Article
Biochemistry & Molecular Biology
Katharina Rindler, Constanze Jonak, Natalia Alkon, Felix M. Thaler, Harald Kurz, Lisa E. Shaw, Georg Stingl, Wolfgang Weninger, Florian Halbritter, Wolfgang M. Bauer, Matthias Farlik, Patrick M. Brunner
Summary: The study identified a specific panel of biomarkers associated with disease progression in mycosis fungoides (MF) patients, which may be used for monitoring MF disease progression. Altered expression of these genes may underlie the switch in clinical phenotype observed in advanced-stage MF.
Article
Hematology
Armando N. Bastidas Torres, Davy Cats, Jacoba J. Out-Luiting, Daniele Fanoni, Hailiang Mei, Luigia Venegoni, Rein Willemze, Maarten H. Vermeer, Emilio Berti, Cornelis P. Tensen
Summary: This study presents a comprehensive genetic characterization of primary cutaneous CD8(+) aggressive epidermotropic cytotoxic T-cell lymphoma (pcAECyTCL) and identifies overactive JAK2 signaling as a central driver of this lymphoma. The findings suggest the potential of JAK2 inhibitors as a therapeutic option for pcAECyTCL patients.
Review
Oncology
Susann Schonefeldt, Tamara Wais, Marco Herling, Satu Mustjoki, Vasileios Bekiaris, Richard Moriggl, Heidi A. Neubauer
Summary: Gamma delta T cells play dual roles in cancer immunity, acting both as anti-tumour agents and promoting tumour growth. While they exhibit rapid cytotoxicity and potential for immunotherapy, their transformation can lead to aggressive lymphomas with poor prognosis and limited treatment options.
Article
Obstetrics & Gynecology
Daniel C. Morse, Katherine E. Park, Vida Chitsazzadeh, Shaoying Li, Ken Young, Jillian R. Gunther, Bouthaina S. Dabaja, Madeleine Duvic
Summary: Primary cutaneous CD8(+) aggressive epidermotropic cytotoxic T-cell lymphoma can present with clinical features incongruent with histological findings, but requires systemic chemotherapy for aggressive treatment. Appropriate clinicopathologic correlation and timely radiation therapy are crucial in preventing excessive or insufficient therapeutic intervention.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2021)
Letter
Oncology
Sophie Voruz, Laurence de Leval, Anne Cairoli
Summary: Primary cutaneous gamma-delta T-cell lymphoma (PCGD-TCL) is a rare and aggressive lymphoma with poor prognosis. Resistance to chemotherapy and lack of standard treatment approach pose difficulties in managing this disease. CD30 expression may offer a potential therapeutic option, with successful outcomes observed in cases treated with Brentuximab Vedotin and Gemcitabine combination therapy.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Medicine, General & Internal
Zhen-Dong He, Hai-Yan Yang, Sheng-Sheng Zhou, Man Wang, Qin-Li Mo, Feng-Xiang Huang, Zhi-Gang Peng
Summary: The combination of chidamide and traditional chemotherapy is effective in primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma, leading to complete remission in this case study.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Dermatology
Apoorva Trivedi, Mariko Yabe, Ahmet Dogan, Zachary D. Epstein-Peterson, Patricia L. Myskowski, Maria E. Arcila, Konstantinos Linos
Summary: Primary cutaneous gamma-delta T-cell lymphoma (PCGDTL) is a rare and diagnostically challenging primary skin lymphoma. We report an extremely rare case of PCGDTL with aberrant expression of B-cell markers.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2023)
Article
Dermatology
Hany Meawad, Joo Y. Song, Matthew L. Ulrickson, Dennis D. Weisenburger
Summary: Primary cutaneous gamma-delta T-cell lymphoma is a rare and aggressive neoplasm with cytologic features that may mimic other types of lymphomas.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2022)
Article
Dermatology
Roger Rovira-Lopez, Fernando Gallardo, Antonio Salar, Lluis Colomo, Ramon M. Pujol
Summary: An 84-year-old woman presented with a 3-month history of papular rash. Histopathological examination revealed atypical lymphoid deep and band-like dermal infiltrates with marked epidermotropism. The expression of B-cell markers and aberrant expression of CD5 were observed in neoplastic cells and circulating lymphocytes, respectively. Staging workup revealed spleen enlargement, bone marrow, and gastrointestinal tract involvement. The case highlights the autoinvolutive and recurrent epidermotropic B-cell atypical cutaneous infiltrates as a characteristic feature of secondary cutaneous involvement in splenic marginal B-cell lymphoma.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Nuh Filizoglu, Salih Ozguven, Tunc Ones, Halil Turgut Turoglu, Tanju Yusuf Erdil
Summary: This article presents a unique case of extranodal natural killer/T-cell lymphoma with widespread cutaneous and subcutaneous involvement on F-18-FDG PET/CT.
