Article
Neurosciences
Karli Mockenhaupt, Katarzyna M. Tyc, Adam McQuiston, Alexandra K. Gonsiewski, Masoumeh Zarei-Kheirabadi, Avani Hariprashad, Debolina D. Biswas, Angela S. Gupta, Amy L. Olex, Sandeep K. Singh, Michael R. Waters, Jeff L. Dupree, Mikhail G. Dozmorov, Tomasz Kordula
Summary: The transcription factor YY1 is expressed in astrocytes and plays a critical role in regulating gene expression and maturation of cerebellar astrocytes. It is also necessary for maintaining the mature phenotype of astrocytes in the adult cerebellum.
Article
Multidisciplinary Sciences
Dan Song, Lisha Kuang, Lin Yang, Lei Wang, Hao Li, Xiu Li, Zhimin Zhu, Chaowei Shi, Haining Zhu, Weimin Gong
Summary: The study reveals the mechanism of stress granule (SGs) formation, demonstrating the interaction of G3BP1 protein with Caprin-1 and USP10 to facilitate or suppress SG formation. The N- and C-terminal domains of Caprin-1 play opposing roles in regulating SG formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cardiac & Cardiovascular Systems
Alexander Akhmedov, Tatsuya Sawamura, Chu-Huang Chen, Simon Kraler, Daria Vdovenko, Thomas F. Luscher
Summary: LOX-1, as a scavenger receptor, plays a crucial role in the development of atherosclerosis, with implications in various cell types, making it a promising diagnostic and therapeutic target for certain cardiovascular diseases.
EUROPEAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Alexander Akhmedov, Tatsuya Sawamura, Chu-Huang Chen, Simon Kraler, Daria Vdovenko, Thomas F. Luescher
Summary: LOX-1, a scavenger receptor that promotes atherosclerotic plaque formation, plays a critical role in the development of cardiovascular diseases. Its expression in various cell types underscores its significance in disease progression, highlighting the potential for LOX-1 as a novel therapeutic target in CVDs prevention and treatment.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Shu-Yi Wei, Yu-Tsung Shih, Hsin-Yi Wu, Wei-Li Wang, Pei Ling Lee, Chih- Lee, Chia-Yu Lin, Yu-Ju Chen, Shu Chien, Jeng-Jiann Chiu
Summary: This study reveals that disturbed flow induces increased expression of phosphorylated YY1 (S118) in endothelial cells, promoting atherosclerosis. This phenomenon is mediated by the direct interaction of CK2 alpha with YY1, and the direct binding of phosphorylated YY1 (S118) with ZKSCAN4.
CIRCULATION RESEARCH
(2021)
Review
Oncology
Zhiying Shao, Wendong Yang, Xiannan Meng, Minle Li, Pingfu Hou, Zhongwei Li, Sufang Chu, Junnian Zheng, Jin Bai
Summary: YY1 is highly expressed in colorectal cancer and is widely recognized as an oncogenic factor throughout the course of the disease. Future studies should take the influence of therapeutic regimens into consideration.
Review
Immunology
Ece Canan Sayitoglu, Robert Arthur Freeborn, Maria Grazia Roncarolo
Summary: Tr1 cells, induced in the periphery under tolerogenic conditions, promote peripheral tolerance through secretion of IL-10 and TGF-beta as well as exerting cytotoxicity. Clinical trials have shown promising results for Tr1 cell therapy in terms of efficacy and safety.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Young-Sun Im, Min-Hee Gwon, Jung-Mi Yun
Summary: PEITC, a naturally occurring isothiocyanate in cruciferous vegetables, has the potential to inhibit foam cell formation and may be a candidate for the treatment and prevention of vascular inflammation and atherosclerosis. It downregulates the expression of key genes related to lipid accumulation and inflammation, while upregulating genes associated with cholesterol efflux.
