Article
Biochemistry & Molecular Biology
Bradley K. Schniers, Devaraja Rajasekaran, Ksenija Korac, Tyler Sniegowski, Vadivel Ganapathy, Yangzom D. Bhutia
Summary: PEPT1 and PEPT2, two proton-coupled peptide transporters, are up-regulated in PDAC cell lines and PDXs. Inhibiting PEPT1 can reduce cancer cell proliferation, highlighting its critical role in cancer cell survival. Tumor-derived lactic acid in the microenvironment supports PEPT1 function, indicating a potential therapeutic target for pancreatic cancer.
BIOCHEMICAL JOURNAL
(2021)
Article
Public, Environmental & Occupational Health
Ming Li, Xiaoyang Duan, Yajie Xiao, Meng Yuan, Zhikun Zhao, Xiaoli Cui, Dongfang Wu, Jian Shi
Summary: This study aimed to understand the tumorigenesis mechanism and explore potential therapeutic targets for pancreatic cancer. Through comprehensive bioinformatics analyses, the study identified key genes and cell types associated with prognosis in pancreatic cancer. The study also revealed specific ligand-receptor pairs that contributed to tumorigenesis. Additionally, BUB1 was identified as a potential prognostic biomarker and therapeutic target for pancreatic cancer.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Rana Smalling, Matthew E. Bechard, Jeff Duryea, Philip J. Kingsley, Evan R. Roberts, Lawrence J. Marnett, Daniel Bilbao, Shaun R. Stauffer, Oliver G. McDonald
Summary: A novel aminopyridine compound was found to target a unique metabolic adaptation in metastatic pancreatic cancer, demonstrating effective anti-metastatic efficacy with minimal toxicity. This discovery could potentially provide new druggable targets for patients with advanced cancers.
Review
Biochemistry & Molecular Biology
Xi Wang, Yiming Chen, Yongjuan Wang, Bangmao Wang, Jie Zhang, Xu Jian
Summary: PEPT1 plays a critical role in the absorption of peptides in the intestinal tract and its abnormal expression in malignant tumors is closely related to tumor progression. It can be considered as a potential molecular biomarker for malignant tumors and can be used for targeted delivery of anti-tumor drugs.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Oncology
Max Piffoux, Erwan Eriau, Philippe A. Cassier
Summary: PDAC is characterized by early metastasis and resistance to therapy, with mutations in KRAS and TP53 showing little clinical efficacy. Autophagy, upregulated in PDAC, plays a role in resistance to treatments, making it a potential therapeutic target. Combining inhibitors of the ERK/MAPK pathway with autophagy inhibitors has shown interesting results in PDAC models and other KRAS-driven cancers.
BRITISH JOURNAL OF CANCER
(2021)
Article
Chemistry, Physical
Hiroto Tachikawa, Tetsuji Iyama
Summary: This study investigated the radiation effects on the catalytic triad Ser-His-Glu and the influence of micro-solvation on its structure. The reaction dynamics and proton transfer rates in different scenarios were calculated based on theoretical analysis, providing insights into the impact of irradiation on Ser-His-Glu.
Review
Medicine, Research & Experimental
Luman Liu, Prakash G. Kshirsagar, Shailendra K. Gautam, Mansi Gulati, Emad Wafa, John C. Christiansen, Brianna M. White, Surya K. Mallapragada, Michael J. Wannemuehler, Sushil Kumar, Joyce C. Solheim, Surinder K. Batra, Aliasger K. Salem, Balaji Narasimhan, Maneesh Jain
Summary: Pancreatic tumors are difficult to treat due to their highly fibrotic and immunosuppressive nature. Nanotechnology offers promising solutions by providing improved drug delivery and immunotherapy-based approaches. This review highlights the potential of nanoscale strategies for treating pancreatic tumors and discusses future research directions.
Article
Oncology
Moein Ala
Summary: C-Myc overexpression in pancreatic cancer is associated with aggressive behavior of cancer cells and can regulate various cellular processes. Recent studies have shown that C-Myc can be targeted directly or indirectly, offering potential therapeutic strategies for pancreatic cancer.
