Article
Medicine, General & Internal
Hee Jeung Lim, Jiyu Sun, Banhyang Min, Myungeun Song, Tae Hun Kim, Byoung Jae Kim, Kyu Ri Hwang, Taek Sang Lee, Hye Won Jeon, Sun Min Kim
Summary: Endometriosis is a major cause of infertility and can lead to adverse pregnancy outcomes. This study compared the clinical characteristics and pregnancy outcomes of women with and without endometriosis, finding that women with endometriosis had significantly more adverse pregnancy outcomes. Additionally, the endometriosis group had a higher rate of cesarean delivery and postpartum complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Chiara Cerra, Roberta Morelli, Daniele Di Mascio, Danilo Buca, Francesca Di Sebastiano, Marco Liberati, Francesco D'Antonio
Summary: Early cesarean delivery in preterm mothers has a high rate of maternal intra- and postoperative complications, including hemorrhage, blood transfusion, and damage to adjacent organs. Women undergoing cesarean delivery at <28 and <26 weeks of gestation have a higher probability of experiencing adverse maternal outcomes.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)
Review
Medicine, General & Internal
Kjerstine Breintoft, Regitze Pinnerup, Tine Brink Henriksen, Dorte Rytter, Niels Uldbjerg, Axel Forman, Linn Hakonsen Arendt
Summary: Women with endometriosis are at increased risk of gestational hypertension, pre-eclampsia, preterm birth, placenta previa, placental abruption, cesarean section, and stillbirth during pregnancy. Some studies suggest a potential association between endometriosis and spontaneous hemoperitoneum and bowel perforation in pregnancy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Obstetrics & Gynecology
Fan Yang, Han Wang, Mengdie Shen
Summary: The prophylactic administration of tranexamic acid (TXA) before cesarean section significantly reduces intraoperative, 2-hour postpartum, and total blood loss, as well as the decline in hemoglobin. However, it does not significantly affect blood loss at 6-hour postpartum. Therefore, prophylactic intravenous TXA is helpful in preventing perioperative bleeding in women undergoing cesarean section.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Review
Obstetrics & Gynecology
Athanasios F. Kallianidis, Douwe Rijntjes, Carolien Brobbel, Olaf M. Dekkers, Kitty W. M. Bloemenkamp, Thomas van den Akker
Summary: This study aims to describe the global incidence, indications, risk factors, outcomes, and management of emergency peripartum hysterectomy, and compare outcomes among different income settings. The study found substantial differences in the incidence of emergency peripartum hysterectomy across income settings, with higher rates observed in lower-income settings. Women in lower-income settings also experienced higher morbidity and mortality related to the procedure.
OBSTETRICS AND GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Megan C. Oakes, Molly Reese, Graham A. Colditz, Carolyn R. T. Stoll, Angela Hardi, Lauren D. Arnold, Antonina I. Frolova
Summary: A total of 14 studies including 11,944 patients were analyzed to evaluate the effectiveness of pharmacologic VTE prophylaxis in postpartum patients. The results suggested that there was no significant difference in the risk of VTE between patients who were exposed to postpartum pharmacologic VTE prophylaxis and those who were unexposed. However, due to the rarity of VTE events, the current literature provided an insufficient sample size to draw a conclusion.
OBSTETRICS AND GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Holly B. Ende, M. James Lozada, David H. Chestnut, Sarah S. Osmundson, Rachel L. Walden, Matthew S. Shotwell, Jeanette R. Bauchat
Summary: This study aimed to identify and quantify risk factors for atonic postpartum hemorrhage through a systematic review of English language studies. Out of 47 potential risk factors identified, 15 were classified as definite or likely risk factors, while the remaining 32 showed no association or had conflicting evidence with atonic postpartum hemorrhage. Many established risk factors were confirmed, with additional novel factors such as hypertension, diabetes, and ethnicity identified.
OBSTETRICS AND GYNECOLOGY
(2021)
Review
Obstetrics & Gynecology
Nathan Obore, Zhang Liuxiao, Yu Haomin, Tao Yuchen, Lina Wang, Yu Hong
Summary: This study evaluated the efficacy and safety of intraoperative cell salvage (IOCS) in women at high risk of postpartum hemorrhage (PPH). The study found that patients who received IOCS had higher postoperative hemoglobin levels, shorter hospital stays, and shorter prothrombin time. Additionally, IOCS use reduced the incidence of adverse events related to allogeneic blood transfusion.
