Review
Biochemistry & Molecular Biology
Jingqian Su, Yingsheng Luo, Shan Hu, Lu Tang, Songying Ouyang
Summary: Diabetes mellitus is a chronic disease with multiple complications and limited treatment options. The development of targeted therapies for type 2 diabetes mellitus is important due to individual variability and resistance to single-target drugs. This review provides an overview of recent therapeutic agents and discusses emerging target-based therapies for T2DM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Bertram Pitt, Gerasimos Filippatos, Rajiv Agarwal, Stefan D. Anker, George L. Bakris, Peter Rossing, Amer Joseph, Peter Kolkhof, Christina Nowack, Patrick Schloemer, Luis M. Ruilope
Summary: Finerenone therapy improved cardiovascular outcomes in patients with type 2 diabetes and stage 2 to 4 CKD with moderately elevated albuminuria or stage 1 or 2 CKD with severely elevated albuminuria, compared to placebo. The risk of the primary outcome event was significantly lower in the finerenone group, primarily driven by a reduction in hospitalization for heart failure.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Endocrinology & Metabolism
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Assefa Agegnehu Teshome, Edgeit Abebe Zewde, Zelalem Tilahun Muche, Muluken Teshome Azezew
Summary: Diabetes Mellitus is a global health issue that can lead to various complications, including cardiovascular diseases such as heart failure. While hypertension and coronary artery disease are commonly associated with heart failure in diabetes patients, it is also prevalent even in the absence of these risk factors. Understanding the cellular and molecular mechanisms by which diabetes increases the risk of heart failure is crucial for developing effective therapeutics to prevent these changes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Irena Patsan, Amanda Tapley, Peter Davoren, Alison Fielding, Elizabeth Holliday, Jean Ball, Andrew Davey, Mieke van Driel, Rachel Turner, Katie Mulquiney, Neil Spike, Kristen FitzGerald, Parker Magin
Summary: This study aimed to describe the temporal trends and associations of Australian general practitioner registrars' prescription and initiation of "new" second-line oral agents compared to sulphonylureas. The results showed a significant increase in the prescription and initiation of "new" medications compared to sulphonylureas over time, with less prescribing for non-English-speaking patients and regional variation.
Article
Cardiac & Cardiovascular Systems
Suzanne Arnold, Kamlesh Khunti, Fabrice Bonnet, Bernard Charbonnel, Hungta Chen, Javier Cid-Ruzafa, Andrew Cooper, Peter Fenici, Marilia B. Gomes, Niklas Hammar, Linong Ji, Gabriela Luporini-Saraiva, Jesus Medina, Antonio Nicolucci, Larisa Ramirez, Marina Shestakova, Iichiro Shimomura, Filip Surmont, Fengming Tang, Jiten Vora, Hirotaka Watada, Mikhail Kosiborod
Summary: In a global cohort of 14,057 patients with type 2 diabetes, 2.1% were diagnosed with heart failure at enrollment. The majority of incident cases of heart failure occurred in outpatients and in the absence of known coronary artery disease, highlighting the need for greater awareness of heart failure risk in patients with type 2 diabetes.
Review
Cardiac & Cardiovascular Systems
Georgios Kostopoulos, Ioannis Doundoulakis, Konstantinos A. Toulis, Thomas Karagiannis, Apostolos Tsapas, Anna-Bettina Haidich
Summary: This study conducted a systematic review of prognostic models for heart failure prediction in patients with type 2 diabetes. Four models, including RECODe, TRS-HFDM, WATCH-DM, and QDiabetes-HF, showed promising performance and could be implemented in clinical practice.
Article
Cardiac & Cardiovascular Systems
C. H. Lee, M. Z. Wu, D. T. W. Lui, C. H. Y. Fong, Q. W. Ren, S. Y. Yu, M. M. A. Yuen, W. S. Chow, J. Y. Huang, A. Xu, K. H. Yiu, K. S. L. Lam
Summary: This study found that serum TSP2 levels were independently associated with incident heart failure and deterioration in diastolic function in patients with type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Endocrinology & Metabolism
Chengcong Chen, Hong Peng, Mingzhu Li, Xiyan Lu, Miao Huang, Yongmei Zeng, Guoqing Dong
Summary: The long-term use of SGLT-2 inhibitors can help reduce the risk of mortality and hospitalization for heart failure in patients with type 2 diabetes mellitus and heart failure.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Min Zhuo, Elvira D'Andrea, Julie M. Paik, Deborah J. Wexler, Brendan M. Everett, Robert J. Glynn, Seoyoung C. Kim, Elisabetta Patorno
Summary: The use of SGLT-2 inhibitors is associated with a reduced risk of incident atrial fibrillation in older adults with type 2 diabetes.
