Article
Chemistry, Analytical
Kevin Arias-Alpizar, Ana Sanchez-Cano, Judit Prat-Trunas, Elena Sulleiro, Pau Bosch-Nicolau, Fernando Salvador, Ines Oliveira, Israel Molina, Adrian Sanchez-Montalva, Eva Baldrich
Summary: This article proposes a microfluidic paper-based analytical device (μPAD) produced using a craft-cutter and stored at room temperature, which is used for partially automated single-step colorimetric magneto-immunoassay. With a simple setup and affordable materials, this μPAD achieves quantitative detection of Plasmodium falciparum lactate dehydrogenase (Pf-LDH) in a shorter time and with higher sensitivity compared to commercial rapid diagnostic tests. The results demonstrate the potential of this μPAD in point-of-care testing.
Article
Chemistry, Analytical
Suchanat Boonkaew, Ilhoon Jang, Eka Noviana, Weena Siangproh, Orawon Chailapakul, Charles S. Henry
Summary: The study demonstrated an electrochemical paper-based analytical device (ePAD) combined with a label-free immunoassay for the simultaneous determination of three important cardiovascular disease biomarkers. The ePAD showed good linearity, low detection limits, and good reproducibility, enabling the simultaneous detection of the three biomarkers in serum samples. The proposed immunosensor can be a great alternative for the early detection of cardiovascular diseases at the point-of-care.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Biotechnology & Applied Microbiology
Yuan Jia, Hao Sun, Jinpeng Tian, Qiuming Song, Wenwei Zhang
Summary: Paper-based point-of-care tests have gained interest for their rapid, low-cost, and instrument-free detection capabilities. This review focuses on the development of paper-based POC devices for detecting SARS-CoV-2, discussing principles, performance, advantages, drawbacks, limitations, and prospects of existing devices in the field.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biophysics
Tinglei Ma, Suyue Ren, Yixiang Wang, Haihan Yu, Lin Li, Xu Li, Luqing Zhang, Jinghua Yu, Yan Zhang
Summary: In recent years, point-of-care testing (POCT) technology has shifted from laboratory determination to practical applications. This article highlights the latest advances and principal issues in the design and fabrication of paper-based bipolar electrode electrochemiluminescence (BPE-ECL) sensors widely used in the POCT field. It discusses the attractive physical and chemical properties of cellulose paper, approaches to enhance paper functionality, and the materials used for fabricating paper-based BPE-ECL sensors. The article also introduces methods to enhance BPE-ECL signal and improve detection accuracy, as well as the application of paper-based BPE-ECL sensors in various fields.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Tania Pomili, Paolo Donati, Pier Paolo Pompa
Summary: The study presents a monolithic and fully integrated paper-based device for the simultaneous detection of three prognostic biomarkers in saliva. The device features a unique design and simple fabrication process, with particles exhibiting visible color changes at non-physiological concentrations.
Article
Biophysics
Yongfeng Zhu, Xia Tong, Qisheng Wei, Guihan Cai, Yuanxin Cao, Chaoying Tong, Shuyun Shi, Fang Wang
Summary: A novel platform for multiplex enzyme detection was developed based on 3D origami microfluidic paper-based device, allowing simultaneous detection of two enzymes' activities without pretreatment procedures. The platform exhibited excellent selectivity, good precision, favorable linear range, and high accuracy, successfully detecting alkaline phosphatase and butyrylcholinesterase in human serum samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Biotechnology & Applied Microbiology
Shamraja S. Nadar, Pravin D. Patil, Manishkumar S. Tiwari, Dinesh J. Ahirrao
Summary: Low-cost paper-based analytical devices are a generation of portable lab-on-chip designs that provide an innovative platform for on/off-site analysis of target analytes, especially in rural and remote areas. These devices offer exciting fundamental features such as ease of fabrication, rapid operation, and precise interpretations, while incorporating enzymes to improve analytical performance. Additionally, they are compact, portable, easy-to-use, and do not require additional sophisticated equipment.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yu-Ting Tsao, Chung-Yao Yang, Yun-Chiao Wen, Ting-Chang Chang, Koji Matsuura, Yu Chen, Chao-Min Cheng
Summary: This study developed a colorimetric semen analytical method that can distinguish semen samples with low total motile sperm concentration from those with normal motile sperm concentration. The method is one-step, inexpensive, and equipment-free, with validation in a 42-sample clinical trial. Visual evaluation and smartphone application were used to assess the results, showing potential for routine healthcare screening and private, in-home self-assessment.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Article
Biophysics
Yixiang Wang, Yumeng Rong, Tinglei Ma, Lin Li, Xu Li, Peihua Zhu, Shuang Zhou, Jinghua Yu, Yan Zhang
Summary: This review systematically discusses the design and fabrication of portable paper-based photoelectrochemical (PEC) sensors for point-of-care testing (POCT). It covers the flexible electronic devices made from paper, photosensitive materials, signal amplification strategies, and applications in medical diagnosis, environmental monitoring, and food safety. The opportunities and challenges of paper-based PEC sensing platforms are also summarized.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Multidisciplinary Sciences
Subhashis Patari, Priyankan Datta, Pallab Sinha Mahapatra
Summary: This study developed a three-dimensional microfluidic device capable of simultaneously detecting multiple chemical adulterants in milk, requiring only 1-2 mL of sample volume to detect 7 adulterants at once. The simple, portable, and user-friendly device is expected to be used for testing liquid foods in resource-limited settings.