CANCER BIOLOGY & THERAPY
(2022)
Review
Cell Biology
Shaoshan Mai, Iwona Inkielewicz-Stepniak
Summary: Platelets have been identified as crucial players in hemostasis, thrombosis, and cancer progression. Research has shown that platelets can promote tumorigenesis and metastasis by interacting with cancer cells in various ways. Understanding the interaction between pancreatic cancer and platelets, as well as the underlying mechanisms, may offer insights into potential diagnostic and therapeutic strategies for combating the devastating disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Yan Luo, Jisheng Hu, Yong Liu, Le Li, Yilong Li, Bei Sun, Rui Kong
Summary: The dissemination of cancer cells through invadopodia is a complex process with crucial implications in cancer progression. Specific cells and molecules involved in invadopodia activity have been identified as potential therapeutic targets in cancer treatment, particularly in pancreatic cancer. However, there is a lack of drugs targeting invadopodia and related clinical trials, highlighting the need for further research and development in this area.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Neurosciences
Ian D. Tomlinson, Oleg Kovtun, Ruben Torres, Laurel G. Bellocchio, Travis Josephs, Sandra J. Rosenthal
Summary: The study focused on developing a novel ligand, IDT785, that effectively studied the cellular trafficking and membrane dynamics of SERT, providing valuable insights into SERT localization and function. The ligand demonstrated biological activity by inhibiting SERT-mediated reuptake of serotonin and enabling membrane labeling of SERT for further research.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Medicine, General & Internal
Jin-Shou Yang, Cheng-Cheng Wang, Jiang-Dong Qiu, Bo Ren, Lei You
Summary: PDAC is an extremely malignant disease with a low survival rate, with arginine metabolism playing a crucial role in its development and progression. Arginine deprivation is considered a potential therapy, but drug resistance may develop during treatment. Arginase 1 may be a potential target for cancer immunotherapy.
CHINESE MEDICAL JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Junsik Sung, Lixin Wang, Dingpei Long, Chunhua Yang, Didier Merlin
Summary: Genetic knockout of PepT1 protein provides resistance to acute colitis and colitis-associated cancer in mouse models. The altered fecal metabolites, particularly tuberonic acid (TA), in PepT1 KO mice play a crucial role in anti-inflammatory effects and epithelial cell healing processes. This study sheds light on the potential mechanisms associated with the protective effects of PepT1 KO.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Chemistry, Analytical
Komila Rasuleva, Keerthi Priya Jangili, Alfred Akinlalu, Ang Guo, Pawel Borowicz, Chen-zhong Li, Dali Sun
Summary: Pancreatic cancer patients often have advanced disease at diagnosis, leading to high mortality rates. Currently, there is a lack of noninvasive and fast screening methods to detect this disease. Tumor-derived extracellular vesicles (tdEVs) carrying information from parent cells have emerged as a promising cancer diagnostic biomarker. However, most tdEV-based assays have practical limitations. To overcome these challenges, a novel diagnostic method called EvIPqPCR was developed, which combines immunoprecipitation (IP) and qPCR quantification to directly detect tumor-derived EVs from serum. This technique has the potential to be a translational assay for cancer screening with weak correlation to prognosis biomarkers and sufficient discriminatory power among different groups.
ANALYTICAL CHEMISTRY
(2023)
Review
Immunology
Xinlei Zou, Canghai Guan, Jianjun Gao, Wujiang Shi, Yunfu Cui, Xiangyu Zhong
Summary: Pancreatic cancer is highly malignant and has limited response to immunotherapies due to its hypoxic and immunosuppressive tumor microenvironment. The formation of tertiary lymphoid structures (TLSs) induced by immune cells can be found in both intra- and peritumor tissues of pancreatic cancer. Intratumoral TLSs are associated with a good prognosis and can be used as an indicator to assess treatment effectiveness. Targeted induction of TLS formation may open up new possibilities for immunotherapy of pancreatic cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Zheng Xu, Ru Liu, Liping Guo, Ziyi Gao, Zicheng Gao, Xiaowei Liu, Jieyun Li, Bin Li, Kehu Yang
Summary: This scientometric investigation provides a comprehensive analysis of the development and emerging research trends in bibliotherapy. The study identifies the leading countries and institutions in the field and highlights the hot topics of research, such as depression and anxiety. The findings of this study serve as a valuable reference for researchers in the field of bibliotherapy.
