Article
Biochemistry & Molecular Biology
Ingrid Vargova, Lucia Machova Urdzikova, Kristyna Karova, Barbora Smejkalova, Tolga Sursal, Veronika Cimermanova, Karolina Turnovcova, Chirag D. Gandhi, Meena Jhanwar-Uniyal, Pavla Jendelova
Summary: The study found that partial neuroprotection and recovery after traumatic spinal cord injury can be achieved by inhibiting the mTOR pathway, with the second-generation inhibitor pp242 showing different effects compared to rapamycin (RAPA) in terms of inflammatory responses and autophagy.
Article
Neurosciences
Junhao Liu, Ruoyao Li, Zucheng Huang, Junyu Lin, Wei Ji, Zhiping Huang, Qi Liu, Xiaoliang Wu, Xiuhua Wu, Hui Jiang, Yongnong Ye, Qingan Zhu
Summary: The study demonstrates that rapamycin can enhance autophagy, promote Schwann cell-mediated remyelination and motor function recovery, resulting in reduced white matter loss and neural tissue damage after cervical spinal cord injury.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Neurosciences
Henry Querfurth, Han-Kyu Lee
Summary: mTOR is involved in regulating energy metabolism, neuronal growth, insulin signaling, and autophagy, playing both beneficial and pathogenic roles in neurodegenerative diseases. Balanced actions of mTOR complexes may have implications for Alzheimer's disease, Parkinson's disease, Huntington's disease, Frontotemporal dementia, and Amyotrophic Lateral Sclerosis. Beyond rapamycin, rapalogs with improved tolerability and delivery modes hold promise in treating age-related conditions.
MOLECULAR NEURODEGENERATION
(2021)
Article
Pharmacology & Pharmacy
Xiangdang Shi, Eva von Weltin, Emma Fitzsimmons, Chau Do, Carolina Caban Rivera, Chongguang Chen, Lee-Yuan Liu-Chen, Ellen M. Unterwald
Summary: The study demonstrates that mTORC1 and p70S6K are required for reconsolidation of cocaine contextual memory, showing their essential roles in the process through mechanisms such as protein phosphorylation and changes in transcriptional levels.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Bo Xu, Jiaqi Fang, Jianguang Wang, Xuehan Jin, Shengfu Liu, Kaihang Song, Ping Wang, Junjian Liu, Shuhao Liu
Summary: This study investigated the protective effect of edaravone on blood spinal cord barrier (BSCB) disruption after spinal cord injury (SCI). The results showed that edaravone treatment promoted functional recovery, improved vascular damage, and up-regulated BSCB-associated proteins in rats with SCI. In vitro experiments also demonstrated that edaravone improved cell viability, restored intercellular junctions, and promoted angiogenic activities. The underlying mechanism may involve the improvement of autophagy and the phosphorylation of RIP1/RIP3/MLKL. Overall, edaravone can be a potential treatment option for SCI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Hai-Yang Liao, Zhi-Qiang Wang, Rui Ran, Kai-Sheng Zhou, Chun-Wei Ma, Hai-Hong Zhang
Summary: Autophagy is crucial in spinal cord injury, with activation having neuroprotective effects but also potentially leading to neuronal death and impaired functional recovery.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Guo Yan Wang, Sen Lin Qin, Yi Ning Zheng, Hui Jun Geng, Lei Chen, Jun Hu Yao, Lu Deng
Summary: This study found that propionate enhances the gluconeogenic capacity of calf hepatocytes by regulating the activity of the mTOR pathway, and it counteracts the inhibitory effect of palmitic acid on gluconeogenesis.
Review
Cell Biology
Xiaojuan Chao, Sha Neisha Williams, Wen-Xing Ding
Summary: This review summarizes the role and potential mechanisms of mTOR in alcohol-associated liver disease (ALD), as well as the feasibility and limitations of targeting mTOR for therapy in this disease.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Cell Biology
Rui-Yu Li, Qi Hu, Xu Shi, Zhen-Yu Luo, Dong-Hua Shao
Summary: Exosomes and autophagy play critical roles in cellular homeostasis following spinal cord injury. Studying their interaction can provide new insights for early therapeutic application of spinal cord injury.
