Article
Engineering, Biomedical
Chenyuan Wang, Yongnian Zeng, Kai-Feng Chen, Jiawei Lin, Qianqian Yuan, Xue Jiang, Gaosong Wu, Fubing Wang, Yong-Guang Jia, Wei Li
Summary: Melanoma, the most aggressive form of skin cancer, is difficult to treat due to frequent drug administration and lack of direct monitoring of drug release. In this study, a self-monitoring microneedle-based drug delivery system was developed for light-controlled chemo-photothermal therapy of melanoma. The system utilized PATC microparticles that encapsulate both a chemotherapeutic drug and a photothermal agent, allowing for direct observation and verification of drug release under light stimuli.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Hai Ma, Guanghao Yu, Jinlai Cheng, Ziyu Zhou, Yu Zhao, Qinghe Zhao, Li Liu, Xiaolu Wei, Miyi Yang
Summary: Conventional tumor chemotherapy is limited by low efficacy and side effects. Nanomaterial-based drug delivery systems have gained interest for cancer treatment, especially for efficient synergistic therapies. In this study, a smart hydrogel drug delivery system was designed with multiple responses to enhance tumor treatment. The system showed excellent rheological properties, accurate stable drug release at tumor sites, and synergistic effects of multiple therapies. In vitro and in vivo experiments demonstrated efficient tumor elimination and good biocompatibility. This study clarifies the antitumor mechanism and provides a new strategy for synergistic photothermal- chemo-chemodynamic therapy.
Article
Chemistry, Multidisciplinary
Shaohui Deng, Shiyin Wang, Zecong Xiao, Du Cheng
Summary: A spatially controlled siRNA activation strategy and co-delivery of Ce6 can achieve tumor-specific siRNA therapy with synergistic drug effects.
Article
Biochemistry & Molecular Biology
Xiuying Liu, Yu Zhang, Hang Wu, Jingwen Tang, Jiao Zhou, Jiulong Zhao, Shige Wang
Summary: A methacrylic gelatin/oxidized dextran/montmorillonite-strontium/polypyrrole (GOMP) hydrogel with a dual network structure was synthesized. The hydrogel demonstrated sustained release of doxorubicin (DOX) due to the network structure. The inclusion of polypyrrole provided conductivity and photo-thermal conversion capacity to the hydrogel, resulting in a high photothermal conversion efficiency of 31.61% under 808 nm laser radiation. The GOMP hydrogel exhibited good swelling properties in solvents and showed excellent biocompatibility and biodegradability in vitro and in vivo. Furthermore, the in vitro and in vivo experiments demonstrated synergistic effects of DOX-loaded GOMP hydrogel on tumor cell apoptosis through chemotherapy and photothermal therapy, while the inclusion of montmorillonite-strontium (MMT-Sr) improved the mechanical properties and promoted bone regeneration. The multifunctional GOMP hydrogel shows great potential for osteosarcoma treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Yu Lu, Peng Zhang, Yifei Zhou, Ruohao Zhang, Xinyu Fu, Jing Feng, Hongjie Zhang
Summary: In this study, a nanocarrier BGT was developed by co-loading glucose oxidase (GOD) and transferrin (TRF) on the porous Bi nanoparticles (NPs) for improving tumor synergistic therapy. The combination of GOD-induced glucose depletion, chemodynamic therapy (CDT), and mild photothermal therapy (PTT) provides an efficient approach for collaborative treatment of tumors. The targeting ability of TRF further enhances the efficacy of the therapy.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Engineering, Biomedical
Feifan Zhou, Meng Wang, Teng Luo, Junle Qu, Wei R. Chen
Summary: By combining photothermal therapy, chemotherapy, and immunotherapy through a nanosystem, researchers developed a treatment strategy that not only destroyed local tumors and inhibited distant metastases in mouse models but also induced long-term survivors with tumor type-specific immunity. This synergistic approach showed potential for treating metastatic cancers by inducing a systemic antitumor response through a local intervention.
