Article
Biotechnology & Applied Microbiology
Jianhua Yang, Xiaoguang Jing, Zimin Wang, Xuejian Liu, Xiaofeng Zhu, Tao Lei, Xu Li, Weimin Guo, Haijun Rao, Mingxue Chen, Kai Luan, Xiang Sui, Yen Wei, Shuyun Liu, Quanyi Guo
Summary: The study comprehensively analyzed the physical properties and cytocompatibility of hydrogels as cell carriers for ADSC transplantation. Rat models of articular cartilage defect were treated with GCS/DF-PEG hydrogel, showing potential for repairing injured cartilage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Wenguang Wang, Yanbin Shi, Guimei Lin, Bingtao Tang, Xuelin Li, Jing Zhang, Xinbing Ding, Guangzhen Zhou
Summary: This paper discusses the application of hydrogels in cartilage repair, including their mechanical properties and materials used. The challenges faced by hydrogels and future research directions are also discussed.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Polymer Science
Yang Feng, Shao-Cong Dai, Khoon Lim, Yogambha Ramaswamy, Ahmad Jabbarzadeh
Summary: Polymeric PVA-based composite hydrogels were fabricated with gellan gum (GG) and their rheological and tribological properties were investigated. Increasing the concentration of GG enhanced the storage modulus of the hydrogels, making them suitable for cartilage regeneration applications. Furthermore, the addition of GG reduced the friction coefficient, increasing the chance of survival under mechanical shear stresses.
Review
Engineering, Multidisciplinary
Liangbin Zhou, Peng Guo, Matteo D'Este, Wenxue Tong, Jiankun Xu, Hao Yao, Martin J. Stoddart, Gerjo J. V. M. van Osch, Kevin Ki-Wai Ho, Zhen Li, Ling Qin
Summary: Articular cartilage (AC) is a flexible connective tissue located on the bone surface in the joints. AC defects are common in physically active individuals. Functionalized hydrogels have emerged as promising substitutes for damaged cartilage in AC repair due to their favorable properties. This article introduces the composition, structure, and function of AC and its defects, and reviews the design and fabrication of functionalized hydrogels for AC repair.
Article
Engineering, Biomedical
Xiaoping Qin, Rui He, Hao Chen, Dejie Fu, Yang Peng, Shuo Meng, Cheng Chen, Liu Yang
Summary: The combination of methacrylic anhydride-modified pullulan and synthetic polymer PEGDA resulted in a hybrid hydrogel system with good biocompatibility and cell support.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Review
Biotechnology & Applied Microbiology
Yunong Ao, En Zhang, Yangxi Liu, Liu Yang, Jun Li, Fuyou Wang
Summary: Nanocomposite hydrogels show promise in cartilage tissue engineering for repair of cartilage defects. This review summarizes the different advanced nanoparticle hydrogels currently used and discusses their application scenarios and future prospects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Polymer Science
Jianghong Huang, Fei Liu, Haijing Su, Jianyi Xiong, Lei Yang, Jiang Xia, Yujie Liang
Summary: Nanocomposite hydrogels, with their ability to mimic natural cartilage structure and exhibit nano-bio effects in response to external stimuli, show great potential as scaffold materials for cartilage tissue engineering. This review article summarizes the recent advances in nanocomposite hydrogels for artificial cartilage, including their preparation methods and application scope, while also highlighting the challenges faced in using hydrogel nanocomposites for cartilage repair.
