Article
Dermatology
Beata Kowalewska, Barbara Jankowiak, Elzbieta Krajewska-Kulak, Rafal Milewski, Marek Sobolewski
Summary: This study revealed that the quality of life and satisfaction of patients with psoriasis are significantly influenced by the stigma associated with the disease. Additionally, education level is closely related to overall satisfaction with life in these patients.
DERMATOLOGY AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Wei-Yu Chen, Shao-Chuan Chen, Shou-Yi Hsu, Yu-An Lin, Chun-Ming Shih, Chun-Yao Huang, Kuo-Hsien Wang, Ai-Wei Lee
Summary: Skin diseases have a significant impact on individuals and society, and there is a need for high attention and effective treatment methods in the medical field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ya-Chu Tsai, Tsen-Fang Tsai
Summary: Psoriasis and atopic dermatitis are now considered to be a spectrum of disease, with overlapping genetic loci and immunopathogenesis. The clinical presentations also have similarities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Anna Balato, Alexander Zink, Graziella Babino, Dario Buononato, Charlotte Kiani, Kilian Eyerich, Stefanie Ziehfreund, Emanuele Scala
Summary: This review examined candidate biomarkers and indicators associated with impaired quality of life in psoriasis and atopic dermatitis patients. Most of the included studies identified genomic or proteomic biomarkers associated with disease activity and quality of life outcomes. Sociodemographic, clinical, and therapeutic factors were also found to be related to reduced quality of life. Considering these factors in drug development programs can enhance the value of biomarkers and improve their future clinical utility as stratification tools.
Article
Psychology, Multidisciplinary
Bonney Reed, Kelly E. Rea, Robyn Lewis Claar, Miranda A. L. van Tilburg, Rona L. Levy
Summary: This study explores the impact of self-esteem and passive coping strategies on health-related quality of life in pediatric patients with inflammatory bowel disease. Results show that self-esteem is positively associated with HRQOL but negatively associated with passive coping. Self-esteem indirectly affects HRQOL through passive coping, particularly catastrophizing.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Roudin Sarama, Priya K. Matharu, Yousef Abduldaiem, Mab P. Correa, Cristiane D. Gil, Karin V. Greco
Summary: Psoriasis and Atopic Dermatitis are common inflammatory skin diseases with immune response dysregulation playing a crucial role in their pathogenesis. In vitro disease models have been widely used to study these conditions, but further development is needed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Youming Guo, Lingling Luo, Jing Zhu, Chengrang Li
Summary: Psoriasis and atopic dermatitis are inflammatory skin diseases with multiple causes and heterogeneity. Despite years of research, there is no cure, and the costs of caring for patients with these diseases are a significant burden on society. Integrating multiple omics datasets allows simultaneous analysis of genes, RNAs, chromatins, proteins, and metabolites, revealing networks between different molecular levels. This review discusses the latest developments in genomics, transcriptomics, proteomics, and metabolomics, and explores how they are used to identify biomarkers and understand the pathogenic mechanisms of these diseases. Finally, strategies for achieving multi-omics integration and the potential of integrative omics and systems biology in advancing our knowledge and treatment of psoriasis and atopic dermatitis are outlined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Dengmei Xia, Yiyi Wang, Yue Xiao, Wei Li
Summary: Single-cell RNA sequencing (scRNA-seq) is a new technology that characterizes molecular heterogeneity at the single-cell level. It provides a deeper understanding of cell diversity in inflammatory skin diseases and sheds new light on cell-cell communication in disease responses. It holds promise as a tool in precision medicine for defining cell subsets with potential treatment targets and characterizing cell-specific responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Natsuko Saito-Sasaki, Yu Sawada
Summary: This review provides detailed information on the interactions among various S100 proteins in inflammatory diseases, highlighting the significant role of S100 proteins as important substances in the inflammatory process of skin tissues.
Review
Biochemistry & Molecular Biology
Giorgia Condro, Marta Guerini, Michela Castello, Paola Perugini
Summary: The skin microbiota plays an important role in maintaining healthy skin, but its balance can be disrupted by various factors, leading to the development of skin diseases. The correlation between diseases like acne vulgaris, atopic dermatitis, rosacea and the skin microbiota is still unclear, and more research is needed to explore the specific subspecies and strains involved.
Article
Biochemistry & Molecular Biology
Aleksandra Klisic, Mirjana Bakic, Vesna Karanikolic
Summary: This study compared serum biomarkers of oxidative stress in patients with psoriasis and atopic dermatitis, finding that catalase exhibited good diagnostic accuracy in distinguishing between the two diseases. The results suggest the potential use of antioxidants as a therapeutic strategy for these skin inflammatory diseases.
