Article
Medicine, Research & Experimental
Shahin Alizadeh-Fanalou, Mohsen Khosravi, Fatemeh Alian, Shirin Rokhsartalb-Azar, Ali Nazarizadeh, Maryam Karimi-Dehkordi, Forogh Mohammadi
Summary: miR-1297, a microRNA with dual functions, exhibits abnormal expression in various human cancers, acting as both a tumor suppressor and an oncogene.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Suliman Khan, De-Yu Zhang, Ji-Yu Zhang, Mian Khizar Hayat, Jingli Ren, Safyan Nasir, Muhammad Fawad, Qian Bai
Summary: The expression and function of miRNAs play a crucial role in the development of HCC, affecting the biological behavior and clinical pathological features of liver cancer. Despite the unclear regulatory mechanisms, the potential of miRNA-based therapy for HCC warrants further exploration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aurora Eliana Merulla, Michele Stella, Cristina Barbagallo, Rosalia Battaglia, Angela Caponnetto, Giuseppe Broggi, Roberto Altieri, Francesco Certo, Rosario Caltabiano, Marco Ragusa, Giuseppe Maria Vincenzo Barbagallo, Cinzia Di Pietro, Michele Purrello, Davide Barbagallo
Summary: This study investigates the role of circSMARCA5 in controlling miRNAs 126-3p and 515-5p in GBM cells, revealing a new subnetwork regulated by circSMARCA5 which affects downstream mRNA targets IGFBP2 and NRAS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyan Lu, Yun Han, Yuwen Han, Menghui Huang, Jun You, Yinglei Liu, Yingying Ding, Yanli Zheng
Summary: MiR-650 regulates the viability, migration, and invasion of ovarian cancer cells by targeting KLF12, and may serve as a potential therapeutic target.
ACTA BIOCHIMICA POLONICA
(2022)
Article
Biochemistry & Molecular Biology
DaoPing Zhou, Juan Gu, YuePing Wang, HuaiGuo Wu, Wei Cheng, QingPing Wang, GuoPei Zheng, XueDong Wang
Summary: The study focused on the impact of NEAT1 on BC cell behavior, particularly invasion, migration, and resistance to chemotherapy, by interacting with miR-141-3p and KLF12. High expression of NEAT1 in serum extracellular vesicles was associated with clinical characteristics in BC patients. EVs facilitate the transportation of NEAT1 to BC cells, leading to increased KLF12 expression and promotion of BC cell invasion, migration, and chemotherapy resistance through the inhibition of miR-141-3p regulation.
CELL AND BIOSCIENCE
(2021)
Review
Multidisciplinary Sciences
Fatemeh Tajik, Fatemeh Alian, Mohammad Yousefi, Ali Azadfallah, Aref Hoseini, Forogh Mohammadi, Maryam Karimi-Dehkordi, Shahin Alizadeh-Fanalou
Summary: miR-372 is a non-coding, single-stranded, endogenous RNA that regulates various biological processes by binding to 3'-UTR mRNAs and controlling gene expression at the post-transcriptional level. It has abnormal expression in many human malignancies, suggesting its role in carcinogenesis, where it can function both as an oncogene and a tumor suppressor.
Article
Oncology
Bing Guan, Qing Li, Hui-Zhen Zhang, Hai-Sheng Yang
Summary: This study identified the role of circular (circ)_NOTCH3 in the development and progression of basal-like breast carcinoma (BLBC). circ_NOTCH3 was found to be upregulated in BLBC tissues and cell lines, promoting proliferation, migration, invasion, and inhibiting apoptosis of BLBC cells. circ_NOTCH3 can bind to miR-205-5p, modulate KLF12 expression, and act as a sponge for miR-205-5p, ultimately promoting the development and progression of BLBC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biology
Junaid Ali Shah, Saadullah Khattak, Mohd Ahmar Rauf, Yong Cai, Jingji Jin
Summary: miRNAs are small non-coding RNA transcripts that regulate gene expression in cells, including tumorigenesis. The miR-371-373 genes are found to be abnormally expressed in various cancers and may serve as molecular biomarkers for cancer diagnosis and prevention. Further studies linking miR-371-373 functions to tumorigenesis suggest their potential applications in cancer diagnosis and treatment.