Review
Biotechnology & Applied Microbiology
Senbo Zhu, Yong Li, Zeju He, Lichen Ji, Wei Zhang, Yu Tong, Junchao Luo, Dongsheng Yu, Qiong Zhang, Qing Bi
Summary: This paper reviews the research progress on advanced injectable hydrogels for repairing cartilage defects. It thoroughly discusses the cross-linking method and structure of injectable hydrogels, and reviews the commonly used polymers, cells, and stimulators in their preparation. Finally, it summarizes the research progress of the latest advanced hydrogels for cartilage repair and the future challenges for injectable hydrogels.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Materials Science, Multidisciplinary
Zixuan Xiao, Shujing Zhao, Xiaoyuan Zhang, Gang Wei, Zhiqiang Su
Summary: This review presents recent advances in the functionalization of PEG hydrogels with peptides for biomedical applications, including preparation methods, functional regulation, and specific applications. This work provides a systematic literature review on this promising topic and facilitates readers in the design of composite materials and functional tailoring of PEG hydrogels with biomolecules.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Engineering, Manufacturing
Frederik Wulle, Oliver Gorke, Sarah Schmidt, Maximilian Nistler, Gunter E. Tover, Oliver Riedel, Alexanser Verl, Achim Weber, Alexanser Southan
Summary: This paper introduces the potential and advantages of multi-axis 3D printing of hydrogels, and demonstrates through experiments the relative flexibility and water absorbency of 3D printed hydrogels compared to conventional molded hydrogels. The research also highlights related research questions, such as cross-linking chemistry and formulation of hydrogel inks.
ADDITIVE MANUFACTURING
(2022)
Article
Polymer Science
Alexandra-Diana Diaconu, Corina-Lenuta Logigan, Catalina Anisoara Peptu, Constanta Ibanescu, Valeria Harabagiu, Cristian Peptu
Summary: Polymer networks based on cyclodextrin and polyethylene glycol were prepared and characterized. The hydrophilic and encapsulation properties were confirmed, and the influence of crosslinking reaction feed was investigated. The thermal water swelling and hydrolytic degradation were studied, and the drug loading and release capacity were evaluated.
Article
Engineering, Biomedical
Min Wang, Zexing Deng, Yi Guo, Peng Xu
Summary: This review summarizes the recent progress and applications of hyaluronic acid-based hydrogels in cartilage tissue engineering. It investigates the multifunctional design of these hydrogels and discusses their potential for future research in cartilage tissue regeneration.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Xiang Zhang, Zhenhao Yan, Guotao Guan, Zijing Lu, Shujie Yan, Azhen Du, Lixiang Wang, Qian Li
Summary: By combining two different hydrogels, a cartilage scaffold with good mechanical properties and strong biocompatibility was successfully produced, promoting cartilage formation.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Article
Polymer Science
Mike Wagenbrenner, Susanne Mayer-Wagner, Maximilian Rudert, Boris Michael Holzapfel, Manuel Weissenberger
Summary: Cartilage has limited regenerative capacity, and cell-based approaches are a promising alternative for the treatment of cartilage defects and osteoarthritis, with MSCs being an attractive cell source often combined with hydrogels. This review focused on the advantages and disadvantages of various hydrogels, as well as different combinations of MSC subpopulations and hydrogels used in cartilage engineering.
Article
Polymer Science
Mahshid Hafezi, Saied Nouri Khorasani, Mohadeseh Zare, Rasoul Esmaeely Neisiany, Pooya Davoodi
Summary: Cartilage tissue engineering aims to develop new biomimetic cartilage to replace injured tissue, using novel engineering and biological approaches. In recent years, advanced hydrogels have been designed and synthesized to improve network crosslinking and self-recovery of implanted scaffolds.
Article
Engineering, Biomedical
Nooshin Zandi, Banafsheh Dolatyar, Roya Lotfi, Yousef Shallageh, Mohammad Ali Shokrgozar, Elnaz Tamjid, Nasim Annabi, Abdolreza Simchi
Summary: The engineered bilayer scaffolds, composed of gelatin nanofibers and composite hydrogels, show promising potential in accelerating wound healing process. The controlled delivery of growth factors on the bilayer scaffolds enhances wound closure and tissue regeneration. The unique structure of the scaffolds mimics the extracellular matrix, providing a platform for tailored growth factor release and improved adhesion to native tissue.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Maryam Khajavi, Abdolmajid Hajimoradloo, Mojgan Zandi, Mohamad Pezeshki-Modaress, Shahin Bonakdar, Abbas Zamani
Summary: The study successfully engineered a cartilage-like scaffold using ECM from sturgeon fish cartilage to stimulate cartilaginous matrix synthesis in human adipose stem cells. The porous scaffold derived from fish cartilage ECM showed excellent potential for cartilage tissue engineering, supporting cell adhesion, proliferation, and chondrogenic differentiation. The scaffold was demonstrated to facilitate the synthesis of specific cartilage proteins, such as collagen type II and aggrecan, making it a promising option for tissue regeneration.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Veterinary Sciences
Mohammad Majidi, Fatemeh Heidarnejad, Mohsen Naseri, Shahin Bonakdar, Maryam Salimi, Roya Yaraee
Summary: Marham-Mafasel can reduce joint inflammation, decrease IL-1 beta gene expression, and show significant therapeutic effects in animal experiments.