Article
Biochemistry & Molecular Biology
Liis Ilves, Aigar Ottas, Bret Kaldvee, Kristi Abram, Ursel Soomets, Mihkel Zilmer, Viljar Jaks, Kulli Kingo
Summary: This study analyzed the metabolomic profiles of patients with atopic dermatitis (AD) and psoriasis (PS), and found clear differences between the two diseases. AD was associated with a deficient barrier function, while PS was associated with elevated cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Brian T. Cheng, Jonathan Silverberg
Summary: The study found a significant association between childhood atopic dermatitis (AD) and chronic school absenteeism in the United States, while there was no statistical difference in chronic absenteeism for children with psoriasis. Parents of children with AD were more likely to miss work for caregiving compared to those without AD, whereas parents of children with psoriasis had similar rates of work absenteeism compared to those without psoriasis.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Mattia Giovannini, Marta Bolis, Simona Barni, Giulia Liccioli, Lucrezia Sarti, Susanna Morelli, Matteo Pontone, Benedetta Pessina, Leonardo Tomei, Claudia Valleriani, Elio Novembre, Francesca Mori
Summary: This study describes the management of an infant with severe atopic dermatitis (AD) and multiple food sensitizations. A low-dose, gradual controlled oral food challenge (OFC) was performed to introduce sensitized foods into the infant's diet without allergic reactions. There is a need for extensive research in the field to improve evidence-based practices.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Dermatology
Silvia Mariel Ferrucci, Stefano Buffon, Angelo Valerio Marzano, Carlo Alberto Maronese
Summary: This report describes a case of phenotypic switching from atopic dermatitis to psoriasis in a 44-year-old male during treatment with upadacitinib. The patient had also experienced a similar course with dupilumab, highlighting the mutual antagonism between atopic dermatitis and psoriasis in predisposed individuals.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Patrick O. Perche, Madison K. Cook, Steven R. Feldman
Summary: This article reviews the efficacy and safety of abrocitinib as an oral medication for patients with moderate-to-severe atopic dermatitis. The study found that abrocitinib is effective in treating atopic dermatitis, with higher efficacy compared to other conventional medications, and has fewer side effects.
ANNALS OF PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Alexandra Taylor, Rohan Singh, Steven R. Feldman
Summary: This review highlights the pharmacokinetics, efficacy, and safety of recently approved calcipotriene and betamethasone dipropionate (C-BD) cream in the treatment of psoriasis. The results showed that C-BD cream was effective and safe, with higher treatment success rates compared to C-BD topical suspension and vehicle. The use of C-BD cream provides a convenient and preferred option for patients with mild-to-moderate psoriasis.
ANNALS OF PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Lindsey A. Mohney, Rohan Singh, Steven R. Feldman
Summary: This study reviews the pharmacokinetics, efficacy, and safety of a newly approved topical Janus kinase 1 (JAK) inhibitor, ruxolitinib (RUX), in patients with atopic dermatitis (AD). The results suggest that RUX is an effective and safe therapy for AD in adult patients.
ANNALS OF PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Rohan Singh, Alexandra Taylor, Milaan A. Shah, Lindsay C. Strowd, Steven R. Feldman
Summary: This study reviewed the pharmacokinetics, efficacy, and safety of tralokinumab in the treatment of atopic dermatitis (AD). Data analysis demonstrated that tralokinumab is effective and safe as a monotherapy, in combination with topical corticosteroids (TCS), and in patients with resistance or contraindication to oral cyclosporine. Tralokinumab, which is associated with overexpression of IL-13, is an efficacious systemic treatment for moderate-to-severe AD.
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Infectious Diseases
Patrick O. Perche, Gabrielle M. Peck, Lillian Robinson, Ayman Grada, Alan B. Fleischer Jr, Steven R. Feldman
Summary: Acne vulgaris is a common reason for patients to seek care from dermatologists in the US, but referring providers may be hesitant to prescribe acne treatments or certain medications. A study analyzed prescription rates for acne therapies from 1993 to 2016 and found that younger patients and privately insured patients were more likely to receive prescription treatments. Dermatologists were more likely to recommend prescription medications compared to family medicine and pediatric providers. Oral minocycline and oral doxycycline were the most commonly prescribed antibiotics, while benzoyl peroxide was the most utilized and recommended over-the-counter drug for acne.
