Article
Chemistry, Multidisciplinary
Hua-Jiang Yu, Qingyang Zhou, Xianyin Dai, Fang-Fang Shen, Ying-Ming Zhang, Xiufang Xu, Yu Liu
Summary: The construction of host-guest-binding-induced phosphorescent supramolecular assemblies is an increasingly significant topic in biomaterial research. Through photooxidation-driven purely organic room-temperature phosphorescence, specific biospecies and physiological events in living cells can be tracked using supramolecular organelle identification.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Nanoscience & Nanotechnology
Muhammad Fayyaz, Musarrat Jabeen, Michael S. Tsipursky, Joseph Irudayaraj
Summary: The study proposes a dextran-based oxygen nanobubble (DONB) platform for treating central retinal artery occlusion (CRAO) by delivering oxygen intravitreally, showing significant recovery in the inner retinal layers. Oxygen distribution measurements, histology, and electroretinography confirmed the efficacy of this approach in treating CRAO.
ACS APPLIED NANO MATERIALS
(2021)
Article
Ophthalmology
Martin Hein, Andrew Mehnert, K. Bailey Freund, Dao-Yi Yu, Chandrakumar Balaratnasingam
Summary: This study investigates the variability of macular perfusion in patients with branch retinal vein occlusion (BRVO) using a novel approach based on optical coherence tomography angiography (OCTA) coefficient of variation (CoV) analysis. It was found that there is an increased variability in microvasculature perfusion in the ischemic regions of the macula affected by BRVO. This new technique has potential applications in studying the pathophysiology of other retinal vascular diseases.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Ophthalmology
Jorge G. Arroyo, Brendan Seto, Keiko Yamada, Ke Zeng, Robert Minturn, Colin A. Lemire
Summary: The study demonstrates that short-term treatment with low-dose normobaric hyperoxia can significantly reduce macular edema in patients with retinal vein occlusion. This treatment approach may serve as an alternative or adjunctive option for managing macular edema in patients who are resistant to or unable to afford anti-VEGF medications.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Ryo Kurobe, Yoshio Hirano, Takaaki Yuguchi, Norihiro Suzuki, Tsutomu Yasukawa
Summary: This study investigated the factors influencing post-treatment visual acuity in patients with CRVO and ME. The results showed a strong association between severe macular ischemia and poor visual prognosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Ho-Man Leung, Sunny Chi-Lik Au
Summary: This article reviews the evidence related to retinal vein occlusion (RVO) occurring after COVID-19 vaccination. All cases presented with visual loss shortly after vaccination, with AstraZeneca and BNT vaccines being the most common. The benefits of COVID-19 vaccination are believed to outweigh its risks to ophthalmic health.
Review
Ophthalmology
Sohan Singh Hayreh
Summary: This article discusses the role of photocoagulation in the treatment of retinal vein occlusion, emphasizing its importance in managing NV and macular edema. Research shows that photocoagulation can prevent and treat NV-related complications in CRVO and BRVO, and recent advancements in treatment options have drastically changed the role and management of photocoagulation in these conditions.
PROGRESS IN RETINAL AND EYE RESEARCH
(2021)
Review
Medicine, General & Internal
Shan Yin, Yanyan Cui, Wanzhen Jiao, Bojun Zhao
Summary: Retinal vein occlusion (RVO) is the second most prevalent cause of retinal vascular disease. Macular edema (ME) is a major complication of RVO and leads to visual impairment. Laser therapy, intravitreal steroid injections, and vascular endothelial growth factor inhibitors are the major therapeutic techniques.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Pasquale Loiudice, Giuseppe Covello, Michele Figus, Chiara Posarelli, Maria Sole Sartini, Giamberto Casini
Summary: This study aimed to evaluate the choroidal vascularity change in eyes with central and branch retinal vein occlusion (RVO). By analyzing the records of 47 patients, it was found that RVO eyes had higher choroidal vascularity index, total choroidal area, and luminal area compared to unaffected eyes. The changes varied according to the type of macular edema.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Shinsuke Nakamura, Anri Nishinaka, Yae Hidaka, Masamitsu Shimazawa, Leo Thomas, Remko A. Bakker, Hideaki Hara
Summary: This study investigated the efficacy of Sema3A neutralizing antibody BI-X and/or anti-VEGF therapy in an RVO mouse model. The results showed that BI-X monotherapy and its combination with anti-VEGF therapy had beneficial effects on intraretinal edema and retinal blood flow. Furthermore, BI-X monotherapy normalized the changes in expression of TNF-alpha and semaphorin-related proteins in the RVO mouse model.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Meiaad Khayat, Jennifer Perais, David M. Wright, Michael Williams, Noemi Lois