Article
Nanoscience & Nanotechnology
Wentao Dang, Ke Yi, Enguo Ju, Yuanyuan Jin, Yanteng Xu, Haixia Wang, Wei-Chih Chen, Kun Wang, Yu Wang, Yu Tao, Mingqiang Li
Summary: A multifunctional local implantation platform was developed for synergistic photothermal therapy and chemotherapy treatment of osteosarcoma. The content of TiN and DOX in the scaffolds can be flexibly adjusted, providing both therapeutic effects and mechanical support for bone tissue. The scaffolds have the potential to be a universal platform for loading different therapeutic agents.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Ruihong Lv, Haohao Wang, Yongsheng Ji, Shanshan Gao, Ning Hao, Shanshan Zhang, Yanna Lv, Qilin Zhang, Xiyu Han, Yanting Liu, Zhigang Xu
Summary: This study developed pH and photothermal responsive doxorubicin/curcumin-loaded degradable dendritic mesoporous silica nanoparticles (DNCPDH), in which curcumin acted as an antitumor sensitizer by increasing intracellular ROS level. The DNCPDH nanocarriers exhibited enhanced chemo-photothermal synergistic tumor treatment, efficient intracellular uptake, and high cellular accumulation.
Article
Chemistry, Multidisciplinary
Xiang Sun, Yanmin Wang, Tao Du, Qiang Zhang, Shuo Li, Qinda Chen, Miao Wang, Xiumin Wang, Lei Ren, Xueqin Zhao
Summary: A cascade synergistic nanosystem, R837/ICG@Lip, was developed to overcome the obstacles of low immunogenicity, immunosuppressive tumor microenvironment, and poor drug permeability in colorectal cancer (CRC). The nanosystem demonstrated NIR-triggered drug release, photothermal conversion efficiency, and phototoxicity against CT26 colorectal cancer cells. In vivo results showed effective accumulation of the nanosystem in tumors and lymph nodes, triggering immunogenic cell death and promoting adaptive antitumor T-cell responses. Combining with an IDO inhibitor further enhanced the antitumor immune response.
CHINESE CHEMICAL LETTERS
(2023)
Article
Engineering, Biomedical
Lin Huang, Mengyang Zhou, Ghulam Abbas, Chao Li, Mengmeng Cui, Xian-En Zhang, Dian-Bing Wang
Summary: A cancer cell membrane-derived nanocarrier was developed for synergistic photothermal/gene therapy. This nanotherapeutic platform showed high biocompatibility, homologous targeting capacity, and efficient payload delivery, leading to enhanced therapeutic efficacy.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Ziming Zhao, Zhaorong Liu, Yabing Hua, Yuanjie Pan, Ge Yi, Shengyue Wu, Cong He, Yanzhuo Zhang, Yihua Yang
Summary: The tumor hypoxic microenvironment can affect the efficacy of various treatments and is associated with tumor recurrence and metastasis. Researchers have developed a biomimetic nanosystem based on ZIF8 that can alleviate hypoxia, provide chemotherapy, and perform photothermal therapy. This nanosystem showed great potential in improving the hypoxic microenvironment and overcoming therapeutic resistance. In addition, the inclusion of catalase in the nanosystem enhanced the chemo-photothermal combined therapy, leading to excellent antitumor effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Yiting Shen, Mingyu Wang, Hong Wang, Juan Zhou, Jinghua Chen
Summary: This study developed a recombinant protein integrating His, HSA, enzyme responsive site, and RGD to co-load DTX and Au NPs for cancer therapy. The RHMH18@AuD NPs exhibited favorable biocompatibility and positive chemo-photothermal synergetic therapy efficiency in in vitro and in vivo experiments.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biophysics
Hong-Ying Xia, Bo-Yi Li, Ranjith Kumar Kankala, Ai-Zheng Chen, Shi-Bin Wang
Summary: Cancer is a severe disease with uncontrolled cell proliferation, causing millions of deaths annually. Despite the availability of various treatments, recent research has shown the potential of nanotherapeutics in providing synergistic therapy. This study demonstrates the assembly of a versatile nanoplatform based on HA-coated MoO2 assemblies for breast carcinoma treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biotechnology & Applied Microbiology
Guoxin Liu, Zhenfu Wen, Fengyu Liu, Yongqian Xu, Hongjuan Li, Shiguo Sun
Summary: A versatile nanoparticle was designed and constructed, which can target multisubcellular organelles, respond to tumor microenvironments, facilitate fluorescence imaging, and provide synergistic chemotherapy and photodynamic/photothermal therapy for the treatment of tumors.
Article
Engineering, Biomedical
Lu Lu, Kui Wang, Chuanchuan Lin, Weihu Yang, Qiaojian Duan, Ke Li, Kaiyong Cai
Summary: A highly drug-loaded nanocomplex was developed for synergistic chemo-photothermal therapy of orthotopic glioblastoma, showing efficient crossing of the blood-brain barrier and targeting of glioma cells in vitro and in vivo. The results suggest the potential of self-assembled nanodrugs as a novel platform for effective glioblastoma therapy.