Review
Immunology
Giuseppe Ancona, Laura Alagna, Claudia Alteri, Emanuele Palomba, Anna Tonizzo, Andrea Pastena, Antonio Muscatello, Andrea Gori, Alessandra Bandera
Summary: The gut microbiota plays a crucial role in human health and disease, and dysbiosis has been associated with respiratory diseases, neurological disturbances, and COVID-19 severity. Recent studies have shown a link between gut dysbiosis and COVID-19, including its gastrointestinal replication and neurological manifestations.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yeganeh Farsi, Azin Tahvildari, Mahta Arbabi, Fateme Vazife, Leonardo A. Sechi, Amir Hashem Shahidi Bonjar, Parnian Jamshidi, Mohammad Javad Nasiri, Mehdi Mirsaeidi
Summary: This study demonstrates significant differences in gut microbiome composition between COVID-19 patients and healthy individuals, suggesting that the gut microbiota may serve as a potential diagnostic, prognostic, and therapeutic strategy for COVID-19.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rong Xu, Pengcheng Liu, Tao Zhang, Qunfu Wu, Mei Zeng, Yingying Ma, Xia Jin, Jin Xu, Zhigang Zhang, Chiyu Zhang
Summary: Children infected with SARS-CoV-2 may experience significant alterations in their upper respiratory and gut microbiomes, characterized by dysbiosis and sustained changes lasting for a considerable period. This could indicate potential long-term complications post-recovery from COVID-19.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Review
Infectious Diseases
Tik Fung Dave Liu, Elena Philippou, Ourania Kolokotroni, Georgios Siakallis, Kenan Rahima, Constantina Constantinou
Summary: Studies have shown significant changes in the composition of gut and airway microbiota in COVID-19 infection, with most indicating a decrease in microbial diversity and development of intestinal dysbiosis in patients. More carefully designed studies are needed to provide conclusive evidence on the role of these microbiota in COVID-19.
Review
Biochemistry & Molecular Biology
Howard Junca, Dietmar H. Pieper, Eva Medina
Summary: The human microbiome has been widely studied for its potential clinical interventions, and disruptions in the microbiota have been associated with various pathological conditions. Microbiome transplantation, such as fecal microbiome transplantation, has shown success in treating certain diseases and is being explored in other areas, such as vaginal disorders and skin pathologies.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Immunology
Indranil Chattopadhyay, Esaki M. Shankar
Summary: Research suggests that alterations in gut microbiome may play a crucial role in determining the clinical outcome of COVID-19 patients. Manipulating gut microbiota could lead to the development of effective therapeutic strategies against the immunopathogenesis and comorbidities of COVID-19.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Kanika Sehgal, Sahil Khanna
Summary: Obesity is a major public health concern, with studies suggesting a link between gut microbiota and obesity. Microbiota restoration therapies are being considered as a potential management approach, but more research is needed to determine the efficacy and safety. Personalized therapies for obese individuals may become possible once the relationships between bacterial strains and human metabolic profiles are better understood.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Immunology
Wan-Ying Deng, Wen-Jia Chen, Hao-Jie Zhong, Li-Hao Wu, Xing-Xiang He
Summary: This case report provides direct clinical evidence for washed microbiota transplantation (WMT) as a novel promising treatment strategy for atopic dermatitis (AD). After three months of WMT treatment, the patient's skin itching was effectively controlled, with noticeable improvement in skin lesions and reduced Staphylococcus aureus. The intestinal flora became more diverse, and the abundance of Bifidobacterium species significantly increased after WMT.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Sijia Li, Siyuan Yang, Yuzheng Zhou, Cyrollah Disoma, Zijun Dong, Ashuai Du, Yongxing Zhang, Yong Chen, Weiliang Huang, Junru Chen, Deqiang Song, Zongpeng Chen, Pinjia Liu, Shiqin Li, Rong Zheng, Sixu Liu, Aroona Razzaq, Xuan Chen, Siyi Tao, Chengping Yu, Tianxu Feng, Wenyan Liao, Yousong Peng, Taijiao Jiang, Jufang Huang, Wei Wu, Liqiang Hu, Linghang Wang, Shanni Li, Zanxian Xia
Summary: The study shows significant alterations of gut microbiota in patients with COVID-19, which are related to disease severity. Analysis of gut microbiome can distinguish COVID-19 patients from healthy individuals, providing new insights for early diagnosis.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Johanna Reinold, Farnoush Farahpour, Christian Fehring, Sebastian Dolff, Margarethe Konik, Johannes Korth, Lukas van Baal, Daniel Hoffmann, Jan Buer, Oliver Witzke, Astrid M. Westendorf, Jan Kehrmann
Summary: The gut microbiome of patients infected with SARS-CoV-2 exhibited differences compared to SARS-CoV-2 negative patients, with lower bacterial richness and specific alterations in microbiome composition. Severe COVID-19 patients showed lower abundance of certain genera related to anti-inflammatory properties and higher levels of pro-inflammatory markers in the blood, suggesting a dysbiosis of the gut microbiome may contribute to the hyperinflammatory immune response in severe COVID-19 cases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Genetics & Heredity
Long H. Nguyen, Daniel Okin, David A. Drew, Vincent M. Battista, Sirus J. Jesudasen, Thomas M. Kuntz, Amrisha Bhosle, Kelsey N. Thompson, Trenton Reinicke, Chun-Han Lo, Jacqueline E. Woo, Alexander Caraballo, Lorenzo Berra, Jacob Vieira, Ching-Ying Huang, Upasana Das Adhikari, Minsik Kim, Hui-Yu Sui, Marina Magicheva-Gupta, Lauren McIver, Marcia B. Goldberg, Douglas S. Kwon, Curtis Huttenhower, Andrew T. Chan, Peggy S. Lai
Summary: The gut microbiome is linked to the severity of COVID-19, with specific microbial taxa and metabolites associated with severe disease. These findings suggest the potential of using the gut microbiome as a biomarker for disease severity and as a target for therapeutic intervention in COVID-19.
