Article
Cell Biology
Xiao-Hong Yao, Tao Luo, Yu Shi, Zhi-Cheng He, Rui Tang, Pei-Pei Zhang, Jun Cai, Xiang-Dong Zhou, Dong-Po Jiang, Xiao-Chun Fei, Xue-Quan Huang, Lei Zhao, Heng Zhang, Hai-Bo Wu, Yong Ren, Zhen-Hua Liu, Hua-Rong Zhang, Cong Chen, Wen-Juan Fu, Heng Li, Xin-Yi Xia, Rong Chen, Yan Wang, Xin-Dong Liu, Chang-Lin Yin, Ze-Xuan Yan, Juan Wang, Rui Jing, Tai-Sheng Li, Wei-Qin Li, Chao-Fu Wang, Yan-Qing Ding, Qing Mao, Ding-Yu Zhang, Shu-Yang Zhang, Yi-Fang Ping, Xiu-Wu Bian
Summary: The study profiles 26 COVID-19 autopsy cases from Wuhan and determines the systemic distribution of SARS-CoV-2 in critically ill patients. It reveals that SARS-CoV-2 may invade multiple organs and utilize physiological barriers as entry ports for systemic dissemination, shedding light on novel COVID-19 treatment development.
Article
Psychiatry
Yin Wu, Linda Kwakkenbos, Richard S. Henry, Marie-Eve Carrier, Maria Gagarine, Sami Harb, Angelica Bourgeault, Lydia Tao, Andrea Carboni-Jim, Zelalem Negeri, Scott Patten, Susan J. Bartlett, Luc Mouthon, John Varga, Andrea Benedetti, Brett D. Thombs
Summary: Factors associated with fear of consequences of COVID-19 among people living with systemic sclerosis (SSc) included the degree of interference from breathing problems and adequacy of financial resources. Interventions for this chronically ill population may benefit from addressing specific clinical issues and considering financial resources and political influences.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Article
Immunology
Cristiane de Freitas Paganoti, Rafaela Alkmin da Costa, Aris T. Papageorghiou, Fabricio da Silva Costa, Silvana Maria Quintana, Luciana Graziela de Godoi, Nataly Adriana Jimenez Monroy, Agatha Sacramento Rodrigues, Rossana Pulcineli Vieira Francisco
Summary: This study found that COVID-19 vaccination plays an important role in reducing the severity of COVID-19 infection among hospitalized pregnant and postpartum women, reducing the risk of intensive care unit admission, intubation, and death.
Article
Immunology
Manica Negahdaripour, Mojtaba Shafiekhani, Seyed Mohammad Iman Moezzi, Sogand Amiri, Shiva Rasekh, Ashkan Bagheri, Pouria Mosaddeghi, Afsaneh Vazin
Summary: This review focuses on the challenges and considerations of COVID-19 vaccination in specific populations, such as patients with autoimmune diseases and those receiving immunosuppressive treatments. While confirmed data is lacking, reaching a consensus on vaccination for these populations is crucial, along with the need for further research and clinical trials to address these issues.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Zhuoying Huang, Shuangfei Xu, Jiechen Liu, Linlin Wu, Jing Qiu, Nan Wang, Jia Ren, Zhi Li, Xiang Guo, Fangfang Tao, Jian Chen, Donglei Lu, Yuheng Wang, Juan Li, Xiaodong Sun, Weibing Wang
Summary: We performed a retrospective cohort study in Shanghai to estimate the effectiveness of inactivated vaccines and compare the effectiveness of booster doses among older individuals. The study included two cohorts: one with a vaccinated group (>= 1 dose) and an unvaccinated group, and another with a booster vaccinated group and a fully vaccinated group. The results showed that both the initial vaccination and booster dose provided substantial protection against SARS-CoV-2 infection and severe/critical Covid-19, with the booster dose offering the greatest protection. These findings highlight the importance of promoting high vaccination uptake among older adults, even in the context of ongoing non-pharmaceutical interventions.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Serena Fineschi
Summary: COVID-19 infection can trigger autoimmune diseases like systemic sclerosis (SSc) and lead to the production of autoantibodies. This case report describes a patient who developed autoantibody production and symptoms affecting the skin and gastrointestinal system after mild COVID-19 infection, eventually being diagnosed with SSc.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Medicine, General & Internal
Peter W. W. Marks, Robert M. M. Califf, Paul A. A. Offit
Summary: The author of this letter criticizes Offit's viewpoint and presents evidence that shows the bivalent boosters have better immunogenicity against emerging variants. Therefore, the author suggests that the bivalent boosters should be deployed throughout the entire population, including against SARS-CoV-2 omicron subvariants BA.4 and BA.5 as well as the ancestral strain.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Rheumatology
Vasiliki-Kalliopi Bournia, George E. Fragoulis, Panagiota Mitrou, Konstantinos Mathioudakis, Anastasios Tsolakidis, George Konstantonis, Ioulia Tseti, Georgia Vourli, Maria G. Tektonidou, Dimitrios Paraskevis, Petros P. Sfikakis
Summary: This study investigated the risk of hospitalization and death associated with COVID-19 in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc) compared to the general population during the first year of the pandemic. The results showed higher incidence rates of COVID-19-associated hospitalization in RA, SLE, and SSc, as well as higher COVID-19-associated death rates in RA. COVID-19-related mortality was increased in RA and SSc patients compared to the general population. Priority vaccination and access to targeted treatments are needed for specific subgroups of patients with rheumatic diseases.
