Journal
METABOLITES
Volume 11, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/metabo11120869
Keywords
PCOS; metabolic syndrome; metabolites; gut microbiota; clinical application
Categories
Funding
- National Key Research and Development Program of China [2018YFC1003200, 2018YFC1003900]
- National Natural Science Foundation of China [82171627, 82022028]
- CAMS Innovation Fund for Medical Sciences [2019-I2M-5-001]
- Key Clinical Projects of Peking University Third Hospital [BYSYZD2019020]
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PCOS is a common endocrine disease in women of reproductive age, with metabolic manifestations such as obesity, insulin resistance, and hyperandrogenism. Metabolomics techniques have revealed various metabolite changes in PCOS patients and animal models, providing insights into potential mechanisms and clinical applications.
Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases among women of reproductive age and is associated with many metabolic manifestations, such as obesity, insulin resistance (IR) and hyperandrogenism. The underlying pathogenesis of these metabolic symptoms has not yet been fully elucidated. With the application of metabolomics techniques, a variety of metabolite changes have been observed in the serum and follicular fluid (FF) of PCOS patients and animal models. Changes in metabolites result from the daily diet and occur during uncommon physiological routines. However, some of these metabolite changes may provide evidence to explain possible mechanisms and new approaches for prevention and therapy. This article reviews the pathogenesis of PCOS metabolic symptoms and the relationship between metabolites and the pathophysiology of PCOS. Furthermore, the potential clinical application of some specific metabolites will be discussed.
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