Article
Geriatrics & Gerontology
Kyum-Yil Kwon, Eun Ji Lee, Mina Lee, Hyunjin Ju, Kayeong Im
Summary: The study aimed to compare the non-motor and fall-related features between tremor-dominant (TD) and postural instability-gait difficulty (PIGD) subtypes in early Parkinson's disease (PD) patients. The results showed that in early PD, PIGD subtype is significantly associated with higher levels of fatigue, gastrointestinal dysfunction, and fall-related features compared to the TD subtype.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Si-Chun Gu, Qing Ye, Chang-De Wang, Shao-Rong Zhao, Jie Zhou, Chen Gao, Yu Zhang, Zhen-Guo Liu, Can-Xing Yuan
Summary: Pingchan granule (PCG) has a long-lasting and extensive symptomatic efficacy for both motor and non-motor symptoms of Parkinson's disease (PD) with good tolerance.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Frank C. Church
Summary: Parkinson's disease is a progressive neurodegenerative disorder that mainly affects older adults. Treatment options include rehabilitation, therapy, restorative programs, maintenance with complementary and alternative medicine, and surgery as a last resort. Currently, there is no cure for PD and the focus is on slowing disease progression and improving quality of life for patients.
Article
Medicine, General & Internal
Diego Santos-Garcia, Ariadna Laguna, Jorge Hernandez-Vara, Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Painceiras, Maria Cristina Iniguez-Alvarado, Iago Garcia Diaz, Silvia Jesus, Maria Teresa Boungiorno, Lluis Planellas, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. Avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Victor Puente, Julio Dotor Garcia-Soto, Carmen Borrue, Berta Solano Vila, Maria Alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso G. Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Manuel Menendez Gonzalez, Manuel Seijo, Javier Ruiz Martinez, Caridad Valero, Monica Kurtis, Jessica Gonzalez Ardura, Ruben Alonso Redondo, Carlos Ordas, Luis M. Lopez M. Diaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir
Summary: This study analyzed sex difference manifestations in Spanish patients with Parkinson's disease (PD) and found important differences. Symptoms such as depression, fatigue, and pain were more frequent and/or severe in females, while symptoms such as hypomimia, speech problems, rigidity, and hypersexuality were more noted in males. Women received a lower levodopa equivalent daily dose and had worse perception of quality of life. After two years of follow-up, the NMS burden increased more significantly in males, while the functional capacity was more impaired in females.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Qu Yi, Yu-Peng Chen, Jiang-Ting Li, Jing-Yi Li, Qi-Xiong Qin, Dan-Lei Wang, Jing-Wei Zhao, Zhi-Juan Mao, Yong-Jie Xiong, Min Zhe, Xue Zheng
Summary: Poor sleep is associated with more severe symptoms in Parkinson's disease (PD), and both insufficient and excessive time spent in bed and nocturnal sleep duration are correlated with higher non-motor symptom burdens. Non-motor symptoms play a mediating role in sleep quality, quality of life, PD severity, and motor symptoms.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Neurosciences
Xiao-Zhong Jing, Xiang-Zhen Yuan, Xingguang Luo, Shu-Yun Zhang, Xiao-Ping Wang
Summary: Nondopaminergic neurotransmitters play a role in Parkinson's disease (PD) and their receptors are potential targets for developing new treatments. This review summarizes the recent findings on nondopaminergic treatments for PD, including drugs to reduce motor complications and improve non-motor symptoms. Several drugs have been approved for managing motor fluctuations and levodopa-induced dyskinesia, while ongoing research is focused on serotonergic and glutamatergic agents. Nondopaminergic drugs also show promise in treating non-motor symptoms such as hallucinations and delusions, daytime sleepiness, depression, and urinary tract symptoms.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Clinical Neurology
Mariana Fernandes, Mariangela Pierantozzi, Alessandro Stefani, Carlo Cattaneo, Erminio A. Bonizzoni, Rocco Cerroni, Nicola Biagio Mercuri, Claudio Liguori
Summary: This study found a high prevalence of NMS in PD patients with motor fluctuations, with psychiatric disorders being more frequent in older patients and those with a longer PD diagnosis duration, while sleep problems were more common in younger patients with a shorter disease duration.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Ali S. Shalash, Eman Hamid, Hanan Elrassas, Eshak Bahbah, Alia H. Mansour, Hadeer Mohamed, Mahmoud Elbalkimy
Summary: This study aimed to compare non-motor symptoms among patients with essential tremor (ET), Parkinson's disease (PD) subtypes, and healthy controls. The results showed that both PD patients and ET patients exhibited more severe non-motor symptoms and depression compared to controls. Identifying different non-motor symptoms profiles is crucial for predicting, assessing, and managing ET and PD subtypes.
