Article
Biotechnology & Applied Microbiology
Nasir Mohajel, Arash Arashkia
Summary: Surveying patenting activity can help coordinate R&D efforts in combating emerging infectious diseases.
NATURE BIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Placide Mbala-Kingebeni, Catherine Pratt, Mbusa Mutafali-Ruffin, Matthias G. Pauthner, Faustin Bile, Antoine Nkuba-Ndaye, Allison Black, Eddy Kinganda-Lusamaki, Martin Faye, Amuri Aziza, Moussa M. Diagne, Daniel Mukadi, Bailey White, James Hadfield, Karthik Gangavarapu, Nella Bisento, Donatien Kazadi, Bibiche Nsunda, Marceline Akonga, Olivier Tshiani, John Misasi, Aurelie Ploquin, Victor Epaso, Emilia Sana-Paka, Yannick Tutu Tshia N'kasar, Fabrice Mambu, Francois Edidi, Meris Matondo, Junior Bula Bula, Boubacar Diallo, Mory Keita, Marie R. D. Belizaire, Ibrahima S. Fall, Abdoulaye Yam, Sabue Mulangu, Anne W. Rimion, Elias Salfati, Ali Torkamani, Marc A. Suchard, Ian Crozier, Lisa Hensley, Andrew Rambaut, Ousmane Faye, Amadou Sall, Nancy J. Sullivan, Trevor Bedford, Kristian G. Andersen, Michael R. Wiley, Steve Ahuka-Mundeke, Jean-Jacques Muyembe Tamfum
Summary: During the Ebola virus disease outbreak in the Democratic Republic of Congo, a young man developed EVD, recovered after receiving monoclonal antibody treatment, but later experienced a relapse, transmitted the virus, and ultimately died.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Infectious Diseases
Luke Nyakarahuka, Sophia Mulei, Shannon Whitmer, Kyondo B. Jackson, Alex M. Tumusiime, Amy Schuh, Jimmy J. Baluku, Allison D. Joyce, Felix R. Ocom, Jayne Tusiime, Joel Montgomery, Stephen Balinandi, Julius Lutwama, John Klena, Trevor Shoemaker
Summary: This publication demonstrates how Uganda managed to control the introduction of Ebola Virus Disease (EVD) from the Democratic Republic of Congo (DRC) in 2019. By intensifying cross-border surveillance and implementing international health regulations, they successfully limited the spread of the virus in Uganda. Three cases were identified and contained, with no onward transmission. This experience can serve as a model for cross-border surveillance and control of infectious disease outbreaks.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Immunology
Akbar Dastjerdi, Nadia Inglese, Tim Partridge, Siva Karuna, David J. Everest, Jean-Pierre Frossard, Mark P. Dagleish, Mark F. Stidworthy
Summary: In the fall of 2019, a fatal encephalitis outbreak in England caused the deaths of more than 200 European hedgehogs. Next-generation sequencing identified a novel arterivirus with a genome coding sequence that is only 43% similar to existing GenBank sequences.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Amy J. Schuh, Jackson Kyondo, James Graziano, Stephen Balinandi, Markus H. Kainulainen, Alex Tumusiime, Luke Nyakarahuka, Sophia Mulei, Jimmy Baluku, William Lonergan, Oren Mayer, Rastus Masereka, Fredrick Masereka, Esther Businge, Alphonse Gatare, Loice Kabyanga, Samuel Muhindo, Raymond Mugabe, Issa Makumbi, Joshua Kayiwa, Milton Makoba Wetaka, Vance Brown, Joseph Ojwang, Lisa Nelson, Monica Millard, Stuart T. Nichol, Joel M. Montgomery, Celine H. Taboy, Julius J. Lutwama, John D. Klena
Summary: The Ebola virus disease outbreak in the Democratic Republic of Congo spread to northeastern DRC, with over 2,000 reported cases and over 1,000 deaths by June 2019. In Western Uganda's Kasese District, three individuals from a Congolese family were confirmed to have EVD, leading to an outbreak declaration by the Ugandan Ministry of Health and a rapid response from various organizations. Despite no EVD cases being detected by the field laboratory, it played a crucial role in patient management and epidemiological surveillance, providing diagnostic results in less than 3 hours.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Multidisciplinary Sciences
Antoine Oloma Tshomba, Daniel-Ricky Mukadi-Bamuleka, Anja De Weggheleire, Olivier M. Tshiani, Richard O. Kitenge, Charles T. Kayembe, Bart K. M. Jacobs, Lutgarde Lynen, Placide Mbala-Kingebeni, Jean-Jacques Muyembe-Tamfum, Steve Ahuka-Mundeke, Dieudonne N. Mumba, Desire D. Tshala-Katumbay, Sabue Mulangu
Summary: The study developed prediction scores to aid healthcare workers in improving decision-making for Ebola virus disease (EVD) suspect-cases during outbreaks. The extended clinical prediction score (ECPS) outperformed the clinical prediction score (CPS) in diagnosing EVD and reducing unnecessary isolation. These tools show promise in enhancing triage decisions during EVD outbreaks but require further validation and evaluation before widespread use.
