Article
Biotechnology & Applied Microbiology
Wei Jiang, Huaiming Wang, Weisheng Chen, Yandong Zhao, Botao Yan, Dexin Chen, Xiaoyu Dong, Jiaxin Cheng, Zexi Lin, Shuangmu Zhuo, Hui Wang, Jun Yan
Summary: In this study, a collagen deep learning (collagen(DL)) classifier based on the 50-layer residual network model was proposed for predicting disease-free survival (DFS) and overall survival (OS) in stage II-III colon cancer (CC) patients. The collagen(DL) classifier was significantly associated with DFS and OS, and improved the prediction performance. Additionally, high-risk stage II and III CC patients with high collagen(DL) classifier showed a favorable response to adjuvant chemotherapy.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Mingsu Shi, Yun Gu, Kaifeng Jin, Hanji Fang, Yifan Chen, Yifan Cao, Xin Liu, Kunpeng Lv, Xudong He, Chao Lin, Hao Liu, He Li, Hongyong He, Jing Qin, Ruochen Li, Heng Zhang, Weijuan Zhang
Summary: High CD47 expression in gastric cancer patients indicates poor prognosis and resistance to fluorouracil-based adjuvant chemotherapy (ACT). There is a positive correlation between M1-polarized macrophages infiltration and CD47 expression in gastric cancer, however, the prognostic value of M1-polarized macrophages is dampened in CD47-high gastric cancer patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Yangyang Wang, Yan Liu, Chunchao Zhu, Xinyu Zhang, Guodong Li
Summary: The study found that the aging-related gene signature is associated with tumor immunity and stromal activation in rectal cancer, and can predict patients' survival outcomes and the benefits of immune and chemotherapy.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Peng Jin, Xiaoyan Ji, Shuai Ma, Wenzhe Kang, Hao Liu, Yang Li, Fuhai Ma, Haitao Hu, Weikun Li, Yantao Tian
Summary: This retrospective study analyzed gastric cancer patients with pathological stage pT1N1M0 and found that adjuvant chemotherapy may provide survival benefits for selected patients. Independent risk factors for reduced survival included sex, number of examined lymph nodes, and receiving AC. Patients were divided into three risk categories based on sex and lymph node status, with significant differences in survival observed between the groups.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yu Mei, Xijia Feng, Tienan Feng, Min Yan, Zhenggang Zhu, Tian Li, Zhenglun Zhu
Summary: This retrospective study examined the role of adjuvant chemotherapy (ACT) in patients with pT2N0M0 gastric cancer who underwent radical resection. The study found that ACT was associated with higher 5-year overall survival and disease-specific survival rates. Patients with pT2N0M0 gastric cancer, regardless of high-risk factors, may be suitable for ACT.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Hongfei Yan, Yang Chen, Zichang Yang, Zhi Li, Xiaofang Che, Jiawen Xiao, Yunpeng Liu, Xiujuan Qu
Summary: An immune signature based on infiltrating immune cells composition was established to predict survival and chemotherapy benefits for gastric cancer patients after surgery. The IS classifier consisting of eight immune cells showed significant prognostic value, especially when combined with TNM stage. Patients with high-IS were more likely to benefit from a specific chemotherapy regimen, and two nomograms were established to screen for suitable patients for adjuvant chemotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Xinyue Li, Jing Yang
Summary: This study investigated the relationship between tumor deposits and clinicopathological characteristics, tumor-infiltrating lymphocytes, and prognosis in gastric cancer. The results showed a significant association between tumor deposits and various characteristics and prognosis of gastric cancer, with patients having more than 4 tumor deposits having a worse prognosis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Deqiang Wang, Ning Wang, Xiaoqin Li, Xiaofeng Chen, Bo Shen, Dongqin Zhu, Liuqing Zhu, Yaping Xu, Yangyang Yu, Yongqian Shu
Summary: The study found that high TMB predicts favorable prognosis in resected gastric cancer, but poor response to postoperative CT/RCT in stage Ib/II subgroup, which may be determined by TMB-associated immune infiltration and hypoxia, respectively.