FOOD SCIENCE & NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Xue Yang, Manling Zhang, Bingxian Xie, Zishan Peng, Janet R. Manning, Raymond Zimmerman, Qin Wang, An-chi Wei, Moustafa Khalifa, Michael Reynolds, Jenny Jin, Matthew Om, Guangshuo Zhu, Djahida Bedja, Hong Jiang, Michael Jurczak, Sruti Shiva, Iain Scott, Brian O'Rourke, David A. Kass, Nazareno Paolocci, Ning Feng
Summary: BDNF expression is decreased in heart failure patients and increased with exercise. Cardiac-specific knockout of TrkB leads to attenuated cardiac response to exercise and worsened heart failure progression under pathological stress. BDNF induces upregulation of PGC-1 alpha through the Yin Yang 1 signaling pathway, regulating cardiac cellular energetics.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ligen Chen, Lingyun Qiao, Yan Guo, Ying Huang, Wei Luo, Yanping Feng
Summary: The study on the location and function of YY1 in chicken testis suggests that it may regulate the development and function of the gonads by controlling the expression of genes in Sertoli cells, affecting the secretion of hormones like androgen and inhibin, thereby modulating the production and differentiation of spermatogonia.
MOLECULAR GENETICS AND GENOMICS
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Antonio-Andres, Gustavo U. Martinez-Ruiz, Mario Morales-Martinez, Elva Jimenez-Hernandez, Estefany Martinez-Torres, Tania V. Lopez-Perez, Laura A. Estrada-Abreo, Genaro Patino-Lopez, Sergio Juarez-Mendez, Victor M. Davila-Borja, Sara Huerta-Yepez
Summary: This study reveals that HIF-1 alpha can transcriptionally regulate YY1, and the expression of HIF-1 alpha positively correlates with YY1 in leukemia patients, suggesting that they may serve as therapeutic targets or biomarkers for ALL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Nami Sato, Nozomu Sakai, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Gaku Ohira, Hisahiro Matsubara, Masayuki Ohtsuka
Summary: YY1 is a transcription factor that plays an important role in CRC progression. Low expression of YY1 was found to be significantly associated with aggressive clinicopathological features, liver metastasis, recurrence, and poor patient survival. Knockdown of YY1 promoted migration and invasion of CRC cells. YY1 was found to suppress the expression of ITGAV and ITGB1, which may lead to the inhibition of CRC cell migration and invasion.
Article
Cardiac & Cardiovascular Systems
Yu Huang, Liangpeng Li, Hongmei Chen, Qiao Liao, Xiaoli Yang, Dezhong Yang, Xuewei Xia, Hongyong Wang, Wei Eric Wang, Lianglong Chen, Chunyu Zeng
Summary: YY1 expression in the heart was significantly stimulated following myocardial infarction. Overexpression of YY1 improved survival rate, cardiac function, scar size, and left ventricular volume in mice, while silencing YY1 had the opposite effects. YY1 alleviated cardiac apoptosis and fibrosis, promoted angiogenesis, T helper 2 cytokine production, M2 macrophage polarization, and enhanced endothelial cell tube formation and migration ability. Enhanced Akt phosphorylation and vascular endothelial growth factor production were observed in the presence of YY1 overexpression. These effects suggest YY1 as a potential therapeutic target for myocardial infarction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Toxicology
Asha Rizor, Edward Pajarillo, Deok-Soo Son, Michael Aschner, Eunsook Lee
Summary: This study reveals the importance of phosphorylation of YY1 via AurkB and CK2 in the repression of EAAT2 under manganese toxicity. These findings provide insights into the role of YY1 phosphorylation in neurodegenerative disorders.
TOXICOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Pan Song, Jian Hong, Yuan Wang, Xuelian Yao, Yiqun Zhan, Ronghua Yin, Miao Yu, Changyan Li, Xiaoming Yang, Changhui Ge
Summary: This study identified and characterized the core regulatory elements of the human ABRO1 gene, mapping them to the ABRO1 promoter region. It was found that YY1 positively regulated human ABRO1 expression by binding to cis-acting elements located at the ABRO1 TSS.
BIOCHEMISTRY AND CELL BIOLOGY
(2021)