Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 66, Issue 9, Pages 432-442Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2016.1236338
Keywords
Bactericidal activity; bone regeneration; electrospinning; rapid prototyping; salicylic acid; silver nanoparticles
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Funding
- FEDER funds through the POCI-COMPETE-Operational Programme Competitiveness and Internationalisation in Axis I-Strengthening research, technological development and innovation [POCI-01-0145-FEDER-007491]
- National Funds by FCT-Foundation for Science and Technology [UID/Multi /00709/2013]
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Bone-limited capacity to fully repair large defects requires the development of new implants. In this context, new approaches have been used to promote bone regeneration and also to avoid the side effects associated with the therapeutics currently used in the clinic. Herein, 3D tricalcium phosphate/alginic acid scaffolds were produced and then coated with an electrospun mesh loaded with two different antibacterial agents, silver nanoparticles, and salicylic acid. The obtained results showed that the produced scaffolds have suitable mechanical properties, swelling, biodegradation, biomineralization activity, enhanced cellular adhesion/proliferation and bactericidal activity, and features essential for bone regeneration.
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