Article
Biochemistry & Molecular Biology
Guanran Zhang, Aiwen Jian, Yundi Zhang, Xiaoli Zhang
Summary: In this study, a risk signature for prognostic prediction and phenotyping of sarcomas was constructed based on RNA sequencing data. The immune properties of the tumor microenvironment were explored, and differential gene expression analysis was performed. Nine hub genes were identified, and two candidate genes were used to construct the risk signature. The signature was found to be accurate and reliable for predicting prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Diamantis Tsilimigras, J. Madison Hyer, Anghela Z. Paredes, Dimitrios Moris, Kota Sahara, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W. Bauer, Sorin Alexandrescu, George A. Poultsides, Shishir K. Maithel, Hugo P. Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, Olivier Soubrane, Bas Groot Koerkamp, Itaru Endo, Kazunari Sasaki, Federico Aucejo, Xu-Feng Zhang, Timothy M. Pawlik
Summary: Overall tumor burden (TB) significantly impacts the prognosis of patients with resectable intrahepatic cholangiocarcinoma (ICC), with higher TB associated with worse survival outcomes. TB can serve as a tool to guide post-resection treatment strategies.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Immunology
Wei Jiang, Xian Yu, Xiaoyu Dong, Chenyan Long, Dexin Chen, Jiaxin Cheng, Botao Yan, Shuoyu Xu, Zexi Lin, Gang Chen, Shuangmu Zhuo, Jun Yan
Summary: This study aimed to investigate the relationship between collagen structure and Immunoscore in colorectal cancer (CRC) patients. A collagen signature was constructed and found to be significantly associated with Immunoscore. The collagen nomogram developed in this study has the potential to predict Immunoscore and identify patients who may benefit from adjuvant chemotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Jian-Xian Lin, Yi-Hui Tang, Guan-Jie Lin, Yu-Bin Ma, Jacopo Desiderio, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Amilcare Parisi, Mark J. Truty, Chang-Ming Huang
Summary: This cohort study compares the survival rates of patients with locally advanced gastric cancer who received adjuvant chemotherapy (AC) and those who did not after neoadjuvant chemotherapy followed by surgery. The study found that AC was associated with improved survival in patients with a lymph node ratio of at least 9%. These findings suggest that the lymph node ratio could be useful in AC selection for locally advanced gastric cancer in future decision-making processes.
Article
Biochemistry & Molecular Biology
Yunze Liu, Haocheng Zheng, Anna Meilin Gu, Yuan Li, Tieshan Wang, Chengze Li, Yixiao Gu, Jie Lin, Xia Ding
Summary: Through the TCGA and GEO databases, we identified 173 metabolism-related genes (MRGs) associated with M2 macrophage infiltration in gastric cancer. Twelve MRGs were adopted as a prognostic signature and used to develop a risk model. Patients in the high-risk group had poorer survival outcomes and were less sensitive to certain drugs. Risk scores were correlated with immune cell infiltration, including CD8+ T cells and M2 macrophages. Single-cell sequencing analysis revealed differences in the expression and distribution of the 12 signature genes in the tumor microenvironment. In vitro experiments confirmed that Sorcin-knockdown gastric cancer cells suppressed M2 polarization of macrophages, inhibiting the proliferation and migration of gastric cancer cells. These findings provide a valuable prognostic signature for evaluating clinical outcomes, treatment options, and potential targets for gastric cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Shenghan Lou, Jian Zhang, Xin Yin, Yao Zhang, Tianyi Fang, Yimin Wang, Yingwei Xue