VETERINARY MEDICINE AND SCIENCE
(2021)
Article
Chemistry, Physical
Mohsen Saeidi, Minjong Lee, Odongo Francis Ngome Okello, Si-Young Choi, Seung Soo Oh, Abdolreza Simchi
Summary: The study investigates the graphitization mechanism of graphitic oxide under ultrafast thermal reduction induced by electromagnetic radiation and Ar+ cation collisions. The prepared spongy graphene structure shows excellent charge storage performance, high electrical conductivity, and stability in multiple applications.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Energy & Fuels
Behnam Nourmohammadi Khiarak, Majdoddin Mojaddami, Zahra Zamani Faradonbeh, Angelina Olegovna Zekiy, Abdolreza Simchi
Summary: The development of active, durable, cost-effective, and stable electrocatalysts is urgently needed in various industries, including renewable energy systems. This article presents an electrochemical analysis of a nanostructured electrocatalyst based on a Cu-Ni-Fe-Cr-Co alloy with enhanced activity for both oxygen and hydrogen reactions in alkaline medium.
Article
Materials Science, Multidisciplinary
Samaneh Aynehband, Maryam Mohammadi, Rana Poushimin, Mahdi Hasanzadeh Azar, Jean-Michel Nunzi, Abdolreza Simchi
Summary: The type of passivating ligands and the ligand exchange method significantly affect the quality and stability of lead sulfide quantum dot films, and thereby impacting the efficiency of optoelectronic devices. Using organic-inorganic perovskites as exchange agents, the replacement of oleic acid ligands with perovskite ligands enhances the film homogeneity and reduces defects. The application of this method improves the stability and performance of field effect phototransistors, demonstrating its importance for next-generation optoelectronic applications.
MATERIALS RESEARCH BULLETIN
(2022)
Article
Chemistry, Analytical
Mohsen Saeidi, Mohammad Ali Amidian, Sana Sheybanikashani, Hossein Mahdavi, Homayoon Alimohammadi, Leila Syedmoradi, Fatemeh Mohandes, Ali Zarrabi, Elnaz Tamjid, Kobra Omidfar, Abdolreza Simchi
Summary: This study proposes a multilayer nanostructure to improve the accuracy and reliability of cardiac troponin-I (cTnI) electrochemical immunosensors. The nanostructure consists of Fe3O4-COOH labeled anti-cTnI monoclonal antibody and anti-cTnI polyclonal antibody conjugated on Au-Ag nanoparticles, which enhances the performance of the immunosensor through signal amplification and increased surface area.
Article
Chemistry, Physical
Hajar Tohidi, Nahid Maleki-Jirsaraei, Abdolreza Simchi, Fatemeh Mohandes, Zahra Emami, Lorenzo Fassina, Fabio Naro, Bice Conti, Federica Barbagallo
Summary: Myocardial infarction is a major cause of death worldwide. Injectable hydrogels have the potential to revolutionize the treatment of heart diseases. In this study, a thermo-responsive and injectable hydrogel based on conjugated chitosan/poloxamers was developed for cardiac repair. Gold nanoparticles were incorporated to tailor the mechanical properties and electrical signal transmission of the hydrogel. The prepared hydrogel demonstrated reversible phase transition, shear-thinning behavior, and good cytocompatibility. It shows great potential as an injectable biomaterial for cardiac tissue regeneration.