CLINICAL NUCLEAR MEDICINE
(2022)
Review
Immunology
Guanyu Qu, Shengli Wang, Zhenlong Zhou, Dawei Jiang, Aihua Liao, Jing Luo
Summary: This article summarizes the current knowledge of the γδT cell phenotype in various tissues in mice and humans, describing the similarities and differences of tissue-resident γδT cells in these two species.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Hao-Kang Li, Tai-Sheng Wu, Yi-Chiu Kuo, Ching-Wen Hsiao, Hsiu-Ping Yang, Chia-Yun Lee, Pei-Ju Leng, Yun-Jung Chiang, Zih-Fei Cheng, Sen-Han Yang, Yan-Liang Lin, Li-Yu Chen, Ciao-Syuan Chen, Yu-Ju Chen, Shih-Chia Hsiao, Sai-Wen Tang
Summary: CD20-targeting CAR T cells have shown significant clinical efficacy in patients with B-cell malignancies, but the manufacturing processes involved limit their widespread application. The development of ACE1831, an allogenic cell product equipped with anti-CD20 antibody, using ACC technology, demonstrates promising results in targeting CD20-expressing cancer cells. The ACC-linked antibody/receptor complex on gamma delta 2 T cells stimulates T cell activation and shows potential for allogenic immunotherapy against relapsed/refractory B-cell lymphoma.
Article
Dermatology
Chika Hirata, Kozo Nakai, Yusuke Kurasawa, Naoki Maekawa, Shuichi Kuniyuki, Keiko Yamagami, Masahiko Ohsawa, Daisuke Tsuruta
Summary: This case report describes a rare primary cutaneous gamma-delta T-cell lymphoma that was initially misdiagnosed as panniculitis-like T-cell lymphoma and was associated with an autoimmune disease. The patient showed improvement in symptoms after treatment, but the diagnosis was corrected to CGD-TCL one year later.
Review
Medicine, General & Internal
Reinhard Dummer, Maarten H. Vermeer, Julia J. Scarisbrick, Youn H. Kim, Connor Stonesifer, Cornelis P. Tensen, Larisa J. Ceskin, Pietro Quaglino, Egle Ramelyte
Summary: Primary cutaneous T cell lymphomas are a diverse group of lymphomas with complex pathophysiology and require interdisciplinary collaboration for diagnosis and treatment. Current treatment options include skin-directed and systemic therapies, with allogeneic hematopoietic stem cell transplantation being the only curative approach. Further research is needed for better treatment strategies.
NATURE REVIEWS DISEASE PRIMERS
(2021)
Article
Biochemistry & Molecular Biology
Tina Petrogiannis-Haliotis, Kevin Pehr, David Roberge, Ryan N. Rys, Yury Monczak, Gizelle Popradi, Lissa Ajjamada, Naciba Benlimame, Christiane Querfeld, Nathalie Johnson, Hans Knecht
Summary: We present a case of CD4+ small/medium-sized pleomorphic lymphoma with extensive lesions in the legs. Immunohistochemistry and flow cytometry analysis showed distinct CD4+ and CD8+ T-cell populations with no CD4/CD8 co-expression. TCR gene rearrangement studies confirmed the neoplastic population to be of T-cytotoxic cell lineage, representing a previously undescribed type of CTCL.
Letter
Dermatology
Maurizio Romagnuolo, Silvia Alberti Violetti, Davide Riva, Francesco Barberi, Chiara Moltrasio
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Maurizio Romagnuolo, Davide Riva, Silvia Alberti Violetti, Alessandra Di Benedetto, Francesco Barberi, Chiara Moltrasio
Summary: This article reports a case of a woman who developed disseminated superficial actinic porokeratosis following the intake of hydroxyurea for a polycythaemia vera. Clinical, dermoscopic, and histopathology data are presented, and the role of the drug as a second-hit mutation trigger is discussed.