CELL AND TISSUE RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Qiong Zhang, Mingfu Liu, Haibin Nong, Yanan Zhang, Yiguang Bai, Pan Liu, Shaohui Zong, Gaofeng Zeng
Summary: TFHL has shown to improve motor function recovery and promote spinal cord tissue repair in rats with spinal cord injury (SCI). It reduces apoptosis and improves the functional status of neurons. TFHL also improves cell morphology, microstructure, and axonal regeneration of damaged spinal motor neurons, and promotes the secretion of neurotrophic factors. Furthermore, TFHL promotes autophagy and related protein expression both in vivo and in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Yuanzhe Ding, Di Zhang, Sheng Wang, Xiaolei Zhang, Jingquan Yang
Summary: Spinal cord injury is a devastating disease causing loss of sensory and motor functions, with a pathological process involving mechanical primary injury and secondary injury. Macrophages play a crucial role in the pathology of SCI, and can be divided into different types. Hematogenous macrophages may have various roles in SCI but their specific function remains controversial.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yun Li, Zhuofan Lei, Rodney M. Ritzel, Junyun He, Hui Li, Harry M. C. Choi, Marta M. Lipinski, Junfang Wu
Summary: Autophagy plays a crucial role in post-spinal cord injury, as inhibiting autophagy can lead to pro-inflammatory activation in microglia and worse functional outcomes, while increasing autophagy can reduce inflammation and improve outcomes.
Article
Neurosciences
Menghon Cheah, Yuyan Cheng, Veselina Petrova, Anda Cimpean, Pavla Jendelova, Vivek Swarup, Clifford J. Woolf, Daniel H. Geschwind, James W. Fawcett
Summary: Sensory dorsal root ganglion (DRG) neurons in the peripheral branch regenerate readily after injury, but not in the central branch. However, expression of a9 integrin and its activator kindlin-1 (a9k1) enables axons to interact with tenascin-C, promoting extensive regeneration and reconnection of sensory axons in the spinal cord. Transcriptomic analyses of adult male rat DRG neurons revealed that a9k1 expression upregulates a known peripheral nerve regeneration program. Coupling a9k1 treatment with dorsal root axotomy leads to extensive central axonal regeneration, accompanied by the expression of a distinctive CNS regeneration program involving genes associated with ubiquitination, autophagy, ER, trafficking, and signaling. Pharmacological inhibition of these processes blocks axon regeneration, validating their causal contributions to sensory regeneration.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Zhiyuan Fang, Xinwei Li, Shu Wang, Qianming Jiang, Juan J. Loor, Xiuhuan Jiang, Lingxue Ju, Hao Yu, Taiyu Shen, Men Chen, Yuxiang Song, Zhe Wang, Xiliang Du, Guowen Liu
Summary: Ketosis can cause liver injury and steatosis, with lysosomes playing a crucial role in liver homeostasis. This study investigates the status of lysosomal function and TFEB transcriptional activity in ketotic cows, finding that the impairment of lysosomal function and TFEB activity may be induced by factors such as growth hormone, TNF-alpha, and free fatty acids. These findings contribute to better understanding the mechanisms of liver injury and steatosis in ketosis.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Medicine, Research & Experimental
Zili He, Jiqing Du, Yu Zhang, Yitie Xu, Qian Huang, Qingwei Zhou, Min Wu, Yao Li, Xie Zhang, Hongyu Zhang, Yuepiao Cai, Keyong Ye, Xiangyang Wang, Yingze Zhang, Qi Han, Jian Xiao
Summary: Increasing evidence suggests that defects in autophagy and autophagy-lysosomal pathway (ALP) may contribute to endothelial barrier disruption following acute traumatic spinal cord injury (SCI). This study investigates whether Kruppel-like factor 2 (KLF2) coordinates ALP in endothelial cells in SCI. The results demonstrate that KLF2 is a key contributor to SCI-mediated ALP dysfunction and blood-spinal cord barrier (BSCB) disruption, and could be a promising pharmacological target for SCI management and treatment.