Article
Materials Science, Multidisciplinary
Fatemeh Mohandes, Hamed Dehghani, Shayan Angizi, Arash Ramedani, Banafsheh Dolatyar, Marzieh Ramezani Farani, Klaus Muellen, Abdolreza Simchi
Summary: This study presents a surface-engineered bimodal magnetic-fluorescent material for dual-mode imaging of cancerous tumors. The polymer-coated nanoparticles based on manganese ferrites exhibit strong magnetic moment and photoluminescence emission. The nanoparticles show great biosafety and colloidal stability, and they can effectively image tumor tissues both in vitro and in vivo.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Samaneh Aynehband, Joshua N. Arthur, Maryam Mohammadi, Jean -Michel Nunzi, Soniya D. Yambem, Abdolreza Simchi
Summary: Phototransistors based on blended MAPbI3 perovskite nanocrystals and P3HT exhibit higher absorption coefficient and unique optical properties, resulting in faster response time and more stable photoresponse compared to pure P3HT phototransistors. The optimized device with a 2:1 weight ratio of MAPbI3 nanocrystals to P3HT achieves an ILIGHT/IDARK ratio of 123, which is 63% higher than in pure P3HT phototransistors. These phototransistors may have potential applications as tunable photosensors due to their ease of fabrication and high sensitivity.
ORGANIC ELECTRONICS
(2023)
Article
Optics
Mahdi Hasanzadeh Azar, Samaneh Aynehband, Habib Abdollahi, Homayoon Alimohammadi, Nooshin Rajabi, Shayan Angizi, Vahid Kamraninejad, Razieh Teimouri, Raheleh Mohammadpour, Abdolreza Simchi
Summary: Recently, organic-inorganic perovskites have shown great potential in enhancing the performance of photovoltaic systems due to their exceptional optical and electronic properties. In this study, the influence of different hole transport layers (HTLs) and perovskite active layers (ALs) on the performance of solar cells was numerically analyzed using the Solar Cell Capacitance Simulator (SCAPS-1D). The results showed that CsSnI3 as the HTL and FAPbI(3) as the AL achieved the highest power conversion efficiency (PCE) of 23.90%. Machine learning (ML) was used to predict the performance metrics of solar cells with approximately 75% accuracy.
Article
Materials Science, Multidisciplinary
Golara Kafili, Elnaz Tamjid, Hassan Niknejad, Abdolreza Simchi
Summary: Recently, decellularized amniotic membranes (dAM) have been modified with sodium alginate and Laponite nanoplatelets to improve their rheological behavior and mechanical durability for 3D bioprinting. The addition of Laponite significantly enhanced the shear-thinning behavior and dynamic mechanical modulus of the hydrogel, enabling the printing of free-standing constructs without compromising biological properties. However, excessive agglomeration of the nanoplatelets at high concentrations was observed, leading to nozzle clogging. Overall, the nanoengineered hydrogel showed suitable structural integrity and biocompatibility, highlighting its potential for tissue engineering applications.
JOURNAL OF MATERIALS SCIENCE
(2023)
Review
Chemistry, Analytical
Mohsen Saeidi, Hossein Chenani, Mina Orouji, MahsaSadat Adel Rastkhiz, Nafiseh Bolghanabadi, Shaghayegh Vakili, Zahra Mohamadnia, Amir Hatamie, Abdolreza (Arash) Simchi
Summary: This review systematically reviews the research progress of hydrogel-based wearable electrochemical biosensors (HWEBs). Hydrogels have excellent properties such as biocompatibility, high porosity, and reliable detection of disease biomarkers. However, most hydrogels suffer from low mechanical strength and electrical conductivity. Researchers have explored various electroactive nanofillers to improve the mechanical and electrochemical properties of hydrogels. The review also discusses the prospects and potential applications of HWEBs in biosensing, healthcare monitoring, and clinical diagnostics.