REPRODUCTIVE SCIENCES
(2022)
Review
Obstetrics & Gynecology
Nada Mostafa Al-dardery, Omar Ahmed Abdelwahab, Mohamed Abouzid, Khaled Albakri, Ali Elkhadragy, Basant E. Katamesh, Rawan Hamamreh, Ahmed B. Mohd, Ahmed Abdelaziz, Abdulrhman Khaity
Summary: This meta-analysis suggests that the administration of TXA is effective in reducing total blood loss and limiting the occurrence of postpartum hemorrhage in women undergoing cesarean birth or vaginal birth. However, for vaginal birth, the use of TXA may increase the occurrence of nausea and/or vomiting.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Obstetrics & Gynecology
Alison DiSciullo, Neggin Mokhtari, Helain Landy, Tetsuya Kawakita
Summary: In women undergoing cesarean delivery, preoperative mild thrombocytopenia was not significantly associated with postpartum hemorrhage, red blood cell transfusion, wound complications, or postpartum emergency department visits.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)
Article
Medicine, General & Internal
Yanhua Zhang, Lu Chen, Weixiao Zhou, Jun Lin, Hong Wen
Summary: This study aimed to develop a nomogram to predict the risk of postpartum hemorrhage in cesarean delivery for twin pregnancies. Propensity score matching was used to create a reliable prediction model, which demonstrated good prediction and clinical utility, providing valuable guidance for clinicians.
FRONTIERS IN MEDICINE
(2023)
Article
Obstetrics & Gynecology
Maryalice Wolfe, Jamil M. Kazma, Ann B. Burke, Homa K. Ahmadzia
Summary: The implementation of a colorimetric quantitative blood loss (QBL) system during cesarean delivery did not improve clinical outcomes. There was no difference in the prevalence of postpartum hemorrhage, amount of blood products transfused, or length of hospital stay. However, there was a significant decrease in ICU admissions.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Review
Obstetrics & Gynecology
Shinya Matsuzaki, Yoshikazu Nagase, Yutaka Ueda, Misooja Lee, Satoko Matsuzaki, Michihide Maeda, Tsuyoshi Takiuchi, Aiko Kakigano, Kazuya Mimura, Masayuki Endo, Takuji Tomimatsu, Tadashi Kimura
Summary: Endometriosis is associated with a higher rate of placenta previa during pregnancy, as well as adverse surgical outcomes including increased intraoperative bleeding and postpartum hemorrhage during cesarean delivery. However, there is limited research on the surgical outcomes of patients with endometriosis developing placenta previa.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)
Review
Obstetrics & Gynecology
Shunya Sugai, Koji Nishijima, Kazufumi Haino, Kosuke Yoshihara
Summary: This study aimed to identify trends in pregnancy outcomes, especially delivery mode, among pregnant patients older than 45 years. A total of 24 retrospective, observational studies were included in the review. The results showed that pregnant patients aged >= 45 years had a significantly higher cesarean delivery rate and a lower emergency cesarean delivery rate compared to those aged <45 years. In addition, older pregnant patients had a lower assisted delivery rate and a higher risk of preeclampsia, gestational diabetes mellitus, placenta previa, placental abruption, postpartum hemorrhage, and preterm birth.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Review
Obstetrics & Gynecology
Ian J. J. Saldanha, Gaelen P. P. Adam, Ghid Kanaan, Michael L. L. Zahradnik, Dale W. W. Steele, Kenneth K. K. Chen, Alex F. F. Peahl, Valery A. A. Danilack-Fekete, Alison M. M. Stuebe, Ethan M. M. Balk
Summary: Various strategies in postpartum care have shown improvement in certain aspects, but there is a need for further research on the most effective delivery strategies to enhance postpartum health.
