Review
Pharmacology & Pharmacy
Zeqi Wang, Yu Yu, Chuqiao Wang, Jin Li, Yan Pang
Summary: This review highlights the aggressive nature of melanoma and the limitations of current treatments. It explores the potential of nanoparticles to overcome these limitations and play an important role in melanoma treatment.
Article
Nanoscience & Nanotechnology
Qiao-Ting Fu, Xiao-Qin Zhong, Mei-Yu Chen, Jia-Yi Gu, Jian Zhao, De-Hong Yu, Fei Tan
Summary: In this study, nanoparticles encapsulating luteolin (LUT) with a reactive oxygen species-responsive material were developed to enhance the water solubility and anti-melanoma effect of LUT. In vitro and in vivo experiments demonstrated that the LUT-loaded nanoparticles effectively inhibited tumor cell proliferation, migration, and invasion, providing a potential solution for the clinical application of LUT in melanoma therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Emile F. van Vliet, Maarten J. Knol, Raymond M. Schiffelers, Massimiliano Caiazzo, Marcel H. A. M. Fens
Summary: Parkinson's disease is characterized by degeneration of dopaminergic neurons, causing dopamine deficiency and motor symptoms. Current treatment using L-DOPA has limitations and side effects. Encapsulation of L-DOPA into nanoparticles can protect it and improve delivery to the brain, reducing required dosages and side effects. Alternative delivery methods, such as intravenous administration and transdermal delivery, enhance therapeutic effects. This review discusses recent advances and future perspectives on NP-mediated L-DOPA delivery to the brain.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Julia German-Cortes, Mireia Vilar-Hernandez, Diana Rafael, Ibane Abasolo, Fernanda Andrade
Summary: Nanotechnology has made significant contributions to cancer treatment by improving the effectiveness and specificity of chemotherapy through the use of nanoparticles, particularly solid lipid nanoparticles (SLNs). SLNs offer higher stability, active targeting, sustained and controlled release, and multifunctional therapy, making them an ideal drug delivery system.
Article
Oncology
Mengdan Xu, Shenglong Li
Summary: This comprehensive review provides an overview of current research on nano-drug delivery systems for melanoma treatment, with a focus on liposomes, polymeric nanoparticles, and inorganic nanoparticles. It discusses the potential of these nanoparticles for targeted drug delivery, as well as their ability to enhance the efficacy of conventional drugs while minimizing toxicity. Furthermore, this review emphasizes the significance of interdisciplinary collaboration in advancing the development of nanomedicines.
Review
Environmental Sciences
B. H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Saad Ali Alshehri, Shadma Wahab, Lalitkumar K. Vora, Raghu Raj Singh Thakur, Prashant Kesharwani
Summary: Lyotropic liquid crystals, specifically cubosomes, are highly promising drug carriers due to their self-assembled, non-lamellar, and mesophase nanostructured properties. Cubosomes exhibit bicontinuous structures formed through the self-organization of amphiphilic lipids and stabilization using steric polymers. They have shown superior entrapment efficiency and stability for hydrophobic drugs compared to liposomes. Additionally, cubosomes have been extensively explored for their safe and effective delivery of therapeutic and contrast agents in cancer treatment and imaging.
ENVIRONMENTAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Durgaramani Sivadasan, Kalaivanan Ramakrishnan, Janani Mahendran, Hariprasad Ranganathan, Arjunan Karuppaiah, Habibur Rahman
Summary: Recent advancements in drug delivery technologies have led to the emergence of nanotechnology as a potential tool in cancer therapeutics. Solid lipid nanoparticles (SLNs) have shown great potential for drug delivery, clinical medicine, and overcoming challenges in cancer therapy. Further research is needed to better understand the biological responses of SLNs and develop therapeutics with reduced side effects. This review focuses on the development, mechanisms, and applications of SLNs in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Andreea Nedelcu, Teodora Mocan, Cristiana Grapa, Lucian Mocan
Summary: Pancreatic cancer is a deadly solid tumor with low survival rates, often requiring surgical treatment, and the development of active nanocarriers presents opportunities for improving outcomes in its treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Biotechnology & Applied Microbiology
Vaishali Sunil Mishra, Preeti Tiwari, Madhu Gupta, Piyush Kumar Gupta
Summary: Lipid-based nanodrug delivery systems have great potential in the therapeutic intervention for leishmaniasis by improving drug solubility and targeted delivery.
