with Pd NSs, SPd NSs exhibit lower photothermal effect, but approximately five times higher tumor inhibition rate. This work calls for further study to activate nanomaterials by strain engineering and surface reconstruction for catalytic therapy of tumors.

Automated summary

Surface reconstruction and lattice tensile strain are utilized to activate the inactive facets of palladium nanosheets, leading to the development of strained palladium nanosheets with photodynamic, catalase-like, and peroxidase-like properties. These strained nanosheets exhibit higher tumor inhibition rate compared to the original palladium nanosheets.