Article
Neurosciences
Alina Solomon, Ron Handels, Anders Wimo, Riitta Antikainen, Tiina Laatikainen, Esko Levalahti, Markku Peltonen, Hilkka Soininen, Timo Strandberg, Jaakko Tuomilehto, Miia Kivipelto, Tiia Ngandu
Summary: The study demonstrates that a multidomain lifestyle intervention can reduce the risk of cognitive impairment in older adults, indicating the preventive potential of the intervention.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Shireen Sindi, Alina Solomon, Ingemar Kareholt, Iiris Hovatta, Riitta Antikainen, Tuomo Hanninen, Esko Levalahti, Tiina Laatikainen, Jenni Lehtisalo, Jaana Lindstrom, Teemu Paajanen, Markku Peltonen, Dharma Singh Khalsa, Benjamin Wolozin, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, Tiia Ngandu, Miia Kivipelto
Summary: This study found that a multidomain lifestyle intervention facilitated LTL maintenance among older people at risk for dementia. The maintenance of LTL was associated with more pronounced cognitive intervention benefits.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
So Young Moon, Seong A. Shin, Jee Hyang Jeong, Chang Hyung Hong, Yoo Kyoung Park, Hae Ri Na, Hong-Sun Song, Hee Kyung Park, Muncheong Choi, Sun Min Lee, Buong-O Chun, Jong-Min Lee, Seong Hye Choi
Summary: In the SUPERBRAIN study, we evaluated the impact of multidomain lifestyle intervention on regional homogeneity (ReHo) in resting-state functional brain magnetic resonance imaging (MRI) data. The facility-based intervention group showed increased ReHo values in the left medial orbitofrontal gyrus and right superior parietal lobule, which were positively correlated with changes in serum brain-derived neurotrophic factor (BDNF). The findings suggest that facility-based preventive strategies may have cognitive benefits through neuroplastic changes in functional processing circuits in the brain areas involved in adaptive learning and internally directed cognition.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Anders Rydstrom, Alexander Darin-Mattsson, Ingemar Kareholt, Tiia Ngandu, Jenni Lehtisalo, Alina Solomon, Riitta Antikainen, Lars Backman, Tuomo Hanninen, Tiina Laatikainen, Esko Levalahti, Jaana Lindstrom, Teemu Paajanen, Satu Havulinna, Markku Peltonen, Shireen Sindi, Hilkka Soininen, Anna Stigsdotter Neely, Timo Strandberg, Jaakko Tuomilehto, Miia Kivipelto, Francesca Mangialasche
Summary: Higher levels of occupational complexity are associated with better baseline cognition. However, the cognitive benefit of intervention did not vary significantly among participants with different levels of occupational complexity, except for occupational complexity related to data being associated with gains in executive function.
ALZHEIMERS & DEMENTIA
(2022)
Review
Nursing
Xiangfei Meng, Shuyan Fang, Shuang Zhang, Huanhuan Li, Dongfei Ma, Yaodong Ye, Jianping Su, Jiao Sun
Summary: Multidomain lifestyle interventions have the potential to reduce the risk of dementia and improve cognitive composite score, but there is no moderate- or high-certainty evidence that these interventions improve global cognition.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2022)
Review
Clinical Neurology
Alina Solomon, Ruth Stephen, Daniele Altomare, Emmanuel Carrera, Giovanni B. Frisoni, Jenni Kulmala, Jose Luis Molinuevo, Peter Nilsson, Tiia Ngandu, Federica Ribaldi, Bruno Vellas, Philip Scheltens, Miia Kivipelto
Summary: Despite the lack of established prevention strategies, there have been multidomain dementia prevention trials targeting various risk factors and disease mechanisms. This suggests the potential for precision risk reduction strategies through Brain Health Services, but more research is needed to determine the effectiveness and implementation of such interventions, especially in low- and middle-income countries.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Clinical Neurology
So Young Moon, Sohui Kim, Seong Hye Choi, Chang Hyung Hong, Yoo Kyoung Park, Hae Ri Na, Hong-Sun Song, Hee Kyung Park, Muncheong Choi, Sun Min Lee, Buong-O Chun, Jong-Min Lee, Jee Hyang Jeong
Summary: In the SUPERBRAIN study in South Korea, a facility-based and home-based intervention was evaluated for its impact on cortical thickness, brain volume, and serum BDNF levels. The results showed that the facility-based intervention led to increased cortical thickness and higher serum BDNF levels, suggesting potential benefits in preventing cognitive impairment and protecting brain health.
