Article
Dentistry, Oral Surgery & Medicine
Neftaha Tazi, Abdelhabib Semlali, Lionel Loubaki, Abdullah Alamri, Mahmoud Rouabhia
Summary: This study found that cannabis smoke condensate (CSC) has adverse effects on gingival epithelial cells, including affecting cell shape and adhesion, reducing cell viability, and causing apoptosis, autophagy, and oxidative stress. CSC also decreased phosphorylation levels in signaling pathway proteins. These findings suggest that cannabis smoke could impair the immune function of gingival epithelial cells, leading to gingivitis and periodontitis.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Immunology
Yuqiang Pei, Jing Zhang, Jingge Qu, Yafei Rao, Danyang Li, Xiaoyan Gai, Yahong Chen, Ying Liang, Yongchang Sun
Summary: C3 is a pivotal element in the complement system and plays a critical role in the pathogenesis of COPD. CSE induces the expression of C3 in airway epithelial cells and C3 knockdown exacerbates oxidative stress and apoptosis caused by CSE, revealing a potential mechanism of C3 in COPD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jinrui Yu, Zheng Jing, Danfeng Shen, Mingcong Yang, Kehao Liu, Kai Xiang, Chongjing Zhou, Xuerui Gong, Yangjia Deng, Yuzhou Li, Sheng Yang
Summary: Cigarette smoking has been reported to increase the risk of periodontitis, and the underlying mechanism of cigarette smoke-related periodontitis is unclear. This study found that quercetin, a plant-derived polyphenolic flavonoid, can alleviate cigarette smoke-related periodontitis by promoting autophagy and reducing oxidative stress damage.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiao-Qing Li, Yi Wang, Shu-Jie Yang, Yu Liu, Xiang Ma, Lu Liu, Si-Hong Li, Dong Niu, Xing Duan
Summary: Maternal diabetes has negative effects on oocyte quality, but melatonin supplementation can protect oocytes from these damages and improve oocyte quality in assisted reproductive technologies.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Jing Zhao, Haibo Xia, Yan Wu, Lu Lu, Cheng Cheng, Jing Sun, Quanyong Xiang, Tao Bian, Qizhan Liu
Summary: Cigarette smoke is a main risk factor for emphysema, and a recent study found that circular RNA can regulate cigarette smoke-induced autophagy and apoptosis in alveolar epithelial cells by inhibiting miRNA. This discovery provides new insights and information for the diagnosis and treatment of emphysema.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Plant Sciences
Xiangming Liu, Yiming Ma, Lijuan Luo, Dandan Zong, Herui Li, Zihang Zeng, Yanan Cui, Weiwei Meng, Yan Chen
Summary: DHQ significantly reverses cigarette smoke-induced ferroptosis via a Nrf2-dependent signaling pathway, exerting protective effects in both in vivo mouse models and in vitro cell cultures.
Article
Biochemistry & Molecular Biology
Natalia Pereira da Silva Araujo, Natalia Alves de Matos, Michel Oliveira, Ana Beatriz Farias de Souza, Thalles de Freitas Castro, Pedro Alves Machado-Junior, Debora Maria Soares de Souza, Andre Talvani, Silvia Dantas Cangussu, Rodrigo Cunha Alvim de Menezes, Frank Silva Bezerra
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of disability and mortality worldwide, with cigarette smoke playing a key role in its development. Quercetin may have potential as a preventive agent for smoke-induced pulmonary emphysema.
Article
Immunology
Yiming Ma, Lijuan Luo, Xiangming Liu, Herui Li, Zihang Zeng, Xue He, Zijie Zhan, Yan Chen
Summary: The study demonstrates the potential role of PFD in regulating inflammation and oxidative stress induced by cigarette smoke extract, reversing pathological changes and reducing levels of inflammatory factors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Clara Barbosa-de-Oliveira, Paolo Oliveira-Melo, Marcos Henrique Goncalves da Silva, Flavio Santos da Silva, Felipe Andrade Carvalho da Silva, Bruno Vinicios Silva de Araujo, Moacir Franco de Oliveira, Aristides Tadeu Correia, Sidnei Miyoshi Sakamoto, Samuel Santos Valenca, Manuella Lanzetti, Martina Schmidt, Emanuel Kennedy-Feitosa
Summary: This study investigates the role of eugenol (EUG) in cigarette smoke-induced acute lung injury (ALI) and how it modulates macrophage activity. The results show that EUG reduces inflammatory response and oxidative stress markers in vivo, and balances oxidative stress and cytokine release in vitro, indicating that it acts as a modulator of macrophage activity.
