Optimizing CSP1 analogs for modulating quorum sensing in Streptococcus pneumoniae with bulky, hydrophobic nonproteogenic amino acid substitutions

Harnessing multiple, non‐proteogenic substitutions to optimize CSP:ComD hydrophobic interactions in group1 Streptococcus pneumoniae

(2021) Tahmina A. Milly et al.   CHEMBIOCHEM

Elucidating the Role and Structure–Activity Relationships of the Streptococcus oligofermentans Competence-Stimulating Peptide

(2021) Ryan W. Mull et al.   ACS Chemical Biology

Designing cyclic competence-stimulating peptide (CSP) analogs with pan-group quorum-sensing inhibition activity in Streptococcus pneumoniae

(2020) Yifang Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of Streptococcus pneumoniae Pan Group Quorum Sensing Modulators

(2019) Bimal Koirala et al.   CHEMBIOCHEM

Defining the hydrophobic interactions that drive competence stimulating peptide (CSP)-ComD binding in Streptococcus pneumoniae

(2018) Bimal Koirala et al.   Beilstein Journal of Organic Chemistry

Antibodies Reactive to Commensal Streptococcus mitis Show Cross-Reactivity With Virulent Streptococcus pneumoniae Serotypes

(2018) Sudhanshu Shekhar et al.   Frontiers in Immunology

Structural Characterization of Competence-Stimulating Peptide Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumoniae

(2018) Yifang Yang et al.   BIOCHEMISTRY

Development of a Dominant Negative Competence Stimulating Peptide (dnCSP) that Attenuates Streptococcus pneumoniae Infectivity in a Mouse Model of Acute Pneumonia

(2018) Bimal Koirala et al.   CHEMBIOCHEM

Targeting Unoccupied Surfaces on Protein–Protein Interfaces

(2017) David Rooklin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exploiting Quorum Sensing To Confuse Bacterial Pathogens

(2013) B. LaSarre et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Streptococcus pneumoniae: the evolution of antimicrobial resistance to beta-lactams, fluoroquinolones and macrolides

(2012) J.E. Cornick et al.   MICROBES AND INFECTION

Streptococcus pneumoniae – a review of carriage, infection, serotype replacement and vaccination

(2012) Sam Mehr et al.   Paediatric Respiratory Reviews

Saturated Alanine Scanning Mutagenesis of the Pneumococcus Competence Stimulating Peptide Identifies Analogs That Inhibit Genetic Transformation

(2012) Chaohui Duan et al.   PLoS One

Rapid Pneumococcal Evolution in Response to Clinical Interventions

(2011) N. J. Croucher et al.   SCIENCE

Inhibition of Competence Development, Horizontal Gene Transfer and Virulence in Streptococcus pneumoniae by a Modified Competence Stimulating Peptide

(2011) Luchang Zhu et al.   PLoS Pathogens

Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates

(2009) Katherine L O'Brien et al.   LANCET

Hyper-Recombination, Diversity, and Antibiotic Resistance in Pneumococcus

(2009) W. P. Hanage et al.   SCIENCE