SCIENTIFIC REPORTS
(2022)
Article
Biophysics
Do Kyoung Han, Jeonghyun Oh, Jaehyeon Lee, Yong Gon Cho, Ju Seong Park, Jong Soon Choi, Dal Sik Kim, Joseph Kwon
Summary: The newly developed paper-based multiplex analytical device (mPAD) has a unique construction and design that allows for simultaneous detection of glutamate dehydrogenase, toxin A, and toxin B, with high sensitivity and accuracy.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biochemistry & Molecular Biology
Javier Hoyo, Arnau Bassegoda, Guillem Ferreres, Dolores Hinojosa-Caballero, Manuel Gutierrez-Capitan, Antoni Baldi, Cesar Fernandez-Sanchez, Tzanko Tzanov
Summary: Current procedures for assessing chronic wound infection are time-consuming and require complex instruments and trained personnel. This study developed a foldable paper-based device for detecting the enzyme myeloperoxidase (MPO) in wound fluids, which is a suitable biomarker for wound infection diagnosis. The device showed efficient analytic performance in ex vivo experiments and correlated strongly with a spectrophotometric assay.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Wei Lai, Yanyang Shi, Jinbiao Zhong, Xinya Zhou, Yang Yang, Zhenyu Chen, Chunsun Zhang
Summary: Liver disease is a significant public health issue, especially in low- and middle-income countries. Detecting and diagnosing liver disease accurately is crucial, and alanine transaminase (ALT) is an important indicator. In this study, a dry chemistry-based electrochemiluminescence (DC-ECL) device was developed for point-of-care testing (POCT) of ALT, providing a reliable and automatic detection method. The results show that the device has a wide detection range, good linearity, and low detection limit, indicating its potential for development of similar POCT analyzers.
Article
Chemistry, Analytical
Sumaira Nishat, Ali Turab Jafry, Andres W. Martinez, Fazli Rabbi Awan
Summary: Paper-based microfluidics is a branch of microfluidics that uses paper or other porous membranes to wick fluids, offering advantages like simpler fabrication, lower cost, and ease of disposal. Its most common application is in the development of point-of-care diagnostic devices, potentially replacing costly and time-consuming laboratory procedures.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Analytical
Hongzhi Luo, Shan Liu, Lina Shi, Zhu Li, Qianwen Bai, Xiaoxin Du, Lijun Wang, He Zha, Chenzhong Li
Summary: The illegal use of beta-adrenergic agonists in livestock growth poses a threat to public health, necessitating the need for rapid on-site detection methods. Paper methods have become the preferred detection method due to their low cost, portability, and ubiquity. Various paper-based fluidic devices, including lateral flow immunoassays and microfluidic paper-based analytical devices, have been developed to detect beta-adrenergic agonist residues.
Article
Environmental Sciences
Zhenliang Li, Xuerui Liu, Shuye Li, Enke Feng, Zhiqiang Wu, Zhiming Yang, Xinxian Ma, Xinning Han
Summary: In this study, shape-controlled Cu2O@CuS nanocubes were successfully prepared and used as photocatalyst materials for the degradation of tetracycline. The experimental results showed that the nanocubes exhibited high degradation efficiency under visible light and maintained a high degradation performance even after multiple uses.
