Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 11, Issue -, Pages 4545-4552Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S104635
Keywords
thioridazine; doxorubicin; codelivery; nanoparticles; breast cancer
Funding
- National Natural Science Foundation [81301907, 81422025, 81572990]
- Sichuan Provincial Youth Science and Technology Fund [2016JQ0020]
- Wu Jieping Medical Foundation [320.6750.12224]
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Cancer chemotherapy can benefit from the combination of different anticancer drugs. Here, we prepared doxorubicin (Dox)- and thioridazine (Thio)-coloaded methoxy poly(ethylene glycol)-poly(L-lactic acid) (MPEG-PLA) nanoparticles (NPs) for breast cancer therapy. These NPs have an average particle size of 27 nm. The drug loading efficiencies of Thio and Dox are 4.71% and 1.98%, respectively. Compared to the treatment of Thio or Dox alone, the combination of Thio and Dox exhibited a synergistic effect in inhibiting the growth of 4T1 breast cancer cells in vitro. In addition, the Thio- and Dox-coloaded MPEG-PLA NPs could efficiently suppress the growth of breast cancer cells in vivo. This study suggests that Thio-and Dox-coloaded MPEG-PLA NPs might have potential applications in breast cancer treatment.
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