Article
Multidisciplinary Sciences
Enoch Kang, Sung Cheol Jung, Soo Kyung Nam, Yujun Park, Soo Hyun Seo, Kyoung Un Park, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Hye Seung Lee
Summary: This study evaluated the prognostic potential of EMT-related miRNAs as biomarkers in colorectal cancer (CRC). The results showed that the tissue expression of miR-200c-3p and the plasma levels of miR-1290 were associated with poor prognosis.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Michelle Xin Liu, Kent-Man Chu
Summary: This study aims to investigate the functional roles of miR-410-3p in primary gastric cancer and the roles of exosomes in regulating miR-410-3p expression. It was found that miR-410-3p was downregulated in gastric cancer and its overexpression inhibited cancer cell proliferation, migration, and invasion. Exosomal miR-410-3p expression was significantly higher than its endogenous expression and exosomes from gastric cancer cells regulated miR-410-3p expression in other cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Cell Biology
Xisheng Liu, Xiaole Meng, Xiao Peng, Qianlan Yao, Fangming Zhu, Zhongyi Ding, Hongze Sun, Xueni Liu, Dan Li, Ying Lu, Huamei Tang, Bin Li, Zhihai Peng
Summary: The global downregulation of miRNA expression, potentially due to defects in miRNA processing machinery, is a hallmark of human cancer. In colorectal cancer (CRC), downregulation of the key regulator of miRNA processing, Argonaute 2 (AGO2), has been found to promote epithelial-mesenchymal transition (EMT) and indicate poor prognosis. Knockdown of AGO2 in CRC cells enhanced migration, invasion, and metastasis, while integrated analyses revealed neuropilin 1 (NRP1) as a new substrate of AGO2 via miR-185-3p. Therapeutically targeting the AGO2/miR-185-3p/NRP1 axis may offer a potential treatment approach for CRC.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Zhenxian Xiang, Guoquan Huang, Haitao Wu, Qiuming He, Chaogang Yang, Rongzhang Dou, Qing Liu, Jialing Song, Yan Fang, Shuyi Wang, Bin Xiong
Summary: Circulating tumor cells are precursors of colorectal cancer metastasis, and the epithelial-mesenchymal transition process facilitates their invasion. This study discovered a positive feedback loop between SNHG16 and YAP1/TEAD1, which promotes colorectal cancer metastasis and tumor progression.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Xijuan Chen, Yingqiang Liu, Qinglan Zhang, Baoxing Liu, Yan Cheng, Yonglei Zhang, Yanan Sun, Junqi Liu
Summary: miR-590-3p delivered through exosomes derived from CAFs enhances radioresistance in CRC by positively regulating the CLCA4-dependent PI3K/Akt signaling pathway.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Medicine, Research & Experimental
Yifan Li, Jing Xun, Botao Wang, Yuan Ma, Lanqiu Zhang, Lei Yang, Ruifang Gao, Jun Guan, Tianyu Liu, Hejun Gao, Ximo Wang, Qi Zhang
Summary: The study found that miR-3065-3p is overexpressed in colorectal cancer and associated with poor prognosis. It promotes the stemness and metastasis of colorectal cancer. CRLF1, as a downstream target of miR-3065-3p, inhibits the stemness of colorectal cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Yi-Qiang Zhang, Shuai-Shuai Shi, Yun-Fei Li, Yang Yang, Peng Bai, Chu-Han Qiao
Summary: This study investigated the effects of exosomal miRNAs released by melatonin-treated gastric cancer cells on gastric cancer. The results showed that melatonin suppressed the progression of gastric cancer by regulating the exosomal miR-27b-3p-ADAMTS5 pathway.
ANTICANCER RESEARCH
(2023)
Article
Genetics & Heredity
Wenhao Pei, Ke Wei, Yulun Wu, Quanwei Qiu, Haitao Zhu, Lingyu Mao, Xiuru Shi, Shiwen Zhang, Yingxiang Shi, Shuang Tao, Huilan Mao, Siyan Pang, Jing Wang, Mulin Liu, Wenrui Wang, Qingling Yang, Changjie Chen
Summary: This study reveals that the molecular processes underlying the interaction between TAMs and tumor-derived exosomal miRNAs in liver metastasis of colorectal cancer are not fully understood. It was confirmed that exosomal miR-203a-3p induced M2 polarization of macrophages by controlling PTEN and activating the PI3K/Akt signaling pathway, thus promoting liver metastasis in colorectal cancer.
