Article
Nanoscience & Nanotechnology
Jianmeng Zhu, Yimin Yang, Jian Wang, Wenzhong Hong, Yiping Li, Zhen Wang, Kaiqiang Li, Zhen Wang
Summary: This study synthesized folate-modified nanomicelles that can release drugs in response to tumor tissue acidity and magnetic field stimulation, achieving targeted delivery to cancer cells. Experimental results demonstrated that these dual-responsive nanomicelles can enhance drug uptake and anticancer efficacy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Manuela Curcio, Alessandro Paoli, Giuseppe Cirillo, Sebastiano Di Pietro, Martina Forestiero, Francesca Giordano, Loredana Mauro, Diana Amantea, Valeria Di Bussolo, Fiore Pasquale Nicoletta, Francesca Iemma
Summary: This study successfully prepared new dual pH/redox-responsive nanoparticles with affinity for folate receptors, demonstrating potential applicability as a new drug vector in cancer therapy.
Article
Engineering, Biomedical
Xianqi Zhu, Lin Li, Jin Tang, Chunyu Yang, Hao Yu, Kunpeng Liu, Ziyan Zheng, Xinggui Gu, Qingsong Yu, Fu-Jian Xu, Zhihua Gan
Summary: In this study, a smart photothermal-chemo therapeutic nano-assembly system was developed to target cancer stem cells (CSCs). By modifying the surface of the nano-assembly, the physiological barriers for CSC targeting were overcome. The nano-assembly effectively eliminated both CSCs and non-CSCs, inhibiting tumor growth and metastasis.
Article
Pharmacology & Pharmacy
Fang Luo, Ting Zhong, Ying Chen, Qianqian Guo, Ling Tao, Xiangchun Shen, Yanhua Fan, Xingjie Wu
Summary: Dual-ligand targeting nanoplatforms have shown promise for improving chemotherapy specificity, but off-target delivery persists as a problem. To address this, a dual-ligand synergistic targeting (DLST) nanoplatform was developed, which guides chemotherapy specifically to cancer cells overexpressing two receptors. This nanoplatform consists of two different nanocarriers decorated with complementary DNA sequences and loaded with singlet oxygen (O-1(2)) photosensitizer and drug, respectively. In vitro evaluation demonstrated its highly specific tumor treatment with minimized long-term toxicity, making it a highly efficient drug delivery system for DLST chemotherapy with great clinical potential.
Article
Engineering, Biomedical
Yuan Gao, Wei Qiu, Mengyun Liang, Xianbin Ma, Mengjie Ye, Peng Xue, Yuejun Kang, Jun Deng, Zhigang Xu
Summary: In this study, active targeting redox-responsive mannosylated prodrug nanocolloids (HM NCs) were constructed for enhanced chemotherapy of colon cancer. HM NCs exhibited superior antitumor activity both in vitro and in vivo and appreciably extended mouse survival rate with good biocompatibility, providing more choices for future clinical translation.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Jianxiong Li, Song Liao, Yanan Wu, Jingyou Bi, Yuchen Han, Yinglong Zhang, Meng Xu, Wenzhi Bi
Summary: Dual-responsive nanoparticles (NP2) that can respond to pH and glutathione [GSH] enhance the delivery efficiency of chemotherapy drugs, stimulate the immune response, and remodel the tumor micro-environment, thereby improving the prognosis of osteosarcoma (OS) patients.
Article
Materials Science, Biomaterials
Shuangling Wang, Jie Lv, Yu Pang, Shuyang Hu, Yulong Lin, Meng Li
Summary: A multifunctional nanoplatform integrating chemotherapy, chemodynamic therapy (CDT), and photoactivation of TRPV1 channels has been established for specific cancer therapy. The nanoplatform displays an enhanced anticancer effect both in vitro and in vivo.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Dongbing Ding, Huihai Zhong, Rongpu Liang, Tianyun Lan, Xudong Zhu, Shengxin Huang, Yong Wang, Jun Shao, Xintao Shuai, Bo Wei
Summary: By combining immunogenic photodynamic therapy with MDSC-targeting immunotherapy, the synergistic treatment effectively inhibits tumor growth while promoting immune responses to prevent tumor recurrence and metastasis.