Article
Microbiology
Aya Ishizaka, Michiko Koga, Taketoshi Mizutani, Prince Kofi Parbie, Diki Prawisuda, Nozomi Yusa, Ayako Sedohara, Tadashi Kikuchi, Kazuhiko Ikeuchi, Eisuke Adachi, Tomohiko Koibuchi, Yoichi Furukawa, Arinobu Tojo, Seiya Imoto, Yutaka Suzuki, Takeya Tsutsumi, Hiroshi Kiyono, Tetsuro Matano, Hiroshi Yotsuyanagi
Summary: The study found that HIV-infected patients have changes in gut microbiome composition, including dysbiosis related to chronic inflammation, with alterations in abundance of certain taxa and associations with inflammatory and anti-inflammatory cytokines. Additionally, HIV-associated dysbiosis shifts the immunological balance towards inflammatory responses.
MICROBIOLOGY SPECTRUM
(2021)
Article
Gastroenterology & Hepatology
Rachel C. Newsome, Josee Gauthier, Maria C. Hernandez, George E. Abraham, Tanya O. Robinson, Haley B. Williams, Meredith Sloan, Anna Owings, Hannah Laird, Taylor Christian, Yilianys Pride, Kenneth J. Wilson, Mohammad Hasan, Adam Parker, Michal Senitko, Sarah C. Glover, Raad Z. Gharaibeh, Christian Jobin
Summary: The study found significant differences in the fecal microbial composition between COVID-19 patients and controls, as well as between actively infected patients and recovered patients. Certain genera like Campylobacter and Klebsiella were enriched in COVID-19 patients with gastrointestinal symptoms. Additionally, a substantial proportion of COVID-19 patients tested positive for fecal SARS-CoV-2 RNA. Further research is needed to explore the functional impact of SARS-CoV-2 on gastrointestinal health.
Article
Gastroenterology & Hepatology
David Schult, Sandra Reitmeier, Plamena Koyumdzhieva, Tobias Lahmer, Moritz Middelhof, Johanna Erber, Jochen Schneider, Juliane Kager, Marina Frolova, Julia Horstmann, Lisa Fricke, Katja Steiger, Moritz Jesinghaus, Klaus-Peter Janssen, Ulrike Protzer, Klaus Neuhaus, Roland M. Schmid, Dirk Haller, Michael Quante
Summary: There is an ongoing debate about the role of the gut microbiome in COVID-19. This study analyzed fecal and saliva samples from COVID-19 patients and controls to investigate the impact of the microbiome on disease severity. The results showed that the composition of the gut and oral microbiota was associated with COVID-19-related complications and disease progression, and a model was developed to estimate mortality based on microbial profiles.
Article
Medicine, General & Internal
Beate Vestad, Thor Ueland, Tori Vigeland Lerum, Tuva Borresdatter Dahl, Kristian Holm, Andreas Barratt-Due, Trine Kasine, Anne Ma Dyrhol-Riise, Birgitte Stiksrud, Kristian Tonby, Hedda Hoel, Inge Christoffer Olsen, Katerina Nezvalova Henriksen, Anders Tveita, Ravinea Manotheepan, Mette Haugli, Ragnhild Eiken, Ase Berg, Bente Halvorsen, Tove Lekva, Trine Ranheim, Annika Elisabeth Michelsen, Anders Benjamin Kildal, Asgeir Johannessen, Lars Thoresen, Hilde Skudal, Bard Reiakvam Kittang, Roy Bjorkholt Olsen, Carl Magnus Ystrom, Nina Vibeche Skei, Raisa Hannula, Saad Aballi, Reidar Kvale, Ole Henning Skjonsberg, Pal Aukrust, Johannes Roksund Hov, Marius Troseid
Summary: Respiratory dysfunction after COVID-19 is associated with altered gut microbiota and persistently elevated LBP levels. Our results suggest a potential gut-lung axis that should be further investigated in relation to long-term pulmonary dysfunction and long COVID.
JOURNAL OF INTERNAL MEDICINE
(2022)