ENVIRONMENTAL TECHNOLOGY
(2023)
Article
Plant Sciences
Han Wang, Yan Liu, Yi-Kai Jang, Si-Yi Wang, Xiao-Mao Li, Juan Pan, Wei Guan, Adnan Mohammed Algradi, Hai-Xue Kuang, Bing-You Yang
Summary: Two new phenylpropanoids and nine known compounds were isolated from Solanum capsicoides leaves. Their structures were determined using spectroscopic methods and comparing with literature. In addition, the compounds showed inhibitory effects on inflammation.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Engineering, Manufacturing
Gangli Yang, Xiaoyan Li, Xu Han, Shanshan Li
Summary: This study investigated the changes in microstructure and grain orientation of the Cu3Sn solder joint during isothermal aging at 420 degrees C. It was found that the original Cu3Sn solder joint transformed into full Cu(41)Sn(11) solder joint and eventually into full alpha(Cu) solder joint during aging. The formation of micro-voids during the conversion process resulted in lower reliability of the solder joint. The average grain sizes of interfacial phases exhibited an initial increase followed by a decrease during aging. The preferred orientations of the different phases were also examined.
SOLDERING & SURFACE MOUNT TECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Yuxuan Zhang, Zhiwei Huang, Jiajie Zhu, Chaonan Li, Zhongbiao Fang, Keda Chen, Yanjun Zhang
Summary: The World Health Organization has reported over 430 million confirmed cases of COVID-19 worldwide, with nearly 6 million deaths. There is a growing need for technologies that can accurately and quickly detect the SARS-CoV-2 virus at early stages. While the qRT-PCR assay is considered the gold standard, it still has limitations. New nucleic acid detection devices and serological testing technologies are being developed, and the demand for specific detection of mutant strains is increasing due to the emergence of highly infectious variants.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Zhijie Wang, Lin Wu, Baolan Li, Ying Cheng, Xiaoling Li, Xicheng Wang, Liang Han, Xiaohong Wu, Yun Fan, Yan Yu, Dongqing Lv, Jianhua Shi, Jianjin Huang, Shaozhang Zhou, Baohui Han, Guogui Sun, Qisen Guo, Youxin Ji, Xiaoli Zhu, Sheng Hu, Wei Zhang, Qiming Wang, Yuming Jia, Ziping Wang, Yong Song, Jingxun Wu, Meiqi Shi, Xingya Li, Zhigang Han, Yunpeng Liu, Zhuang Yu, An-Wen Liu, Xiuwen Wang, Caicun Zhou, Diansheng Zhong, Liyun Miao, Zhihong Zhang, Hui Zhao, Jun Yang, Dong Wang, Yingyi Wang, Qiang Li, Xiaodong Zhang, Mei Ji, Zhenzhou Yang, Jiuwei Cui, Beili Gao, Buhai Wang, Hu Liu, Lei Nie, Mei He, Shi Jin, Wei Gu, Yongqian Shu, Tong Zhou, Jian Feng, Xinmei Yang, Cheng Huang, Bo Zhu, Yu Yao, Xiongwen Tang, Jianjun Yu, Ellen Maher, Hui Feng, Sheng Yao, Patricia Keegan, Jie Wang
Summary: The CHOICE-01 study investigated the efficacy and safety of toripalimab in combination with chemotherapy as a first-line treatment for advanced non-small-cell lung cancer (NSCLC). The study found that toripalimab plus chemotherapy significantly improved progression-free survival (PFS) and overall survival (OS) compared to placebo.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Yifan Lai, Xiaolu Hu, Guibing Shi, Juntao Yu, Li Wang, Zhifeng Gao
Summary: In order to conserve energy, the loss and efficiency of a brushless direct current (BLDC) motor were investigated. By replacing the silicon steel stator with an amorphous metal stator and improving the motor design, the motor efficiency was improved by 4.76% and the weight was reduced by 11.36%.
JOURNAL OF ELECTRICAL ENGINEERING & TECHNOLOGY
(2023)
Review
Medicine, Research & Experimental
Xueru Wang, Gang Xu, Hanyu Liu, Zhengtao Chen, Susu Huang, Jiushu Yuan, Chunguang Xie, Lian Du
Summary: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes, and finding effective treatments for DPN is crucial. Schwann cells (SCs) play an important role in the development of DPN by inhibiting apoptosis. Previous studies have shown the potential of Chinese herbal medicine (CHM) in treating DPN. This review explores the effects of CHM on SCs apoptosis through different pathological pathways and provides new insights for treating DPN.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Genetics & Heredity
Dandan Li, Xiaomei Li, Xintong Liu, Zhao Zhang
Summary: This study conducted a comprehensive genome-wide analysis of the bZIP gene family (RcbZIPs) in rose, revealing their phylogenetic relationships, gene structure, chromosome localizations, gene duplication, and potential functions. The expression analysis showed significant differential expression of 16 RcbZIPs in response to Botrytis cinerea infection, suggesting their candidate role in regulating rose's response to gray mold infection. Virus-induced gene silencing (VIGS) and overexpression (OE) studies demonstrated the involvement of RcbZIP17 in rose's resistance to gray mold. This study provides valuable information for further investigation into the function of the bZIP gene family in rose.