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
Gianluca Avallone, Carlo Alberto Maronese, Eleonora Quattri, Gabriele Roccuzzo, Luca Mastorino, Silvia Alberti-Violetti, Stefano Ramoni, Anna Lucchini, Sergio Delmonte, Pietro Quaglino, Angelo Valerio Marzano, Simone Ribero
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Italo F. Aromolo, Carlo A. Maronese, Gianluca Avallone, Andrea Beretta, Francesca L. Boggio, Giulia Murgia, Dario A. Marletta, Francesca Barei, Carlo G. Carrera, Stefano Ramoni, Alessandra Di Benedetto, Angelo V. Marzano
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Gianluca Tavoletti, Gianluca Avallone, Carlo A. Maronese, Francesca L. Boggio, Angelo V. Marzano, Gianluca Nazzaro
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
Italo F. Aromolo, Carlo A. Maronese, Paolo Bortoluzzi, Angelo Marzano
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
Gianluca Avallone, Carlo Alberto Maronese, Claudio Conforti, Paolo Fava, Luigi Gargiulo, Angelo Valerio Marzano, Cesare Massone, Luca Mastorino, Andrea Paradisi, Alessandro Pileri, Pietro Quaglino, Nathalie Rizzo, Simone Ribero, Gabriele Roccuzzo, Gianluca Tavoletti, Carlo Alberto Vignoli, Iris Zalaudek, Emilio Berti, Silvia Alberti-Violetti
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Dermatology
Carlo Alberto Maronese, Gianluca Avallone, Italo Francesco Aromolo, Cristina Beatrice Spigariolo, Eleonora Quattri, Stefano Ramoni, Carlo Giovanni Carrera, Angelo Valerio Marzano
Summary: Mpox is a viral disease caused by a double-stranded DNA orthopoxvirus. It was initially regarded as a zoonosis and manifests with nonspecific prodromes and a cutaneous eruption. In 2022, it transitioned from a neglected zoonotic disease to a sexually transmitted infection of international concern. The recent outbreak showed unique clinical features and challenges in recognition and management.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Gianluca Nazzaro, Carlo A. Maronese, Giovanni Casazza, Serena Giacalone, Cristina B. Spigariolo, Gabriele Roccuzzo, Gianluca Avallone, Stefania Guida, Gabriella Brancaccio, Paolo Broganelli, Giovanni Pellacani, Francesca Farnetani, Emanuela Passoni, Aimilios Lallas, Giuseppe Argenziano, Angelo V. Marzano
Summary: In this retrospective multicenter study, researchers identified dermoscopic features that aid in distinguishing small diameter melanomas (=5 mm) from equivocal melanocytic nevi measuring =5 mm. They found that the presence of atypical pigment network, blue-white veil, pseudopods, peripheral radial streaks, and more than one color can be used as dermoscopic predictors for the assessment of flat, non-facial melanocytic lesions measuring =5 mm.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Valentina Bellani, Giorgio Alberto Croci, Cristina Bucelli, Carlo Alberto Maronese, Sara Alberti, Alessandra Iurlo, Daniele Cattaneo
Summary: Lymphomatoid papulosis (LyP) is a benign condition that can be associated with hematologic diseases. Hypereosinophilic syndromes are a group of disorders characterized by high levels of eosinophils in the blood. In this case report, two patients with LyP and myeloid neoplasm with eosinophilia achieved complete remission of both conditions after starting treatment with imatinib.
JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
G. Tavoletti, G. Avallone, C. Conforti, G. Roccuzzo, C. A. Maronese, M. A. Mattioli, P. Quaglino, I. Zalaudek, A. V. Marzano, S. Ribero, S. Alberti-Violetti
Summary: Vitiligo is a chronic autoimmune skin disorder with limited treatment options. Topical therapies, such as corticosteroids and calcineurin inhibitors, are preferred to systemic treatments due to their fewer side effects. Recently, a topical formulation of the selective JAK1/2 inhibitor ruxolitinib has been approved for the treatment of non-segmental vitiligo in patients aged >12 years. This review discusses the efficacy and safety of topical ruxolitinib, as well as issues related to its use in specific populations and treatment duration.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Medicine, General & Internal
Gianluca Avallone, Carlo Alberto Maronese, Giulia Murgia, Carlo Giovanni Carrera, Luca Mastorino, Gabriele Roccuzzo, Paolo Dapavo, Silvia Alberti-Violetti, Pietro Quaglino, Simone Ribero, Angelo Valerio Marzano
Summary: This study aimed to compare the efficacy of IL-17 and IL-23 inhibitors in treating pustular and erythrodermic psoriasis. The results showed that IL-17 inhibitors had higher effectiveness in treating these conditions, while the efficacy of IL-23 inhibitors remains unknown.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Dermatology
Carlo Alberto Maronese, Stefano Ramoni, Gianluca Avallone, Serena Giacalone, Eleonora Quattri, Valeria Gaspari, Luca Rapparini, Silvia Robuffo, Sergio Delmonte, Martina Merli, Marco Tutone, Giulia Facci, Andrea Carugno, Michele Parietti, Alessandra Latini, Eugenia Giuliani, Paolo Sena, Simone Ribero, Pietro Quaglino, Bianca Maria Piraccini, Angelo Valerio Marzano
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)