OBSTETRICS AND GYNECOLOGY
(2023)
Letter
Obstetrics & Gynecology
Shinya Matsuzaki, Harue Hayashida, Shoji Kamiura
REPRODUCTIVE SCIENCES
(2023)
Article
Obstetrics & Gynecology
Eiji Kobayashi, Mamoru Kakuda, Yutaka Ueda, Tadashi Kimura
Summary: Laparoscopic radical hysterectomy (LRH) has been shown to have similar oncologic outcome as abdominal radical hysterectomy (ARH) for cervical cancer in retrospective studies. However, recent research indicates that minimally invasive approaches are associated with a higher rate of recurrence and death. The reasons for the poorer prognosis of LRH compared to ARH are currently unclear.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Oncology
Atsuko Sakakibara, Takeo Nakayama, Hiroyuki Uchida, Youichi Odagiri, Yuri Ito, Toshiro Katayama, Yutaka Ueda, Toshihiro Higuchi, Koichi Terakawa, Kunihiko Matsui, Kikuko Miyazaki, Ikuo Konishi
Summary: Contrary to other developed countries, in Japan, recent years have seen increases in cervical cancer incidence and mortality among young people. However, the human papillomavirus (HPV) vaccine program, a key measure for avoiding cervical cancer, has been virtually suspended. This study aimed to determine the current status and future trends of cervical cancer and precancerous lesions in Japan. The findings revealed an increasing cervical disease burden among reproductive age females in Japan, and projections show that without effective implementation of HPV vaccine programs and screening, there will be further increases in cervical cancer incidence and mortality.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Cell Biology
Yu Ito, Jumpei Kondo, Masamune Masuda, Shinya Matsuzaki, Kunishige Onuma, Mizuki Kanda, Yuko Watanabe, Hitomi Sakaguchi, Kiyoshi Yoshino, Yutaka Ueda, Shoji Kamiura, Tadashi Kimura, Masahiro Inoue
Summary: Selecting the best treatment for individual patients with cancer is crucial for improving clinical outcomes. Recent progress in organoid culture may offer new possibilities for personalized medicine. However, the sensitivity assay using organoids is not currently able to predict clinical outcomes.
Article
Oncology
Yusuke Oji, Naoki Kagawa, Hideyuki Arita, Norifumi Naka, Ken-ichiro Hamada, Hidetatsu Outani, Yasushi Shintani, Yoshito Takeda, Eiichi Morii, Kenzo Shimazu, Motoyuki Suzuki, Sumiyuki Nishida, Jun Nakata, Akihiro Tsuboi, Miki Iwai, Sae Hayashi, Rin Imanishi, Sayaka Ikejima, Mizuki Kanegae, Masahiro Iwamoto, Mayu Ikeda, Kento Yagi, Haruka Shimokado, Hiroko Nakajima, Kana Hasegawa, Soyoko Morimoto, Fumihiro Fujiki, Akira Nagahara, Atsushi Tanemura, Yutaka Ueda, Tsunekazu Mizushima, Masato Ohmi, Takayuki Ishida, Manabu Fujimoto, Norio Nonomura, Tadashi Kimura, Hidenori Inohara, Seiji Okada, Haruhiko Kishima, Naoki Hosen, Atsushi Kumanogoh, Yoshihiro Oka, Haruo Sugiyama
Summary: Therapeutic options for rare cancers are limited, necessitating the development of novel strategies. Our clinical study showed that a biweekly WT1 Trio peptide vaccine induced stronger immune responses against WT1 compared to a weekly WT1-CTL peptide vaccine. The vaccine was confirmed to be safe, with only one patient experiencing severe adverse events. Fifteen out of 45 patients achieved stable disease after 3 months of treatment, suggesting that WT1-targeted immunotherapy may be a potential strategy for rare cancers.
Review
Biochemistry & Molecular Biology
Yuki Takemoto, Shinya Matsuzaki, Satoko Matsuzaki, Mamoru Kakuda, Misooja Lee, Harue Hayashida, Michihide Maeda, Shoji Kamiura
Summary: This study aimed to review the current evidence on type III vasa previa. A systematic review showed that type III vasa previa accounts for 5.7% of vasa previa cases. The characteristics and obstetric outcomes of type III vasa previa were similar to type I vasa previa. Further studies are warranted to obtain more evidence on type III vasa previa.
Article
Orthopedics
Mamoru Kakuda, Eiji Kobayashi, Shinya Matsuzaki, Yutaka Ueda, Kiyoshi Yoshino, Tadashi Kimura
Summary: This study validates the impact of an educational system for first assistant laparoscopic surgeon residency. Through the use of slide-set tools and video reviews, our training has been shown to improve residents' scores and help them master skills similar to those of experienced attending doctors.