Article
Chemistry, Multidisciplinary
Lu Liang, Wen-yan Xu, Ao Shen, Hui-yu Cen, Zhi-jun Chen, Lin Tan, Ling-min Zhang, Yu Zhang, Ji-jun Fu, Ai-ping Qin, Xue-ping Lei, Song-pei Li, Yu-yan Qin, Jiong-hua Huang, Xi-yong Yu
Summary: The methylation of miR-148a-3p promoter is associated with the clinical features of LUAD, and hypermethylation of miR-148a-3p is closely related to lymph node metastasis. miR-148a-3p inhibits the growth, migration, invasion, and cytoskeleton reorganization of lung adenocarcinoma cells by targeting MAP3K9 and suppressing the epithelial-mesenchymal transition. This study suggests that miR-148a-3p and MAP3K9 may serve as novel therapeutic targets for LUAD treatment with potential clinical applications.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Medicine, Research & Experimental
Lunpo Wu, Meng Xue, Sanchuan Lai, Jingyu Chen, Yifeng Lin, Ning Ding, Jing Zhong, Shujie Chen, Liangjing Wang
Summary: The study found that exosomes derived from colorectal cancer cells can be transferred to normoxic cells in a hypoxic microenvironment, promoting cell proliferation and migration. miRNA microarray analysis revealed that miR-4299 expression was significantly increased in hypoxic exosomes, and the upregulation of miR-4299 may depend on HIF-1α. Additionally, overexpression of miR-4299 promoted tumor growth and metastasis both in vitro and in vivo, and the expression level of its target gene ZBTB4 was decreased in tumor tissues.
Review
Medicine, Research & Experimental
Ghader Babaei, Mehdi Asghari Vostakolaei, Masoumeh Rajabi Bazl, Shiva Gholizadeh-Ghaleh Aziz, Elham Gholipour, Kazem Nejati-Koshki
Summary: Exosomes play fundamental roles in cell-cell communications and are associated with cancer metastasis by modulating EMT and CSCs.
Article
Medicine, Research & Experimental
Lin Zhou, Jian Li, Yaping Tang, Mei Yang
Summary: The study revealed that exosomal LINC00659 derived from CAFs promotes CRC cell proliferation, invasion, and migration through the miR-342-3p/ANXA2 pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Yujuan Zhang, Yu Men, Jianyang Wang, Puyuan Xing, Jun Zhao, Junling Li, Danfei Xu, Zhouguang Hui, Wei Cui
Summary: The study aimed to analyze the clinical relevance of heterogeneous phenotypes of peripheral circulating tumor cells (CTCs) in patients with non-small cell lung cancer (NSCLC). The results showed that pure hybrid epithelial/mesenchymal CTCs were more strongly associated with metastasis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yimei Jiang, Qingqing Qiu, Xiaoqian Jing, Zijia Song, Yaqi Zhang, Changgang Wang, Kun Liu, Feng Ye, Xiaopin Ji, Fangxiu Luo, Ren Zhao
Summary: The tumor microenvironment plays a crucial role in the development of colorectal cancer (CRC). This study demonstrates that tumor-associated fibroblasts (CAFs) release exosomes containing miR-181b-3p, which promote CRC progression by regulating SNX2 expression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Shengkui Qiu, Li Xie, Chen Lu, Chao Gu, Yiwen Xia, Jialun Lv, Zhe Xuan, Lang Fang, Jing Yang, Lu Zhang, Zheng Li, Weizhi Wang, Hao Xu, Bowen Li, Zekuan Xu
