Article
Nutrition & Dietetics
Marta Portero-Tresserra, Neus Galofre-Lopez, Elisabet Pallares, Claudia Gimenez-Montes, Carlos Barcia, Roser Granero, Divka Rojic-Becker, Anna Vale-Martinez, Margarita Marti-Nicolovius, Gemma Guillazo-Blanch
Summary: Age-related changes in the brain significantly impact hippocampal structure and function, leading to cognitive impairments such as deteriorating spatial object recognition (SOR) memory. Both intrinsic factors like neuroinflammation and lifestyle factors like diet can influence aging-related brain function and cognitive performance. This study aimed to evaluate the effects of caloric restriction (CR) on SOR memory, hippocampal neuron loss, neurogenesis, and inflammation in aged male rats. The results showed that CR attenuated the decline in SOR memory, hippocampal neuron loss, and microglial activation associated with aging, while also reducing neurogenesis in the dentate gyrus.
Article
Biochemistry & Molecular Biology
Kyu Ri Hahn, Woosuk Kim, Hyo Young Jung, Hyun Jung Kwon, Dae Won Kim, In Koo Hwang, Yeo Sung Yoon
Summary: Feeding mice a diet enriched with cuprizone can induce demyelination in the corpus callosum and increase neural progenitor cells in the dentate gyrus. This damage is more pronounced in young adult mice and may be associated with changes in BDNF and pCREB levels.
NEUROCHEMICAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Wei Xiong, Rongzi Li, Boying Li, Xifan Wang, Huihui Wang, Yanan Sun, Xiaoyu Wang, Yixuan Li, Fazheng Ren
Summary: Memory impairment is a characteristic of brain aging, and enhancing neurogenesis is a potential method for mitigating it. Nobiletin (NOB), a natural flavonoid derived from citrus peels, was found to attenuate memory impairment and restore hippocampal neurogenesis in aging mice. Furthermore, NOB inhibited inflammation and improved viability and differential ability of cells. Overall, NOB is a potential candidate for improving brain function by enhancing neurogenesis.
Article
Clinical Neurology
Yu-Qing Li, C. Shun Wong
Summary: AMPK deficiency in mice did not affect the number of newborn neurons in adult hippocampal neurogenesis, but resulted in decreased proliferation of neural progenitor cells. Inhibition of neurogenesis was observed after irradiation regardless of genotypes, with further loss of early neural progenitor cells and neuroblasts in AMPK-deficient mice compared to wild-type mice.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2021)
Article
Oncology
Zoe Schmal, Ben Hammer, Andreas Mueller, Claudia E. Ruebe
Summary: Despite advances in hippocampus-sparing radiation therapy, radiation-induced injury to the neural stem cell compartment may impact neurocognitive functions. Low doses of ionizing radiation induced inflammatory responses in the hippocampus, with activated microglia and reactive astrocytes, suggesting a shift from neurogenesis to gliogenesis. These findings emphasize the importance of limiting radiation dose to preserve neurocognitive functions, particularly in the juvenile hippocampus.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Medicine, Research & Experimental
Hee Ra Park, Heeeun Lee, Won-Kyung Cho, Jin Yeul Ma
Summary: This study found that water extract of Lilii Bulbus (WELB) can improve memory and spatial memory in mice, as well as promote hippocampal neurogenesis, suggesting its potential for treating neurodegenerative diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Tracy A. Bedrosian, Judith Houtman, Juan Sebastian Eguiguren, Saeed Ghassemzadeh, Nicole Rund, Nicole M. Novaresi, Lauren Hu, Sarah L. Parylak, Ahmet M. Denli, Lynne Randolph-Moore, Takashi Namba, Fred H. Gage, Tomohisa Toda
Summary: The age-dependent decline of lamin B1 in adult neural stem/progenitor cells is associated with alterations in adult hippocampal neurogenesis and anxiety-like behavior in mice, indicating a role in stem cell aging and mood regulation.
