Article
Immunology
Joao Paulo Bras, Isabelle Guillot de Suduiraut, Olivia Zanoletti, Silvia Monari, Mandy Meijer, Jocelyn Grosse, Mario Adolfo Barbosa, Susana Gomes Santos, Carmen Sandi, Maria Ines Almeida
Summary: This study suggests that male rats with high-CORT stress responsiveness exhibit increased anhedonia and passive coping responses in adulthood following peripubertal stress exposure. Additionally, exposure to peripubertal stress leads to increased hippocampal TNF-alpha expression, which correlates with passive coping responses. Furthermore, peripubertal stress has long-term effects on hippocampal microglia, particularly in high-CORT stress-responsive rats.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biotechnology & Applied Microbiology
Peng Sun, Zheng Wang, Tong Wu, Shishuai Zuo, Xiaoyu Huang, Zilian Cui, Dong Zhang
Summary: This study developed injectable, adhesive, and self-healing composite hydrogels loaded with oxybutynin hydrochloride, which provided relief to overactive bladder by decreasing the expression of Orail and STIM1 in rats.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Hailah M. ALmohaimeed, Zuhair M. Mohammedsaleh, Ashwaq H. Batawi, Maha Jameal Balgoon, Osama Ibrahim Ramadan, Hasan Ahmed Baz, Soad Al Jaouni, Nasra Naeim Ayuob
Summary: Cinnamomum cassia and Zingiber officinale in combination exhibit synergistic effects in improving blood glucose levels, reducing neuroinflammation, enhancing antioxidant capacity, and alleviating depressive-like behaviors in diabetic rats. This combination therapy shows superior efficacy compared to single administration of either ginger or cinnamon, providing a promising alternative or complementary supplement for managing diabetes and its neurological and psychiatric complications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Heeji Jo, Eun Jung Bae, Narasaem Lee, Jae Won Kwon, Suhan Cho, Sung Joon Kim, Jin Hee Ahn, Chul-Seung Park
Summary: The compound TTQC-1 was found to be a novel activator of the BKCa channel, which is highly expressed in bladder smooth muscle and involved in muscle relaxation. TTQC-1 increased the conductance and shifted the activation voltage of BKCa channels, and its activation effects were dependent on specific auxiliary subunits and intracellular Ca2+ concentrations. Additionally, oral administration of TTQC-1 decreased urination frequency in hypertensive rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Rui Wang, Ming Hong, Jingyi Huang, Na Zhou, Yao Zhang, Siyuan Xu, Jiaye Liu, Junjie Yuan, Lusiqi Zhang, Linyuan Huang, Ping Huang, Bo Tan, Hong-ying Cao
Summary: This research explores the neurotoxicity of low-dose cyclophosphamide on the urinary bladder of rats through in vivo and in vitro studies. The results indicate that low-dose CYP treatment induces nerve injury, leading to bladder pain and overactive bladder in female rats. The up-regulation of Nlrp6 and Casp11 may contribute to these pathological changes.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Plant Sciences
Zhihui Sun, Yan Tie, Xinyi Tong, Mingchang Cheng, Yushan Wu, Pingxiang Xu, Ming Xue, Liping Xu, Xuelin Zhou
Summary: This study investigates the biological mechanisms and key targets of Suo-Quan-Wan (SQW) on overactive bladder (OAB) in spontaneously hypertensive rats (SHR). The results show that SQW significantly improves urinary parameters and histological changes in the bladder of SHR. The involvement of arachidonic acid metabolism and purine metabolism in SQW treatment is also identified. The downregulation of certain proteins, such as CYP1B1, TBXAS1, ALOX5, and PDE4B, is found to affect the metabolism of AA and cAMP, leading to the activation of downstream proteins involved in bladder function.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Lih-Lian Chen, Yuh-Chiang Shen, Chih-Chun Ke, Zuha Imtiyaz, Hui- Chen, Chin-Hsien Chang, Mei-Hsien Lee
Summary: The study indicates that treatment with cinnamon patch may be an effective and safe complementary therapy for overactive bladder (OAB), leading to significant improvements in OAB symptoms.