Article
Microbiology
Wenwu Yao, Zhangnv Yang, Xiuyu Lou, Haiyan Mao, Hao Yan, Yanjun Zhang
Summary: A cost-effective, multipathogen and high-throughput method was developed for simultaneous detection of Ebola virus and other pathogens associated with hemorrhagic fever, demonstrating excellent specificity, sensitivity, and concordance with real-time PCR analysis.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Virology
Stephen Balinandi, Shannon Whitmer, Sophia Mulei, Charity Nassuna, Godfrey Pimundu, Tonny Muyigi, Markus Kainulainen, Elizabeth Shedroff, Inna Krapiunaya, Florine Scholte, Luke Nyakarahuka, Alex Tumusiime, Jackson Kyondo, Jimmy Baluku, Jocelyn Kiconco, Julie R. Harris, Alex R. Ario, Atek Kagirita, Henry K. Bosa, Isaac Ssewanyana, Susan Nabadda, Henry G. Mwebesa, Jane R. Aceng, Diana Atwine, Julius J. Lutwama, Trevor R. Shoemaker, Joel M. Montgomery, Pontiano Kaleebu, John D. Klena
Summary: Uganda experienced five Ebola disease outbreaks caused by Bundibugyo virus (n = 1) and Sudan virus (SUDV) (n = 4) from 2000 to 2021. The fifth Sudan virus disease outbreak in Mubende district in 2022 resulted in a total of 142 confirmed cases and 22 probable cases. Genetic analysis of the new variant showed its close relatedness to the Nakisamata SUDV sequence from 2011 and provided valuable information for diagnostics and future therapy development.
JOURNAL OF VIROLOGY
(2023)
Review
Emergency Medicine
Summer Chavez, Alex Koyfman, Michael Gottlieb, William J. Brady, Brandon M. Carius, Stephen Y. Liang, Brit Long
Summary: Ebolavirus, the causative agent of Ebola virus disease (EVD), has been responsible for sporadic outbreaks in sub-Saharan Africa since 1976. EVD is highly transmissible, especially to healthcare workers. This review provides a concise overview of EVD presentation, diagnosis, and management for emergency clinicians. Treatment mainly involves supportive care and two approved monoclonal antibody treatments.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Immunology
Joseph Humphrey Kofi Bonney, Terrel Sanders, Deborah Pratt, Bright Agbodzi, Dennis Laryea, Nana Kwame Fredua Agyeman, Selassie Kumordjie, Keren Attiku, Patience Lartekai Adams, Gideon Aning Boateng, Sally-Ann Ohene, Christopher Tamal, Gifty Mawuli, Clara Yeboah, Samuel Dadzie, Chrysantus Kubio, Franklin Asiedu-Bekoe, John Kofi Odoom
Summary: Yellow fever outbreak in Ghana resulted in severe casualties. The outbreak primarily affected unvaccinated nomadic communities. Molecular amplification methods were used for diagnosis and provided important DNA sequences. Advanced molecular diagnostic techniques helped control the spread of the outbreak.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Immunology
Mirjam Groger, Peter Akhideno, Christine J. Kleist, Femi O. Babatunde, Osahogie Edeawe, Julia Hinzmann, ThankGod Akhigbe, Joy Nwatuzor, Gloria Eifediyi, Jonas Mueller, Mette Hinrichs, Meike Pahlmann, Francisca Naana Sarpong, Christine Wagner, Anke Thielebein, Louis Aihonwalan, Till Koch, Maria Riedner, Ephraim Ogbaini-Emovon, Sylvanus Okogbenin, Stephan Guenther, Sebastian G. Wicha, Michael Ramharter, Lisa Oestereich, Sophie Duraffour, Cyril Erameh
Summary: This study examines the pharmacokinetics of ribavirin in the treatment of Lassa fever and finds consistent exposure across patients. While ribavirin shows low antiviral efficacy, it may have anti-inflammatory effects. Further research is needed to determine the role of ribavirin in the treatment of Lassa fever.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Cell Biology
Cassio M. Fontes, Barbara D. Lipes, Jason Liu, Krystle N. Agans, Aiwei Yan, Patricia Shi, Daniela F. Cruz, Garrett Kelly, Kelli M. Luginbuhl, Daniel Y. Joh, Stephanie L. Foster, Jacob Heggestad, Angus Hucknall, Maiken H. Mikkelsen, Carl F. Pieper, Roarke W. Horstmeyer, Thomas W. Geisbert, Michael D. Gunn, Ashutosh Chilkoti
Summary: This study presents a new ultrasensitive point-of-care immunoassay, the EBOV D4 assay, which can be used for early detection, containment, and treatment of Ebola virus outbreaks in low-resource settings.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
David Philpott, Neil Rupani, Monique Gainey, Eta N. Mbong, Prince Imani Musimwa, Shiromi M. Perera, Razia Laghari, Mija Ververs, Adam C. Levine
Summary: This study investigates the outcomes of pregnant women, fetuses, and newborns during the Ebola outbreak in Democratic Republic of Congo from 2018 to 2020. The results show that pregnancy was not associated with increased mortality among women with Ebola, but the outcomes of pregnancies were still poor.