Article
Multidisciplinary Sciences
Kyum-Yil Kwon, Suyeon Park, Eun Ji Lee, Mina Lee, Hyunjin Ju
Summary: The study revealed that fall-related risk factors in patients with early Parkinson's disease (PD) were highly associated with gastrointestinal dysautonomia.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Kaixin Dou, Jiangnan Ma, Xue Zhang, Wanda Shi, Mingzhu Tao, Anmu Xie
Summary: This study aimed to develop clinical risk models using non-motor predictors to distinguish between early Parkinson's disease (PD) and healthy individuals. In addition, prognostic models were constructed to predict the progression of non-motor symptoms in de novo PD patients at a 5-year follow-up.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Neurosciences
Segolene De Waele, Patrick Cras, David Crosiers
Summary: This article summarizes the research findings on apathy in Parkinson's disease, discusses the prevalence rates and screening tools, formulates patient-tailored treatment recommendations, and explores the clinical manifestations and prognosis of the Park apathy phenotype. It aims to provide a clinical and patient-oriented perspective on the vast theoretical knowledge available.
Article
Clinical Neurology
Meimei Zhang, Yawen Gan, Xuemei Wang, Zhan Wang, Tao Feng, Yumei Zhang
Summary: This study investigated the correlation between non-motor symptoms and dual-task gait performance in patients with Parkinson's disease (PD). The results showed that dual-task gait performance can reflect the burden of non-motor symptoms in early-stage PD, and gait cycle duration is a valuable parameter for further research and management of PD.
NEUROLOGICAL SCIENCES
(2023)
Review
Neurosciences
Xiao-Zhong Jing, Hui-Jia Yang, Reyisha Taximaimaiti, Xiao-Ping Wang
Summary: Dopamine (DA) agonists are excellent dopamine replacement therapy for Parkinson's disease (PD) patients and are crucial in controlling motor and non-motor symptoms. Each DA agonist has unique characteristics, efficacy, and safety profile. Understanding DA agonists helps clinicians balance clinical efficacy and side effects.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Neurosciences
Daniele Urso, Lucia Batzu, Giancarlo Logroscino, K. Ray Chaudhuri, Joana B. Pereira
Summary: This study investigated the potential of cerebrospinal fluid (CSF) and serum neurofilament light (NfL) levels as biomarkers for predicting the progression of nonmotor symptoms (NMS) in Parkinson's disease (PD) patients. The findings showed that both CSF and serum NfL levels were associated with the progression of depression and anxiety in PD patients, with serum NfL showing stronger associations with NMS.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Yuanyan Cao, Qian Si, Renjie Tong, Xu Zhang, Chunlin Li, Shanhong Mao
Summary: This study investigated the dynamic functional connectivity changes during Parkinson's disease (PD) duration and its correlations with non-motor symptoms. The results showed that PD patients during follow-up had lower connection between frontoparietal network and sensorimotor network compared to baseline period. Dynamic FC analysis revealed four distinct states, with state 2 showing positive coupling within and between sensorimotor network and visual network, while state 3 showed hypo-coupling through all resting state networks (RSN). Furthermore, the non-motor symptom scores positively correlated with the mean dwell time of state 3 during PD follow-up. Overall, these findings suggest that PD patients during follow-up spent more time in hypo-coupling state, and the decrease of positive coupling state may be related to the worsening of non-motor symptoms.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Romella Durrani, Meng Wang, Emily Cox, Elisabeth Irving, Feryal Saad, Cheryl R. McCreary, Andrew E. Beaudin, Myrlene Gee, Krista Nelles, Tolulope T. Sajobi, Zahinoor Ismail, Richard Camicioli, Eric E. Smith
Summary: Neuroimaging biomarkers, including altered white matter diffusivity, cerebrovascular reactivity, and atrophy, are closely associated with cognitive dysfunction in cerebral amyloid angiopathy (CAA).
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Geriatrics & Gerontology
Alexandra Sammartino-Arbour, Ariane Dufour, Valerie Frenette, Marie-France Forget, Marie-Andree Bruneau, Simon Ducharme, Richard Camicioli, Quoc Dinh Nguyen, Philippe Desmarais
Summary: The onset of neuropsychiatric symptoms in older adults may indicate the early signs of neurodegenerative disorders. The relationship between somatic symptoms and related disorders (SSRD) and the subsequent development of neurodegenerative disorders is still uncertain. This study critically reviewed studies exploring the association between SSRD and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Fronto-temporal dementia, and Lewy body dementia.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Clinical Neurology
W. R. Wayne Martin, John R. Younce, Meghan C. Campbell, Brad A. Racette, Scott A. Norris, Mwiza Ushe, Susan Criswell, Albert A. Davis, Isabel Alfradique-Dunham, Baijayanta Maiti, Nigel J. Cairns, Richard J. Perrin, Paul T. Kotzbauer, Joel S. Perlmutter
Summary: This study investigates the relationship between Parkinson's disease (PD) with dementia and cortical proteinopathies. The study finds that neocortical Lewy bodies are commonly present in PD patients with dementia, but also appear in those without dementia. Other factors may contribute to PD dementia, aside from the classic neuropathological features.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Nabeela Nathoo, Myrlene Gee, Krista Nelles, Jacqueline Burt, Hongfu Sun, Peter Seres, Alan H. Wilman, Christian Beaulieu, Fang Ba, Richard Camicioli
Summary: This study found that susceptibilities in basal ganglia and extra-basal ganglia structures are related to qualitative measures of gait impairment and freezing of gait in Parkinson's disease.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Meeting Abstract
Clinical Neurology
Danielle Munsterman, Sarina Falcione, Rebecca Long, Twinkle Joy, Mike Clarke, Andrew E. Beaudin, Richard Camicioli, Eric E. Smith, Glen Jickling
Meeting Abstract
Clinical Neurology
Danielle Munsterman, Sarina Falcione, Rebecca Long, Twinkle Joy, Mike Clarke, Andrew E. Beaudin, Richard Camicioli, Eric E. Smith, Glen Jickling
Article
Neuroimaging
Hannes Almgren, Alexandru Hanganu, Milton Camacho, Mekale Kibreab, Richard Camicioli, Zahinoor Ismail, Nils D. Forkert, Oury Monchi
Summary: Brain atrophy in Parkinson's disease varies in different brain regions, even in the early stage. This study examines the relationship between cortical curvature and thickness in PD diagnosis, motor symptoms, and cognitive performance. The findings indicate an interaction effect between motor symptoms and age, as well as the impact of diagnosis and rigidity on the curvature-thickness association in patients with longer disease durations.