Article
Biotechnology & Applied Microbiology
Shu Zhou, Jinjun Li, XiaoNa Zhang, Wen Xiong
Summary: This study investigated the role of miR-124 in AMP-stimulated neuroinflammation and its molecular mechanism. The findings showed that miR-124 can modulate microglia activation via targeting KLF6, accelerating M2 polarization and alleviating neurodegeneration induced by AMP.
Review
Biochemistry & Molecular Biology
Sujitha Jayaprakash, Mangala Hegde, Bandari BharathwajChetty, Sosmitha Girisa, Mohammed S. Alqahtani, Mohamed Abbas, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Cancer is a deadly disease that is strongly related to genetic changes and post-translational modifications. The E3 ubiquitin ligases, particularly NEDD4, play a crucial role in regulating cellular processes by controlling protein degradation and substrate ubiquitination. NEDD4 has both tumor-suppressive and oncogenic roles in various malignancies. This review summarizes the function of NEDD4 in cancer development, including its role in cell survival, proliferation, autophagy, migration, invasion, metastasis, epithelial-mesenchymal transition, chemoresistance, and multiple signaling pathways. Additionally, the significance of NEDD4 as a potential target for cancer treatment is discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Retraction
Cell Biology
Zaiqing Zhang, Gongzeng Luo, Chuandong Yu, Guisheng Yu, Rui Jiang, Xuefeng Shi
Summary: The study found that microRNA-493-5p inhibits proliferation and metastasis of osteosarcoma cells by targeting Kruppel-like factor 5. However, the experimental results could not be verified, leading to the retraction of the article.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Genetics & Heredity
Ekjot Kaur, Ritu Agrawal, Sagar Sengupta
Summary: DNA damage repair response is crucial for maintaining genome integrity, in which BLM plays a key role in regulating DNA replication, recombination, and repair pathways. Mutations in the BLM gene lead to Bloom syndrome, characterized by genetic instability, premature aging, and predisposition to cancer. Additionally, alterations in BLM have been associated with increased sensitivity to chemotherapeutic drugs in certain cancers, suggesting a potential pro-oncogenic function.
FRONTIERS IN GENETICS
(2021)
Review
Cell Biology
Xavier T. R. Moore, Lilia Gheghiani, Zheng Fu
Summary: Polo-like kinase 1 (PLK1) regulates various biological processes through phosphorylating more than 600 substrates. Among them, members of the FOX family of transcription factors (FOX TFs), including FOXM1, FOXO1, FOXO3, and FOXK1, are regulated by PLK1. This review discusses the effects of PLK1 on FOX TFs, their prognostic significance in cancer, and the approaches used to disrupt PLK1 and FOX TF-mediated signaling networks. Therapeutic targeting of PLK1-regulated FOX TFs in human cancers is also discussed.
Article
Respiratory System
Hajime Maeda, Hongwei Yao, Hayato Go, Kelsey E. E. Huntington, Monique E. De Paepe, Phyllis A. A. Dennery
Summary: This study found that hyperoxia can induce senescence in lung epithelial cells and increase the expression of miR-34a-5p, which is partly regulated by the upregulation of the KLF4 signaling pathway. Inhibiting miR-34a-5p or KLF4 can mitigate the detrimental effects of hyperoxia on the neonatal lung.
RESPIRATORY RESEARCH
(2022)
Review
Cell Biology
Ziyan Xie, Junye Chen, Chenyu Wang, Jiahao Zhang, Yanxiang Wu, Xiaowei Yan
Summary: This review summarizes the function and regulation mechanism network of KLF5 in vascular remodeling, highlighting its roles in cell proliferation, phenotype switch, extracellular matrix deposition, inflammation, and angiogenesis. The review also emphasizes the potential therapeutic applications of KLF5 in treating vascular disorders.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)