Article
Multidisciplinary Sciences
Anoop T. Ambikan, Nazif Elaldi, Sara Svensson- Akusjaervi, Binnur Bagci, Ayse Nur Pektas, Roger Hewson, Gokhan Bagci, Mehmet Arasli, Sofia Appelberg, Adil Mardinoglu, Vikas Sood, Akos Vegvari, Rui Benfeitas, Soham Gupta, Ilhan Cetin, Ali Mirazimi, Ujjwal Neogi
Summary: This study analyzed the trajectory of host response and metabolic changes following CCHFV infection, revealing that antiviral immune responses are regulated by genes and signaling pathways. The reorganization of metabolism during the acute phase contributes to pathogenicity, while downregulated metabolic processes during the convalescent phase may lead to metabolic rewiring.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Analytical
Pei-Shan Tsai, Pin-Xian Du, Batuhan Birol Keskin, Nan-Yao Lee, Shu-Wen Wan, Ya-Lan Lin, Wen-Yu Su, Pei-Chun Lin, Wei-Hsun Lin, Hsi-Chang Shih, Tzong-Shiann Ho, Guan-Da Syu
Summary: This study aims to analyze the humoral immunity and cross-reactivity in dengue patients using a multiplexed protein microarray. The results show that patients with severe dengue have higher levels of IgG antibodies against multiple Flavivirus antigens. Logistic regression analysis identifies groups of markers that can effectively distinguish dengue patients from healthy controls and hospitalized patients from mild cases.
ANALYTICAL CHEMISTRY
(2023)
Article
Infectious Diseases
Gianpiero Tebano, Grace Li, Bojana Beovic, Julia Bielicki, Adrian Brink, Mushira A. Enani, Brian Godman, Sylvia Lemos Hinrichsen, Dan Kibuule, Levy-Hara Gabriel, Oyinlola Oduyebo, Mike Sharland, Sanjeev Singh, Heiman F. L. Wertheim, Dilip Nathwani, Celine Pulcini
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2019)
Letter
Infectious Diseases
Oladipupo Ipadeola, Yuki Furuse, Elsie A. Ilori, Chioma C. Dan-Nwafor, Kachikwulu O. Akabike, Anthony Ahumibe, Winifred Ukponu, Lawal Bakare, Gbenga Joseph, Muhammad Saleh, Esther Namukose Muwanguzi, Adebola Olayinka, Geoffrey Namara, Dhamari Naidoo, Akanimo Iniobong, Michael Amedu, Nkem Ugbogulu, Favour Makava, Olawunmi Adeoye, Chukwuemeka Uzoho, Chimezie Anueyiagu, Tochi J. Okwor, Nwando G. Mba, Adejoke Akano, Abiodun Ogunniyi, Amina Mohammed, Ayodele Adeyemo, Dike K. Ugochukwu, Emmanuel Agogo, Chikwe Ihekweazu
JOURNAL OF INFECTION
(2020)
Article
Immunology
Kolawole Salami, Pierre-Stephane Gsell, Adebola Tolulope Olayinka, Diadie Maiga, Pierre Formenty, Peter G. Smith, Vasee Moorthy
Article
Public, Environmental & Occupational Health
Kenneth I. Onyedibe, Nathan Y. Shehu, Daniela Pires, Samson E. Isa, Mark O. Okolo, Simji S. Gomerep, Comfort Ibrahim, Sunday J. Igbanugo, Rachel U. Odesanya, Adebola Olayinka, Daniel Z. Egah, Didier Pittet
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2020)
Review
Infectious Diseases
Nuhu Tanko, Rebecca Olajumoke Bolaji, Adebola Tolulope Olayinka, Busayo Olalekan Olayinka
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2020)
Letter
Immunology
Lena Faust, Alexandra J. Zimmer, Mikashmi Kohli, Senjuti Saha, Jody Boffa, Marlon L. Bayot, Ifeanyi Nsofor, Leonel Campos, Tivani Mashamba-Thompson, Rosa Herrera, Elom Emeka, Suvesh Shrestha, Cesar Ugarte-Gil, Achilles Katamba, Imran Pambudi, David Bichara, Roger I. Calderon, Namatullah Ahmadzada, Muhammad Aamir Safdar, Chaitali Nikam, Carolina dos Santos Lazari, Hamidah Hussain, Myint Myint Win, Kyaw Zin Than, Anthony Ahumibe, Brenda Waning, Madhukar Pai