Editorial Material
Dermatology
Heli Patel, Steven R. Feldman
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Christopher Alihosseini, Hannah Kopelman, Mallory Zaino, Steven R. Feldman
Summary: This study reviewed the safety and efficacy of avacopan for the treatment of ANCA-associated vasculitis. The results showed that avacopan can improve remission rates and reduce side effects caused by steroid use. Therefore, avacopan may be a new option for the treatment of ANCA-associated vasculitis.
ANNALS OF PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Diem-Phuong D. Dao, Jessica N. Pixley, Zeynep M. Akkurt, Steven R. Feldman
Summary: This article evaluates the effectiveness, safety, pharmacology, and clinical applications of topical sirolimus 0.2% gel for treating tuberous sclerosis complex (TSC)-associated facial angiofibromas. The gel showed improvement in tumor size and redness without any serious adverse events. It is considered a safe and effective noninvasive alternative to surgical procedures for TSC-related angiofibromas.
ANNALS OF PHARMACOTHERAPY
(2023)
Letter
Dermatology
Jessica N. Pixley, Mallory L. Zaino, Christina L. Kontzias, Rachel E. Tao, Steven R. Feldman
Summary: This study aimed to determine if showing patients their facial characteristics using an AI application would increase their use of sunscreen. The findings showed a decrease in self-reported sunscreen usage after the study, while skincare product usage remained unchanged.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
Rachel E. Tao, Jessica N. Pixley, Phillip G. Holovach, Alan B. Fleischer Jr, Steven R. Feldman
Summary: Off-label treatments are commonly used for pediatric psoriasis, with topical treatments, especially unapproved tacrolimus, being the most common approach. This may indicate a hesitance to use corticosteroids in children.
DERMATOLOGY AND THERAPY
(2023)
Review
Infectious Diseases
Rachel E. Tao, Stuti Prajapati, Jessica N. Pixley, Ayman Grada, Steven R. Feldman
Summary: Tetracycline-class drugs are commonly used in dermatology for treating skin diseases. This study reviewed the available evidence on whether taking these drugs with food affects their absorption and clinical efficacy. The study found that co-administration with food decreased systemic absorption of tetracycline, while the impact on doxycycline and minocycline varied. Oral sarecycline showed decreased absorption with food. Only sarecycline demonstrated limited or no impact of food intake on clinical efficacy. The study suggested considering patient adherence when choosing to take doxycycline, minocycline, and sarecycline with food.
Review
Pharmacology & Pharmacy
Rithi J. J. Chandy, Diem-Phuong D. Dao, Cristian C. C. Rivis, Divya M. M. Shan, Steven R. R. Feldman
Summary: The objective of this study was to compare the safety and efficacy of noncorticosteroid topical treatments for plaque psoriasis. A literature search was conducted, and relevant articles and clinical trial data were analyzed. Six classes of noncorticosteroid topicals were studied, and the results showed that they are effective and safe for treating plaque psoriasis.
JOURNAL OF PHARMACY TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Heli A. A. Patel, Rishab R. R. Revankar, Sofia T. T. Pedroza, Shaveonte Graham, Steven R. R. Feldman
Summary: Understanding the genetic factors in psoriasis can help improve targeted treatment strategies. This review discusses the genes associated with psoriasis pathogenesis and their connection to available treatment options. Searching various databases, relevant genetic markers and treatments were identified. Gene variants involved in inflammatory pathways, such as interleukins and interferons, are commonly implicated in psoriasis. Some treatments, like IL23 and TYK2 inhibitors, target genes associated with psoriasis. Multiple genes are involved in psoriasis pathogenesis, providing potential avenues for developing new treatment strategies and improving outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Rachel E. Tao, Jessica N. Pixley, Christina L. Kontzias, Steven R. Feldman
Summary: Drug efficacy is best evaluated through randomized, controlled, double-blind clinical trials, while safety assessment is more challenging. The Medical Dictionary for Regulatory Activities (MedDRA) is used to track and categorize adverse events (AE) during clinical trials. This study reviewed recent clinical trials on atopic dermatitis to demonstrate the importance of understanding MedDRA in evaluating adverse events related to herpes simplex virus (HSV) infection.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Review
Dermatology
Gaurav N. Pathak, Rithi J. Chandy, Vidisha Naini, Steven R. Feldman, Babar K. Rao
Summary: This study analyzed clinical trials on vitiligo and found that less than half of the trials used quality of life (QoL) assessments, with DLQI and CDLQI being the commonly used tools. As the number of trials increases, vitiligo-specific questionnaires may be more suitable for evaluating unique vitiligo-related concerns.
DERMATOLOGIC THERAPY
(2023)