Journal
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
Volume 306, Issue 7, Pages 580-585Publisher
ELSEVIER GMBH
DOI: 10.1016/j.ijmm.2016.05.017
Keywords
Latent infection; Within-host evolution; Mutation rate; Genome sequencing; Pathogen evolution
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Funding
- Novo Nordisk Foundation [NNF7651]
- Lundbeck Foundation [R151-2013-14628]
- Lundbeck Foundation [R151-2013-14628] Funding Source: researchfish
- Novo Nordisk Fonden [NNF13OC0007651] Funding Source: researchfish
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The genome of Mycobacterium tuberculosis (Mtb) of latently infected individuals may hold the key to understanding the processes that lead to reactivation and progression to clinical disease. We report here analysis of pairs of Mtb isolates from putative prolonged latent TB cases. We identified two confirmed cases, and used whole genome sequencing to investigate the mutational processes that occur over decades in latent Mtb. We found an estimated mutation rate between 0.2 and 0.3 over 33 years, suggesting that latent Mtb accumulates mutations at rates similar to observations from cases of active disease. (C) 2016 Elsevier GmbH. All rights reserved.
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