Article
Food Science & Technology
Mercia Maria Alfinete Sulumindine Inroga, Medelin Marques da Silva, Rufino Fernando Flores Cantillano, Karina Paese, Silvia Staniscuaski Guterres, Simone Hickmann Flores, Alessandro de Oliveira Rios
JOURNAL OF CULINARY SCIENCE & TECHNOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Juliana Dias Aguiar, Marlus da Silva Pedrosa, Sergio Hiroshi Toma, Koiti Araki, Marcia Martins Marques, Igor Studart Medeiros
Summary: This study evaluated the antibacterial effect, cytotoxicity, and microtensile bond strength of an adhesive system containing silver nanoparticles. The results showed that incorporating 500 or 1000 ppm of silver nanoparticles had an antibacterial effect without altering cytotoxicity, and the SBMP with 500 ppm had higher microtensile bond strength after 1 year.
Article
Optics
Luiz M. M. Barreto, Davinson M. da Silva, Antonio D. Santos, Koiti Araki, Cid B. de Araujo, Luciana R. P. Kassab
Summary: Multilayer graphene (MLG) thin films were produced by depositing them on a cobalt buffer-layer prepared at 500 degrees C and subsequently thermal annealing. The annealing process allowed the transformation of amorphous carbon to graphene through diffusion and nucleation. The thicknesses of the cobalt and MLG thin films were measured as 55 and 54 nm, respectively, by atomic force microscopy. Raman spectroscopy confirmed the presence of MLG based on the intensity ratio of the 2D and G bands (I2D/IG), which was found to be 0.4 for the annealed graphene thin film. Additional analysis using transmission electron microscopy supported the Raman results. Moreover, the MLG films exhibited significant nonlinear absorption behavior at 980 nm and can be utilized as optical limiters.
Review
Chemistry, Inorganic & Nuclear
Josue M. Goncalves, Artur Luis Hennemann, Jose G. Ruiz-Montoya, Paulo R. Martins, Koiti Araki, Lucio Angnes, Reza Shahbazian-Yassar
Summary: The demand for alternative energy conversion and storage methods has led to the development of novel nanostructured materials. Metal-glycerolates and their derivatives have emerged as promising materials with various morphologies and compositions. This review focuses on the synthesis of micro- and nanostructures derived from metal-glycerolates, their applications in supercapacitors, batteries, and water splitting electrocatalysts. The utilization of these materials as electrode materials is a recent trend, with the majority of references published between 2018 and 2022. The review also discusses the challenges, future perspectives, and directions for these promising materials.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Physical
Cristofher Victor Vivas Palomares, Yan Borges Barreto, Natalia Marchesan Bexiga, Sergio Hiroshi Toma, Jonnatan Julival dos Santos, Koiti Araki, Adriano Mesquita Alencar, Antonio Carlos Bloise
Summary: This study investigates the metabolic changes in cells exposed to nanoparticles and their response to cytotoxicity manipulation. The findings suggest that improving wound healing treatments can be achieved by modulating cellular activity through fine-tuning exposure parameters.
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2023)
Article
Biochemistry & Molecular Biology
Gabriel P. Bacil, Guilherme R. Romualdo, Priscila M. F. D. Piagge, Daniel R. Cardoso, Mathieu Vinken, Bruno Cogliati, Luis F. Barbisan
Summary: This study investigated the hepatic metabolomic profile in a hybrid model of NASH in mice and found that the strain-dependent hepatic metabolomic signature might be linked to the distinct underlying mechanisms of NASH.
Article
Toxicology
Bruna dos Santos Rodrigues, Kaat Leroy, Milos Mihajlovic, Sybren De Boever, Sarah Vanbellingen, Bruno Cogliati, Joeri L. Aerts, Mathieu Vinken
Summary: Currently, there are no validated in vitro assays for testing the non-genotoxic carcinogenic potential of chemicals. Therefore, the two-year rodent bioassay remains the standard method for identifying these chemicals. Transcriptomic and proteomic analyses have provided a comprehensive understanding of non-genotoxic carcinogenesis, but functional changes at the transcriptional and translational levels have not been addressed. This study tested proposed in vitro biomarkers of non-genotoxic hepatocarcinogenicity using a 3-dimensional model, and found that spheroid cultures of human liver cells may be suitable tools for investigating chemical-induced hepatocarcinogenicity, but the mechanisms and read-outs studied are not eligible biomarkers for detecting non-genotoxic carcinogens.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Rodrigo Ken Kawassaki, Mariana Romano, Mayara Klimuk Uchiyama, Roberta Mansini Cardoso, Mauriicio S. Baptista, Sandra H. P. Farsky, Khallil Taverna Chaim, Robson Raphael Guimaraes, Koiti Araki
Summary: A novel ultrasmall paramagnetic nanoparticle (UPN), decorated with iron oxide on 3 nm titanium dioxide nanoparticles, has been developed as a potential alternative blood-pool contrast agent to gadoteric acid (GA) for MR angiography. It exhibits comparable relaxometric parameters to GA and has strong and prolonged contrast enhancement before renal excretion.