Article
Chemistry, Multidisciplinary
Shi-feng Chu, Zhao Zhang, Xin Zhou, Wen-bin He, Bo Yang, Li-yuan Cui, Hong-yuan He, Zhen-zhen Wang, Nai-hong Chen
Summary: Elevated corticosterone levels can lead to aging and major depression disorder, but its role in late life depression (LLD) is not well understood. In an experiment with female rats, those with low-level CORT displayed reduced depressive symptoms and memory defects compared to those with high-level CORT or sham surgery. Enhanced glutamatergic transmission was also observed in the low-level CORT rats, potentially contributing to the alleviation of LLD symptoms.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Endocrinology & Metabolism
Ron S. Newfield, Kyriakie Sarafoglou, Patricia Y. Fechner, Natalie J. Nokoff, Richard J. Auchus, Maria G. Vogiatzi, George S. Jeha, Nagdeep Giri, Eiry Roberts, Julia Sturgeon, Jean L. Chan, Robert H. Farber
Summary: This study evaluated the safety, tolerability, and efficacy of crinecerfont in adolescents with classic 21OHD CAH. After 14 days of oral crinecerfont administration, participants showed substantial reductions in adrenal androgens and androgen precursors. These results are consistent with a study of crinecerfont in adults with classic 21OHD CAH.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Douglas Luchristt, C. Emi Bretschneider, Kimberly Kenton, Melissa Simon, Oluwateniola Brown
Summary: This study found that non-Hispanic Black individuals were less likely to use beta 3-adrenoceptor agonists compared to anticholinergic medications, reflecting potential inequities in prescribing practices and contributing to healthcare disparities.
Article
Pharmacology & Pharmacy
Kuang-Ming Liao, Ka-Lok Lio, Yu-Ju Chou, Chen-Chun Kuo, Chung-Yu Chen
Summary: The study aimed to evaluate the relationship between OAB medication adherence and different types of medication with UTI risk. The study found that during the follow-up period, neither adherence nor different types of medication had an impact on UTI risk, regardless of UTI history or sex.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ulrich Mehnert, Matthias Walter, Lorenz Leitner, Thomas M. Kessler, Patrick Freund, Martina D. Liechti, Lars Michels
Summary: Overactive bladder (OAB) is a global problem that affects the quality of life of patients and increases healthcare costs. This study found differences in supraspinal connectivity between OAB patients and healthy controls, particularly in the frontal and prefrontal cortices.
Article
Neurosciences
Chung-Wei Hsu, Sabrina Wang
Summary: The study suggests that activation of OX-A neurons can promote resilient behaviors under stressful situations in a learned helplessness (LH) animal model of depression, and that OX-A and OX-B neuropeptides exhibit dissimilar functions in LH behaviors.
Article
Medicine, General & Internal
Naoko Izumi, Tomohiro Matsuo, Yoshihisa Matsukawa
Summary: This study investigated the association between physician-patient communication and patient satisfaction with overactive bladder (OAB) medical care, as well as clinical effectiveness. The findings suggest that adequate physician-patient communication significantly contributes to improving clinical effectiveness and satisfaction with medical care in OAB patients, thereby increasing treatment continuation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Amalia Davila-Hernandez, Roberto Gonzalez-Gonzalez, Sonia Guzman-Velazquez, Olivia Tania Hernandez Hernandez, Sergio R. Zamudio, Lucia Martinez-Mota
Summary: This study suggests that AC can improve depressive symptoms in socially isolated male rats, potentially by modulating neuroendocrine and hippocampal molecular alterations.
