Personalized modulation of coagulation factors using a thrombin dynamics model to treat trauma-induced coagulopathy

Variations and obstacles in the use of coagulation factor concentrates for major trauma bleeding across Europe: outcomes from a European expert meeting

(2021) Vladimir Černý et al.   European Journal of Trauma and Emergency Surgery

Trauma-induced coagulopathy

(2021) Ernest E. Moore et al.   Nature Reviews Disease Primers

Accelerating availability of clinically-relevant parameter estimates from Thromboelastogram point-of-care device

(2020) Michelle A. Pressly et al.   Journal of Trauma and Acute Care Surgery

Comparison of fresh frozen plasma vs. coagulation factor concentrates for reconstitution of blood

(2020) Johannes Gratz et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Towards patient-specific management of trauma hemorrhage: the effect of resuscitation therapy on parameters of thromboelastometry

(2019) N.P. Juffermans et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Dynamic multi-outcome prediction after injury: Applying adaptive machine learning for precision medicine in trauma

(2019) S. Ariane Christie et al.   PLoS One

Pathophysiological Response to Trauma-Induced Coagulopathy

(2019) Patricia Duque et al.   ANESTHESIA AND ANALGESIA

Mathematical model of thrombin generation and bleeding phenotype in Amish carriers of Factor IX:C deficiency vs. controls

(2019) S. Gupta et al.   THROMBOSIS RESEARCH

Impact of a goal-directed factor-based coagulation management on thromboembolic events following major trauma

(2019) Anais L. Stein et al.   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

Outcomes following trauma laparotomy for hypotensive trauma patients

(2018) Max Marsden et al.   Journal of Trauma and Acute Care Surgery

Outcomes following trauma laparotomy for hypotensive trauma patients

(2018) Max Marsden et al.   Journal of Trauma and Acute Care Surgery

Kreuth IV: European consensus proposals for treatment of haemophilia with coagulation factor concentrates

(2017) P. L. F. Giangrande et al.   HAEMOPHILIA

Use of factor concentrates for the management of perioperative bleeding: guidance from the SSC of the ISTH

(2017) A. Godier et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mortality after emergent trauma laparotomy

(2017) John A. Harvin et al.   Journal of Trauma and Acute Care Surgery

Targeted clinical control of trauma patient coagulation through a thrombin dynamics model

(2017) Amor A. Menezes et al.   Science Translational Medicine

Point-of-Care Coagulation Monitoring in Trauma Patients

(2017) Philipp Stein et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Machine Learning for Predicting Outcomes in Trauma

(2017) Nehemiah T. Liu et al.   SHOCK

Clinical evaluation of glycoPEGylated recombinant FVIII: Efficacy and safety in severe haemophilia A

(2017) Tatiana Andreeva et al.   THROMBOSIS AND HAEMOSTASIS

Mortality after emergent trauma laparotomy

(2017) John A. Harvin et al.   Journal of Trauma and Acute Care Surgery

Association Between Ratio of Fresh Frozen Plasma to Red Blood Cells During Massive Transfusion and Survival Among Patients Without Traumatic Injury

(2017) Tomaz Mesar et al.   JAMA Surgery

Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a single-centre, parallel-group, open-label, randomised trial

(2017) Petra Innerhofer et al.   Lancet Haematology

Acute traumatic coagulopathy: pathophysiology and resuscitation

(2016) J.W. Simmons et al.   BRITISH JOURNAL OF ANAESTHESIA

Precision Medicine for Critical Illness and Injury

(2016) Timothy G. Buchman et al.   CRITICAL CARE MEDICINE

Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy

(2016) Mark Walsh et al.   CURRENT DRUG TARGETS

Detailed Description of All Deaths in Both the Shock and Traumatic Brain Injury Hypertonic Saline Trials of the Resuscitation Outcomes Consortium

(2015) Samuel A. Tisherman et al.   ANNALS OF SURGERY

Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma

(2015) John B. Holcomb et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Factor IX complex for the correction of traumatic coagulopathy

(2015) Bellal Joseph et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Measuring thrombin generation as a tool for predicting hemostatic potential and transfusion requirements following trauma

(2014) Jessica C. Cardenas et al.   Journal of Trauma and Acute Care Surgery

Changing Patterns of In-Hospital Deaths Following Implementation of Damage Control Resuscitation Practices in US Forward Military Treatment Facilities

(2014) Nicholas R. Langan et al.   JAMA Surgery

Trauma Bleeding Management

(2013) Herbert Schöchl et al.   ANESTHESIA AND ANALGESIA

Is there value in kinetic modeling of thrombin generation? Yes

(2012) K. G. MANN   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration

(2012) Bryan A. Cotton et al.   Journal of Trauma and Acute Care Surgery

Extracellular histone release in response to traumatic injury

(2012) Matthew E. Kutcher et al.   Journal of Trauma and Acute Care Surgery

The Prothrombotic Phenotypes in Familial Protein C Deficiency Are Differentiated by Computational Modeling of Thrombin Generation

(2012) Kathleen E. Brummel-Ziedins et al.   PLoS One

The Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) Study

(2012) John B. Holcomb et al.   JAMA Surgery

Damage Control Resuscitation Is Associated With a Reduction in Resuscitation Volumes and Improvement in Survival in 390 Damage Control Laparotomy Patients

(2011) Bryan A. Cotton et al.   ANNALS OF SURGERY

Critical Role of Activated Protein C in Early Coagulopathy and Later Organ Failure, Infection and Death in Trauma Patients

(2011) Mitchell Jay Cohen et al.   ANNALS OF SURGERY

Effect of Blood Products Transfusion on the Development of Postinjury Multiple Organ Failure

(2010) Jeffrey L. Johnson   ARCHIVES OF SURGERY

Ensembles of uncertain mathematical models can identify network response to therapeutic interventions

(2010) Deyan Luan et al.   Molecular BioSystems

Review article: Coagulation cascade and therapeutics update: Relevance to nephrology. Part 1: Overview of coagulation, thrombophilias and history of anticoagulants

(2009) REBECCA L C ADAMS et al.   NEPHROLOGY

Protein C Depletion Early After Trauma Increases the Risk of Ventilator-Associated Pneumonia

(2009) Mitchell J. Cohen et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

The OPALS Major Trauma Study: impact of advanced life-support on survival and morbidity

(2008) I. G. Stiell et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Hypercoagulability after trauma: Hemostatic changes and relationship to venous thromboembolism

(2008) R. Selby et al.   THROMBOSIS RESEARCH