Article
Chemistry, Physical
Mohammadali Beheshti, Mohsen Saeidi, MahsaSadat Adel-Rastkhiz, Shohreh Shahrestani, Ali Zarrabi, Jing Bai, Abdolreza Simchi, Samineh Akbarmolaie
Summary: To address the stability issue of ZIF-67, an efficient electrocatalyst consisting of gold and silver nanostructures electrodeposited on a cobalt-based metal-organic framework (Au-Ag@ZIF-67) has been introduced for electrochemical CO2 reduction reaction (CO2RR). The results show that Au-Ag@ZIF-67 exhibits excellent structural stability, enhanced CO2 absorption, and improved catalytic activity towards CO gas, making it a promising development for CO2 gas elimination in the environment.
CATALYSIS SCIENCE & TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Hazal Ezgi Gultekin, Gokcen Yasayan, Ayca Bal-Ozurk, Ashkan Bigham, Abdolreza (Arash) Simchi, Atefeh Zarepour, Siavash Iravani, Ali Zarrabi
Summary: Wound healing is a complex process that requires effective management. Upconversion nanoparticles (UCNPs) have emerged as promising materials for wound dressing due to their unique properties. Functionalized with antibacterial agents, UCNPs have enhanced antibacterial properties and can deliver therapeutic agents to the wound site. They can also convert near-infrared light for therapy and diagnosis. However, the use of UCNPs in wound dressing faces challenges of stability, biocompatibility, efficient incorporation, scalability, and cost-effectiveness.
MATERIALS HORIZONS
(2023)
Article
Materials Science, Biomaterials
Christopher Igwe Idumah, I. C. Nwuzor, S. R. Odera, U. J. Timothy, U. Ngenegbo, F. A. Tanjung
Summary: This paper presents recent advancements in drug delivery applications of polymeric hydrogel nanoarchitectures and hydrogel derivatives, including the incorporation of nanoparticulates and the enhancement of the chemical, biological, electrical, and mechanical properties of hydrogels. The application of magnetically responsive and smart hydrogels as drug delivery systems is also discussed.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2024)
Article
Materials Science, Biomaterials
Remya K. Rajan, Sunitha Chandran, Annie John, Ramesh Parameswaran
Summary: This study outlines the fabrication and characterization of pamidronate (PDS) embedded nanofibrous scaffolds based on polycaprolactone/polycaprolactone-polyethyleneglycol-polycaprolactone (PCL/CEC) blends for osteoporotic bone defect management. The electrospinning technique was utilized to fabricate PDS-loaded scaffolds, and the effect of PDS on the blends was evaluated in terms of surface morphology, wettability, biodegradability, and in vitro cytocompatibility. The results showed that the PCL/CEC-PDS scaffolds had a fibroporous architecture, appropriate mechanical properties, and the ability to support cell growth, indicating their potential for managing osteoporotic bone defects.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2024)
Article
Materials Science, Biomaterials
Kubra Aydin, Handan Sevim, Hatice Kaplan Can
Summary: This study aims to develop a new dental material by designing, synthesizing, and characterizing nanocomposites, and evaluate their cytotoxic effects on human gingival fibroblasts. The results of this research will contribute to a better understanding of the properties and safety of this material, providing reference for clinical applications in dentistry.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2024)
Review
Materials Science, Biomaterials
Angelica Jimenez-Rosales, Stefani Cortes-Camargo, Pedro Estanislao Acuna-Avila
Summary: The immune response to drug-delivering systems and implanted medical devices based on biomaterials is complex, and the goal is to design biomaterials that can respond to stimuli, preserve tissue function, and optimize cellular structures. Understanding the material's structure and location, as well as the severity of damage and other factors, is crucial in developing biocompatible biomaterials.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2024)
Article
Materials Science, Biomaterials
Fatemeh Daliri Shadmehri, Ehsan Karimi, Ehsan Saburi
Summary: Bone tissue engineering utilizes polymeric scaffolds and stem cells to create a supportive matrix resembling the in vivo environment for bone repair. The study found that a composite matrix of polycaprolactone and fibrin enhanced the differentiation of adipose-derived stem cells into osteo-like cells.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2024)