Article
Geriatrics & Gerontology
Ruth Stephen, Tiia Ngandu, Yawu Liu, Markku Peltonen, Riitta Antikainen, Nina Kemppainen, Tiina Laatikainen, Jyrki Lotjonen, Juha Rinne, Timo Strandberg, Jaakko Tuomilehto, Ritva Vanninen, Hilkka Soininen, Miia Kivipelto, Alina Solomon
Summary: The study investigated the association between change in CAIDE score and change in neuroimaging biomarkers, finding that reduction in CAIDE score during the intervention was associated with less decline in hippocampus volume. This exploratory finding needs further testing and validation in larger studies.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Biology
Osman Shabir, Ben Pendry, Llywelyn Lee, Beth Eyre, Paul S. Sharp, Monica A. Rebollar, David Drew, Clare Howarth, Paul R. Heath, Stephen B. Wharton, Sheila E. Francis, Jason Berwick
Summary: Neurovascular coupling is key for brain health, but its disruption is linked to neurological diseases like dementia. This study examines cortical haemodynamics in mouse models of Alzheimer's disease and atherosclerosis, finding reduced blood volume, altered haemoglobin levels, and neuroinflammation in atherosclerosis, as well as increased amyloid-beta plaques in the hippocampus. Importantly, electrode insertion worsens cortical spreading depression and leads to prolonged hypoxia in diseased animals. Atherosclerosis can negatively affect neurovascular health, and cardiovascular comorbidities can worsen Alzheimer's-related plaques.
Article
Geriatrics & Gerontology
Sun Min Lee, Sohui Kim, Jee Hyang Jeong, Chang Hyung Hong, Yoo Kyoung Park, Hae Ri Na, Hong-Sun Song, Hee Kyung Park, Muncheong Choi, Buong-O Chun, Seong Hye Choi, Jong-Min Lee, So Young Moon
Summary: This study evaluated the impact of facility-based and home-based interventions on white matter integrity and found that enhanced cognitive reserve after multidomain intervention can be revealed by changes in brain imaging.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Tiia Ngandu, Jenni Lehtisalo, Saana Korkki, Alina Solomon, Nicola Coley, Riitta Antikainen, Lars Backman, Tuomo Hanninen, Jaana Lindstrom, Tiina Laatikainen, Teemu Paajanen, Satu Havulinna, Markku Peltonen, Anna Stigsdotter Neely, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, Miia Kivipelto
Summary: Active participation in multidomain lifestyle interventions is associated with better cognitive functioning, especially in overall cognition and executive function. Future interventions should be more intensive and support adherence to lifestyle changes.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Jeroen Bruinsma, Irene Heger, Vasileios S. Loukas, Thomas Kassiotis, Georgia Karanasiou, Dimitrios I. Fotiadis, Sten Hanke, Rik Crutzen
Summary: This study explores the public's openness towards dementia risk reduction and willingness towards changing lifestyle behavior to reduce future dementia risk. The results indicate that many individuals have difficulty understanding the concept of dementia risk reduction and hold ambivalent attitudes towards behavior change. Support is needed for individuals who face barriers such as negative self-image, engaging in multiple unhealthy behaviors, and holding unrealistic perceptions about lifestyle change.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
H. H. Feldman, S. Belleville, H. B. Nygaard, M. Montero-Odasso, J. Durant, J. -L. Lupo, C. Revta, S. Chan, M. Cuesta, P. J. Slack, S. Winer, P. W. H. Brewster, S. M. Hofer, A. Lim, A. Centen, D. M. Jacobs, N. D. Anderson, J. D. Walker, M. R. Speechley, G. Y. Zou, H. Chertkow
