Article
Chemistry, Medicinal
Baskar Selvaraj, Dae Woon Kim, Jin-Soo Park, Hak Cheol Kwon, Heesu Lee, Ki-Yeon Yoo, Jae Wook Lee
Summary: Compound 1 demonstrated neuroprotective effects by inhibiting cellular Ca2+ uptake and reducing ROS accumulation in response to glutamate-induced neurotoxicity. It also showed inhibition of the MAPK signaling pathway, leading to decreased levels of pro-apoptotic proteins and AIF translocation to the nucleus. Overall, compound 1 effectively protected neuronal cells from apoptotic cell death.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Ji Yun Baek, Kiwon Jung, Young-Mi Kim, Hyun-Young Kim, Ki Sung Kang, Young-Won Chin
Summary: The study demonstrated that gamma-mangostin has a protective effect against glutamate-induced cell damage by reducing reactive oxygen species production, stimulating heme oxygenase-1 expression, and inhibiting the intrinsic mitochondrial apoptotic pathway in HT22 cells.
Article
Neurosciences
Xue Wang, Wuqiong Zhang, Pengfei Ge, Miaomiao Yu, Hongmei Meng
Summary: This study found that Parthanatos mechanism is involved in hippocampal neuronal death following seizures, possibly initiated by ROS.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Medicine, Research & Experimental
Yaodong Zhang, Shixin Ding, Yali Chen, Zhenghao Sun, Junyan Zhang, Yuli Han, Xianan Dong, Zhirui Fang, Weizu Li
Summary: The study showed that LPS exposure induced significant neuronal damage in HT22 cells, while treatment with ginsenoside Rg1 (Rg1) significantly reduced LPS-induced neuronal damage. Rg1 may protect neurons by inhibiting NOX2-NLRP1 inflammasome activation and ROS production.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mauricio Tavares Jacques, Luciano Saso, Marcelo Farina
Summary: Neuron-glia interactions are crucial for maintaining the central nervous system's stability. Microglial cells, as important support cells in the brain, play a role in responding to disruptions in this stability. In this study, the researchers investigated the potential protective effects of activated microglia on neuronal cells against ferroptosis, an iron-dependent form of cell death. The findings suggest that activated microglial cell-derived molecules may contribute to the protection of neuronal cells against ferroptosis, highlighting the potential for controlling this cell death mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Chatrawee Duangjan, Panthakarn Rangsinth, Shaoxiong Zhang, Xiaojie Gu, Michael Wink, Tewin Tencomnao
Summary: The study investigated the beneficial effects of V. vinifera leaf extract on neuroprotection and antioxidant properties, showing its potential in combating oxidative stress and aging. VVE extract demonstrated positive impact on antioxidant properties and neuroprotective effects.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Wanchanok Nantacharoen, Seung Joon Baek, Waluga Plaingam, Somsri Charoenkiatkul, Tewin Tencomnao, Monruedee Sukprasansap
Summary: The CNP extract and resveratrol have protective effects against glutamate-induced neurotoxicity by inhibiting apoptosis and increasing antioxidant enzyme expression. They activate the SIRT1/Nrf2 survival mechanism to inhibit oxidative neurotoxicity and promote neuronal survival.
Article
Chemistry, Physical
Soeun Kim, Phil Jun Lee, Bo Fang, SeonJu Park, Kandasamy Saravanakumar, Navabshan Irfan, Chau Ha Pham, Guijae Yoo, Hee Min Yoo, Namki Cho
Summary: This study isolated three novel phenolic glycosides (1-3) and 12 known compounds (4-15) from the roots of Populus tomentiglandulosa. The compounds (5, 7, and 11) with the 1-hydroxy-6-oxo-2-cyclohexenecarboxylate (HCH) moiety showed strong neuroprotective effects. Among these compounds, tremulacin (TRC, compound 5) was found to have the ability to prevent glutamate-induced apoptosis and showed potential as a treatment option for neurological diseases like Alzheimer's and Parkinson's.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biology
Parinee Kittimongkolsuk, Nattaporn Pattarachotanant, Siriporn Chuchawankul, Michael Wink, Tewin Tencomnao
Summary: The study established the neuroprotective effects of LR's ethanol extract (LRE) both in vitro and in vivo, suggesting potential for LRE as a candidate neuroprotectant.
