Article
Chemistry, Physical
Qian Wang, Xuan Zhao, Fei Yu, Po-Han Fang, Liu Liu, Xinyue Du, Weihua Li, Dalian He, Ying Bai, Saiqun Li, Jin Yuan
Summary: This study develops an injectable photocurable bioadhesive hydrogel (F20HD5) for sutureless closure of penetrating corneal wounds. The hydrogel exhibits high transparency, wound-sealing ability, proper viscosity, biodegradability, and excellent biocompatibility. The hydrogel effectively closed corneal incisions and injuries, facilitating the repair of injured corneas with minimal tissue loss and improved outcomes.
Article
Engineering, Biomedical
Ines A. Barroso, Kenny Man, Thomas J. Hall, Thomas E. Robinson, Sophie E. T. Louth, Sophie C. Cox, Anita K. Ghag
Summary: Corneal transplantation is the current gold standard treatment for severe corneal diseases and injuries. However, the shortage of donor tissue remains a challenge. Additionally, the difficult instillation and drainage of antibiotic eye drops in ocular surgery is an issue of concern. In this study, antimicrobial silk-based hydrogels were developed, which can be photoactivated in situ and fully adapt to the shape of corneal injuries. These hydrogels have the potential to facilitate corneal regeneration and could be applied in various soft tissue engineering fields.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Engineering, Biomedical
Meiyan Li, Ruoyan Wei, Chang Liu, Haowei Fang, Weiming Yang, Yunzhe Wang, Yiyong Xian, Kunxi Zhang, Yong He, Xingtao Zhou
Summary: Corneal transplantation is limited by donor corneas, so developing bioadhesive corneal patches with Transparency, Epithelium & Stroma generation, Suturelessness, and Toughness is of great value. A light-curable hydrogel based on GelMA, F127DA & AF127 co-assembled bi-functional micelles, and COL I is designed for repairing damaged cornea. The hydrogel patch possesses transparent, highly tough, and strongly bio-adhesive performance after UV irradiation for 5 minutes.
BIOACTIVE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Promita Bhattacharjee, Mark Ahearne
Summary: This paper provides an overview of different crosslinking techniques and chemical additives used in hydrogels for corneal tissue engineering, drug delivery, or corneal repair. Factors influencing the success of a crosslinker, such as material composition, dosage, fabrication method, immunogenicity, and toxicity, are considered. The choice of crosslinking technique significantly affects the biocompatibility, mechanical properties, and chemical structure of hydrogels suitable for corneal tissue engineering and regenerative applications.
Article
Engineering, Biomedical
Xuanren Shen, Saiqun Li, Xuan Zhao, Jiandong Han, Jiaxin Chen, Zilong Rao, Kexin Zhang, Daping Quan, Jin Yuan, Ying Bai
Summary: A hybrid hydrogel consisting of porcine decellularized corneal stroma matrix and methacrylated hyaluronic acid was developed, which could integrate with corneal tissue and repair focal corneal damage. The hydrogel exhibited excellent adhesion properties, enabling suture-free repair, and possessed cornea-matching transparency, low swelling ratio, slow degradation, and enhanced mechanical properties. Experimental results demonstrated the effectiveness of this hybrid hydrogel in a rabbit corneal stromal defect model.
BIOACTIVE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Ines A. Barroso, Kenny Man, Thomas E. Robinson, Sophie C. Cox, Anita K. Ghag
Summary: A gelatine methacryloyl (GelMA) adhesive that can crosslink in situ within 2 minutes using UV or visible light has been successfully developed. The adhesive exhibits strong adhesion, non-toxicity, and the ability to fill corneal wounds and restore ocular curvature. It has the potential to be used as a stromal filler or sealant for corneal and conjunctival applications.
BIOENGINEERING-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Yuna Qian, Kejia Xu, Liangliang Shen, Mali Dai, Zelin Zhao, Yujing Zheng, Haiou Wang, Hailin Xie, Xuan Wu, Decheng Xiao, Qinxiang Zheng, Jinyi Zhang, Yang Song, Jianliang Shen, Wei Chen
Summary: In this study, a high-transparent bioadhesive hydrogel composed of GelMA and DMA was developed for ocular surgery. The bioadhesive hydrogel overcomes the weaknesses of mussel-inspired adhesive copolymers and shows favorable properties such as high light transmission, mechanical strength, adhesive strength, and biocompatibility. It can effectively treat ocular injuries and complications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Cell Biology
Jingjing Wu, Hyunwoo Yuk, Tiffany L. Sarrafian, Chuan Fei Guo, Leigh G. Griffiths, Christoph S. Nabzdyk, Xuanhe Zhao
Summary: This study introduces an off-the-shelf bioadhesive gastrointestinal (GI) patch that can rapidly and robustly repair GI defects without the need for sutures. The patch has been shown to be biocompatible and degradable, and has demonstrated successful sealing and healing of GI defects in animal models.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Engineering, Environmental
Woo Hyung Park, Jaeyun Lee, Hyo Jeong Kim, Kye Il Joo, Hyung Joon Cha
Summary: This study develops a novel bioadhesive for sutureless full-thickness skin grafting, which minimizes scar formation and accelerates wound healing. The bioadhesive demonstrates high adhesive strength and sustained release of dual drugs to enhance re-epithelialization and collagen deposition while reducing scar formation.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Polymer Science
Michael Zanon, Laura Montalvillo-Jimenez, Paula Bosch, Raquel Cue-Lopez, Enrique Martinez-Campos, Marco Sangermano, Annalisa Chiappone
Summary: Surgical interventions play a crucial role in modern medicine, but the rehabilitation process is essential for patients with post-treatment consequences. This study proposes a sodium alginate hydrogel, synthesized using a thiol-yne reaction, which demonstrates good self-standing properties and desirable mechanical, rheological, and topographical behavior. The hydrogels are also cytocompatible and have the potential to be used in tissue engineering and regenerative medicine.