Article
Medicine, Research & Experimental
Mohammad Reza Sepand, Armin Salek Maghsoudi, Amir Shadboorestan, Kayvan Mirnia, Mehdi Aghsami, Mohammad Raoufi
Summary: Although numerous studies have been conducted on the mechanisms of cigarette smoking toxicity in the past three decades, there are still some aspects that remain unclear. Recent developments have raised hopeful indicators that enhance our understanding of cigarette-induced cell death, proposing suggestions for detoxification and therapeutic interventions.
Article
Immunology
Deqing Yang, Dan Xu, Tao Wang, Zhicheng Yuan, Lian Liu, Yongchun Shen, Fuqiang Wen
Summary: Pre-treatment with MitoQ significantly attenuated cigarette smoke-induced airway inflammation and mucus hypersecretion in mice, potentially by modulating mitochondrial function and the NF-kappa B signal pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Qing Song, Zi-Jing Zhou, Shan Cai, Yan Chen, Ping Chen
Summary: Smoking-induced oxidative stress contributes to cell apoptosis in emphysema mice. Pifithrin-alpha and N-Acetylcysteine can reduce cell apoptosis, lung damage and oxidative stress, while promoting the expression of Bcl-2 and suppressing the expression of Bax, caspase-3, and cleaved caspase-3. NAC treatment even inhibits the expression of p53.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Siddhi Jain, Sneha Durugkar, Pritam Saha, Sharad B. Gokhale, V. G. M. Naidu, Pawan Sharma
Summary: This study examined the efficacy of azithromycin alone and in combination with dexamethasone in treating cigarette smoke-induced acute lung inflammation. The results showed that azithromycin inhibited airway fibrosis, inflammation, and cell toxicity caused by cigarette smoke, and improved lung function. Further research is needed to validate the therapeutic efficacy of azithromycin as a treatment for COPD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Hongxiang Hong, Xu Lu, Qun Lu, Chao Huang, Zhiming Cui
Summary: Sinomenine, a natural compound from Sinomenium acutum, has shown beneficial effects in various CNS disorders, including cerebral ischemia, traumatic brain injury, Alzheimer's disease, Parkinson's disease, and epilepsy. Its mechanisms of action involve inhibition of oxidative stress, neuroinflammation, and neuronal apoptosis. Sinomenine also exhibits anti-glioma effects and improves morphine dependence and sleep disturbance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Livia Interdonato, Ylenia Marino, Rosalia Crupi, Enrico Gugliandolo, Francesco Macri, Davide Di Paola, Alessio Filippo Peritore, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: This study evaluated the modulation of autophagy, oxidative stress, and apoptosis with Acai Berries in a rat model of endometriosis. The results showed that Acai Berry inhibited the phosphorylation of PI3K, AKT, and ERK1/2, promoting autophagy, and exerted regulatory effects on cell apoptosis and oxidative stress.