Article
Neurosciences
Zifeng Wu, Hanyu Liu, Enshi Yan, Xinying Zhang, Yuanyuan Wang, Chaoli Huang, Teng He, Liying Miao, Ling Yang, Riyue Jiang, Changyong Qi, Cunming Liu, Di Wang, Chun Yang
Summary: The abnormal composition of gut microbiota plays an essential role in the comorbidity of chronic pain and anxiety. Increasing the level of Desulfovibrio may alleviate chronic pain-anxiety comorbidity.
PSYCHOPHARMACOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Liangliang Yu, Jingxuan Yin, Chengwei Gao, Changgui Lin, Xiang Shen, Shixun Dai, Qing Jiao
Summary: In this study, a series of halogen-doped Na3SbS4 samples were synthesized using the solid-state method, and the relationship between crystal structure and Na+ ion conductivity was investigated through X-ray diffraction and Raman spectroscopy. The symmetric sodium battery assembled with the Na2.85SbS3.85Br0.15 electrolyte showed stable cycling for over 100 hours at room temperature with a current density of 0.1 mA/cm(2). This research provides a method to manufacture novel solid sodium electrolytes by exploring the effect of halogen doping in Na3SbS4.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Yining Chen, Wenxin Xu, Xin Zheng, Xuantao Huang, Nianhua Dan, Meng Wang, Yuwen Li, Zhengjun Li, Weihua Dan, Yunbing Wang
Summary: A two-layered self-powered electrical-stimulator-based wound dressing (SEWD) was designed, which integrated bionic tree-like piezoelectric nanofibers and adhesive hydrogel with biomimetic electrical activity. The SEWD showed good mechanical properties, adhesion properties, self-powered properties, high sensitivity, and bio-compatibility. In vitro and in vivo experiments demonstrated that SEWD converts mechanical energy into electricity to stimulate cell proliferation and wound healing.
Article
Agriculture, Multidisciplinary
Feng Jin, Ye Zhou, Pu Zhang, Ruimin Huang, Wei Fan, Baoxin Li, Guangzhu Li, Xiaobo Song, Dong Pei
Summary: This study investigated the development and accumulation of oil in walnut kernels. The researchers found that the oil content and oil bodies increased during the development of the kernels, especially in the early stages. They also identified key genes and proteins involved in fatty acid synthesis and oil body formation. These findings provide important insights into the molecular mechanism of oil biosynthesis in walnuts and potential strategies for genetic improvement.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Applied
Yang Li, Haoran Wang, Lijuan Wang, Ju Qiu, Zaigui Li, Lili Wang
Summary: In this study, the structure and digestive property of starch isolated from wheat bran of different particle size were investigated and compared with wheat flour starch. Results showed that cell-scale milling caused significant destruction of crystalline regions and double helix, and increase in starch digestibility. Wheat bran starch had more resistant starch and lower digestibility compared to wheat flour starch, which were highly correlated with its thinner lamellas, more double helix proportion and compact fractal. This study contributes to the application of bran starch and highlights the effect of supramolecular structure on bran starch digestibility.
Article
Computer Science, Information Systems
Wei Lin, Liang-Chih Yu
Summary: This study proposes a domain-distilled method to address the data scarcity problem in dimensional sentiment analysis. By using a domain discriminator to distinguish feature domains and maximizing the prediction loss, the proposed method improves the ability to learn domain-invariant features. Experimental results show that the proposed domain-distilled BERT outperforms the original BERT and other deep learning models in predicting dimensional sentiment scores.
JOURNAL OF INFORMATION SCIENCE AND ENGINEERING
(2023)
Article
Agricultural Engineering
Zhongkai Zhou, Siyu Zhang, Na Jiang, Haifang Zhang, Lili Wang, Weiming Xiu, Jianning Zhao, Dianlin Yang
Summary: addressing the issue of greenhouse gas and ammonia emissions in wheat fields, the study evaluated the impact of different fertilization practices on soil emissions. The results showed that the use of organic and inorganic fertilizers together increased soil carbon and nitrogen levels, while reducing emissions of greenhouse gases and ammonia.
JOURNAL OF THE ASABE
(2023)