Article
Engineering, Biomedical
Jia Liu, Yongrui Huang, Weiya Yang, Xiaomin Sun, Yingni Xu, Yuehai Peng, Wenjing Song, Jin Yuan, Li Ren
Summary: In this study, a bioadhesive hydrogel for sutureless conjunctival transplantation was developed based on a semi-interpenetrating polymer network. The hydrogel showed high adhesion strength and improved tissue repair without scar, making it a promising alternative to suture for ocular surface reconstruction.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Chengkun Liu, Chang Liu, Zhiyuan Liu, Zhuang Shi, Shihai Liu, Xiaojuan Wang, Xiaoqiang Wang, Fang Huang
Summary: A thermogelling chitosan/glycerophosphate formulation was developed by incorporating dihydrocaffeic acid (DHCA), which significantly enhanced gel-forming capacity and tissue adherence. The thermosensitive hydrogels showed improved hemostasis and reduced blood loss in both in vitro and in vivo models. The results demonstrated the potential of enhancing thermogelling and bioadhesion of chitosan-based hydrogels through noncovalent supramolecular mechanisms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Sina Sharifi, Mohammad Mirazul Islam, Hannah Sharifi, Rakibul Islam, Darrell Koza, Felisa Reyes-Ortega, David Alba-Molina, Per H. Nilsson, Claes H. Dohlman, Tom Eirik Mollnes, James Chodosh, Miguel Gonzalez-Andrades
Summary: Gelatin-based adhesives have been widely used in biomedical applications due to their excellent biocompatibility and mechanical properties. By simple chemical modification, an elastic protein-based hydrogel with excellent biomimetic properties can be obtained, demonstrating potential for various biomedical applications.
BIOACTIVE MATERIALS
(2021)
Review
Polymer Science
Yingshuo Xiong, Xiaoran Zhang, Xintao Ma, Wenqi Wang, Feiyan Yan, Xiaohan Zhao, Xiaoxiao Chu, Wenlong Xu, Changmei Sun
Summary: Bioadhesive hydrogels have been extensively studied for their outstanding properties, with potential applications in biomedicine. Researchers summarized the properties, applications, and future prospects of bioadhesive hydrogels.
Article
Chemistry, Applied
Soledad Roig-Sanchez, Doron Kam, Nanthilde Malandain, Ela Sachyani-Keneth, Oded Shoseyov, Shlomo Magdassi, Anna Laromaine, Anna Roig
Summary: Acrylate hydrogels are potential soft tissue implants, but their weak mechanical properties and dimensional changes in liquids limit their applications. By fabricating double network hydrogels, the mechanical properties and swelling behavior of acrylate hydrogels can be improved.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Biomedical
Jianqiu Yang, Zhenzhen Huang, Jiang Tan, Jingye Pan, Shixuan Chen, Wenbing Wan
Summary: By functionalizing a decellularized pomelo peel with an adhesive hydrogel and antibacterial materials, the hybrid wound dressing can effectively inhibit bacterial infection, promote granulation tissue formation and angiogenesis, and reduce scar formation during wound healing.
BIOACTIVE MATERIALS
(2024)
Article
Engineering, Biomedical
Yong Mei, Xiaohua Qin, Zhenyu Yang, Shiyao Song, Xiaoting Liu, Chong Wu, Jieying Qian, Xiaowan Huang, Yunjiao Zhang, Weiling He
Summary: This article presents a novel nanoparticle for treating KRAS-TP53 co-mutation in gastrointestinal cancers. The nanoparticle can degrade mutant p53 proteins (mutp53) and deliver the drug AMG510 to inhibit mutant KRAS and mutp53 signaling pathways. The results show that the nanoparticle can effectively reduce cell proliferation and migration, and demonstrate remarkable therapeutic efficacy in a tumor-bearing mouse model.
BIOACTIVE MATERIALS
(2024)