Article
Immunology
Qiaoli Hua, Danwen Zheng, Bo Yu, Xinghua Tan, Qiumin Chen, Longde Wang, Jing Zhang, Yuntao Liu, Heng Weng, Yihang Cai, Xiaohua Xu, Bing Feng, Guangjuan Zheng, Banghan Ding, Jianwen Guo, Zhongde Zhang
Summary: This study aimed to evaluate the effectiveness of inactivated vaccines against the Delta and Omicron variants. The results showed that two-dose vaccination reduced pneumonia, disease severity, and the duration of viral shedding in Delta cases, while two doses were insufficient for Omicron and booster vaccination should be prioritized.
Review
Clinical Neurology
Masoud Etemadifar, Hosein Nouri, Maristella Pitzalis, Maria Laura Idda, Mehri Salari, Mahshid Baratian, Sepide Mahdavi, Amir Parsa Abhari, Nahad Sedaghat
Summary: Studies have shown that patients with multiple sclerosis receiving disease-modifying therapies may have lower immune response after COVID-19 vaccination. B-cell depletion therapies may accelerate post-vaccination antibody waning. Real-world data suggests that patients receiving certain therapies have higher incidence and severity of breakthrough COVID-19. Therefore, optimizing immune response and ensuring its durability are necessary in the COVID-19 vaccination policy for these patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Editorial Material
Medicine, General & Internal
Lawrence O. Gostin, Daniel A. Salmon, Heidi J. Larson
Summary: This Viewpoint discusses the possibility of US states, businesses, health care facilities, and schools and universities mandating coronavirus vaccination as a requirement for employment or service.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Infectious Diseases
Manish Sadarangani, Phyumar Soe, Hennady P. Shulha, Louis Valiquette, Otto G. Vanderkooi, James D. Kellner, Matthew P. Muller, Karina A. Top, Jennifer E. Isenor, Allison McGeer, Mike Irvine, Gaston De Serres, Kimberly Marty, Julie A. Bettinger
Summary: This study analyzed the impact of COVID-19 vaccination on pregnant individuals. The results showed that COVID-19 mRNA vaccines have a good safety profile in pregnancy, with a lower chance of significant health events in pregnant individuals.
LANCET INFECTIOUS DISEASES
(2022)
Article
Clinical Neurology
Dominika Stastna, Frederik Elberling, Luigi Pontieri, Elisabeth Framke, Dana Horakova, Jiri Drahota, Petra Nytrova, Melinda Magyari
Summary: This study evaluated the difference in relapse occurrence pre- and post-COVID-19 vaccination in Danish patients with relapsing multiple sclerosis. The findings showed that there was no significant increase in relapse activity following the administration of the first dose of the COVID-19 vaccine.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Giorgia Teresa Maniscalco, Cristina Scavone, Annamaria Mascolo, Valentino Manzo, Elio Prestipino, Gaspare Guglielmi, Maria Luisa Aiezza, Santolo Cozzolino, Adele Bracco, Ornella Moreggia, Daniele Di Giulio Cesare, Antonio Rosario Ziello, Angela Falco, Marida Massa, Massimo Majolo, Eliana Raiola, Roberto Soprano, Giuseppe Russo, Giuseppe Longo, Vincenzo Andreone, Annalisa Capuano
Summary: This study aimed to evaluate the safety profile of mRNA-based COVID-19 vaccines in patients with multiple sclerosis (MS). The results showed that the Pfizer-BioNTech vaccine was safe for MS patients, with adverse event following immunization (AEFI) rates similar to those in the general population. Larger studies with longer follow-up are needed to further confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Min-Taek Lee, Moon Seong Baek, Tae Wan Kim, Sun-Young Jung, Won-Young Kim
Summary: This nationwide population-based study aimed to determine whether COVID-19 hospitalization was associated with incident cardiovascular outcomes. The study found that hospitalized patients with COVID-19 were not at an increased risk of cardiovascular outcomes compared to patients with non-COVID-19 pneumonia.