MICROBES AND INFECTION
(2020)
Article
Biology
Eme Ekeng, Serges Tchatchouang, Blaise Akenji, Bassira Boubacar Issaka, Ifeoluwa Akintayo, Christopher Chukwu, Ibrahim Dan Dano, Sylvie Melingui, Sani Ousmane, Michael Oladotun Popoola, Ariane Nzouankeu, Yap Boum, Francisco Luquero, Anthony Ahumibe, Dhamari Naidoo, Andrew Azman, Justin Lessler, Shirlee Wohl
Summary: Researchers conducted a regional sequencing study in Nigeria on 46 recent V. cholerae isolates from Cameroon, Niger, and Nigeria, revealing that all isolates belonged to the T12 V. cholerae seventh pandemic lineage. This indicated continuous transmission of the T12 lineage within West Africa since 2009, providing a reference model for future surveillance efforts.
Article
Infectious Diseases
Adebola Tolulope Olayinka, Josephine Bourner, George O. Akpede, Joseph Okoeguale, Chukwuyem Abejegah, Nnennaya A. Ajayi, Christian Akude, Oluwafemi Ayodeji, Daniel G. Bausch, Hilde de Clerck, Chioma Dan-Nwafor, Jake Dunning, Cyril Erameh, Justus Ndulue Eze, Pierre Formenty, Annelies Gillesen, Sulaiman Jalloh, Marie Jaspard, Tolulope Jegede, Jacob Maikere, Denis Malvy, Ephraim Ogbaini-Emovon, Olalekan Ezekial Ojo, Sylvanus Okogbenin, Kwame O'Neill, Maria-Lauretta Orji, Sampson Omagbemi Owhin, Michael Ramharter, Robert J. Samuels, Nathan Shehu, Laura Merson, Alex Paddy Salam, Nzelle Delphine Kayem, Peter Horby, Chikwe Ihekweazu, Piero Olliaro
Summary: This study discusses and determines the core components of future clinical trials for Lassa fever, achieving a consensus position. It is the first clinical development work on this disease in 40 years and contributes to ongoing research investment in the field.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Chioma Dan Nwafor, Elsie Ilori, Adebola Olayinka, Chinwe Ochu, Rosemary Olorundare, Edwin Edeh, Tochi Okwor, Oyeronke Oyebanji, Esther Namukose, Winifred Ukponu, Michael Olugbile, Usman Adekanye, Nastassya Chandra, Hikaru Bolt, Geofrey Namara, Oladipupo Ipadeola, Yuki Furuse, Solomon Woldetsadik, Adejoke Akano, Akanimo Iniobong, Michael Amedu, Chimezie Anueyiagu, Lawal Bakare, Anthony Ahumibe, Gbenga Joseph, Chibuzo Eneh, Muhammad Saleh, Naidoo Dhamari, Ihekerenma Okoli, Mairo Kachalla, Rita Okea, Collins Okenyi, Favour Makava, Catherine Makwe, Nkem Ugbogulu, Fritz Fonkeng, Everistus Aniaku, Emmanuel Agogo, Nwando Mba, Olusola Aruna, Patrick Nguku, Chikwe Ihekweazu
Summary: Globally, effective emergency response to disease outbreaks is often hindered by poor coordination. However, the use of an incident management system (IMS) in line with a One Health approach, involving collaboration between government and non-governmental agencies, has been shown to significantly improve response outcomes for zoonotic diseases such as Lassa fever. The 2019 LF outbreak in Nigeria was effectively managed through coordinated efforts using an IMS and a One Health approach, which included activating Emergency Operation Centers, developing action plans, deploying rapid response teams, and conducting post-outbreak reviews.