Article
Biochemistry & Molecular Biology
Ho Yong Kim, Jin Ho Lee, Jeong-Won Yun, Jin-Ho Park, Bong-Wook Park, Gyu-Jin Rho, Si-Jung Jang, Ji-Sung Park, Hee-Chun Lee, Young Min Yoon, Tae Sung Hwang, Dong Hoon Lee, June-Ho Byun, Se Heang Oh
Article
Medicine, General & Internal
Jin-Eun Chung, Jin-Ho Park, Jeong-Won Yun, Young-Hoon Kang, Bong-Wook Park, Sun-Chul Hwang, Yeong-Cheol Cho, Iel-Yong Sung, Dong Kyun Woo, June-Ho Byun
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2016)
Article
Engineering, Biomedical
Jin Ho Lee, Dong Kyun Woo, Tae Ho Kim, Jun Goo Kang, Jeong-Won Yun, Jin-Ho Park, Bong-Wook Park, Young-Hoon Kang, Gyu-Jin Rho, Si-Jung Jang, Ji-Sung Park, Hee-Chun Lee, Young Min Yoon, Tae Sung Hwang, Deok Ryong Kim, Sun-Chul Hwang, Dong Hoon Lee, Ho Young Kim, Se Heang Oh, June-Ho Byun
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2017)
Article
Pharmacology & Pharmacy
Sumin Son, Jinho Park, Hyodeok Seo, Hyun Tae Lee, Yong-Seok Heo, Hak-Sung Kim
JOURNAL OF DRUG TARGETING
(2020)
Article
Chemistry, Multidisciplinary
Tae Yoon Kim, Jin Ho Park, Ha Eun Shim, Dae Seong Choi, Dong-Eun Lee, Ji-Joon Song, Hak-Sung Kim
JOURNAL OF CONTROLLED RELEASE
(2019)
Article
Biochemistry & Molecular Biology
Sukyo Jeong, Yoo-Kyoung Sohn, Yoonjoo Choi, Jinho Park, Hak-Sung Kim
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Jin-Ho Park, Young-Hoon Kang, Sun-Chul Hwang, Se Heang Oh, June-Ho Byun
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Multidisciplinary
Tae Yoon Kim, You Ree Nam, Jin Ho Park, Dong-Eun Lee, Hak-Sung Kim
Article
Biochemistry & Molecular Biology
Mingyo Kim, Yongho Choe, Heewon Lee, Min-Gyu Jeon, Jin-Ho Park, Hae Sook Noh, Yun-Hong Cheon, Hee Jin Park, Jaehun Park, Sung Jae Shin, Kyunglim Lee, Sang-Il Lee
Summary: The study demonstrates the pivotal role of HRF/TCTP in the pathogenesis of rheumatoid arthritis (RA), with HRF/TCTP significantly associated with inflammatory responses and joint destruction. Inhibiting HRF/TCTP with dimerized HRF/TCTP-binding peptide-2 (dTBP2) shows promising therapeutic effects in RA patients and collagen-induced arthritis (CIA) mice, highlighting HRF/TCTP as a potential novel biomarker and therapeutic target for the diagnosis and treatment of RA.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Biology
Jin-Ho Park, Su A. Park, Young-Hoon Kang, So Myeong Hwa, Eun-Byeol Koh, Sun-Chul Hwang, Se Heang Oh, June-Ho Byun
Summary: Zinc enhances osteogenesis by promoting osteoblastic differentiation and activities, as well as by indirectly inhibiting osteoclastic bone resorption through a reduced RANKL/OPG ratio in co-cultured osteoblasts and osteoclasts.
Article
Pharmacology & Pharmacy
Dasom Kim, Jin-Ho Park, Tae-Yoon Kim, Dong-Gun Kim, June-Ho Byun, Hak-Sung Kim
Summary: The study shows that genetic fusion of a human serum albumin-specific protein binder (rHSA) can enhance the blood half-life and biological activity of human interleukin-15 (hIL-15). The fusion construct increases the secretion of activated T cells, prolongs the half-life in mice, and demonstrates anti-tumor activity through the activation of T cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Jin-Ho Park, Eun-Byeol Koh, Young-Jin Seo, Hye-Seong Oh, Ju-Yeong Won, Sun-Chul Hwang, June-Ho Byun
Summary: Tiron has dual effects on mitochondrial function and osteoblastic differentiation in human periosteum-derived cells (hPDCs). It increases mitochondrial activity and inhibits cellular senescence, but has detrimental effects on osteoblastic differentiation by reducing alkaline phosphatase activity and mineralization. Furthermore, it reduces ROS production and mitochondrial protein levels in differentiating cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Biomaterials
Ho Yong Kim, Jin-Ho Park, Min Ji Kim, Jin Ho Lee, Se Heang Oh, June-Ho Byun
Summary: The study showed that the Continuous group provided a better environment for osteogenic differentiation, while the Biomimetic group promoted more significant new bone formation than expected. Results indicated that continuous supply of VEGF from VEGF-loaded biomaterial at early stages may hinder new bone formation.
BIOMATERIALS SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jin-Ho Park, Bong-Wook Park, Young-Hoon Kang, Sung-Hoon Byun, Sun-Chul Hwang, Deok Ryong Kim, Dong Kyun Woo, June-Ho Byun
CELL BIOCHEMISTRY AND FUNCTION
(2017)