Summary: This study found that miR-519a-3p expression levels in exosomes were higher in gastric cancer liver metastasis (GC-LM) patients, and high expression indicated a worse prognosis. GC-derived exosomes mainly accumulated in the liver and were internalized by intrahepatic macrophages. Further research revealed that miR-519a-3p activated the MAPK/ERK pathway by targeting DUSP2, inducing M2-like polarization of macrophages and promoting angiogenesis and intrahepatic premetastatic niche formation. These findings suggest that miR-519a-3p plays a critical role in the interaction between primary GC cells and intrahepatic macrophages.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Weisong Zhang, Chaogang Yang, Shuyi Wang, Zhenxian Xiang, Rongzhang Dou, Zaihuan Lin, Jinsen Zheng, Bin Xiong
Summary: The study found that SDC2 and TFPI2 were highly methylated in CRC, and integrated detection of them in stool samples has the potential to be an effective and noninvasive tool for early screening of CRC.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Guoquan Huang, Zhenxian Xiang, Haitao Wu, Qiuming He, Rongzhang Dou, Zaihuan Lin, Chaogang Yang, Sihao Huang, Jialin Song, Ziyang Di, Shuyi Wang, Bin Xiong
Summary: This study found that BDNF-AS is highly expressed in gastric cancer and peritoneal metastasis tissues, and its overexpression is associated with gastric cancer progression and poor prognosis. BDNF-AS overexpression protects gastric cancer cells from ferroptosis and promotes the progression of gastric cancer and peritoneal metastasis. Mechanistically, BDNF-AS regulates the transcription of FBXW7 by recruiting WDR5, thus affecting the ubiquitination of VDAC3.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Tingna Chen, Qiuming He, Zhenxian Xiang, Rongzhang Dou, Bin Xiong
Summary: The study utilized WGCNA to identify three gene modules significantly correlated with gastric cancer and analyzed differentially correlated gene pairs within these modules using DiffCorr. GEMIN5 and PFDN2 were identified as key genes in the regulatory network, with their differential expression validated in cell lines and patient tissues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Guoquan Huang, Zhenxian Xiang, Haitao Wu, Qiuming He, Rongzhang Dou, Chaogang Yang, Jialin Song, Sihao Huang, Shuyi Wang, Bin Xiong
Summary: This study investigated the mechanism of peritoneal metastasis (PM) in gastric cancer (GC) through lncRNA gene sequencing and protein profiling analysis. The study identified the inhibitory role of the SEMA3B-AS1/HMGB1/FBXW7 axis in PM by regulating BGN protein ubiquitination.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Zaihuan Lin, Jialin Song, Yuke Gao, Sihao Huang, Rongzhang Dou, Panyi Zhong, Guoquan Huang, Lei Han, Jinsen Zheng, Xinyao Zhang, Shuyi Wang, Bin Xiong
Summary: In this study, we found that HIF-1α promotes the stability of SLC7A11 by upregulating lncRNA-PMAN, thereby inhibiting iron overload in GC cells. These findings provide theoretical support for the identification of diagnostic biomarkers and therapeutic targets for peritoneal metastasis in gastric cancer.