Review
Nanoscience & Nanotechnology
Tobias Achu Muluh, Zhuo Chen, Yi Li, Kang Xiong, Jing Jin, ShaoZhi Fu, JingBo Wu
Summary: In recent years, there has been a significant increase in research on abnormal cell growth, particularly focusing on the management, treatment, and prevention of tumor recurrence. Cancer immunotherapy aims to educate the body's defensive system to prevent, control, and eliminate tumor cells, with the use of nanoparticles enhancing its effectiveness. By utilizing nanoparticles for precise delivery of immunotherapies to targeted neoplasms, immunotherapy can be a promising approach for cancer treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Tianli Luo, Qizhen Zheng, Leihou Shao, Tianyu Ma, Lanqun Mao, Ming Wang
Summary: Rationally designed GPX4 degrader can enhance ferroptosis induction efficiency, while the intracellular delivery of this degrader using biodegradable lipid nanoparticles enables cell-selective ferroptosis induction.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Pharmacology & Pharmacy
Aishwarya Shivashankarappa, K. R. Sanjay, Dhruvi Shah, Aishwarya Tagat
Summary: This study demonstrates the use of gold nanoparticles as an effective drug delivery vehicle for photodynamic cancer therapy targeting skin melanoma cells. Gold nanoparticles were synthesized from the medicinal plant Decalepis hamiltonii and conjugated with an anti-cancer drug 5-aminolevulinic acid (5-ALA). The activated gold-5ALA conjugates showed a deleterious effect on cancer cells with no significant effect on normal cells, indicating specific targeting towards cancer cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Eleen Dayana Mohamed Isa, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman, Martin R. Gill
Summary: Mesoporous silica nanoparticles (MSNs) as drug delivery agents show great potential in cancer treatment by enhancing efficacy and reducing side effects. Through the development of smart DDAs and the capability to efficiently trap cargo molecules, MSNs have a bright future in both the diagnosis and treatment of cancer.
Article
Multidisciplinary Sciences
Cheng Gao, Qingfu Wang, Junyan Li, Cheryl H. T. Kwong, Jianwen Wei, Beibei Xie, Siyu Lu, Simon M. Y. Lee, Ruibing Wang
Summary: This study reports an in vivo strategy to construct cell-based nanomedicine carriers using bacteria-mimetic gold nanoparticles, which are selectively phagocytosed by immune cells and self-assemble into intracellular aggregates. The optimized carriers improve drug delivery and enhance antitumor immunotherapy through photothermal treatment and immune checkpoint blockade.
Article
Medicine, Research & Experimental
Cheng Wang
Summary: Nanomedicine represents a promising approach for improving drug delivery systems (DDSs), and the development of cell/tissue-based lipid carriers is a promising strategy.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Rafael Pepineli, Alexandre C. Santana, Filipe M. O. Silva, Thauany M. Tavoni, Noedir A. G. Stolf, Irene L. Noronha, Raul C. Maranhao
Summary: The study aimed to investigate the protective effects of lipid core nanoparticles loaded with paclitaxel (LDE-PTX) on rat aortic allograft from immunological damage. Results showed that LDE-PTX effectively prevented vasculopathy associated with rejection, offering a potent therapeutic tool for post-transplantation.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Oncology
Edmundo Luis Rodrigues Pereira, Danielle Cristinne Azevedo Feio, Joao Pojucan Lobo Tavares, Natalia Megumi Morikawa, Debora Fernandes Deus, Carolina Graziani Vital, Elaine Rufo Tavares, Raul Cavalcante Maranhao
Summary: This study investigated the in vivo uptake of lipid nanoparticles (LDE) by human cerebral tumors. Results showed that LDE can concentrate in brain malignant tumors and may be used to carry drugs directed against those tumors.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Rheumatology
Maria G. Lang, Carmen G. C. Vinagre, Eloisa Bonfa, Fatima R. Freitas, Sandra G. Pasoto, Tatiane S. Brito, Luciana P. C. Seguro, Raul C. Maranhao, Eduardo F. Borba
Summary: This study demonstrates for the first time that hydroxychloroquine (HCQ) promotes the transfer of unesterified cholesterol, leading to increased levels of high-density lipoprotein (HDL) in systemic lupus erythematosus (SLE) patients. This beneficial effect may contribute to the reduced atherosclerosis reported in SLE.
