Concern for Dirofilaria immitis and Macrocyclic Lactone Loss of Efficacy: Current Situation in the USA and Europe, and Future Scenarios

Heartworm disease – Overview, intervention, and industry perspective

(2021) Sandra Noack et al.   International Journal for Parasitology-Drugs and Drug Resistance

Simultaneous Exposure to Angiostrongylus vasorum and Vector-Borne Pathogens in Dogs from Italy

(2021) Simone Morelli et al.   Pathogens

Dirofilaria spp. and Angiostrongylus vasorum: Current Risk of Spreading in Central and Northern Europe

(2021) Hans-Peter Fuehrer et al.   Pathogens

Treatment of Dogs with Severe Heartworm Disease

(2020) Marisa K. Ames et al.   VETERINARY PARASITOLOGY

Laboratory assays reveal diverse phenotypes among microfilariae of Dirofilaria immitis isolates with known macrocyclic lactone susceptibility status

(2020) Jeba R. J. Jesudoss Chelladurai et al.   PLoS One

Prevalence and risk factors for selected canine vector-borne diseases in Greece

(2019) Athanasios Angelou et al.   Parasites & Vectors

ProHeart® 12, a moxidectin extended-release injectable formulation for prevention of heartworm (Dirofilaria immitis) disease in dogs in the USA for 12 months

(2019) Tom L. McTier et al.   Parasites & Vectors

Preventive efficacy of oral moxidectin at various doses and dosage regimens against macrocyclic lactone-resistant heartworm (Dirofilaria immitis) strains in dogs

(2019) Tom L. McTier et al.   Parasites & Vectors

Laboratory and field studies to investigate the efficacy of a novel, orally administered combination product containing moxidectin, sarolaner and pyrantel for the prevention of heartworm disease (Dirofilaria immitis) in dogs

(2019) Kristina Kryda et al.   Parasites & Vectors

Managing anthelmintic resistance in cyathostomin parasites: Investigating the benefits of refugia-based strategies

(2019) Dave M. Leathwick et al.   International Journal for Parasitology-Drugs and Drug Resistance

Perspectives on the utility of moxidectin for the control of parasitic nematodes in the face of developing anthelmintic resistance

(2019) Roger K. Prichard et al.   International Journal for Parasitology-Drugs and Drug Resistance

The prevalence of Dirofilaria immitis and D. repens in the Old World

(2019) Claudio Genchi et al.   VETERINARY PARASITOLOGY

Wolbachia , doxycycline and macrocyclic lactones: New prospects in the treatment of canine heartworm disease

(2018) L. Kramer et al.   VETERINARY PARASITOLOGY

Clinical validation of molecular markers of macrocyclic lactone resistance in Dirofilaria immitis

(2018) Cristina Ballesteros et al.   International Journal for Parasitology-Drugs and Drug Resistance

Canine and feline dirofilariosis in a highly enzootic area: first report of feline dirofilariosis in Greece

(2018) Anastasia Diakou et al.   PARASITOLOGY RESEARCH

Efficacy of oral moxidectin against susceptible and resistant isolates of Dirofilaria immitis in dogs

(2017) Tom L. McTier et al.   Parasites & Vectors

Does evaluation of in vitro microfilarial motility reflect the resistance status of Dirofilaria immitis isolates to macrocyclic lactones?

(2017) Mary J. Maclean et al.   Parasites & Vectors

A diagnostic algorithm for evaluating cases of potential macrocyclic lactone–resistant heartworm

(2017) Andrew R. Moorhead et al.   Parasites & Vectors

Clinical benefits of incorporating doxycycline into a canine heartworm treatment protocol

(2017) C. Thomas Nelson et al.   Parasites & Vectors

Genetic profiles of ten Dirofilaria immitis isolates susceptible or resistant to macrocyclic lactone heartworm preventives

(2017) Catherine Bourguinat et al.   Parasites & Vectors

Examination of the “susceptibility gap” in the treatment of canine heartworm infection

(2017) Dwight D. Bowman et al.   Parasites & Vectors

Evaluation of the larval migration inhibition assay for detecting macrocyclic lactone resistance in Dirofilaria immitis

(2017) Christopher C. Evans et al.   VETERINARY PARASITOLOGY

Dirofilaria infections in dogs in different areas of Greece

(2016) Anastasia Diakou et al.   Parasites & Vectors

Efficacy of four commercially available heartworm preventive products against the JYD-34 laboratory strain of Dirofilaria immitis

(2016) Byron L. Blagburn et al.   Parasites & Vectors

The emergence of macrocyclic lactone resistance in the canine heartworm, Dirofilaria immitis.

