Journal
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Volume 38, Issue 1, Pages 30-38Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijmm.2016.2601
Keywords
fibroblast growth factor; fibroblast growth factor receptor; fibroblast growth factor receptor-like protein 1; cell proliferation; cell adhesion
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Funding
- Swiss National Science Foundation [31003A-143350]
- Novartis Foundation for Medical-Biological Research [15A006]
- Swiss National Science Foundation (SNF) [31003A_143350] Funding Source: Swiss National Science Foundation (SNF)
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Fibroblast growth factor receptor (FGFR)-like protein 1 (FGFRL1) is the most recently discovered member of the FGFR family. Owing to the fact that it interacts with FGF ligands, but lacks the intracellular tyrosine kinase domain, several researchers have speculated that it may function as a decoy receptor and exert a negative effect on cell proliferation. In this study, we performed overexpression experiments with TetOn-inducible cell clones and downregulation experiments with siRNA oligonucleotides, and found that FGFRL1 had absolutely no effect on cell growth and proliferation. Likewise, we did not observe any influence of FGFRL1 on ERK1/2 activation and on the phosphorylation of 250 other signaling proteins analyzed by the Kinexus antibody microarray. On the other hand, with bacterial petri dishes, we observed a clear effect of FGFRL1 on cell adhesion during the initial hours after cell seeding. Our results suggest that FGFRL1 is a cell adhesion protein similar to the nectins rather than a signaling receptor similar to FGFR1-FGFR4.
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