Summary: The CAN-THUMBS UP study aims to develop an interactive online Brain Health Support Program intervention to positively influence dementia literacy and lifestyle risk factors. The study will enroll and retain a Platform Trial Cohort of individuals at risk of dementia, and evaluate the effectiveness of the intervention through various measurements. This fully remote study provides an accessible and convenient approach to research in the participants' home environment.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Eun Hye Lee, Geon Ha Kim, Hee Kyung Park, Hae Jin Kang, Yoo Kyoung Park, Hye Ah Lee, Chang Hyung Hong, So Young Moon, Woorim Kang, Hyun-Seok Oh, Hai-Jeon Yoon, Seong Hye Choi, Jee Hyang Jeong
Summary: The SUPERBRAIN-based multidomain intervention with nutritional supplements has shown significant improvement in cognition and gut microbiota in patients with early symptomatic Alzheimer's disease who were amyloid-positive by PET.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Wing Shan Yu, Luca Aquili, Kah Hui Wong, Amy Cheuk Yin Lo, Leanne Lai Hang Chan, Ying-Shing Chan, Lee Wei Lim
Summary: Noninvasive visual stimulation is a novel concept that may be applicable for treating dementia. This study found that transcorneal electrical stimulation (TES) improved memory performance in aged mice and a mouse model of Alzheimer's disease, and reduced plaque deposition in the hippocampus of male 5XFAD mice. The findings suggest that TES shows promise as a potential treatment for cognitive dysfunction.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Clinical Neurology
K. A. Abbott, J. M. Posma, S. Garcia-Perez, C. Udeh-Momoh, S. Ahmadi-Abhari, L. Middleton, G. Frost
Summary: Diet is an important modifiable factor in reducing the risk of Alzheimer's Disease and age-related cognitive decline. However, accurate assessment of dietary exposures is challenging due to misreporting and measurement errors. The use of -omics technologies can improve reliability and provide new insights into pre-disease indicators and preventive targets for cognitive aging and dementia.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
J. Ford, D. Kafetsouli, H. Wilson, C. Udeh-Momoh, M. Politis, S. AhmadiAbhari, I Rabiner, L. T. Middleton
Summary: Neuroimaging plays a crucial role in Alzheimer's disease and related dementia research, helping us understand the brain's structure, function, and disease progression. Technological advancements in this field have provided powerful tools to visualize and study the brain, bringing us closer to the goal of dementia prevention.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
B. Zheng, B. Su, C. Udeh-Momoh, G. Price, I Tzoulaki, E. P. Vamos, A. Majeed, E. Riboli, S. Ahmadi-Abhari, L. T. Middleton
Summary: This study found that cardiovascular and non-cardiovascular comorbidities in patients with type 2 diabetes are associated with an increased risk of dementia. Preventing and effectively managing these comorbidities is crucial for maintaining cognitive health in patients with diabetes.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2022)
Editorial Material
Clinical Neurology
G. Price, C. Udeh-Momoh, M. Kivipelto, Lefkos T. Middleton
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2022)
Review
Clinical Neurology
Martha del Campo, Henrik Zetterberg, Sam Gandy, Chiadi U. Onyike, Fabricio Oliveira, Chi Udeh-Momoh, Alberto Lleo, Charlotte E. Teunissen, Yolande Pijnenburg