Correction
Oncology
W. Zhang, C. Yang, S. Wang
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Oncology
Jialin Song, Zaihuan Lin, Qing Liu, Sihao Huang, Lei Han, Yan Fang, Panyi Zhong, Rongzhang Dou, Zhenxian Xiang, Jinsen Zheng, Xinyao Zhang, Shuyi Wang, Bin Xiong
Summary: This study found that miR-192-5p/RB1 promotes epithelial-mesenchymal transition (EMT) and regulates interleukin-10 (IL-10) secretion through nuclear factor-kappaBp65 (NF-kappa Bp65), affecting the differentiation of regulatory T (Treg) cells, thus promoting gastric cancer (GC) growth and metastasis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Correction
Biochemistry & Molecular Biology
Zaihuan Lin, Jialin Song, Yuke Gao, Sihao Huang, Rongzhang Dou, Panyi Zhong, Guoquan Huang, Lei Han, Jinsen Zheng, Xinyao Zhang, Shuyi Wang, Bin Xiong
Article
Biochemistry & Molecular Biology
Haitao Wu, Zhenxian Xiang, Guoquan Huang, Qiuming He, Jialing Song, Rongzhang Dou, Chaogang Yang, Shuyi Wang, Bin Xiong
Summary: Peritoneal metastasis (PM) is common in gastric cancer (GC), and the interaction between cancer-associated fibroblasts (CAFs) and cancer cells in PM is not well understood. In this study, biglycan (BGN) was identified as a key factor in this process. High expression of BGN in GC tissues correlated with poor prognosis. BGN promoted tumor progression and the transformation of mesothelial cells (MCs) into cancer-associated fibroblast like cells (CAFLCs). Conversely, CAFLCs-derived fibroblast activation protein (FAP) facilitated the growth and spread of GC cells. The interaction between GC-derived BGN and toll like receptor 2 (TLR2)/TLR4 on MCs activated the NF-KB pathway and promoted the transformation of MCs into CAFLCs. CAFLCs-derived FAP activated the JAK2/STAT3 signaling pathway in GC. This study reveals a positive feedback loop involving BGN/FAP-STAT3 that facilitates PM of GC and provides potential targets for GC metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Qiuming He, Chaogang Yang, Zhenxian Xiang, Guoquan Huang, Haitao Wu, Tingna Chen, Rongzhang Dou, Jialing Song, Lei Han, TianTian Song, Shuyi Wang, Bin Xiong
Summary: In this study, we identified LINC00924 as a key player in gastric cancer peritoneal metastasis. LINC00924 promotes fatty acid oxidation and uptake, allowing matrix-detached gastric cancer cells to survive and form spheroids. The mechanism involves the regulation of alternative splicing of Mnk2 and the p38 MAPK/PPARa signaling pathway.
CELL DEATH & DISEASE
(2022)
Retraction
Oncology
Xiaobin Lin, Shuyi Wang, Min Sun, Chunxiao Zhang, Chen Wei, Chaogang Yang, Rongzhang Dou, Qing Liu, Bin Xiong
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Jinsen Zheng, Rongzhang Dou, Xinyao Zhang, Bo Zhong, Chenggang Fang, Qian Xu, Ziyang Di, Sihao Huang, Zaihuan Lin, Jialin Song, Shuyi Wang, Bin Xiong
Summary: The overexpression of LINC00543 in colorectal cancer tissues is associated with advanced TNM stage and poorer prognosis of CRC patients. LINC00543 promotes tumorigenesis and metastasis of CRC cells by enhancing EMT and remodeling the TME.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Rongzhang Dou, Lei Han, Chaogang Yang, Yan Fang, Jinsen Zheng, Chenxi Liang, Jialin Song, Chen Wei, Guoquan Huang, Panyi Zhong, Keshu Liu, Qian Peng, Chunwei Peng, Bin Xiong, Shuyi Wang
Summary: This study reveals that the overexpression of LINC00501 in gastric cancer (GC) is associated with the progression and metastasis of GC. LINC00501 promotes the epithelial-mesenchymal transition and angiogenesis of GC by recruiting hnRNPR to activate the transcription of SLUG. This research provides insights into the important role of LINC00501 in GC and suggests it as a potential biomarker and therapeutic target for GC.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Zhenxian Xiang, Guoquan Huang, Haitao Wu, Qiuming He, Chaogang Yang, Rongzhang Dou, Qing Liu, Jialing Song, Yan Fang, Shuyi Wang, Bin Xiong
Summary: Circulating tumor cells are precursors of colorectal cancer metastasis, and the epithelial-mesenchymal transition process facilitates their invasion. This study discovered a positive feedback loop between SNHG16 and YAP1/TEAD1, which promotes colorectal cancer metastasis and tumor progression.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yan Fang, Rongzhang Dou, Sihao Huang, Lei Han, Hang Fu, Chaogang Yang, Jialin Song, Jinsen Zheng, Xinyao Zhang, Keshu Liu, Zhenxian Xiang, Xinghua Zhang, Shuyi Wang, Bin Xiong
Summary: Gastric cancer promotes adipose tissue differentiation and peritoneal metastasis through the LAMC1 pathway, resulting in the formation of pre-metastatic niches and colonization of gastric cancer cells in the peritoneum.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)