Summary: Low tumour purity in gastric cancer is associated with poorer clinical outcomes, shorter survival time, faster recurrence, and specific tumour phenotypes. In addition, low tumour purity is strongly linked to immune and stromal cell functions, and patients with low purity may not benefit significantly from adjuvant chemotherapy. Comprehensive evaluation of tumour purity can provide insights into GC molecular mechanisms and aid in the development of individualised treatment strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Jin Wu, Yuan Tian, Wei Liu, Hong Zheng, Yuanyin Xi, Yuzhao Yan, Ying Hu, Bin Liao, Minghao Wang, Peng Tang
Summary: A novel 12 gene-signature has been identified in this study to predict the response to neoadjuvant chemotherapy and prognosis in breast cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ting Wang, Wenjun Pan, Hang Zheng, Hongping Zheng, Zhejun Wang, Jia J. Li, Chuxia Deng, Jun Yan
Summary: This study aimed to evaluate the predictive accuracy of patient-derived tumor organoid culture models for responses to chemotherapy regimens in stage IV colorectal cancer. The results showed that the organoid culture model effectively predicts individual patient responses to existing chemotherapy regimens.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Gastroenterology & Hepatology
Weisheng Chen, Shumin Dong, Xiumin Liu, Guangxing Wang, Shuoyu Xu, Shangtong Lei, Shuangmu Zhuo, Jun Yan
Summary: This study established a collagen signature in the tumor microenvironment to effectively predict recurrence and survival in patients with T4N0M0 colon cancer. The new model combining collagen signature with clinicopathological risk factors showed better prognostic value than the clinicopathological model alone.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Oncology
Meiting Fu, Dexin Chen, Fuzheng Luo, Guangxing Wang, Shuoyu Xu, Yadong Wang, Caihong Sun, Xueqin Xu, Aimin Li, Shuangmu Zhuo, Side Liu, Jun Yan
Summary: A nomogram based on collagen features extracted from preoperative biopsies showed good discrimination and calibration in predicting lymph node metastasis in colorectal cancer. This nomogram can be beneficial for tailored treatment and prognostic predictions in CRC preoperatively.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Wei Jiang, Min Li, Jie Tan, Mingyuan Feng, Jixiang Zheng, Dexin Chen, Zhangyuanzhu Liu, Botao Yan, Guangxing Wang, Shuoyu Xu, Weiwei Xiao, Yuanhong Gao, Shuangmu Zhuo, Jun Yan
Summary: The study found a strong association between CFs in the tumor microenvironment and treatment response to nCRT, and the developed CFs nomogram is effective for predicting individual response to nCRT among rectal cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Editorial Material
Oncology
Wei Jiang, Min Li, Jie Tan, Mingyuan Feng, Jixiang Zheng, Dexin Chen, Zhangyuanzhu Liu, Botao Yan, Guangxing Wang, Shuoyu Xu, Weiwei Xiao, Yuanhong Gao, Shuangmu Zhuo, Jun Yan
ANNALS OF SURGICAL ONCOLOGY
(2021)
Editorial Material
Oncology
Wei Jiang, Yuanhong Gao, Shuangmu Zhuo, Jun Yan
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Kai Li, Zhiming Li, Botao Yan, Jie Tan, Dexin Chen, Weisheng Chen, Wei Jiang, Jun Yan
Summary: This study investigated the use of carbon nanoparticles to improve the retrieval of station 253 nodes in rectal cancer patients. It was found that the preoperative submucosal injection of carbon nanoparticles increased the number of retrieved station 253 nodes, and the retrieval of at least 4 station 253 nodes was necessary for standard D3 lymph node dissection in rectal cancer.
