Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume 48, Issue 5, Pages 2155-2165Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2016.3399
Keywords
alpha-mangostin; breast cancer; apoptosis; PI3K; Akt; MAPK
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Funding
- Royal Golden Jubilee Ph.D. Program, Thailand Research Fund [PHD/0312/2550]
- Strategic Wisdom and Research Institute, Srinakharinwirot University
- Research Division, Faculty of Medicine, Srinakharinwirot University
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alpha-Mangostin extracted from mangosteen, Garcinia mangostana Linn. is known as 'queen of fruits'. The anticancer activity of alpha-mangostin through apoptosis induction and related signaling pathways in human breast cancer T47D cells was investigated. Human epidermal growth factor receptor 2 (HER2) and mitogen-activated protein kinase (MAPK) signaling have been shown to play important roles in apoptosis. The results showed that a-mangostin induced cell proliferation inhibition, DNA fragmentation, nuclear condensation, increased cleaved caspase-3 and cleaved caspase-9, but decreased Bcl-2 and Mcl-1 expression. Mitochondrial dysfunction and cytochrome c release were also detected. In addition, phosphorylation of ER alpha, HER2, PI3K, Akt and ERK1/2 were downregulated whereas p-JNK1/2 and p-p38 were upregulated. These results indicated that alpha-mangostin induced apoptosis associated with HER2/PI3K/Akt and MAPK signaling pathways suggesting that alpha(-)mangostin may be used as food supplement or a potential therapeutic compound for breast cancer.
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