Article
Immunology
Jiangong Wang, Bin Liu, Fengjiao Sun, Yong Xu, Haiyun Luan, Meizi Yang, Chaoyun Wang, Tiantian Zhang, Zhenyu Zhou, Haijing Yan
Summary: This study found that inhibition of H3R reduced microglia activity and promoted a shift from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype in microglia, thereby attenuating lipopolysaccharide-induced neuroinflammation in mice. Additionally, inhibition of H3R rescued the impairments of neurogenesis and cognitive function caused by neuroinflammation. Mechanistically, the neuroprotective effects of H3R inhibition were mediated by histamine-dependent activation of H2R and reinforcement of CREB-CBP interaction, which led to increased release of anti-inflammatory cytokines and brain-derived neurotrophic factor, as well as decreased release of pro-inflammatory cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cristina Cachan-Vega, Ignacio Vega-Naredo, Yaiza Potes, Juan Carlos Bermejo-Millo, Adrian Rubio-Gonzalez, Claudia Garcia-Gonzalez, Eduardo Antuna, Manuel Bermudez, Jose Gutierrez-Rodriguez, Jose Antonio Boga, Ana Coto-Montes, Beatriz Caballero
Summary: This study evaluated the effects of chronic melatonin treatment on neurodegeneration and hippocampal neurogenesis in aged and neurodegenerative brains. The findings suggest that melatonin can decrease neurodegenerative processes and improve the functionality of adult hippocampal neurogenesis.
Article
Cell Biology
Hong Wang, Zhao-Wu Ma, Feng-Ming Ho, Gautam Sethi, Feng Ru Tang
Summary: Ionizing radiation induces brain inflammation and impairs neurogenesis via microglial activation and apoptosis. The molecular mechanisms and causal relationship between microglial activation and neurogenesis impairment are still unclear.
Article
Cell Biology
Peng Chen, ZhiLei Guo, Benhong Zhou
Summary: Alzheimer's disease is a common form of dementia that significantly impacts the quality of life for the elderly. Hippocampal dysfunction plays a pivotal role in neurodegeneration in Alzheimer's patients and understanding the impact of neurogenesis on aging and cognitive deficits is crucial for advancing research in this field.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Ana Catarina Ferreira, Fernanda Marques
Summary: Lipocalin-2 (LCN2) is an acute phase protein involved in iron binding. Recent studies have found that LCN2 plays a significant role in regulating iron levels and redox state. In the central nervous system, the absence of LCN2 affects neural stem cell proliferation and differentiation, impacting hippocampal-dependent tasks. Additionally, stress and voluntary running are known regulators of neurogenesis. This study shows that LCN2-null mice do not respond to chronic stress exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Ji Yeon Hong, Jae-Jun Ban, Qing-Ling Quan, Ji-Eun Eom, Hee Soon Shin, Jin Ho Chung
Summary: Tomato and lemon extracts can reduce cellular oxidative stress and increase neurogenesis, while the mixture of the two shows synergistic effects in anti-oxidation and hippocampal neurogenesis.
Article
Oncology
Zoe Schmal, Claudia E. Ruebe
Summary: Radiation-induced brain injury significantly affects the neurocognitive functions of brain cancer survivors, especially in pediatric patients. This study investigated the underlying mechanisms of radiation-induced brain injury by analyzing different hippocampal subregions in a mouse model. The findings suggest that region-specific differences in radiosensitivity are primarily determined by the presence of proliferating neuroprogenitors.
Article
Behavioral Sciences
Nicole L. Reitz, Polliana T. Nunes, Lisa M. Savage
Summary: Adolescent intermittent ethanol exposure in rats can lead to damage in the critical circuit for learning and memory, resulting in spatial behavior impairments during aging. There are differences in cognitive impairments among rats of different sexes and ages, especially in tasks related to ethanol exposure.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