(2015) ADRIAN J. WOLSTENHOLME et al.   PARASITOLOGY

Laboratory Evaluation of the Efficacy of 10 % Imidacloprid + 2.5 % Moxidectin Topical Solution (Advantage® Multi, Advocate®) for the Treatment of Dirofilaria immitis Circulating Microfilariae in Dogs

(2015) Dwight D. Bowman et al.   PARASITOLOGY RESEARCH

Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance

(2015) Catherine Bourguinat et al.   VETERINARY PARASITOLOGY

Establishment of macrocyclic lactone resistant Dirofilaria immitis isolates in experimentally infected laboratory dogs

(2014) Cassan N Pulaski et al.   Parasites & Vectors

Heartworm ‘lack of effectiveness’ claims in the Mississippi delta: Computerized analysis of owner compliance – 2004–2011

(2014) Clarke E. Atkins et al.   VETERINARY PARASITOLOGY

Effects of doxycycline on heartworm embryogenesis, transmission, circulating microfilaria, and adult worms in microfilaremic dogs

(2014) J.W. McCall et al.   VETERINARY PARASITOLOGY

High level expression of a glutamate-gated chloride channel gene in reproductive tissues of Brugia malayi may explain the sterilizing effect of ivermectin on filarial worms

(2014) Ben Wen Li et al.   International Journal for Parasitology-Drugs and Drug Resistance

Development of an in vitro bioassay for measuring susceptibility to macrocyclic lactone anthelmintics in Dirofilaria immitis

(2013) Christopher C. Evans et al.   International Journal for Parasitology-Drugs and Drug Resistance

Human and Animal Dirofilariasis: the Emergence of a Zoonotic Mosaic

(2012) F. Simon et al.   CLINICAL MICROBIOLOGY REVIEWS

Macrocyclic Lactones in the Treatment and Control of Parasitism in Small Companion Animals

(2012) Thomas J. Nolan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets

(2012) Christelle Godel et al.   FASEB JOURNAL

Heartworms, macrocyclic lactones, and the specter of resistance to prevention in the United States

(2012) Dwight D Bowman   Parasites & Vectors

Dirofilaria immitis and Wolbachia pipientis: a thorough investigation of the symbiosis responsible for canine heartworm disease

(2011) Jake McHaffie   PARASITOLOGY RESEARCH

Evidence for Macrocyclic Lactone Anthelmintic Resistance in Dirofilaria immitis

(2011) Timothy G. Geary et al.   Topics in Companion Animal Medicine

Correlation between loss of efficacy of macrocyclic lactone heartworm anthelmintics and P-glycoprotein genotype

(2011) Catherine Bourguinat et al.   VETERINARY PARASITOLOGY

Genetic polymorphism in Dirofilaria immitis

(2011) Catherine Bourguinat et al.   VETERINARY PARASITOLOGY

Macrocyclic lactone resistance in Dirofilaria immitis

(2011) Catherine Bourguinat et al.   VETERINARY PARASITOLOGY

Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi

(2010) Y. Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding Feline Heartworm Infection: Disease, Diagnosis, and Treatment

(2010) Alice C.Y. Lee et al.   Topics in Companion Animal Medicine

Epidemiological survey of canine heartworm disease on the island of Gran Canaria (Canary Islands – Spain) between 2000 and 2008

(2010) J.A. Montoya-Alonso et al.   VETERINARY PARASITOLOGY

Heartworm Biology, Treatment, and Control

(2009) Dwight D. Bowman et al.   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

An Analysis of Genetic Diversity and Inbreeding in Wuchereria bancrofti: Implications for the Spread and Detection of Drug Resistance

(2008) Thomas S. Churcher et al.   PLoS Neglected Tropical Diseases