Article
Multidisciplinary Sciences
Eiichiro Kanda, Atsushi Suzuki, Masaki Makino, Hiroo Tsubota, Satomi Kanemata, Koichi Shirakawa, Toshitaka Yajima
Summary: A novel machine learning model was developed to predict the risk of developing CKD/HF in early-stage T2DM patients, showing good predictive performance in external validation. Early diagnosis and intervention based on ML models may improve the prognosis of high-risk patients.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Kershaw V. Patel, Muhammad Shahzeb Khan, Matthew W. Segar, Judy L. Bahnson, Katelyn R. Garcia, Jeanne M. Clark, Ashok Balasubramanyam, Alain G. Bertoni, Muthiah Vaduganathan, Michael E. Farkouh, James L. Januzzi, Subodh Verma, Mark Espeland, Ambarish Pandey
Summary: Evaluation of baseline and longitudinal changes in cardiometabolic health indicates their contribution to heart failure risk among adults with type 2 diabetes.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Arnaud D. Kaze, Prasanna Santhanam, Sebhat Erqou, Rexford S. Ahima, Alain Bertoni, Justin B. Echouffo-Tcheugui
Summary: The study found an association between microvascular disease (MVD) and an increased risk of heart failure (HF) in individuals with type 2 diabetes mellitus. Even after adjusting for other known risk factors, MVD remained significantly related to incident HF. Different types of MVD may have varying impacts on the development of HF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Endocrinology & Metabolism
Abhinav Sharma, Yinggan Zheng, Justin A. Ezekowitz, Cynthia M. Westerhout, Jacob A. Udell, Shaun G. Goodman, Paul W. Armstrong, John B. Buse, Jennifer B. Green, Robert G. Josse, Keith D. Kaufman, Darren K. McGuire, Giuseppe Ambrosio, Lee-Ming Chuang, Renato D. Lopes, Eric D. Peterson, Rury R. Holman
Summary: By using cluster analysis machine-learning algorithms, this study identified four distinct phenotypes among patients with type 2 diabetes mellitus and atherosclerotic cardiovascular disease. Further cardiovascular phenotyping is warranted to inform patient care and optimize clinical trial designs.
Article
Cardiac & Cardiovascular Systems
Anders Holt, Jarl E. Strange, Nina Nouhravesh, Sebastian Kinnberg Nielsen, Mariam Elmegaard Malik, Anne -Marie Schjerning, Lars Kober, Christian Torp-Pedersen, Gunnar H. Gislason, Patricia McGettigan, Morten Schou, Morten Lamberts
Summary: This study found an association between short-term use of NSAIDs and an increased risk of first-time hospitalization for heart failure in patients with type 2 diabetes. Patients in subgroups with advanced age, elevated HbA1c levels, and new users of NSAIDs were particularly susceptible.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Gilbert Ho, Alysha Ali, Yoshiki Takamatsu, Ryoko Wada, Eliezer Masliah, Makoto Hashimoto
Summary: Aging and pre-existing conditions in older patients can increase the severity and complications of SARS-CoV-2, potentially leading to chronic conditions. Understanding the inflammatory mechanisms involved may contribute to the development of novel therapies for both the acute and chronic disorders associated with COVID-19.
DRUG DISCOVERY TODAY
(2021)
Article
Medicine, General & Internal
Mingzhu Xu, Lihua Yan, Jialiang Xu, Xiangjun Yang, Tingbo Jiang
Article
Multidisciplinary Sciences
Shuqiang Zhang, Jialiang Xu, Zhisong He, Feng Xue, Tingbo Jiang, Mingzhu Xu
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Shipeng Dang, Zhen-Ye Zhang, Ku-Lin Li, Jie Zheng, Ling-Ling Qian, Xiao-Yu Liu, Ying Wu, Chang-Ying Zhang, Xiao-Xi Zhao, Zhi-Ming Yu, Ru-Xing Wang, Tingbo Jiang
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Xuguang Xu, Tingbo Jiang, Yong Li, Liusha Kong
Summary: This study demonstrated that endostatin improved cardiac dysfunction and hemodynamics, attenuated cardiac fibrosis and hypertrophy in MI-induced HF rats by inhibiting oxidative stress. Additionally, Nox4 overexpression inhibited the cardiac protective effects of endostatin.
BIOSCIENCE REPORTS
(2021)
Article
Physiology
Lin Liu, Xinyu Yang, Yiyu Gu, Tingbo Jiang, Jialiang Xu, Mingzhu Xu
Summary: The ACEF score has been identified as an effective predictor of poor in-hospital outcomes, worse cardiac recovery after 30 days, and higher rates of MACE, all-cause death, and heart failure at 1 year in patients with acute fulminant myocarditis, indicating its potential for assessing prognosis in these patients.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yunjuan Sun, Jialiang Xu, Zhisong He, Xujie Cheng, Tingbo Jiang
Summary: This study in a Chinese population investigated the clinical characteristics, angiographic findings, and clinical outcomes of young adults with acute myocardial infarction. Compared to older patients, young patients had different clinical features, such as milder condition and lower risk of death during hospitalization.
CARDIOLOGY JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Zuoxiang Wang, Mingyang Zhang, Yinan Xu, Yiyu Gu, Yumeng Song, Tingbo Jiang
Summary: Bioinformatic analysis identified differences and independent pathways between NIHF and IHF, as well as common potential markers and therapeutic targets in both types of heart failure.
PHARMACOGENOMICS & PERSONALIZED MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jie Zheng, Meng Wang, Qun-feng Tang, Feng Xue, Ku-lin Li, Shi-peng Dang, Xiao-yu Liu, Xiao-xi Zhao, Chang-ying Zhang, Zhi-ming Yu, Bing Han, Ting-bo Jiang, Yan Yao, Ru-Xing Wang
Summary: This study found that ablation technology, CHA(2)DS(2)-VASc score, history of cerebrovascular accident/transient ischemic attack, and low ejection fraction are associated with SCEs, with ablation technology being the only independent risk factor. Furthermore, RMN can significantly reduce the incidence of SCEs resulting from AF ablation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
