Aberrant translation regulated by METTL1/WDR4‐mediated tRNA N7‐methylguanosine modification drives head and neck squamous cell carcinoma progression

The expanding world of tRNA modifications and their disease relevance

(2021) Tsutomu Suzuki   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor microenvironment in head and neck squamous cell carcinoma: Functions and regulatory mechanisms

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N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression

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A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82

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Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer

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Establishment and characterization of patient-derived xenografts as paraclinical models for head and neck cancer

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Disruption of the RNA modifications that target the ribosome translation machinery in human cancer

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(2020) Qi Liu et al.   NUCLEIC ACIDS RESEARCH

Direct activation of tRNA methyltransferase-like 1 (Mettl1) gene by thyroid hormone receptor implicates a role in adult intestinal stem cell development and proliferation during Xenopus tropicalis metamorphosis

(2020) Wonho Na et al.   Cell and Bioscience

METTL3 Promotes Tumorigenesis and Metastasis through BMI1 m6A Methylation in Oral Squamous Cell Carcinoma

(2020) Lin Liu et al.   MOLECULAR THERAPY

METTL1-mediated m7G methylation maintains pluripotency in human stem cells and limits mesoderm differentiation and vascular development

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Gene Expression Profile at the Motor Endplate of the Neuromuscular Junction of Fast-Twitch Muscle

(2020) Kun Huang et al.   Frontiers in Molecular Neuroscience

Tumor-promoting macrophages prevail in malignant ascites of advanced gastric cancer

(2020) Hye Hyeon Eum et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

TET2 chemically modifies tRNAs and regulates tRNA fragment levels

(2020) Chongsheng He et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The nature of the modification at position 37 of tRNAPhe correlates with acquired taxol resistance

(2020) Yu Pan et al.   NUCLEIC ACIDS RESEARCH

Head and neck squamous cell carcinoma

(2020) Daniel E. Johnson et al.   Nature Reviews Disease Primers

Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap

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Put the Pedal to the METTL1: Adding Internal m7G Increases mRNA Translation Efficiency and Augments miRNA Processing

(2019) Konstantinos Boulias et al.   MOLECULAR CELL

tRNA Deregulation and Its Consequences in Cancer

(2019) Mafalda Santos et al.   TRENDS IN MOLECULAR MEDICINE

Nucleotide resolution profiling of m7G tRNA modification by TRAC-Seq

(2019) Shuibin Lin et al.   Nature Protocols

Overexpressed methyltransferase-like 1 (METTL1) increased chemosensitivity of colon cancer cells to cisplatin by regulating miR-149-3p/S100A4/p53 axis

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PI3K/AKT/mTOR signaling as a molecular target in head and neck cancer

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Mettl1/Wdr4-Mediated m 7 G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation

(2018) Shuibin Lin et al.   MOLECULAR CELL

Integrating single-cell transcriptomic data across different conditions, technologies, and species

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Transcriptome-wide Analysis of Roles for tRNA Modifications in Translational Regulation

(2017) Hsin-Jung Chou et al.   MOLECULAR CELL

MODOMICS: a database of RNA modification pathways. 2017 update

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ALKBH1-Mediated tRNA Demethylation Regulates Translation

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Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity

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Efficient and quantitative high-throughput tRNA sequencing

(2015) Guanqun Zheng et al.   NATURE METHODS

ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments

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Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA

(2014) Schraga Schwartz et al.   CELL

Erratum: Corrigendum: Global quantification of mammalian gene expression control

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Translating mRNAs strongly correlate to proteins in a multivariate manner and their translation ratios are phenotype specific

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The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments

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Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death

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EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX study

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tRNA Stabilization by Modified Nucleotides

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4E-BP1 Is a Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways that Integrates Their Function in Tumors

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Cell-type-specific isolation of ribosome-associated mRNA from complex tissues

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Extensions to decision curve analysis, a novel method for evaluating diagnostic tests, prediction models and molecular markers

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SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs

(2008) Xiaoju Max Ma et al.   CELL