Article
Public, Environmental & Occupational Health
Oluwatosin Wuraola Akande, Kelly Osezele Elimian, Ehimario Igumbor, Lauryn Dunkwu, Chijioke Kaduru, Olubunmi Omowunmi Olopha, Dabri Olohije Ohanu, Lilian Nwozor, Emmanuel Agogo, Olusola Aruna, Muhammad Shakir Balogun, Olaolu Aderinola, Anthony Ahumibe, Chinedu Arinze, Sikiru Olanrewaju Badaru, William Nwachukwu, Augustine Olajide Dada, Cyril Erameh, Khadeejah Hamza, Tarik Benjamin Mohammed, Nnaemeka Ndodo, Celestina Obiekea, Chinenye Ofoegbunam, Oladipo Ogunbode, Cornelius Ohonsi, Ekaete Alice Tobin, Rimamdeyati Yashe, Afolabi Adekaiyaoja, Michael C. Asuzu, Rosemary Ajuma Audu, Muhammad Bashir Bello, Shaibu Oricha Bello, Yusuf Yahaya Deeni, Yahya Disu, Gbenga Joseph, Chidiebere Ezeokafor, Zaiyad Garba Habib, Christian Ibeh, Ifeanyi Franklin Ike, Emem Iwara, Rejoice Kudirat Luka-Lawal, Geoffrey Namara, Tochi Okwor, Lois Olajide, Oluwafunke Olufemi Ilesanmi, Solomon Omonigho, Ferdinand Oyiri, Koubagnine Takpa, Nkem Usha Ugbogulu, Priscilla Ibekwe, John Oladejo, Elsie Ilori, Chinwe Lucia Ochu, Chikwe Ihekweazu
Summary: This study compared the epidemiological features of the first and second waves of COVID-19 in Nigeria. The second wave saw an increase in confirmed cases among females and individuals 30 years old or younger, while confirmed cases decreased among urban residents and individuals with recent travel history. The majority of cases were asymptomatic at diagnosis in both waves.
Article
Immunology
Jonathan W. Ashcroft, Adebola Olayinka, Nnaemeka Ndodo, Kuiama Lewandowski, Martin D. Curran, Chioma Dan Nwafor, Kingsley Madubuike, Helen Bagnall, Abdulmajid S. Musa, Adama Ahmad, Afolabi Akinpelu, Adesola Adeleye, Chukwuji Martin, Adejoke Akano, Michael Onoja, Akanimo Iniobong, Winifred Ukponu, Chinedu Arinze, Else Ilori, Nwando Mba, Benedict Gannon, Anthony Ahumibe, Chikwe Ihekweazu
Summary: During the 2018 Lassa fever outbreak in Nigeria, samples from patients with suspected Lassa fever but negative Lassa virus PCR results were analyzed using custom gene expression array cards and metagenomic sequencing. The results revealed no single etiology, but bacterial and viral pathogens (including mixed coinfections) were detected.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Nubwa Medugu, Philip Nwajiobi-Princewill, Shuwaram A. Shettima, Manga M. Mohammed, Yahaya Mohammed, Kennedy Wariso, Comfort N. Akujobi, Oyinlola O. Oduyebo, Kenneth C. Iregbu
Summary: The study in Nigeria revealed high rates of resistance in Staphylococcus aureus, especially towards commonly used antibiotics. Methicillin-resistant strains showed higher resistance to all antibiotics tested. Urgent measures such as antibiotic stewardship programs and regular surveillance are recommended to improve clinical outcomes.
NIGERIAN JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Alero Ann Roberts, Iretiolu Fajolu, Philip Oshun, Chioma Osuagwu, Opeyemi Awofeso, Edamisan Temiye, O. Oyin Oduyebo
NIGERIAN POSTGRADUATE MEDICAL JOURNAL
(2020)
Article
Medicine, General & Internal
Olawale Olatunbosun Adamson, Michael Olayinka Adeyemi, Olalekan Micah Gbotolorun, Omoniyi Omolola Oduyebo, Olalekan Odeniyi, Wasiu Lanre Adeyemo
AFRICAN HEALTH SCIENCES
(2019)