Article
Health Care Sciences & Services
Kimberly A. Mc Cord, Mahrukh Imran, Danielle B. Rice, Stephen J. McCall, Linda Kwakkenbos, Margaret Sampson, Ole Frobert, Chris Gale, Sinead M. Langan, David Moher, Clare Relton, Merrick Zwarenstein, Edmund Juszczak, Brett D. Thombs, Lars G. Hemkens
Summary: Reporting of RCTs using registries is often poor, particularly in terms of details on data linkage and quality. Better reporting is needed for appropriate interpretation of the results of these trials.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Health Care Sciences & Services
Stephen J. McCall, Mahrukh Imran, Lars G. Hemkens, Kimberly Mc Cord, Linda Kwakkenbos, Margaret Sampson, Sena Jawad, Merrick Zwarenstein, Clare Relton, Sinead M. Langan, David Moher, Ole Frobert, Brett D. Thombs, Chris Gale, Edmund Juszczak
Summary: This study aims to describe the characteristics of randomized controlled trials conducted using electronic health records (EHRs) and evaluate the completeness and transparency of their reporting. The study found that some important items were underreported in RCTs using EHRs, and the use of the CONSORT-ROUTINE extension may improve reporting quality.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Otorhinolaryngology
Esther Deuning-Smit, Jose A. E. Custers, Spela Mirosevic, Robert P. Takes, Femke Jansen, Johannes A. Langendijk, Chris H. J. Terhaard, Robert J. Baatenburg de Jong, C. Rene Leemans, Johannes H. Smit, Linda Kwakkenbos, Irma M. Verdonck-de Leeuw, Judith B. Prins
Summary: This study assessed the course of fear of cancer recurrence in newly diagnosed head and neck cancer patients. It found that the majority of patients experience a decline in fear of cancer recurrence after diagnosis, but one in five patients continue to have persistent high fear of cancer recurrence up to 6 months post-treatment. Younger age, negative adjustment, passive coping, reassuring thoughts, and less avoidance were associated with higher levels of fear of cancer recurrence.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Lonneke M. A. Wijnhoven, Jose A. E. Custers, Linda Kwakkenbos, Judith B. Prins
Summary: This study investigates the course of adjustment disorder symptoms in breast cancer survivors up to 5 years post-treatment. The results show that these symptoms fluctuate within 1 year and are associated with factors such as age, daily activity ability, social support, neuroticism, and optimism.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Esther Deuning-Smit, Evie E. M. Kolsteren, Linda Kwakkenbos, Jose A. E. Custers, Rosella P. M. G. Hermens, Judith B. Prins
Summary: This study aimed to identify barriers and facilitators for implementing the evidence-based blended SWORD intervention in routine psycho-oncological care. The study found barriers and facilitators in six domains, including innovation, professionals, patients, social context, organization, and economic and political context. Implementation strategies should target patient, professional, organizational, and economic and political domains.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Rehabilitation
Amanda Wurz, Delaney Duchek, Kelsey Ellis, Mannat Bansal, Marie-Eve Carrier, Lydia Tao, Laura Dyas, Linda Kwakkenbos, Brooke Levis, Ghassan El-Baalbaki, Danielle B. Rice, Yin Wu, Richard S. Henry, Laura Bustamante, Sami Harb, Shannon Hebblethwaite, Scott B. Patten, Susan J. Bartlett, John Varga, Luc Mouthon, Sarah Markham, Brett D. Thombs, S. Nicole Culos-Reed
Summary: This study explored the impact of the videoconference-based supportive care program (SPIN-CHAT program) on individuals with systemic sclerosis (SSc) during early COVID-19. Interviews with trial participants and research team members revealed that the program had positive effects on psychological health, provided SSc-specific support, created a safe space for group interaction, reduced boredom, and offered self-management skills.
DISABILITY AND REHABILITATION
(2023)
Article
Surgery
Ietske Siemann, Ingrid Kleiss, Carien Beurskens, Jose Custers, Linda Kwakkenbos
Summary: The objective of this study was to evaluate the sociodemographic and disease-related factors, as well as coping style, associated with social interaction and social appearance anxiety in individuals with unilateral facial palsy. The results showed that higher age and greater use of emotion-focused coping were associated with lower social interaction anxiety scores, while greater use of avoidant coping was associated with higher social interaction anxiety scores. Higher age, male sex, and greater use of emotion-focused coping were associated with lower social appearance anxiety scores, while greater use of avoidant coping was associated with higher social appearance anxiety scores.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Oncology
Esther Deuning-Smit, Jose A. E. Custers, Linda Kwakkenbos, Rosella P. M. G. Hermens, Judith B. Prins
Summary: The Distress Thermometer (DT) and its accompanying problem list have limited capacity in detecting fear of cancer recurrence (FCR), indicating a need for more effective measures to improve patient access to psychosocial care in oncology practice.