Article
Neurosciences
Wei Li, Ying Zhang, Jianrui Lv, Yong Zhang, Jie Bai, Luming Zhen, Xijing He
Summary: This study explores the role and mechanism of histone lysine demethylase 4A (KDM4A) in spinal cord injury (SCI). The findings demonstrate that miR-137 targets KDM4A, which then downregulates SFRP4 to ameliorate SCI in a Wnt/β-Catenin-dependent manner.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Computer Science, Interdisciplinary Applications
Teng Lu, Jiakun Ren, Zhongwei Sun, Jing Zhang, Kai Xu, Lu Sun, Pinglin Yang, Dong Wang, Yueyun Lian, Jingjing Zhai, Yali Gou, Yanbing Ma, Shengfeng Ji, Xijing He, Baohui Yang
Summary: This study proposes a convenient method to predict the biomechanical effects of a targeted cage elastic modulus (cage-E) on transforaminal lumbar interbody fusion (TLIF) using parametric finite element analysis. The logarithmic regression models and functional equations successfully establish the relationship between cage-E and the biomechanical properties of TLIF. The decrease in cage-E reduces the risks of cage subsidence, breakage, and pseudarthrosis, while increasing the risk of instrumentation failure.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Cell Biology
Yuhuan Li, Sangjo Kang, Dalia Halawani, Yiqun Wang, Chrystian Junqueira Alves, Aarthi Ramakrishnan, Molly Estill, Li Shen, Fengtao Li, Xijing He, Roland H. Friedel, Hongyan Zou
Summary: This study reveals the crucial role of macrophages in peripheral nerve regeneration and highlights the importance of contact avoidance mediated by Plexin-B2 in the formation of regeneration tracks.
GENES & DEVELOPMENT
(2022)
Article
Cell Biology
Ying-Jie Zhao, Hao Qiao, Dong-Fan Liu, Jie Li, Jia-Xi Li, Su-E Chang, Teng Lu, Feng-Tao Li, Dong Wang, Hao-Peng Li, Xi-Jing He, Fang Wang
Summary: This study found that lithium can protect the spinal cord and promote recovery after injury by inhibiting inflammation, reducing oxidative stress, and blocking pyroptosis. Additionally, lithium exerts neuroprotective effects through the activation of the Nrf2/heme oxygenase-1 pathway.
NEURAL REGENERATION RESEARCH
(2022)
Article
Cell Biology
Fang Wang, Jiaxi Li, Yingjie Zhao, Dong Guo, Dongfan Liu, Su'e Chang, Hao Qiao, Jie Li, Yubing Yang, Chengyi Zhang, Rui Wang, Fengtao Li, Dong Wang, Haopeng Li, Xijing He
Summary: This study explored the mechanisms underlying miRNA-mediated ferroptosis in a spinal cord injury (SCI) rat model. It was found that upregulated miRNA miR-672-3p promoted ferroptosis by downregulating the ferroptosis suppressor protein FSP1. On the other hand, miR-672-3p inhibitor had the opposite effect.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Clinical Neurology
Quanjin Zang, Jiaxi Li, Yanming Liu, Haopeng Li, Kai Cao, Shuai Guo, Ke Li, Lei Sun, Xijing He
Summary: The study designed a self-designed biomimetic artificial atlanto-odontoid joint (BAAOJ) replacement for correcting atlantoaxial disorders. Compared with traditional fusion surgery, this replacement can preserve the normal range of motion and stability of the cervical spine. The results showed that the BAAOJ implantation had good range of motion and stability in all directions.
Article
Orthopedics
Jialiang Li, Pengrong OuYang, Xijing He, Xinyu Wei, Zhongwei Sun, Hui Dong, Zhijing Wen, Yibin Wang, Pengzhen Gu, Teng Lu, Ning Liu, Haopeng Li
Summary: A novel motion-preserving artificial cervical disc and vertebra complex has been designed to reduce adjacent segment disease (ASD) by minimizing the range of motion and stress of adjacent discs. Biomechanical tests showed that the designed complex provided physiological mobility and stability, reduced compensatory motion of adjacent intervertebral discs, and alleviated stress changes of adjacent discs.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Neurosciences
Tao Huang, Zhiqiang Jia, Liping Fang, Zhijian Cheng, Jixian Qian, Fujun Xiong, Feng Tian, Xijing He
Summary: EVs-derived miR-511-3p from hypoxia preconditioned AD-MSCs ameliorates spinal cord injury (SCI) via TRAF6/S1P/NF-κB pathway, suggesting that miR-511-3p may be a potential therapeutic target for SCI.
