Article
Chemistry, Multidisciplinary
Zhiwei Chen, Yaoji Sun, Jiawei Wang, Xi Zhou, Xiangjian Kong, Jiashen Meng, Xingcai Zhang
Summary: The intelligent responsive drug delivery system has great potential in cancer precision therapy by intelligently releasing antitumor drugs through pH response and thermal stimulation.
Article
Biotechnology & Applied Microbiology
Fan Li, Yan Liang, Miaochen Wang, Xing Xu, Fen Zhao, Xu Wang, Yong Sun, Wantao Chen
Summary: The pH cascade-responsive micellar nanoplatform with nucleus-targeted ability effectively combines synergistic chemo-photodynamic therapy for cancer treatment. The novel multifunctional nanoplatform demonstrates high anticancer efficacy both in vitro and in vivo, making it a promising candidate for synergistic anticancer therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biophysics
Ning Zhang, Daquan Wang, Tingting Yang, Xunan Jing, Lingjie Meng
Summary: To enhance the efficacy of chemotherapy and minimize the toxicity of small molecule anti-cancer drugs, researchers have developed a novel polymer-based nanocarrier that can rapidly degrade and release drugs in the tumor microenvironment. This carrier efficiently delivers doxorubicin, exhibiting a high kill efficiency against tumor cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Engineering, Biomedical
Yusheng Chen, Mengluan Gao, Lingjian Zhang, Enna Ha, Xin Hu, Rujia Zou, Li Yan, Junqing Hu
Summary: The study introduces biodegradable Fe-doped MoOx (FMO) nanowires as an anti-tumor nanoreagent with excellent photothermal and magnetic properties, chemodynamic therapy effects, and pH-dependent degradation behavior, demonstrating great potential for MRI image-guided cancer therapy.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Environmental
Bo Cheng, Ke Kong, Linjie Zhang, Rongjian Sa, Tengteng Gu, Yuan Rui, Ruihu Wang
Summary: In this study, ultrathin Fe-Mn-O hetero-nanosheets were fabricated through a simple chemical reaction, exhibiting lower overpotential for oxygen evolution reaction and good stability. It was also discovered that interlayer reconstruction occurred during the reaction, and the triggering effect of fl-FeOOH on electronic coupling was revealed.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Polymer Science
Xing Wang, Ya-Qiang Wang, De-Cheng Wu
Summary: In the current crisis of antibiotic resistance, there is an urgent need for an effective multi-pathway collaborative approach to enhance antibacterial activity. In this study, a hyperbranched polyacetal quaternary ammonium (Hyper-ace-QA) with efficient antibacterial function was synthesized using efficient click strategies. The high molecular weights can be obtained through UV irradiation, and the grafting ratio can be easily adjusted. Hyper-ace-QA has good biocompatibility and can be used as a potential antibacterial dressing. Furthermore, the integration of quaternary ammonium characteristics and pH-triggered curcumin release facilitates antibacterial activity against gram-positive Staphylococcus aureus.
CHINESE JOURNAL OF POLYMER SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Hatai Jongprasitkul, Vijay Singh Parihar, Sanna Turunen, Minna Kellomaki
Summary: The challenges of poor printability and low printing accuracy in hyaluronic acid-based bioinks for extrusion-based 3D bioprinting are tackled by developing a bioink consisting of gallic acid-functionalized hyaluronic acid (HAGA) and hyaluronic acid methacrylate (HAMA). The blend's HAGA component enables viscosity modulation, resulting in improved injectability and printability. Postprinting, the HAMA component is photocrosslinked to create a hydrogel with both HAGA and HAMA networks, showing sufficient printing quality and accuracy. The bioink also has enhanced viscoelastic properties, tissue adhesion, and antioxidant activity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Environmental
Yibin Tong, Junqing Li, Junchen Peng, Dandan Dong, Fei He, Mingyuan Zhu, Chaofeng Huang
Summary: The Fe-N-C adsorbent shows superior desulfurization capability and recyclability, effectively removing sulfur compounds without significant deactivation. By modulating the material structure, the binding strength of adsorption sites can be optimized to enhance desulfurization efficiency.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Yuzhe Sun, Edward W. Davis
Summary: A tubular-shaped Janus nanoparticle based on polydopamine that responds to near-infrared, magnetic, and pH stimuli is reported. The robust tubular polydopamine structure was obtained by optimizing the halloysite template-to-dopamine ratio during synthesis. The inner and outer surfaces of the tube were exposed at different steps of the template-sonication-etching process, enabling the differential surface modification of these surfaces. The resulting magnetic Janus nanoparticles responded to pH, temperature, and magnetic fields, and the release rates of adsorbed doxorubicin from the nanoparticles were influenced by these stimuli.