Summary: The study aimed to evaluate anatomic-functional associations at sites of retinal lesions in RVO patients. The results showed decreased retinal sensitivity at sites of RVO lesions, with impaired function in ischemic areas not recovering after treatment and even worsened with reperfusion.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Medicine, General & Internal
Ziyi Zhu, Yongan Meng, Igor Kozak, Manyun Xie, Youling Liang, Bin Yan, Liang Zhou, Pingbo Ouyang, Xiaoxi Yao, Jing Luo
Summary: The study showed that the macular microvascular structures remained stable in most RVO patients after anti-VEGF treatment, with some patients experiencing reperfusion or aggravation of macular ischemia. Macular ISI may be a better indicator for evaluating macular perfusion status in RVO patients compared to VD.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jayoung Ahn, Daniel Duck-Jin Hwang
Summary: This study evaluated longitudinal changes in peripapillary retinal nerve fiber layer (pRNFL) thickness in eyes affected with branch and central retinal vein occlusion (BRVO and CRVO, respectively) and fellow eyes. It found that the global pRNFL thickness of fellow eyes in the BRVO and CRVO groups decreased significantly at 24 months compared to baseline, while the fellow eyes of patients with CRVO had significantly lower pRNFL thickness at 12 and 24 months compared to those of the BRVO and normal control groups. These results suggest that fellow eyes of patients with BRVO and CRVO are susceptible to pRNFL damage.
SCIENTIFIC REPORTS
(2021)
Review
Ophthalmology
Francesco Romano, Francesca Lamanna, Pierre Henry Gabrielle, Kelvin Y. C. Teo, Maurizio Battaglia Parodi, Pierluigi Iacono, Samantha Fraser-Bell, Elisa E. Cornish, Marco Nassisi, Francesco Viola, Aniruddha Agarwal, Anindya Samanta, Jay Chhablani, Giovanni Staurenghi, Alessandro Invernizzi
Summary: Retinal vein occlusion is a common retinal vascular disorder that affects both men and women equally. The diagnosis and management of this condition have improved significantly over the past few decades, with new imaging techniques and alternative treatment options available. Despite the better long-term outcomes, there are still cases that require more aggressive approaches, such as surgery. This comprehensive review aims to combine old and new research to provide retina specialists with updated knowledge on the pathophysiology, clinical features, and treatment strategies of retinal vein occlusion.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ingrid U. Scott, Neal L. Oden, Paul C. Vanveldhuisen, S. Michael, B. A. Blodi
Summary: There is a nonlinear association between central subfield thickness (CST) on spectral-domain OCT and concurrent visual acuity letter score (VALS) in eyes treated initially with afli-bercept or bevacizumab for macular edema associated with central retinal vein occlusion (CRVO) or hemiretinal vein occlusion (HRVO). The best expected VALS is observed when post-treatment CST is close to the estimated inflection points.
Article
Chemistry, Physical
Dong Ryun Lee, Kyung Hyung Lee, Wenhao Shao, Cho Long Kim, Jinsang Kim, Jun Yeob Lee
CHEMISTRY OF MATERIALS
(2020)
Article
Multidisciplinary Sciences
M. Tuan Trinh, Gregory Smail, Krishnandu Makhal, Da Seul Yang, Jinsang Kim, Stephen C. Rand
NATURE COMMUNICATIONS
(2020)
Article
Nanoscience & Nanotechnology
Ramin Ansari, Wenhao Shao, Seong-Jun Yoon, Jinsang Kim, John Kieffer
Summary: The emission bandwidth of thermally activated delayed fluorescence (TADF) is primarily determined by the charge transfer character of the molecule, rather than its propensity for rotational motion. Rational molecular design can result in organic emitters exhibiting sharp emission spectra.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Deokwon Seo, Terry C. Major, Do Hyun Kang, Sungbaek Seo, Kangwon Lee, Robert H. Bartlett, Jinsang Kim
Summary: A self-signaling PDA liposome microarray was developed to detect activated platelets in whole blood samples in a single step, and successfully distinguished the effects of an antiplatelet drug on activated platelets through intense fluorescence signals.
Article
Materials Science, Multidisciplinary
Dukhan Kim, Emily A. Mueller, Da Seul Yang, Danielle E. Fagnani, Jinsang Kim, Anne J. McNeil
Summary: This study demonstrates that a single copolymer containing a conjugated poly(3-hexylthiophene) backbone and fullerene-functionalized side chains can serve as a general blend stabilizer, suppressing phase separation in multiple conjugated polymer/fullerene thin film blends as well as in a photovoltaic device.