BRAIN RESEARCH BULLETIN
(2022)
Article
Oncology
Jing Li, Chenguang Zhao, Yuhuan Li, Junxiang Wen, Shuang Wang, Difan Wang, Hui Dong, Dong Wang, Yonglin Zhao, Xiaohui Wang, Xijing He, Jie Qin
Summary: This study found that the co-culture of M1 macrophages with OS cells significantly inhibited the growth of tumor cells by inducing apoptosis. Furthermore, the secretion of HSPA1L by M1 macrophages exerted an anti-tumor effect through the IRAK1 and IRAK4 pathways. In vivo experiments demonstrated that the culture supernatant of OS-stimulated M1 macrophages significantly inhibited the growth of OS, while silencing Lgals3bp promoted the progression of OS. Therefore, modulating TAMs may be a promising and effective therapeutic approach in treating OS.
Article
Medicine, Research & Experimental
Chao Zu, Jingyuan Li, Xijing He, Le Ji, Xia Li
Summary: This study investigated the key immune-related genes (IRGs) and competing endogenous RNA (ceRNA) mechanisms associated with spinal cord injury (SCI). The results revealed that PLXNB2 and hsa_circ_0026646 were upregulated in SCI, while miR-331-3p was downregulated. It was also found that hsa_circ_0026646 correlated with PLXNB2 through targeting miR-331-3p in SCI pathogenesis.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Wenxin Ma, Weidong Jin, Xijing He, Yuhang Sun, Huquan Yin, Zili Wang, Shiyuan Shi
Summary: This study found that patients with spinal tuberculosis have elevated levels of RANKL and decreased levels of OPG, indicating a disturbance in bone homeostasis. Additionally, it was observed that Mtb can enter osteoblast cells and stimulate the secretion of IL-6 while impairing the secretion of OPG. The CD40 molecule is a potential therapeutic target for treating bone destruction in spinal tuberculosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Yuhuai Liu, Qinghua Tan, Jie Qin, Yan Cai, Ning Ning, Rui Zhang, Bo Dong, Xijing He, Dong Wang, Bo Zhao
Summary: Age significantly affects dural tear and fever, while gender, revision surgery, primary diagnosis, and procedure type only affect the rate of dural tear. The prophylactic use of antibiotics has no impact on the incidence of surgical site infection when fever occurs after drainage removal in patients with dural tear.
MEDICAL SCIENCE MONITOR
(2022)
Article
Critical Care Medicine
Ranran Kong, Ayushi S. Patel, Takashi Sato, Feng Jiang, Seungyeul Yoo, Li Bao, Abhilasha Sinha, Yang Tian, Maya Fridrikh, Shuhui Liu, Jie Feng, Xijing He, Jiantao Jiang, Yuefeng Ma, Karina Grullon, Dawei Yang, Charles A. Powell, Mary Beth Beasley, Jun Zhu, Eric L. Snyder, Shaomin Li, Hideo Watanabe
Summary: This study refines the classification of small-cell lung cancer (SCLC) using epigenomic profiles and identifies the core regulatory circuitry of NKX2-1 and SOX1 super-enhancers in defining the SCLC-Aa subtype. The findings highlight the epigenomic heterogeneity of SCLC-A and provide insights into the maintenance of neuronal lineage state.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Clinical Neurology
Baohui Yang, Teng Lu, Xijing He, Haopeng Li
Summary: This study analyzed the reasons for misdiagnosis of spinal dural arteriovenous fistula (SDAVF) by orthopedic surgeons and proposed measures to improve the diagnosis of this disease. The results showed that it is important for orthopedic surgeons to be aware of the specific clinical manifestations and magnetic resonance imaging features of SDAVF, especially in patients with bladder and bowel dysfunction. Timely multidisciplinary teamwork and avoidance of early use of steroids or inappropriate surgery are important measures. This study is of great significance in improving the understanding of SDAVF among orthopedic surgeons.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cell Biology
Guo-Yu Wang, Zhi-Jian Cheng, Pu-Wei Yuan, Hao-Peng Li, Xi-Jing He
Summary: Olfactory ensheathing cell transplantation has positive effects on restoring locomotor function and regulating the expression of chondroitin sulfate proteoglycans in spinal cord injury, inhibiting scar formation, and increasing the number of regenerated nerve fibers.
NEURAL REGENERATION RESEARCH
(2021)