PSYCHOLOGY HEALTH & MEDICINE
(2023)
Article
Environmental Sciences
Yu Qin, Meixuan Li, Jiani Han, Gecheng Cui, Weiping Du, Kehu Yang
Summary: This study explored the research hotspots and trends of Kinesio Taping in the past decade through bibliometric analysis. The results revealed that pain relief, sports injury prevention and treatment, and proprioception enhancement for improved postural control were important research areas in the field of Kinesio Taping.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Junjie Cao, Renzhi Pei, Ying Lu, Zhongzheng Zheng, Zhiyang Yuan, Daiyang Li, Pisheng Zhang, Xuhui Liu, Dong Chen, Xiaohong Du, Lieguang Chen, Shuangyue Li, Peipei Ye, Tiantian Wang
Summary: The study found that the modified antithymocyte globulin-post-transplant cyclophosphamide combination can decrease the risk of acute and chronic graft-versus-host disease and improve graft-versus-host disease and relapse-free survival in high-risk acute myeloid leukemia and myelodysplastic syndrome patients after allogeneic hematopoietic stem cell transplantation.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Wenlin Lu, Xuhui Liu, Linghui Zhao, Shirong Yan, Qingyun Song, Cao Zou, Xun Li
Summary: This study investigated the role and mechanism of miR-22-3p in heart failure, and found that its overexpression inhibits cell activity and promotes cell apoptosis. MiR-22-3p increases the risk of heart failure damage by negatively regulating FURIN.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Xu Chi, Qian Chen, Zhi-An Lan, Xirui Zhang, Xiong Chen, Xinchen Wang
Summary: Conjugated polymers (CPs) have received increasing attention in photocatalysis due to their stability and molecular tunability. In this study, a new efficient cyano (CN) engineering approach was proposed to enhance the photocatalytic performance of CPs. Three CP-based photocatalysts with different CN contents were synthesized to investigate the relationship between CN functionalization and photocatalytic activity. Experimental and theoretical studies revealed that CN functionalization strengthened the donor-acceptor (D-A) interaction, enhanced light absorption, charge separation/transfer efficiency, hydrophilicity of CPs, and facilitated the output of photoinduced electrons from CPs to Pt cocatalyst.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Plant Sciences
Hongling Zhang, Guiqiong Li, Min Jiang, Changling Zhao, Pengyu Zhao, Chen Wang, Guosong Wen, Feng Zhou, Wenhua Dongchen, Shaozhong Xu, Ting Mu, Fanlai Meng, Xinglei Xiao, Di Yang, Zhengjie Liu, Ya Zhou, Qin Xiong
Summary: The expression of flavonoid synthesis-related genes in Panax notoginseng stems shows multi-peak curves, and the distribution of total flavonoid and anthocyanin content in the stems is asymmetric, mainly concentrated in the upper parts. The correlations between gene expression and flavonoid accumulation are highly diverse.
ACTA PHYSIOLOGIAE PLANTARUM
(2023)
Review
Endocrinology & Metabolism
Liangying Hou, Qi Wang, Bei Pan, Rui Li, Yanfei Li, Juanjuan He, Tianzhu Qin, Liujiao Cao, Na Zhang, Changhao Cao, Long Ge, Kehu Yang
Summary: The study aimed to determine the effects of different exercise modalities in patients with type 2 diabetes mellitus. Results showed that various exercise modalities can improve glycemic control in diabetes patients, with supervised exercises being the most effective. Flexibility and balance exercises also have benefits, but the impact on TG levels remains unclear.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Physics, Multidisciplinary
Xingxing Yang, Yang Li, Xin Guo, Meiling Ding, Jingxuan Yang
Summary: This paper proposes a strategy to reduce energy consumption by storing and transmitting regenerative energy of trains through multi-agent simulation. By optimizing the train operation time and dwell time, the traction energy consumption is reduced, and the accuracy of the simulation model is validated in a practical case study.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2023)
Review
Obstetrics & Gynecology
Liu Yang, Lufang Feng, Lijuan Huang, Xuejiao Li, Wenwen Qiu, Kehu Yang, Jie Qiu, Haihong Li
Summary: This study conducted a meta-analysis to identify the association between maternal factors and intrauterine growth retardation (IUGR), and found that smoking, primiparity, prepregnancy BMI < 18.5, poor gestational weight gain, pregnancy-induced hypertension, anemia, and hypoproteinemia were associated with IUGR. These findings could contribute to the development of risk prediction models and improve management and education for child-bearing or early pregnant women.