Article
Oncology
Felisbina Queiroga, Bruno Cogliati
Article
Nanoscience & Nanotechnology
Zahid U. Khan, Latif U. Khan, Mayara K. Uchiyama, Fernanda M. Prado, Rodrigo L. Faria, Israel F. Costa, Sayuri Miyamoto, Koiti Araki, Magnus Gidlund, Hermi F. Brito, Paolo Di Mascio
Summary: In biomedical sciences, it is important to utilize multifunctional nanoparticles of similar size that have tunable emission. This study developed a method using interfacial ion exchange to synthesize color-tunable CdSe/ZnS quantum dots (QDs). The QDs showed wide-range color-tunability without a significant change in size. The study also evaluated the biocompatibility, bioimaging, and delivery pathways of the QDs for future photodynamic therapy.
ACS APPLIED NANO MATERIALS
(2023)
Article
Physiology
Beatriz Santos Geoffroy Correa, Silvana de Barros, Julia Braga Vaz, Maria Angelica Peres, Mayara Klimuk Uchiyama, Alexandre Alves da Silva, Luzia Naoko Shinohara Furukawa
Summary: According to a study, hypertensive individuals taking anti-hypertensive drugs from renin-angiotensin system inhibitors may experience a more severe progression of the COVID-19 disease due to potential increases in ACE2 expression. The study investigated the ACE1 and ACE2 axes and hydroxychloroquine in the lungs and adipose tissue of male and female rats. The results showed that losartan and captopril reduced blood pressure and ACE2 expression in certain tissues, while hydroxychloroquine had different effects on blood pressure and ACE expression depending on the rat strain and sex.
PHYSIOLOGICAL REPORTS
(2023)
Article
Medicine, Research & Experimental
Matheus de Castro Leao, Isabella di Piazza, Sarah Jorge Caria, Milena Fronza Broering, Sandra Helena Poliselli Farsky, Mayara Klimuk Uchiyama, Koiti Araki, Kennedy Bonjour, Bruno Cogliati, Adriana Raffin Pohlmann, Silvia Staniscuaski Guterres, Inar Alves Castro
Summary: MLNC-DHA-a1 nanocapsules have the potential to promote macrophage polarization in vitro and are well-tolerated in vivo. However, they also increase the levels of pro-inflammatory cytokines, indicating the need for further research to identify the specific compound triggering the immune response.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Gastroenterology & Hepatology
Bruno Cogliati, Chittampalli N. Yashaswini, Shuang Wang, Daniela Sia, Scott L. Friedman
Summary: Liver fibrosis is a significant risk factor for liver cancer development and progression. Recent studies have identified specific subpopulations of hepatic stellate cells (HSCs) and cancer-associated fibroblasts (CAFs) that play dual roles in promoting or preventing fibrosis and cancer. Integrative analysis of single-cell transcriptomics and spatial RNA sequencing data has revealed the heterogeneity among these subpopulations and their distinct gene expression signatures and functions. Understanding these roles and pathways will contribute to the development of biomarkers, prognosis assessment, and new therapies for liver cancer prevention and treatment.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Veterinary Sciences
Renata D. Mazaro, Douglas M. Lorenzetti, Suzana M. G. Leite, Eduardo K. Masuda, Leonardo D. Da Costa, Rosemeri O. Vasconcelos, Antonio Flavio M. Dantas, Luciana C. Lacerda, Tereza Cristina Da Silva, Marco Aurelio A. Motta, Bruno Cogliati, Rafael A. Fighera
Summary: This study aimed to investigate the correlation between the macroscopic presentation and histological subtypes of cutaneous non-epitheliotropic lymphoma in dogs. The results showed that multiple, nodular or placoid skin lesions predominantly on the trunk and limbs were consistent with ALTCL, while solitary skin nodules or plaques were more likely to be PTCL-NOS. Subcutaneous tissue involvement suggested SPTCL or rarely DLBCL. Mycosis fungoides was the most commonly observed epitheliotropic cutaneous lymphoma in dogs.
PESQUISA VETERINARIA BRASILEIRA
(2023)
Article
Chemistry, Physical
Leandro Rezende Franco, Kalil Cristhian Figueiredo Toledo, Tiago Araujo Matias, C. Moyses Araujo, Koiti Araki, Kaline Coutinho
Summary: This study investigates the structural and electronic properties of mononuclear polypyridine ruthenium complexes in aqueous solution. The research highlights the significance of accurately modeling solvent effects and provides insights into the electronic structure of these complexes.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