BRAIN RESEARCH BULLETIN
(2021)
Review
Plant Sciences
Karol Rojek, Anna Serefko, Ewa Poleszak, Aleksandra Szopa, Andrzej Wrobel, Malgorzata Guz, Jianbo Xiao, Krystyna Skalicka-Wozniak
Summary: Aromatic grasses of Cymbopogon genus are widely used in traditional medicine, and their essential oils and active substances have been studied for potential therapeutic effects, especially in the treatment of neurological and mental disorders. Many scientists suggest that plants from the Cymbopogon genus are ideal candidates for further pharmaceutical research.
PHYTOCHEMISTRY REVIEWS
(2022)
Article
Obstetrics & Gynecology
Andrzej Wrobel, Izabela Winkler, Tomasz Rechberger, Katarzyna Skorupska, Pawel Miotla
Summary: This study assessed the efficacy of collagen patches in preventing lymphoceles, and found that patients with TachoSil patches had lower drainage volume and a decreased tendency of lymphocele occurrence after completion of adjuvant therapy.
GINEKOLOGIA POLSKA
(2022)
Article
Obstetrics & Gynecology
Wlodzimierz Baranowski, Klaudia Stangel-Wojcikiewicz, Magdalena E. Grzybowska, Andrzej Malinowski, Tomasz Rechberger, Edyta Wlazlak, Tomasz Kluz, Elzbieta Najorczyk-Swiesciak, Artur Rogowski, Grzegorz Surkont
Summary: The Polish Society of Gynecologists and Obstetricians (PSGO) published guidelines for the management of recurrent pelvic organ prolapse, recommending sacrocolpopexy as the method of choice for surgical repair. However, the higher risk of complications associated with sacrocolpopexy compared to vaginal surgeries should be taken into consideration.
GINEKOLOGIA POLSKA
(2022)
Article
Obstetrics & Gynecology
Edyta Wlazlak, Tomasz Kluz, Tomasz Rechberger, Wlodzimierz Baranowski, Artur Rogowski, Magdalena E. Grzybowska, Konrad Futyma, Klaudia Stangel-Wojcikiewicz, Paulina Pajak, Elzbieta Narojczyk-Swiesciak, Bartlomiej Burzynski, Radoslaw Maksym, Grzegorz Surkont
Summary: This translation provides an overview of the Guideline for the diagnostic assessment of pelvic organ prolapse (POP) in women, developed by the Urogynecology Section of the Polish Society of Gynecologists and Obstetricians. It includes the steps and indications for the diagnostic assessment, emphasizing the individualization of the process.
GINEKOLOGIA POLSKA
(2022)
Article
Medicine, General & Internal
Katarzyna Jankiewicz, Michal Bogusiewicz, Lukasz Nowakowski, Tomasz Rechberger, Artur Rogowski, Pawel Miotla
Summary: This study evaluated urinary NGF levels in POP patients involving the anterior vaginal wall and found that it was significantly increased in pure OAB patients. However, NGF cannot serve as a biomarker for OAB in patients with POP, and it is not a predictive factor for the resolution of OAB symptoms after POP surgical treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Monika Elzbieta Jach, Anna Serefko, Maria Ziaja, Marek Kieliszek
Summary: In recent years, consumer demand for healthy food has increased, prompting scientists to search for innovative methods of food production. Yeast protein biomass is a promising source of easily digestible protein with nutritional benefits. The production of yeast protein can also contribute to waste purification.
Article
Neurosciences
Anna Serefko, Gabriela Bielecka-Papierz, Sylwia Talarek, Aleksandra Szopa, Piotr Skalecki, Bernadeta Szewczyk, Maria Radziwon-Zaleska, Ewa Poleszak
Summary: The study found that mephedrone in mice demonstrates stimulating locomotor activity and psychological effects, with a development of tolerance upon repeated administration. Additionally, it shows potential for anxiolytic effects and improved spatial memory, but has no impact on recognition memory.