Summary: Frontotemporal dementia (FTD) is a neurodegenerative disorder with diverse clinical and pathological features. The development of specific diagnostic biomarkers, disease staging markers, and treatment response markers is important but challenging.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Patrick Oeckl, Marina Bluma, Marco Bucci, Steffen Halbgebauer, Konstantinos Chiotis, Anna Sandebring-Matton, Nicholas J. Ashton, Guglielmo Di Molfetta, Lana Grotschel, Miia Kivipelto, Kaj Blennow, Henrik Zetterberg, Irina Savitcheva, Agneta Nordberg, Markus Otto
Summary: Plasma beta-synuclein levels were found to be higher in individuals with Alzheimer's disease and mild cognitive impairment with amyloid-beta positivity. It demonstrated good discrimination and prediction of amyloid-beta status. The correlation between plasma beta-synuclein and amyloid-beta PET was observed in multiple cortical regions. These findings suggest that beta-synuclein is not a direct marker of amyloid-beta pathology and highlight the different longitudinal dynamics of synaptic degeneration and amyloid deposition in Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2023)
Editorial Material
Clinical Neurology
Gladys Maestre, Maria Carrillo, Raj Kalaria, Daisy Acosta, Larry Adams, Thierry Adoukonou, Kazeem Akinwande, Joshua Akinyemi, Rufus Akinyemi, Onoja Akpa, Suvarna Alladi, Ricardo Allegri, Raul Arizaga, Faheem Arshad, Oyedunni Arulogun, David Ndetei, Olusegun Baiyewu, Thomas Issac, Tarek Bellaj, Judith Boshe, Carol Brayne, David Brodie-Mends, Richard Brown, Jennifer Cahn, Nkouonlack Cyrille, Albertino Damasceno, Ranil de Silva, Rohan de Silva, Mamuka Djibuti, Anna Jane Dreyer, Ratnavalli Ellajosyula, Temitope Farombi, Bernard Fongang, Stefania Forner, Rob Friedland, Noe Garza, Antoine Gbessemehlan, Eliza (Eleni-Zacharoula) Georgiou, Riadh Gouider, Ishtar Govia, Lea Grinberg, Maelenn Guerchet, Seid Gugssa, Joy Louise Gumikiriza-Onoria, Deborah Gustafson, Eef Hogervorst, Michael Hornberger, Agustin Ibanez, Masafumi Ihara, Ozama Ismail, Thomas Issac, Linus Joensson, Celestin Kaputu, Wambui Karanja, Jackline Karungi, Desire Tshala-Katumbay, Brian Kunkle, Joseph H. Lee, Iracema Leroi, Raphaella Lewis, Gill Livingston, Francisco Lopera, Kamada Lwere, Facundo Manes, Lingani Mbakile-Mahlanza, Pedro Mena, Bruce Miller, Athanase Millogo, Abdul Mohamed, Christine Musyimi, Victoria Mutiso, Noeline Nakasujja, David Ndetei, Sam Nightingale, Alfred K. Njamnshi, Gabriela Novotni, Primrose Nyamayaro, Solomon Nyame, Julius Ogeng'o, Adesola Ogunniyi, Maira Okada De Oliveira, Njideka Okubadejo, Martin Orrell, Akintunde Orunmuyi, Mayowa Owolabi, Stella Paddick, Margaret A. Pericak-Vance, Zvezdan Pirtosek, Felix Potocnik, Bill Preston, Rema Raman, Kirti Ranchod, Mie Rizig, Monica Rosselli, Roy Deepa, Upal Roy, Marufjon Salokhiddinov, Mary Sano, Fred Sarfo, Claudia L. Satizabal, Diego Sepulveda-Falla, Sudha Seshadri, Claire Sexton, Ingmar Skoog, Peter St George-Hyslop, Claudia Suemoto, Jeremy Tanner, Prekshya Thapa, Kamadore Toure, Valentine Ucheagwu, Chinedu Udeh-Momoh, Victor Valcour, Jeffery Vance, Mathew Varghese, Jaime Vera, Richard Walker, Wendy Weidner, Walsh Sebastian, Patrice Whitehead Gay, Henrik Zetterberg, Yared Zewde
ALZHEIMERS & DEMENTIA
(2023)
Review
Public, Environmental & Occupational Health
Dagfinn Aune, Sabrina Schlesinger, Yahya Mahamat-Saleh, Bang Zheng, Chinedu T. T. Udeh-Momoh, Lefkos T. T. Middleton