Article
Biotechnology & Applied Microbiology
Ting Zhao, Ce Liang, Yanrong Zhao, Xiangdong Xue, Zhao Ma, Jinlong Qi, Haitao Shen, Shaokun Yang, Jia Zhang, Qingzhong Jia, Qing Du, Deying Cao, Bai Xiang, Hailin Zhang, Xianrong Qi
Summary: A dual pH-responsive peptide (DPRP) was designed and synthesized for co-delivering PLK-1 specific siRNA and anticancer agent DTX. Results showed that under mildly acidic conditions, the system could enhance drug penetration, improve cellular uptake, and ultimately exhibit significant anti-tumor effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xiao Chu, Liufang Zhang, Yiling Li, Yue He, Yu Zhang, Chang Du
Summary: This study develops a nanocatalytic platform that enhances the efficacy of chemodynamic therapy (CDT) for osteosarcoma treatment. The platform depletes excess glutathione (GSH) and triggers the generation of highly toxic hydroxyl radicals by converting endogenous hydrogen peroxide. Both in vitro and in vivo experiments demonstrate the significantly improved anti-osteosarcoma effect of the synergistic chemodynamic/photothermal/chemo-therapy.
Article
Nanoscience & Nanotechnology
Li Wan, Yuting Cao, Chen Cheng, Rui Tang, Nianhong Wu, Ying Zhou, Xialin Xiong, Hongye He, Xiaohong Lin, Qinqin Jiang, Xiaoting Wang, Xun Guo, Dong Wang, Haitao Ran, Jianli Ren, Yang Zhou, Zhongqian Hu, Pan Li
Summary: Photothermal therapy (PTT) is a noninvasive technique that uses light to generate heat for tumor thermal ablation. However, current photothermal agents (PTAs) derived from exogenous materials have poor tumor targeting and short circulation time. This study developed a pH-responsive nanoprobe, created by coating cancer cell membranes onto polydopamine (PDA)-CaCO3 nanoparticles (CPCaNPs), for image-guided PTT. The CPCaNPs showed enhanced ultrasonic signals and efficient PTT of primary tumors in the acidic microenvironment. Additionally, combining immune checkpoint pathway blockade significantly inhibited tumor recurrence and metastasis. These biomimetic pH-responsive CPCaNPs show great potential for clinical translation in precise PTT immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Won Hur, Yeongwon Park, Eunbi Seo, Seong Eun Son, Seongnyeon Kim, Hyemyung Seo, Gi Hun Seong
Summary: Targeted tumor therapy using TME-responsive nanoplatforms is a promising strategy for selectively killing cancer cells. In this study, a multi-component metal-organic framework nanocomposite, ZIF@GOx@PBNPs, was developed, which exhibited cascade catalytic activity within the TME. The nanocomposites released glucose oxidase (GOx) and Prussian blue nanoparticles (PBNPs) in the acidic TME, enabling starvation therapy and sequential Fenton reaction for chemodynamic therapy. The cascade catalytic reactions enhanced reactive oxygen species production and caused oxidative damage to DNA, leading to remarkable tumor growth inhibition.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Song Zhang, Jia Lv, Peng Gao, Qiuyu Feng, Hui Wang, Yiyun Cheng
Summary: This study presented a dendrimer engineered with a high density of 4-diethylaminophenyl groups on the surface, which could efficiently assemble with cargo proteins in serum solutions, enabling intracellular protein delivery. The dendrimer exhibited pH-responsive disassembly behavior after cell internalization, successfully delivering various cargo proteins into living cells with maintained bioactivity. This provides a convenient and efficient strategy for designing polymers with high serum-tolerance in cytosolic protein delivery.
Review
Pharmacology & Pharmacy
Bharath Singh Padya, Abhijeet Pandey, Muralidhar Pisay, K. B. Koteshwara, Raghu Chandrashekhar Hariharapura, Kuruveri Udaya Bhat, Swati Biswas, Srinivas Mutalik
Summary: Interdisciplinary applications of nanopharmaceutical sciences show great potential in enhancing pharmacokinetics, efficacy, and safety of cancer therapy. Different nanotechnological approaches, including polymeric, lipidic and inorganic nanoplatforms, have been experimented for the treatment of skin cancer. Stimuli-responsive nanoplatforms, surface engineering, conjugation with drugs, and multimodal effects are discussed as strategies for potentiating nanoparticles application for cancer therapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)