NEUROIMAGE-CLINICAL
(2023)
Letter
Clinical Neurology
John R. Younce, W. R. Wayne Martin, Joel S. Perlmutter
ANNALS OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Ipinuoluwakiye Fatokun, Myrlene Gee, Krista Nelles, Fang Ba, Mahsa Dadar, Simon Duchesne, Breni Sharma, Mario Masellis, Sandra E. Black, Quincy J. Almeida, Eric E. Smith, Frederico Pieruccini-Faria, Manuel Montero-Odasso, Richard Camicioli
Summary: This study aimed to investigate the relationship between dual task cost (DTC) and white matter hyperintensities (WMH) in Lewy body disorders. The results showed that increased DTC was associated with higher frontal WMH burden, and increased age was associated with higher DTC. This indicates the importance of the association between DTC and WMH in Lewy body disorders.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Breni Sharma, Andrew E. Beaudin, Emily Cox, Feryal Saad, Krista Nelles, Myrlene Gee, Richard Frayne, David G. Gobbi, Richard Camicioli, Eric E. Smith, Cheryl R. McCreary
Summary: This study used MRI and quantitative susceptibility mapping (QSM) to detect brain iron content in patients with CAA and found no significant difference compared to the normal control group. However, the study did not provide evidence of an association between brain iron content and cognitive abilities.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Chih-Hao Chen, Mary Klir Khnaijer, Andrew E. Beaudin, Cheryl R. McCreary, Myrlene Gee, Feryal Saad, Richard Frayne, Zahinoor Ismail, G. Bruce Pike, Richard Camicioli, Eric E. Smith
Summary: In this study, researchers investigated whether cerebral amyloid angiopathy (CAA) is associated with subcortical atrophy. They found that CAA patients did not show substantial atrophy of subcortical volumes compared to Alzheimer's disease (AD) or healthy controls, except for the putamen. Differences in findings may be due to heterogeneity in CAA presenting syndromes or severity.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Hannes Almgren, Milton Camacho, Alexandru Hanganu, Mekale Kibreab, Richard Camicioli, Zahinoor Ismail, Nils D. Forkert, Oury Monchi
Summary: Patients with Parkinson's Disease often experience cognitive decline and accurate prediction of this decline is crucial for early intervention. This study aimed to develop and evaluate a multimodal machine learning model for predicting continuous cognitive decline in early PD patients. Data from 213 PD patients in the PPMI database were used to train and test the model.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Manuel Montero-Odasso, Guangyong Zou, Mark Speechley, Quincy J. Almeida, Teresa Liu-Ambrose, Laura E. Middleton, Richard Camicioli, Nick W. Bray, Karen Z. H. Li, Sarah Fraser, Frederico Pieruccini-Faria, Nicolas Berryman, Maxime Lussier, J. Kevin Shoemaker, Surim Son, Louis Bherer
Summary: This randomized clinical trial investigates the effects of aerobic-resistance exercise, cognitive training, and vitamin D supplementation on cognition in older adults with mild cognitive impairment (MCI). The results show that a 20-week multidomain intervention of aerobic-resistance exercise and computerized cognitive training has a greater effect in improving cognition compared to exercise alone, and these improvements are maintained at 12-month follow-up. The addition of vitamin D does not enhance the effect. These findings suggest that pairing aerobic and resistance exercises with sequential computerized cognitive training may improve cognition in older adults with MCI.
Article
Neuroimaging
Milton Camacho, Matthias Wilms, Pauline Mouches, Hannes Almgren, Raissa Souza, Richard Camicioli, Zahinoor Ismail, Oury Monchi, Nils D. Forkert
Summary: This work aimed to develop and evaluate a robust explainable deep learning model for PD classification. A total of 2,041 T1-weighted MRI datasets from 13 different studies were collected, and a CNN model was trained using Jacobian maps to achieve high accuracy in distinguishing PD patients from healthy controls.
NEUROIMAGE-CLINICAL
(2023)