Summary: A systematic review and meta-analysis found that diabetes mellitus and prediabetes were associated with an increased risk of developing Parkinson's disease. This association was consistent across different geographic regions, sexes, and subgroups, and diabetes patients with complications had a higher risk. Further research is needed to investigate the role of age of onset, duration, complications, glycemic level, and management of diabetes in relation to Parkinson's disease risk.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Neurosciences
Vilma Alanko, Adhara Gaminde-Blasco, Tania Quintela-Lopez, Raul Loera-Valencia, Alina Solomon, Ingemar Bjorkhem, Angel Cedazo-Minguez, Silvia Maioli, Graziella Tabacaru, Maria Latorre-Leal, Carlos Matute, Miia Kivipelto, Elena Alberdi, Anna Sandebring-Matton
Summary: Oxidized cholesterol metabolite 27-hydroxycholesterol (27-OH) is a potential link between hypercholesterolemia and neurodegenerative diseases as it can cross the blood-brain barrier. This study found that high levels of 27-OH can impact oligodendrocyte function and contribute to the disconnection of neural networks in neurodegenerative diseases.
Article
Immunology
Dickson O. Adedeji, Jasper Holleman, Robert-Paul Juster, Chinedu T. Udeh-Momoh, Ingemar Kareholt, Goran Hagman, Malin Aspo, Sofia Adagunodo, Krister Hakansson, Miia Kivipelto, Alina Solomon, Shireen Sindi
Summary: This study aims to assess the association between allostatic load (AL) and Alzheimer's disease (AD) biomarkers as well as cognitive function. The results showed that higher AL was associated with increased brain amyloid accumulation, suggesting that AL may play a role in the pathophysiology of AD/dementia.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2023)
Article
Clinical Neurology
A. Sadlon, P. Takousis, E. Evangelou, I. Prokopenko, P. Alexopoulos, C. -M. Udeh-Momoh, G. Price, L. Middleton, Robert Perneczky
Summary: Investigating miRNA as a blood biomarker for early cognitive decline in older adults is important for identifying individuals with Alzheimer's disease (AD) before symptoms appear. The study found that six miRNAs were downregulated in the blood of individuals with low cognitive performance, indicating involvement of apoptosis and inflammation in early stages of AD. Polymorphisms within these miRNAs were associated with CSF levels of amyloid-beta 42, soluble-TREM2, and BACE1 activity.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)
Article
Cell Biology
Clara Vila-Castelar, Chinedu Udeh-Momoh, Neelum T. Aggarwal, Michelle M. Mielke
Summary: Studies have found sex and/or gender differences in Alzheimer's disease, but little research has been conducted on other dementias. This article highlights the sex and gender differences in other forms of dementia, explores sociocultural factors, and provides a framework for future global studies.
Article
Clinical Neurology
C. Udeh-Momoh, B. Zheng, A. Sandebring-Matton, G. Novak, M. Kivipelto, L. Jonsson, L. Middleton
Summary: This study validated the capacity of plasma A beta 42/A beta 40 measured using six different assays to predict amyloid positivity in cognitively unimpaired participants and discriminating between cognitively unimpaired and Alzheimer's disease cases. The use of ultrasensitive immunoassays and high-performance immunoprecipitation coupled with mass spectrometry for measurement of plasma A beta 42/A beta 40 showed diagnostic value in detecting PET amyloid positivity, with potential clinical utility in AD prevention trials and clinical care.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2022)