ASIAN JOURNAL OF ENDOSCOPIC SURGERY
(2023)
Letter
Obstetrics & Gynecology
Shinya Matsuzaki, Takeya Hara, Masayuki Endo, Tadashi Kimura
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Oncology
Ai Yoshino, Eiji Kobayashi, Takahiro Tsuboyama, Hideyuki Fukui, Noriyuki Tomiyama, Kazuaki Sato, Eiichi Morii, Eiji Nakatani, Naoko Komura, Ikuko Sawada, Yusuke Tanaka, Kensuke Hori, Akihiko Yoshimura, Ryoko Takahashi, Tadashi Iwamiya, Tsuyoshi Hisa, Sadako Nishimura, Toshihiro Kitai, Hiromi Yokota, Mariko Shindo, Hiromi Miyata, Namiko Hashimoto, Kanako Sakiyama, Hazuki Abe, Yutaka Ueda, Tadashi Kimura
Summary: The purpose of this study was to investigate the clinical practices of diagnosing multicystic cervical lesions in order to develop a more appropriate diagnostic algorithm for gastric-type adenocarcinoma (GAS) and its precursors. Clinical information for 159 surgically treated patients was collected and reviewed, and the combination of cytology and MRI findings significantly improved the diagnostic accuracy for differentiating benign disease from premalignancy and malignancy.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Yuko Watanabe, Yutaka Ueda, Asami Yagi, Sayaka Ikeda, Emiko Oka, Mamoru Kakuda, Satoshi Nakagawa, Kosuke Hiramatsu, Ai Miyoshi, Eiji Kobayashi, Toshihiro Kimura, Tadashi Kimura
Summary: In November 2021, the Japanese government reversed its 2013 decision to suspend the proactive recommendation for HPV vaccination. However, the implementation of routine and catch-up vaccinations for young girls did not go as planned. A nationwide questionnaire survey conducted in September 2022 revealed disparities among municipalities in their HPV vaccine notification processes. Monitoring HPV vaccination rates and incidence rates of cervical cancer and precancerous lesions in each municipality will be important for future research.
Article
Oncology
Yuji Kamei, Eiji Kobayashi, Eiji Nakatani, Mayu Shiomi, Masaaki Sawada, Mamoru Kakuda, Aska Toda, Satoshi Nakagawa, Kosuke Hiramatsu, Yasuto Kinose, Tsuyoshi Takiuchi, Ai Miyoshi, Michiko Kodama, Kae Hashimoto, Toshihiro Kimura, Yutaka Ueda, Kenjiro Sawada, Tadashi Kimura
Summary: This study assesses the feasibility of minimally invasive surgery (MIS) for well-selected epithelial ovarian cancer (EOC) patients. Data from a single center from 2017 to 2022 were reviewed, and a meta-analysis of similar studies comparing laparoscopy and laparotomy outcomes was performed. The results support the possibility of conducting MIS for EOC in well-selected patients.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Seiji Mabuchi, Tomoyuki Sasano, Naoko Komura, Michihide Maeda, Shinya Matsuzaki, Tsuyoshi Hisa, Shoji Kamiura, Toshitaka Morishima, Isao Miyashiro
Summary: A population-based study was conducted to investigate the efficacy of minimally invasive surgery in the treatment of uterine-confined and node-negative cervical cancer in Japan. The results showed that there was no difference in survival outcomes between minimally invasive surgery and open surgery in Japanese patients with FIGO 2018 stage I cervical cancer.
Review
Biochemistry & Molecular Biology
Shinya Matsuzaki, Yutaka Ueda, Satoko Matsuzaki, Hitomi Sakaguchi, Mamoru Kakuda, Misooja Lee, Yuki Takemoto, Harue Hayashida, Michihide Maeda, Reisa Kakubari, Tsuyoshi Hisa, Seiji Mabuchi, Shoji Kamiura
Summary: The placenta has important physiological functions and complications related to abnormal placentas are not well studied. This study reviewed 48 studies published between 1974 and 2022 to determine the outcomes and prevalence of patients with abnormal placentas. The cumulative prevalence of different types of abnormal placentas was reported, along with their associations with adverse pregnancy outcomes.
Article
Oncology
Seiji Mabuchi, Naoko Komura, Tomoyuki Sasano, Mina Sakata, Shinya Matsuzaki, Tsuyoshi Hisa, Shoji Kamiura, Toshitaka Morishima, Isao Miyashiro
Summary: The aim of this study was to compare the survival outcomes of different histological subtypes of cervical cancer in stage IVB. The results indicated that patients with small-cell neuroendocrine carcinoma (SCNEC) had the shortest survival. Furthermore, SCNEC was associated with significantly decreased survival compared to other histological subtypes, except for those treated with surgery.