REPRODUCTIVE SCIENCES
(2023)
Review
Sport Sciences
Meng Xu, Chen Tian, Yong Wang, Shanshan Liang, Yiyun Wang, Xiuxia Li, Kehu Yang
Summary: This study conducted an umbrella review to summarize the evidence of associations between Pilates and multiple health outcomes, and evaluated the strength and validity of these associations. It found that Pilates can reduce body mass index and body fat percentage, relieve pain and disability, and improve sleep quality and balance. However, the certainty of the evidence was mostly low, and further high quality randomized controlled trials are needed to support these promising findings.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2023)
Article
Chemistry, Physical
Ye Ji, Xi-Lian Guo, Jia-Yu Yang, Hai-Han Zhang, Xu-Hui Liu, Ming-Xing Song, Zheng-Kun Qin, Jia Wang, Fu-Quan Bai
Summary: In this article, six novel heterocyclic Ir(III) complexes were designed and calculated using DFT and TD-DFT. The bands of the lowest-lying absorptions and lowest energy emissions, as well as the spectral properties, frontier molecular orbitals, and spin-orbital coupling values, were studied. These complexes exhibit low efficiency roll-off properties, which is significant for the development of OLEDs.
Article
Biochemistry & Molecular Biology
Guoshun Liu, Xuhui Liu, Xingdong Ma, Xiaoqi Tang, Xiaobin Zhang, Jianxia Dong, Yunfei Ma, Xiaobei Zang, Ning Cao, Qingguo Shao
Summary: Dual-ion batteries (DIBs) are a new type of energy storage device that store both anions and cations. Combining graphite cathodes with high-capacity silicon anodes can improve the energy density of DIBs.
Review
Emergency Medicine
Qi Zhou, Wenbo Meng, Yanhan Ren, Qinyuan Li, Marja A. Boermeester, Peter Muli Nthumba, Jennifer Rickard, Bobo Zheng, Hui Liu, Qianling Shi, Siya Zhao, Zijun Wang, Xiao Liu, Zhengxiu Luo, Kehu Yang, Yaolong Chen, Robert G. Sawyer
Summary: This study reviewed the effectiveness of intraoperative peritoneal lavage (IOPL) with saline in patients with intra-abdominal infections (IAIs). The findings suggest that IOPL with saline does not significantly reduce the risk of mortality, intra-abdominal abscess, incisional surgical site infection, postoperative complication, reoperation, and readmission when compared to non-IOPL. Therefore, routine use of IOPL with saline in patients with IAIs is not supported.
WORLD JOURNAL OF EMERGENCY SURGERY
(2023)
Article
Materials Science, Multidisciplinary
Lingjie Meng, Xuhui Liu, Qingxiang Hong, Yan Ji, Lingtao Wang, Qiuyang Zhang, Jie Chen, Changjiang Pan
Summary: In this study, a Zn2+-loaded polydopamine (PDA/Zn2+) coating was prepared on an alkali-heat-treated magnesium alloy surface inspired by mussel adhesion protein. The coating showed excellent wettability and selective promotion of albumin adsorption. Furthermore, the corrosion resistance, hemocompatibility, and endothelialization of the modified magnesium alloys were significantly improved with the increase of Zn2+ content in the coating.
Article
Oncology
Peng Xie, Siqing Wu, Zichong Kuo, Huidong Tian, Qiangsheng He, Yanfei Li, Ningning Mi, Linmin Hu, Haitong Zhao, Wenjing Li, Bin Xia, Jinqiu Yuan, Kehu Yang, Changhua Zhang, Yulong He
Summary: This study aimed to investigate the individual and joint effects of modifiable healthy lifestyle and metabolic health status on colorectal cancer incidence and mortality. The results showed that adherence to a healthy lifestyle could substantially reduce the burden of colorectal cancer, and behavioral lifestyle changes should be encouraged for colorectal cancer prevention even in participants with metabolic syndrome.
FRONTIERS IN ONCOLOGY
(2023)