Article
Psychology, Multidisciplinary
Nasim Badaghi, Mette van Kruijsbergen, Judith Prins, Saskia Kelders, Linda Cillessen, Felix Compen, Rogier Donders, Linda Kwakkenbos, Anne Speckens
Summary: The Buddy trial aims to evaluate the effectiveness of blended and unguided online mindfulness-based cognitive therapy (eMBCT) on psychological distress among cancer patients and survivors. It also seeks to explore the impact on other psychological outcomes and investigate treatment effect moderators. The trial utilizes a parallel three-armed randomized controlled design and involves Dutch-speaking adult cancer patients or survivors as participants. The study results will contribute to improving eMBCT interventions and enhancing adherence among cancer patients and survivors.
Article
Public, Environmental & Occupational Health
Amanda Wurz, Kelsey Ellis, Delaney Duchek, Mannat Bansal, Marie-Eve Carrier, Lydia Tao, Laura Dyas, Linda Kwakkenbos, Brooke Levis, Ghassan El-Baalbaki, Danielle B. Rice, Yin Wu, Richard S. Henry, Laura Bustamante, Sami Harb, Shannon Hebblethwaite, Scott B. Patten, Susan J. Bartlett, John Varga, Luc Mouthon, Sarah Markham, Brett D. Thombs, S. Nicole Culos-Reed
Summary: This study explored the acceptability and successful implementation of the SPIN-CHAT program and trial, and the results indicate that both the research team members and trial participants had a positive perception of the program and trial. These findings are crucial for the design and improvement of other supportive care programs aiming to promote psychological health during and beyond the COVID-19 pandemic.
TRANSLATIONAL BEHAVIORAL MEDICINE
(2023)
Article
Medicine, General & Internal
Quentin Kirren, Camille Daste, Frantz Foissac, Hendy Abdoul, Sophie Alami, Marie-Eve Carrier, Linda Kwakkenbos, Marie-Martine Lefevre-Colau, Francois Rannou, Agathe Papelard, Alexandra Roren, Brett D. Thombs, Luc Mouthon, Christelle Nguyen
Summary: This study aimed to explore differences in disability perception between patients and care providers in systemic sclerosis (SSc) through a cross-sectional internet-based mirror survey. Results showed that care providers' rates were higher than those of patients in all domains of the ICF-65 questionnaire. This difference was associated with care providers' characteristics, including organ-based specialty, younger age, and following patients with longer disease duration.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Sabrina Provencher, Richard S. Henry, Carolina Bacalao, Marie-Eve Carrier, Linda Kwakkenbos, Brett D. Thombs
Summary: This study investigated whether the informational and support needs of people with SSc differ based on the time since their diagnosis. The findings revealed that individuals who were recently diagnosed with systemic sclerosis had higher needs in terms of discussing medical care as well as other aspects such as spirituality, talking with family and friends, financial issues, and sexual issues.
JOURNAL OF SCLERODERMA AND RELATED DISORDERS
(2023)
Correction
Psychology, Multidisciplinary
Nasim Badaghi, Mette van Kruijsbergen, Judith Prins, Saskia Kelders, Linda Cillessen, Felix Compen, Rogier Donders, Linda Kwakkenbos, Anne Speckens
Article
Medicine, General & Internal
Robyn K. Wojeck, Mitchell R. Knisely, Donald E. Bailey, Tamara J. Somers, Linda Kwakkenbos, Marie -Eve Carrier, Warren R. Nielson, Susan J. Bartlett, Vanessa L. Malcarne, Marie Hudson, Brooke Levis, Andrea Benedetti, Luc Mouthon, Brett D. Thombs, Susan G. Silva, SPIN Investigator
Summary: This study aimed to identify classes of individuals with similar symptom clusters in systemic sclerosis and evaluate associated characteristics. The majority of systemic sclerosis patients showed consistency between symptom levels and sociodemographic and disease-related variables. However, there was a group with low mental health symptoms despite high levels of other symptoms. This study highlights the importance of developing coping strategies and improving quality of life for systemic sclerosis patients.
Article
Psychology, Multidisciplinary
Adina Coroiu, Chelsea Moran, Linda Kwakkenbos, Brett D. Thombs, Annett Korner
Summary: The purpose of this study was to develop and test a new scale for assessing knowledge about melanoma risk factors and early detection/secondary prevention. The results showed that the scale comprised of 6 items with high factor loadings, and higher scores were associated with younger age and more positive attitudes about melanoma prevention. The scale scores were not associated with biological sex, education level, melanoma stage, or past skin checks.
CURRENT PSYCHOLOGY
(2023)