ACS APPLIED POLYMER MATERIALS
(2021)
Correction
Nanoscience & Nanotechnology
Bo-Hyun Kim, Wontae Kim, Taemin Kim, Byoung Min Ko, Soon-Jik Hong, Kangtaek Lee, Jinsang Kim, Sung-Ho Song, Sunjong Lee
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Bo-Hyun Kim, Wontae Kim, Taemin Kim, Byoung Min Ko, Soon-Jik Hong, Kangtaek Lee, Jinsang Kim, Sung-Ho Song, Sunjong Lee
Summary: This study demonstrates that a fluorophore can enhance its fluorescence quantum yield through hydrogen bonding, providing a new strategy for fluorophore design. Additionally, the fluorophore embedded in a polymer matrix can selectively detect specific gases, which is crucial for the development of fluorescence sensing systems.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Wenhao Shao, Hanjie Jiang, Ramin Ansari, Paul M. Zimmerman, Jinsang Kim
Summary: Metal-free purely organic phosphors (POPs) are emerging materials for display technologies, solid-state lighting, and chemical sensors. The study presents a novel design concept for POPs that maximizes SOC efficiency by tightly coupling heavy atom effects and orbital angular momentum, leading to efficient room-temperature phosphorescence with lifetimes below the millisecond regime. This strategy enables a high degree of control over POP properties through discrete tuning of heavy atom effects and orbital angular momentum within the proposed design.
Review
Chemistry, Multidisciplinary
Wenhao Shao, Jinsang Kim
Summary: This Account summarizes important molecular design and matrix engineering strategies to tackle the challenges of low SOC efficiency and nonradiative decay in purely organic phosphors (POPs). SOC is mostly promoted by heavy atom effects and the El-Sayed rule, while engineering the matrices of POPs is critical to effectively suppress nonradiative decay. Future research can focus on molecular design descriptors, such as heavy atom oriented orbital angular momentum manipulation, to further enhance SOC efficiency in purely organic materials.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Deokwon Seo, Ramin Ansari, Kangwon Lee, John Kieffer, Jinsang Kim
Summary: There is an increasing need for fast and accurate assessment of various health conditions, and polydiacetylenes (PDA) have great potential due to their unique stress-sensitive optical properties. However, the inherent sensitivity limit of PDA sensors poses a challenge. In this study, a novel approach was developed to improve the sensitivity and limit of detection by preoccupying the surface of PDA liposomes with optimized amount of dummy molecules. The dummy strategy showed significant improvement in sensitivity and detection limit, and was successfully applied to different target molecules.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Wenhao Shao, Jie Hao, Hanjie Jiang, Paul M. Zimmerman, Jinsang Kim
Summary: Metal-free organic triplet emitters, with tunable emission and responsive to environmental stimuli, have great potential in solid-state lighting, sensors, and anti-counterfeiting systems. A novel excited-state intramolecular proton transfer system is proposed, showing simultaneous activation of thermally activated delayed fluorescence and room-temperature phosphorescence from both keto and enol tautomers.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Biophysics
Do Hyun Kang, Yingying Zeng, Muneesh Tewari, Jinsang Kim
Summary: A versatile organic room-temperature phosphorescence-based biosensor platform has been developed, which combines oxygen-sensitive lipid-polymer hybrid nanoparticles and signal-amplifying enzymatic oxygen scavenging reaction for high sensitivity detection. When incorporated into a sandwich DNA hybridization assay, the sensor demonstrates sequence-specific detection of a cell-free cancer biomarker with a sub-picomolar detection limit. This method is compatible with detecting cell-free nucleic acids in human urine samples and can be adapted for detecting biomarkers of clinical importance.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Materials Science, Multidisciplinary
Jiwon Lim, Shuo Zhang, Luyang Wang, Deokwon Seo, Malitha C. Dickwella Widanage, Kevin P. Pipe, Ayyalusamy Ramamoorthy, Jinsang Kim
Summary: DHI-free PCA coating using 3,4-dihydroxybenzylamine hydrobromide provides a smooth and uniform surface with preserved primary amine groups, offering an alternative strategy for surface amine functionalization. Additionally, DHI-free PCA improves the thermal conductivity of graphene-polymer composites.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Lixin Zang, Wenhao Shao, Onas Bolton, Ramin Ansari, Seong Jun Yoon, Jung-Moo Heo, John Kieffer, Adam J. Matzger, Jinsang Kim
Summary: This study investigates the dual phosphorescence emission characteristics and the effect of the environment on pure organic phosphors. The results show that the emission of pure organic phosphors gradually red-shifts with increasing solvent polarity, which is related to the T-1 to T-2 energy level conversion. Additionally, the decay curves and decay rates of pure organic phosphors vary depending on the matrix they are in.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