Article
Neurosciences
Shuang Chen, Qin Zou, Qiang Guo, Yongmin Chen, Xi Kuang, Yukang Zhang, Yan Liu, Wengang Wu, Ge Li, Linzhi Tu, Jingyi Tong, Songrong Li, Lin Ma, Qifu Li
Summary: The study demonstrated that SPARC plays a crucial role in nerve injury of CNS diseases by regulating autophagy levels in hippocampal nerve cells. Its knockdown can reduce glutamate-induced nerve injury, suggesting a potential therapeutic target for CNS diseases.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Food Science & Technology
Wenqi Wang, Yidi Qu, Siyu Li, Jinyu Chu, Hongxin Yang, Lirong Teng, Di Wang
Summary: In this study, the neuroprotective effect of Curculigoside (CCG) on oxidative stress mediated mitochondrial dysfunction was investigated. CCG showed significant protective effects on damaged cells and transgenic mice, improving memory and behavior impairments, reducing protein deposition and neurofibrillary fiber tangles, and suppressing oxidative stress. The mechanism of action may involve the regulation of proteins related to mitochondrial dysfunction through the AMPK/Nrf2 signaling pathway.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Neurosciences
RuiJin Xie, TianXiao Li, XinYu Qiao, HuiYa Mei, GuoQin Hu, LongFei Li, Chenyu Sun, Ce Cheng, Yin Cui, Ni Hong, Yueying Liu
Summary: Epilepsy is common in children, with SE occurring more frequently and leading to drug-resistant epilepsy in some cases. Current antiepileptic drugs have adverse effects necessitating the development of new therapeutic drugs.
Article
Nutrition & Dietetics
Emily F. Bengson, Cole A. Guggisberg, Thomas W. Bastian, Michael K. Georgieff, Moon-Suhn Ryu
Summary: NCOA4 plays a crucial role in neuronal cells by mediating ferritin degradation and facilitating iron release. Silencing of NCOA4 impairs ferritin turnover and is cytotoxic under iron restriction. Abnormal ferritinophagy associated with NCOA4 may have implications for genetic pathways of neurodevelopment and neurodegenerative diseases.
FRONTIERS IN NUTRITION
(2023)
Review
Cell Biology
Yiran Sun, Chenchen Yan, Libo He, Shixie Xiang, Pan Wang, Zhonghua Li, Yuanzhao Chen, Jie Zhao, Ye Yuan, Wang Wang, Xiaowei Zhang, Pan Su, Yunfang Su, Jinlian Ma, Jiangyan Xu, Quekun Peng, Huifen Ma, Zhishen Xie, Zhenqiang Zhang
Summary: Alzheimer's disease (AD), a chronic and progressive neurodegenerative disease, poses a serious threat to the health of the elderly. The microscopic features of the AD brain are amyloid plaques and neurofibrillary tangles. Despite extensive research, there are still no effective drugs to halt the progression of AD. Ferroptosis, a type of programmed cell death, has been shown to promote the development of AD, and inhibiting neuronal ferroptosis can improve cognitive impairment. Calcium (Ca2+) dyshomeostasis has been found to be closely related to AD pathology, driving ferroptosis through various pathways. This paper reviews the roles of ferroptosis and Ca2+ in AD pathology and suggests that targeting the homeostasis of Ca2+ to restrain ferroptosis may be an innovative approach for AD treatment.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Qiang Gao, Chi Zhang, Jiaxin Li, Han Xu, Xiaocheng Guo, Qi Guo, Chen Zhao, Haixu Yao, Yuhan Jia, Hui Zhu
Summary: More research is needed to understand how melatonin protects neurons. This study investigated the role of long non-coding RNA (lncRNA) NEAT1 in melatonin's ability to defend against H2O2-induced oxidative injury in mouse neurons. The results showed that melatonin upregulates NEAT1, leading to stabilization of the mRNA and protein levels of Slc38a2 and reducing oxidative injury-induced apoptosis and cell toxicity. This research may have implications for the treatment of oxidative injury-induced hippocampal degeneration associated with aging using melatonin and its target lncRNA NEAT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)