Letter
Surgery
Wei Jiang, Jun Yan
Article
Surgery
Xiumin Liu, Yuting Tang, Zhiming Li, Jie Tan, Jixiang Zheng, Mingyuan Feng, Jinliang Wan, Shijie Wang, Kemao Qiu, Hongli Ji, Jun Yan
Summary: The study evaluated anastomotic microcirculation in different perfusion models using CLE, finding that poor perfusion led to reduced capillaries, lower blood cell flow, and more severe intestinal adhesion and ischemia, with a higher incidence of anastomotic leakage and abdominal infection. This suggests that CLE is a feasible technique for real-time imaging and intraoperative evaluation in various anastomotic perfusion situations, laying the groundwork for future in vivo research in humans.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Xiaoyu Dong, Ying Huang, Xian Yu, Mingjin Huang, Wei Jiang, Dexin Chen, Guangxing Wang, Shuangmu Zhuo, Pan Chi, Jun Yan
Summary: This study quantitatively analyzed collagen alterations and established a collagen score (CS) in the tumor microenvironment to evaluate its relationship with the prognosis of patients with locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (nCRT). The CSIM-CT, created based on collagen area, number of collagen fibers, and a Gabor textural feature, predicted 3-year disease-free survival (DFS) and overall survival (OS) with high accuracy. A nomogram using the CSIM-CT showed good prognostic value in predicting individual prognosis.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Wei Jiang, Shijie Wang, Jinliang Wan, Jixiang Zheng, Xiaoyu Dong, Zhangyuanzhu Liu, Guangxing Wang, Shuoyu Xu, Weiwei Xiao, Yuanhong Gao, Shuangmu Zhuo, Jun Yan
Summary: This study investigated the association between collagen features in the tumor microenvironment and pathological complete response (pCR) in locally advanced rectal cancer (LARC) patients receiving neoadjuvant chemoradiotherapy (nCRT). A prediction model was developed and validated, and showed good discrimination and calibration in predicting pCR. The collagen signature in the tumor microenvironment was significantly associated with pCR, and the prediction model could be useful for individualized prediction of pCR in LARC patients before nCRT.
Article
Optics
Shuhao Qian, Guangxing Wang, Jia Meng, Shenyi Jiang, Lingxi Zhou, Jianping Lu, Zhihua Ding, Shuangmu Zhuo, Zhiyi Liu
Summary: Ovarian cancer, with its complex histotypes and different treatment plans, lacks a screening test. This study developed a new metric called local coverage and combined it with overall density to successfully distinguish different types of ovarian tissue, providing a sensitive biomarker for tumor progression. Quantitative, multi-parametric SHG imaging may serve as a potential screening tool for ovarian cancer.
Review
Oncology
Linhai Yang, Yulun Chen, Shuting Ling, Jing Wang, Guangxing Wang, Bei Zhang, Hengyu Zhao, Qingliang Zhao, Jingsong Mao
Summary: Optical coherence tomography (OCT) is a non-invasive imaging technique that has become the gold standard for diagnosis in ophthalmology. It can rapidly detect diseased tissues and identify optical characteristics in the early stage of disease, which is significant for early diagnosis of tumor diseases.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Jinliang Wan, Shijie Wang, Botao Yan, Yuting Tang, Jixiang Zheng, Hongli Ji, Yaowen Hu, Baoxiong Zhuang, Haijun Deng, Jun Yan
Summary: This study investigated the feasibility of using ICG as a tracer in D3 lymph node dissection for sigmoid and rectal cancer. The results showed that ICG can safely guide D3 lymph node dissection and increase the number of harvested D3 lymph nodes in patients with sigmoid and rectal cancer.
Article
Gastroenterology & Hepatology
Wei Jiang, Huaiming Wang, Jixiang Zheng, Yandong Zhao, Shuoyu Xu, Shuangmu Zhuo, Hui Wang, Jun Yan
Summary: This study aimed to quantitatively analyze collagen structural changes caused by preoperative chemoradiotherapy and investigate the relationship between collagen changes and anastomotic leakage (AL). The results showed that preoperative chemoradiotherapy significantly increased the risk of AL. The study also developed an AL-SVM classifier to predict the risk of AL in rectal cancer patients undergoing preoperative chemoradiotherapy.
GASTROENTEROLOGY REPORT
(2022)