Article
Nanoscience & Nanotechnology
Liuwei Zhang, Haonan Zheng, Hongyan Cui, Xiaolan Yin, Cheng Zhang, Yue Wang, Yan Zhao, Jiaqi Lin, Zheng Wang, Jingyun Wang, Qixian Chen
Summary: One challenge in antitumor therapy is delivering the therapeutic agent precisely to cancerous cells. This study developed a redox-responsive polymeric dual-prodrug nanocarrier that could activate and release cytotoxic chemotherapy drugs and an immune checkpoint inhibitor simultaneously within tumor cells, resulting in significant cytotoxicity. This dual-prodrug delivery system shows great potential in chemotherapy and immunotherapy.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Mao Li, Chen Liu, Jieli Yin, Guoyan Liu, Dengyue Chen
Summary: Nanotechnology has advanced the development of multifunctional nanoparticles, but their complicated preparation methods hinder their optimization for tumor therapy. The emerging microfluidic technology allows for the one-step preparation of multifunctional nanoliposomes with controllable properties, enabling targeted tumor treatment.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Mao Li, Chen Liu, Jieli Yin, Guoyan Liu, Dengyue Chen
Summary: Cancer is a major disease that remains unconquered by humans. Nanotechnology has advanced the development of multifunctional nanoparticles for tumor imaging and therapy. However, the complicated preparation methods of these nanoparticles result in poor reproducibility and high production costs. Microfluidic technology provides a promising approach for the one-step preparation of multifunctional nanoliposomes with controllable properties. The prepared nanoliposomes exhibit synergistic photodynamic and chemodynamic effects for targeted tumor therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Xuan Meng, Lin Wang, Ning Zhao, Delong Zhao, Yongli Shen, Yuan Yao, Wenjie Jing, Shuli Man, Yujie Dai, Yanjun Zhao
Summary: This study reports a hybrid nanocarrier that targets glycolysis and redox balance simultaneously for cancer therapy. The nanocarrier, composed of pH-and ATP-responsive ZIF-8 core and poloxamer 407 coating, delivers glucose oxidase and 3-bromopyruvate to liver hepatocellular carcinoma cells, effectively inhibiting cellular energy metabolism and reducing cell viability. This approach enriches the available strategies for anti-tumor treatment.
ACTA BIOMATERIALIA
(2023)
Article
Polymer Science
Yuxin Feng, Yan Long, Jiahe Guo, Xiaofan Yang, Heng Song
Summary: In this study, a low cytotoxic water-soluble flexible organic framework was synthesized and a facile strategy was developed for efficient photo-chemotherapy under fluorescence imaging, thereby improving tumor treatment efficacy.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Jingjun Sun, Shuangjiu Zhu, Weixuan Xu, Guoqin Jiang
Summary: In this study, a complex nanoparticle was developed for synergistic chemo-photothermal therapy of breast cancer. The nanoparticles exhibited good photothermal effects and triggered drug release through temperature and redox responsiveness. In vitro studies showed effective induction of apoptosis in breast cancer cells through inhibition of heat shock proteins and the JAK-STAT signaling pathway. In a breast tumor-bearing mice model, the nanoparticles demonstrated significant inhibitory effects on cancer growth.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Fan Li, Yan Liang, Miaochen Wang, Xing Xu, Fen Zhao, Xu Wang, Yong Sun, Wantao Chen
Summary: The pH cascade-responsive micellar nanoplatform with nucleus-targeted ability effectively combines synergistic chemo-photodynamic therapy for cancer treatment. The novel multifunctional nanoplatform demonstrates high anticancer efficacy both in vitro and in vivo, making it a promising candidate for synergistic anticancer therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)