Journal
JOURNAL OF INFLAMMATION RESEARCH
Volume 15, Issue -, Pages 865-880Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/JIR.S347231
Keywords
inflammation; long-chain polyunsaturated fatty acids; age-related macular degeneration
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Funding
- National Natural Science Foundation of China [81800429]
- Nature Science Foundation of Hubei Province [2020CFB612]
- Young and Middle-Aged Medical Backbone Talents of Wuhan [WHQG201902]
- Application Foundation Frontier Project of Wuhan [2020020601012221]
- Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund [znpy2019001]
- Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University [ZNJC202007]
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This review summarizes the regulatory effects of long-chain polyunsaturated fatty acids (LCPUFA) on inflammation in age-related macular degeneration (AMD) and discusses their possible clinical applications.
Age-related macular degeneration (AMD) is a blinding eye disease, whose incidence strongly increases with ages. The etiology of AMD is complex, including aging, abnormal lipid metabolism, chronic inflammation and oxidative stress. Long-chain polyunsaturated fatty acids (LCPUFA) are essential for ocular structures and functions. This review summarizes the regulatory effects of LCPUFA on inflammation in AMD. LCPUFA are related to aging, autophagy and chronic inflammation. They are metabolized to pro- and anti-inflammatory metabolites by various enzymes. These metabolites stimulate inflammation in response to oxidative stress, causing innate and acquired immune responses. This review also discusses the possible clinical applications, which provided novel targets for the prevention and treatment of AMD and other age-related diseases.
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