Article
Multidisciplinary Sciences
Filipe M. O. Silva, Priscila C. Carvalho, Elerson L. Costalonga, Rafael Pepineli, Raul Maranhao, Irene Noronha
Summary: The study found that paclitaxel carried in lipid core nanoparticles has a preventive effect on peritoneal fibrosis in rats, making it a potential candidate for future clinical trials.
Article
Oncology
Carolina G. Vital, Raul C. Maranhao, Fatima R. Freitas, Brigitte M. Van Eyll, Silvia R. Graziani
Summary: The study found that LDE-PTX treatment reduced toxicities, relieved bone pain, and possibly prolonged progression-free survival in some patients. Further clinical investigation is warranted.
JOURNAL OF BONE ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Maria Carolina Guido, Natalia de Menezes Lopes, Camila Inagaki Albuquerque, Elaine Rufo Tavares, Leonardo Jensen, Priscila de Oliveira Carvalho, Thauany Martins Tavoni, Ricardo Ribeiro Dias, Lygia da Veiga Pereira, Francisco Rafael Martins Laurindo, Raul Cavalcante Maranhao
Summary: In this study, it was found that LDEMTX treatment can prevent the development of aortic lesions in a murine model of Marfan syndrome. LDEMTX reduced inflammation and fibrosis, and lowered the expression of inflammatory factors. These findings suggest that LDEMTX may be a potential candidate for clinical studies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Camila Inagaki Albuquerque, Elaine Rufo Tavares, Maria Carolina Guido, Priscila Oliveira Carvalho, Thauany Martins Tavoni, Natalia Menezes Lopes, Bruna Miranda de Oliveira Silva, Leonardo Jensen, Noedir Antonio Groppo Stolf, Raul Cavalcante Maranha
Summary: This study demonstrated that lipid core nanoparticles (LDE) carrying the anti-cancer agent daunorubicin have anti-atherosclerotic effects. In an experiment conducted on New Zealand male rabbits, the atherosclerotic lesions in the LDE-daunorubicin group were 50% smaller compared to the LDE group. LDE-daunorubicin reduced atherosclerotic lesions through different mechanisms without observable toxicities.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dalila Pinheiro Leal, Gustavo Henrique Ferreira Goncalinho, Thauany Martins Tavoni, Karen Lika Kuwabara, Ana Paula Paccanaro, Fatima Rodrigues Freitas, Celia Maria Cassaro Strunz, Luiz Antonio Machado Cesar, Raul Cavalcante Maranhao, Antonio de Padua Mansur
Summary: This study demonstrated the association between energy restriction and atorvastatin treatment with changes in lipid profile, serum Sirt-1 concentrations, and HDL function.
Letter
Ophthalmology
Marcelo L. Occhiutto, Thais H. M. Passos, Fatima R. Freitas, Raul C. Maranhao, Vital P. Costa
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Fabiana C. Juliani, Ana Paula M. Chacra, Marcio H. Miname, Wilson Salgado Filho, Marjorie H. Mizuta, Cinthia E. Jannes, Jose E. Krieger, Raul C. Maranhao, Raul D. Santos, Viviane Z. Rocha
Meeting Abstract
Cardiac & Cardiovascular Systems
P. G. S. Braga, T. M. Tavoni, R. V. Baroni, F. R. Freitas, M. C. Guido, M. J. N. N. Alves, G. A. Rocha, A. L. L. Bachi, C. E. Negrao, M. W. Vaisberg, R. C. Maranhao
Meeting Abstract
Cardiac & Cardiovascular Systems
M. C. Guido, N. M. Lopes, P. O. Carvalho, A. O. Silva, L. Jensen, L. V. Pereira, R. R. Dias, F. R. M. Laurindo, R. C. Maranhao
Meeting Abstract
Cardiac & Cardiovascular Systems
M. C. Guido, N. M. Lopes, C. I. Albuquerque, E. R. Tavares, L. Jensen, P. O. Carvalho, L. V. Pereira, R. R. Dias, F. R. M. Laurindo, R. C. Maranhao
Meeting Abstract
Cardiac & Cardiovascular Systems
Fabiana Cordeiro Juliani, Marcio Hiroshi Miname, Maria Helane Costa Gurgel Castelo, Ana Paula Marte Chacra, Wilson Salgado, Elaine dos Reis Coutinho, Cinthia Elim Jannes, Alexandre Pereira, Jose Eduardo Krieger, Raul Cavalcante Maranhao, Raul Santos, Viviane Zorzanelli Rocha
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)