Article
Obstetrics & Gynecology
Ewa Rechberger, Andrzej Wrobel, Beata Kulik-Rechberger, Pawel Miotla, Tomasz Rechberger
Summary: This study aimed to investigate the non-inferiority of Femistina compared with Canephron in reducing symptomatic urinary tract infections (UTI) in the first six months following midurethral sling surgery. The results showed that Femistina was not inferior to Canephron in preventing lower urinary tract infections after the surgery.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Kajetan Juszczak, Jan Adamowicz, Lukasz Zapala, Tomasz Kluz, Przemyslaw Adamczyk, Artur Wdowiak, Iwona Bojar, Marcin Misiek, Magdalena Emilia Grzybowska, Klaudia Stangel-Wojcikiewicz, Ewa Poleszak, Marta Pokrywczynska, Tomasz Drewa, Andrzej Wrobel
Summary: This study investigated the effects of Potentilla chinensis extract (PCE) on urinary bladder function in cyclophosphamide-induced hemorrhagic cystitis (HC). The results showed that PCE attenuated detrusor overactivity and reversed the biochemical changes in the urothelium, detrusor muscle, and urine caused by HC. PCE may be a potential supportive treatment for patients undergoing cyclophosphamide-based chemotherapy.
SCIENTIFIC REPORTS
(2022)
Article
Behavioral Sciences
Gabriela Bielecka-Papierz, Anna Serefko, Aleksandra Szopa, Sylwia Talarek, Andrzej Wrobel, Bernadeta Szewczyk, Maria Radziwon-Zaleska, Malgorzata Koltun-Jasion, Ewa Poleszak
Summary: This study investigated the potential involvement of the L-arginine-NO-cGMP pathway in the development of sensitization to mephedrone-induced hyperlocomotion. The results showed that inhibition of neuronal nitric oxide synthase (NOS) effectively prevented this process, while non-selective inhibition of NOS may have a dual effect.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Aleksandra Szopa, Mariola Herbet, Anna Pachuta-Stec, Joanna Lachowicz, Kamil Pawlowski, Magdalena Iwan, Dominika Jarecka-Florek, Oliwia Krasinska, Anna Serefko, Ewa Poleszak, Monika Pitucha
Summary: The aim of the studies was to evaluate the antiproliferative potential of new derivatives containing 4-nitrophenyl group against human tumor cell lines and its impact on developmental toxicity in zebrafish model. The results showed that APS-1 and APS-18 compounds reduced the viability of human tumor lines, with APS-18 showing strong and selective antiproliferative activity against all neoplastic cell lines, particularly glioblastoma. The fish embryo acute toxicity test demonstrated that APS-1 and APS-18 did not cause morphological abnormalities in zebrafish embryos, indicating their potential for further research and development of safer drugs with better anticancer properties.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lukasz Zapala, Grzegorz Niemczyk, Piotr Zapala, Artur Wdowiak, Iwona Bojar, Tomasz Kluz, Aleksandra Szopa, Anna Serefko, Piotr Radziszewski, Andrzej Wrobel
Summary: This paper aimed to investigate whether the selective cannabinoid CB1 receptor agonist ACEA could reverse the effects of corticosterone (CORT) on depressive and overactive bladder potential. Through experiments on 48 female rats, it was found that ACEA could restore CORT-induced bladder dysfunction and depressive behavior, as well as regulate urine and other biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Szopa, Mariola Herbet, Ewa Poleszak, Anna Serefko, Agnieszka Czylkowska, Iwona Piatkowska-Chmiel, Kamila Kasperek, Andrzej Wrobel, Paulina Prewencka, Bernadeta Szewczyk
Summary: The study evaluated the antidepressant-like effects of an IMI-Zn complex compound on mice and compared its efficacy with separate administration of imipramine and zinc. The results showed that the IMI-Zn complex exhibited dose-dependent antidepressant potential similar to individual treatments of imipramine and zinc. The study also found that acute stress did not significantly affect oxidative stress parameters. Developing the IMI-Zn complex could simplify treatment and improve patient compliance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)